Eggs of all animals contain mRNAs and proteins that are supplied to or deposited in the egg as it develops during oogenesis. These maternal gene products regulate all aspects of oocyte development, and an embryo fully relies on these maternal gene products for all aspects of its early development, including fertilization, transitions between meiotic and mitotic cell cycles, and activation of its own genome. Given the diverse processes required to produce a developmentally competent egg and embryo, it is not surprising that maternal gene products are not only essential for normal embryonic development but also for fertility. This review provides an overview of fundamental aspects of oocyte and early embryonic development and the interference and genetic approaches that have provided access to maternally regulated aspects of vertebrate development. Some of the pathways and molecules highlighted in this review, in particular, Bmps, Wnts, small GTPases, cytoskeletal components, and cell cycle regulators, are well known and are essential regulators of multiple aspects of animal development, including oogenesis, early embryogenesis, organogenesis, and reproductive fitness of the adult animal. Specific examples of developmental processes under maternal control and the essential proteins will be explored in each chapter, and where known conserved aspects or divergent roles for these maternal regulators of early vertebrate development will be discussed throughout this review. Table of Contents: Introduction / Oogenesis: From Germline Stem Cells to Germline Cysts / Oocyte Polarity and the Embryonic Axes: The Balbiani Body, an Ancient Oocyte Asymmetry / Preparing Developmentally Competent Eggs / Egg Activation / Blocking Polyspermy / Cleavage/ Mitosis: Going Multicellular / Maternal-Zygotic Transition / Reprogramming: Epigenetic Modifications and Zygotic Genome Activation / Dorsal-Ventral Axis Formation before Zygotic Genome Activation in Zebrafish and Frogs / Maternal TGF-β and the Dorsal-Ventral Embryonic Axis / Maternal Control After Zygotic Genome Activation / Compensation by Stable Maternal Proteins / Maternal Contributions to Germline Establishment or Maintenance / Perspective / Acknowledgments / References
In 1907 the Probation of Offenders Act introduced a system which allowed offenders to be rehabilitated at home under supervision, rather than being sent to prison. This book explores how the probation system was used to regulate the private lives, emotions and behaviours of people in Britain between 1907 and 1962. Access to the private sphere, both physically and psychologically, meant that the probation system was particularly well-suited to offences related to intimate and personal relations. With each chapter focusing on a particular type of offence, including wife assault, attempted suicide, male sexual offences and female prostitution, Settle shows how experiences of the probationers were shaped by the everyday practices of probation, and assesses the extent to which probation was successful in rehabilitating offenders and protecting the public. Also examining the role of probation officers in marriage reconciliation, the book explores how ideas about gender and domesticity were crucial to both the process of rehabilitation and the endeavour to make the home a safe environment in which these domestic ideals could come into fruition. Probation and Policing of the Private Sphere in Britain enriches our understanding of the role of the state in policing, monitoring and promoting the well-being of its citizens, and explores the nuances of probation's dual purpose as a form of social control as well as a social work service designed to help the most vulnerable in society.
A Tale of Uncharted Love on the Open Seas In this enchanting and highly original retelling of Jane Austen's Pride and Prejudice, Elizabeth Bennet sets out for the new world aboard the grand ship Pemberley's Promise. She's prepared for an uneventful voyage until a chance encounter with the handsome, taciturn Mr. Darcy turns her world upside down. When Elizabeth falls ill, Darcy throws convention overboard in a plan that will bind them to each other more deeply than he ever could have imagined. But the perils of their ocean voyage pale in comparison to the harsh reality of society's rules that threaten their chance at happiness. When they return to the lavish halls of England, will their love survive? What readers say: "Kara Louise is an incredible storyteller." "Such a sweet and romantic 'what if' scenario for Pride and Prejudice fans! A must have for your P&P library!" "Romantic, creative, and witty.
A masterful and deeply troubling exposé, Witness is the culmination of almost five years' work for award-winning investigative journalist Louise Milligan. Charting the experiences of those who have the courage to come forward and face their abusers in high-profile child abuse and sexual assault cases, Milligan was profoundly shocked by what she found. During this time, the #MeToo movement changed the zeitgeist, but time and again during her investigations Milligan watched how witnesses were treated in the courtroom and listened to them afterwards as they relived the associated trauma. Then she was a witness herself in the trial of the decade, R v George Pell. Through these experiences, interviews with high-profile members of the legal profession, including judges, prosecutors and the defence lawyers who have worked in these cases, along with never-before-published court transcripts, Milligan lays bare the flaws that are ignored and exposes a court system that is sexist, unfeeling and weighted towards the rich and powerful. In Witness, Milligan reveals the devastating reality that within the Australian legal system truth is never guaranteed and, for victims, justice is often elusive. And even when they get justice, the process is so bruising, they wish they had never tried.
