The value of ultrasound contrast agents (USCA) in everyday clinical practice depends on the pharmacokinetics, the signal processing, and the contrast-specific imaging modalities. Second-generation USCA, are blood pool agents that do not leak into the organ tissue to be examined but remain in the intravascular compartment increasing the Doppler signal amplitude during their dynamic vascular phase. Taking advantage of the stability of their microbubbles, they can withstand the acoustic pressure of insonation much better than first-generation contrast media, which results in an increased half-life of the agent and, consequently, in a prolonged diagnostic window. Concomitant with the improvement of contrast agents, different contrast-specific imaging modalities have been developed which, used in combination with USCA and a low mechanical index, allow continuous real-time grey-scale imaging. These recent technical improvements have opened new possibilities in the use of USCA in a variety of indications. Written by internationally renowned experts, the contributions gathered in this book give an overview of current and possible future new applications of USCA in routine and clinical practice.
X-ray imaging is a corner stone of breast cancer diagnosis. By exploiting the phase shift of X-rays rather than their attenuation, phase-contrast tomography has the potential to dramatically increase the visibility of small and low contrast features, thus leading to better diagnosis. This thesis presents research on the first synchrotron-based project developing a clinical phase-contrast breast computed tomography (CT) setup at Elettra, the Italian Syncrotron Radiation Facility. This book includes a comprehensive theoretical background on propagation-based phase-contrast imaging, exploring and extending the most recent image formation models. Along with theory, many practical implementation and optimization issues, ranging from detector-specific processing to setup geometry, are tackled on the basis of a large number of experimental evidences. Most of the modelling results and data analysis have general validity, being a valuable framework for optimization of phase-contrast setups. Results obtained at synchrotron are also compared with "real world" laboratory sources: both a first-of-its-kind comparison with one of the few hospital breast CT systems and a state-of-the-art implementation of monochromatic phase-contrast micro-tomography with a conventional rotating anode source are presented. On a more general level, this work sheds a light on the importance of synchrotron-based clinical programs, which are key to trigger the long-anticipated transition of phase-contrast imaging from synchrotrons to hospitals.
Technological advancements are contributing to shape future business models and the industrial scenario. Companies face the challenge of having to adapt to the frequently shifting technology landscape. Therefore, organizations must exploit technological advances to thrive in the digital revolution. This book presents and discusses emerging digital business models in the Industry 4.0. These models are illustrated with real case studies and include data-driven, platform, smart factory and servitization among others. The book introduces a detailed classification to help organizations to redesign their current business models and discusses how to gain unique competitive advantages. The book includes not only theoretical concepts to understand the context of digital transformation but also an assessment framework to enable and support innovation in organizations and create new revenue streams. The book will be of interest to students and professionals alike who want to understand the core of the Industry 4.0.
By developing object calculi in which objects are treated as primitives, the authors are able to explain both the semantics of objects and their typing rules, and also demonstrate how to develop all of the most important concepts of object-oriented programming languages: self, dynamic dispatch, classes, inheritance, protected and private methods, prototyping, subtyping, covariance and contravariance, and method specialization. An innovative and important approach to the subject for researchers and graduates.
How 16th century Venetian silk manufacturers met the challenge of demand for lighter and cheaper fabric. The manufacture of luxury textiles, such as silk, was central to an Italian Renaissance economy based on status and conspicuous consumption. From the rapidly changing fashions that drove demand to the jobs created for craftsmen, weavers, and merchants, the wealth and prestige associated with silk throughout Europe made it Italy's leading export industry. In this important book, Luca Molà examines the silk industry in Renaissance Venice amid changing markets, suppliers, producers, and government regulations. Drawing on archival research and a vast amount of European scholarship, Molà documents the innovations Venetians made in manufacturing and marketing to spur the silk industry. He uncovers the alliance between manufacturers and government to promote the industry in a changing international economic environment. Through flexible laws, quality was regulated to meet the varying requirements of an increasing range of customers. Molà also analyzes state policy that favored the development and organization of silk producers throughout the Terraferma. His findings contribute in an important way to the ongoing scholarly assessment of Venice's place in the economy of the Renaissance and the Mediterranean world.
Recent decades have seen many economic history books and articles published about working men and women, small and big entrepreneurs, guilds and state manufactures, farmers and journeymen, and children and citizens. Studies have been conducted both at a macro and a micro level, at a global and at a local scale and with regional and national approaches aimed at analysing cultural, social and economic phenomena associated with the world of work. Yet, there is still new ground to be covered. This book aims to fill a gap in early modern history by presenting new insights in the study of global labour history. It considers the whole Italian peninsula as one geographical unit of analysis, encompassing all of the features that characterize labour cultures during the early modern period. It details the evolution of forms of labour in both agriculture and manufacture and the role of labour as an economic, social and cultural factor in the evolution of the Italian area.
Untangling Smart Cities: From Utopian Dreams to Innovation Systems for a Technology-Enabled Urban Sustainability helps all key stakeholders understand the complex and often conflicting nature of smart city research, offering valuable insights for designing and implementing strategies to improve the smart city decision-making processes. The book drives the reader to a better theoretical and practical comprehension of smart city development, beginning with a thorough and systematic analysis of the research literature published to date. It addition, it provides an in-depth understanding of the entire smart city knowledge domain, revealing a deeply rooted division in its cognitive-epistemological structure as identified by bibliometric insights. Users will find a book that fills the knowledge gap between theory and practice using case study research and empirical evidence drawn from cities considered leaders in innovative smart city practices.
Reconnect With Your Inner WildFrom wild harvesting, finding your own paths and reading hiking guides, to just stepping outside and appreciating nature, Re-Wild brings you 50 practices to bringing nature home. Book a stay here! Beginner’s hiking guide to pro wild harvesting. Divided by levels of difficulty, this nature guide book gives swaths of practical advice. From simple things like how to feel at home in nature and learning fun nature facts to finding a trail if you’re lost to foraging plants, mushrooms, herbs, or wild harvesting knick-knacks on nature trails, this hiking book has something to teach you. Connect with nature. In the day-to-day, we can lose ourselves in the stress and anxiety of the world we have built. Nature is enough to help you reconnect physically and spiritually to your roots. Simple practices such as taking a walk in the woods or swimming in a cold lake can help you to get outside your head and become one with nature. Immerse yourself in the beautiful images of places you've never been and find the most primitive form of peace we have ever known with Re-Wild. Inside Re-Wild, you’ll find: 50 accessible and simple practices to reconnect with nature A stirring mix of evocative illustrations and photographs Tips on everything from wild harvesting to mindfulness, helping readers from both a practical and conceptual point of view If you liked The Nature Fix, Surviving the Wild, or The Forager’s Guide to Wild Foods, you’ll love Re-Wild.
THE LANDMARK GUIDE TO ADULT CARDIAC, CONGENITAL CARDIAC, AND GENERAL THORACIC SURGERY--COMPLETELY UPDATED AND REVISED IN FULL COLOR An essential guide for daily clinical practice and a thorough review for the cardiothoracic boards, Johns Hopkins Textbook of Cardiothoracic Surgery is filled with authoritative guidance on surgical techniques and pre- and postoperative strategies for managing cardiothoracic disease. The content of this trusted classic reflects the rapidly changing field of cardiothoracic surgery. In addition to the basic curriculum required for certification, you will find coverage of advanced concepts, controversial issues, and new technologies. Johns Hopkins Textbook of Cardiothoracic Surgery provides an in-depth look at the full-spectrum of disorders and their surgical and medical management options, including congenital, acquired, and neoplastic diseases. Supporting this detailed coverage is an easy-to-navigate design and step-by-step explanations of the most complex operations. THE SECOND EDITION IS HIGHLIGHTED BY: NEW board review Q&A Ten NEW chapters including: Surgical Therapies for Atrial Fibrillation, Management of Adults with Congenital Heart Disease, and Stem Cells for Cardiac Surgical Disease NEW full-color illustrations An increased number of decision-making flow charts that will prove valuable when preparing for cases and examinations Key Concepts that highlight epidemiology, pathophysiology, clinical features, diagnostic and treatment strategies, and outcomes for each topic NOTE: This book was previously known as the Johns Hopkins Manual of Cardiothoracic Surgery but the second edition has been renamed to better reflect its scope and comprehensive nature.
The value of ultrasound contrast agents (USCA) in everyday clinical practice depends on the pharmacokinetics, the signal processing, and the contrast-specific imaging modalities. Second-generation USCA, are blood pool agents that do not leak into the organ tissue to be examined but remain in the intravascular compartment increasing the Doppler signal amplitude during their dynamic vascular phase. Taking advantage of the stability of their microbubbles, they can withstand the acoustic pressure of insonation much better than first-generation contrast media, which results in an increased half-life of the agent and, consequently, in a prolonged diagnostic window. Concomitant with the improvement of contrast agents, different contrast-specific imaging modalities have been developed which, used in combination with USCA and a low mechanical index, allow continuous real-time grey-scale imaging. These recent technical improvements have opened new possibilities in the use of USCA in a variety of indications. Written by internationally renowned experts, the contributions gathered in this book give an overview of current and possible future new applications of USCA in routine and clinical practice.
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