The only guide to cover the whole application process, from choosing a course to results day, plus essential insider advice from admissions tutors Large target audience - over 200,000 people apply for creative arts courses each year A whole chapter dedicated to architecture, an increasingly popular course, including specific preparation and personal statement advice
Incredible in its attention to detail, this history of Tazewell County, Virginia—its people, towns, development, and progress—will prove a valuable addition to the libraries of natives, historians, and genealogists alike. The work delves into the original settling of the region and the discovery of vast coal deposits, especially the Pocahontas Coal Field.
Recent years have seen a burgeoning of novels that respond to the environmental issues we currently face. Among these, Louise Squire defines environmental crisis fiction as concerned with a range of environmental issues and with the human subject as a catalyst for these issues. She argues that this fiction is characterized by a thematic use of "death," through which it explores a "crisis" of both environment and self. Squire refers to this emergent thematic device as "death-facing ecology". This device enables this fiction to engage with a range of theoretical ideas and with popular notions of death and the human condition as cultural phenomena of the modern West. In doing so, this fiction invites its readers to consider how humanity might begin to respond to the crisis.
Three Heroines of New England Romance: Their true Stories herein set forth by Mrs Harriet Spoffard, Miss Louise Imogen Guiney, and Miss Alice Brown: Priscilla by Harriet Prescott Spofford. Agnes Surriage by Alice Brown. Martha Hilton by Louise Imogen Guiney. Notes by Edmund H. Garrett. Harriet Elizabeth Prescott Spofford was an American writer of novels, poems and detective stories. One of the United States's most widely-published authors,her career spanned more than six decades and included many literary genres, such as short stories, poems, novels, literary criticism, biographies, and memoirs. She also wrote articles on household decorative art and travel as well as children's literature. Louise Imogen Guiney was an American poet, essayist and editor, born in Roxbury, Massachusetts. Alice Brown was an American novelist, poet and playwright, best known as a writer of local color stories. She also contributed a chapter to the collaborative novel, The Whole Family (1908).
Relevant for experienced and emerging social work and human service practitioners alike, this book explores the uniquely challenging, yet seemingly ubiquitous issue of youth violence. It provides an authentic and accessible discussion of the theories and evidence that inform practice with youth violence alongside the voices of practitioners and the young people they work with. These voices are drawn from work with the Name.Narrate.Navigate (NNN) program for youth violence. NNN provides a trauma-informed, culturally safe preventive-intervention for young people who use and experience violence, and specialist training for the workers who support them. The program embraces creative methods as a bridge between contemporary evidence on trauma and violence and Aboriginal healing practice. The dual focus of the program is informed and interconnected by action research involving Aboriginal Elders and community members, practitioners, and key service stakeholders, including young people with a lived experience of violence. This book is ideal for use in professional cross-disciplinary programs, such as criminology, sociology, social work, and psychology, across post-secondary, vocational, and university sectors.
A soldier’s daughter unravels the secrets of her father’s experience in the Pacific Theater in this “graceful, understated” World War II memoir for fans of The Things They Carried (The New York Times Book Review) Louise Steinman’s American childhood in the fifties was bound by one unequivocal condition: “Never mention the war to your father.” That silence sustained itself until the fateful day Steinman opened an old ammunition box left behind after her parents’ death. In it, she discovered nearly 500 letters her father had written to her mother during his service in the Pacific War and a Japanese flag mysteriously inscribed to Yoshio Shimizu. Setting out to determine the identity of Yoshio Shimizu and the origins of the silken flag, Steinman discovered the unexpected: a hidden side of her father, the green soldier who achingly left his pregnant wife to fight for his life in a brutal 165-day campaign that changed him forever. Her journey to return the “souvenir” to its owner not only takes Steinman on a passage to Japan and the Philippines, but also returns her to the age of her father’s innocence, where she learned of the tender and expressive man she’d never known. Steinman writes with the same poignant immediacy her father did in his letters. Together, their stories in The Souvenir create an evocative testament to the ways in which war changes one generation and shapes another.
New York Times bestselling author SQuire Rushnell and his wife Louise DuArt share 21 brand-new and 9 classic true-life stories of extraordinary “Godwinks” at Christmastime, proving that what some thought was “coincidence” wasn't coincidence at all, but a supernatural “hotline” from God. Think back to when you were a kid and someone you loved gave you a little wink across the dining room table, like Mom or Dad or Grandma. You didn't say, “What do you mean by that?” You knew. It meant: “Hey kid, I'm proud of you.” That's what a Godwink is: a message of reassurance from above, directly to you, out of seven billion people on the planet, saying “Hey kid...I have you on my mind right now. I love you. You’re never alone.” A Godwink can be an unexpected connection to someone you love, a mysterious pathway to a life-changing opportunity, unanticipated income out of the blue, or an answered prayer that makes you say “wow”! Godwinks let you know that God is always extending you a tangible connection to Him, like a firm handrail on dark, wobbly stairs. Now, just in time for the holiday season, comes Godwinks Christmas Stories, a collection of astonishing true-life stories centered around Christmas that demonstrate how God has shown Himself in the lives of others. He’ll do the same for you. Husband and wife authors SQuire Rushnell and Louise DuArt remind you that Godwinks are like wondrous gifts left on your doorstep. Their aim with this book is to help you open the door and open your gifts of hope and encouragement.
Peter Cook has a good life as a bound boy by a master who treats him like a son. Everything changes the day that Peter discovers that his master has died of the black plague and he is thrown out of the great house. Peter soon meets a group of people called Separatists—because they have chosen to separate from the established Church of England. Join young Peter and his friends, as they make the long and dangerous trip across the Atlantic Ocean. There they meet the Native American people whom they called Indians. Peter befriends one of them, Squanto, and celebrates the first Thanksgiving as a Pilgrim.
I practise my shock-horror face in the mirror for the seventh time. 'My husband, he's . . . dead.' Bethan Phillips has only one thing on her mind: killing her rich and elderly husband for his fortune. But after several thwarted attempts, it is a horrific accident while holidaying together in Snowdonia that takes Humphrey down. Now she must pretend he's alive, continuing social gatherings alone under the guise he is undertaking business abroad. Because someone witnessed her leaving Humphrey to die, and should the police investigate his death they'll discover the series of 'accidents' he's survived in the previous few days... and it won't take them long to connect the dots. There are many reasons Bethan would rather the police didn't look too closely at her. Or the life she lived before becoming Bethan Philips. Unfortunately for her, DI Emma Locke is on the case. A gripping new psychological thriller, Kiss Me, Kill Me is smart, sly and unforgettable. You won't be able to put it down. What readers are saying about Kiss Me, Kill Me: 'Kiss Me, Kill Me is fantastic! Strong characters and a story with some laugh out loud moments!' - 5* reader review 'OH baby!!! This was a great psychological thriller! It had a strong female lead and will leave you wanting more!' - 5* reader review 'Wow this book will take you on a twisty road of physiological turns and murder. It was perfect from start to finish' - 4* reader review 'Oh this was a good read! Murder, mystery and intrigue just oozes out the pages' - 5* reader review 'An excellent psychological thriller that will leave you on the edge of your seat until the last page' - 5* reader review 'An in-your-face thriller. Great book that really gets in your head' - 5* reader review 'This was a fast paced read with lots of amazing twists... A great psychological thriller that will keep you gripped from the first page until the end!' - 4* reader review
London. A mother's world falls apart the day the police come knocking to tell her that her son is dead. Murdered, apparently without motive, outside a fast food restaurant. But when a witness comes forward, Honour realises her beloved son had a secret life beyond anything she imagined... Newport. When a hit and run incident nearly kills Sinead and her children, she is forced to face the truth. Someone wants her dead. She knows exactly what he looks like. But he seems to know her too. All her secrets. All her lies. Everything she tried to leave behind. Something connects these two cases. And as the stakes rise, DI Locke must untangle the web of deceit – before someone else dies. I Know You is the first in a gripping new crime thriller series featuring DI Emma Locke, perfect for fans of Cara Hunter and Carol Wyer.
This book is to give credit to those immigrants who contributed to the growth and economic development of Blackford County. Indiana when oil and gas were discovered here in the late 19th century. In the immigrants eyes this was the fulfillment of their dreams to come to a new hand and have the opportunity for a better life for themselves and their families. Truly, America was a Melting Pot and our small community proves that.
Certainly Miles Standish was not of the demigods, if he was of the heroes. No Puritan ascetic he, by nature or belief. One might imagine him some soul that failed to find incarnation among the captains and pirates of the great Elizabeth’s time, the Raleighs and Drakes and Frobishers, and who, coming along a hundred years too late, did his best to repair the mistake. A choleric fellow, who had quarrelled with his kin, and held himself wronged by them of his patrimony; of a quarrelsome race, indeed, that had long divided itself into the Catholic Standishes of Standish and the Protestant Standishes of Duxbury; a soldier who served the Queen in a foreign garrison, and of habits and tastes the more emphasized because he was a little man; supposed never to have been of the same communion as those with whom he cast in his lot,—it is not easy to see the reason of his attraction to the Pilgrims in Holland. Perhaps he chose his wife, Rose, from among them, and so united himself to them; if not that, then possibly she herself may have been inclined to their faith, and have drawn him with her; or it may have been that his doughty spirit could not brook to see oppression, and must needs espouse and champion the side crushed by authority. For the rest, at the age of thirty-five the love of adventure was still an active passion with him. That he was of quick, but not deep affections is plain from the swiftness with which he would fain have consoled himself after the death of Rose, his wife; and, that effort failing, by his sending to England for his wife’s sister Barbara, as it is supposed, and marrying her out of hand. That he was behind the spirit of the movement with which he was connected may be judged by his bringing home and setting up the gory head of his conquered foe; for although he was not alone in that retrograde act, since he only did what he had been ordered to do by the elders, yet the holy John Robinson, the inspirer and conscience of them all, cried out at that, “Oh that he had converted some before he killed any!” Nevertheless, that and other bloody deeds seem to have been thoroughly informed with his own satisfaction in them. His armor, his sword, his inconceivable courage, his rough piety, that “swore a prayer or two,”—all give a flavor of even earlier times to the story of his day, and bring into the life when certain dainties were forbidden, as smacking of Papistry, a goodly flavor of wassail-bowls, and a certain powerful reminiscence of the troops in Flanders. That such a nature as the fiery Captain’s could not exist without the soothing touch of love, could not brook loneliness, and could not endure grief, but must needs arm himself with forgetfulness and a new love when sorrow came to him in the loss of the old, is of course to be expected. If he were a little precipitate in asking for Priscilla’s affection before Rose had been in her unnamed grave three months, something of the blame is due to the condition of the colony, which made sentimental considerations of less value than practical ones,—an evident fact, when Mr. Winslow almost immediately on the death of his wife married the mother of Peregrine White, not two months a widow, hardly more a mother.
EPDF and EPUB available Open Access under CC-BY-NC licence. Based on groundbreaking original research, this book provides a comprehensive account of the issues surrounding pregnancy and parenthood for young people in and leaving care. Featuring the voices of care-experienced parents, together with reflections from practitioners, it offers valuable insights into the issues facing this group. Using qualitative data to explore why parenthood is such an important issue for young people in and leaving care, this book shows what can be learned from their experiences in order to improve outcomes for parents and children in the future. The author highlights the practical and emotional needs of care-experienced parents and gives clear advice for practitioners on how these needs might be better addressed through summary points, practice guidance and recommendations for policy and practice.
PHYSICS. Visually interesting and easy to understand. This series presents basic physical science by asking a question, answering it, then giving three hands-on activities to try. Ages 9+
Each state government produces large varieties and quantities of useful information that are largely unknown outside their state of origin. This book leads the public to the most useful information sources produced by each state, as well as to depository libraries that will facilitate more effective research. For each of the 50 states, important publications are detailed, along with information on how to obtain them. The publications' topics range from crime statistics to vital statistics, business statistics, health information, statistical abstracts, education directories, state budgets, economic indicators, state laws and legal information, and more. Tapping State Government Information Sources has a broader focus than previously published books in this subject area, most of which have focused solely on depository laws, useful state publications, or indexes to state publications. This book covers all three. The first chapter describes print and electronic sources that provide information about all 50 states. Each state's resources are then described in individual chapters. When possible, information about how to order a copy of the source is given, as are Web addresses for titles that are available online. At the beginning of each state chapter, the state's legal definition of public document or its equivalent is given, which may be of interest to librarians in states that are reexamining their own depository laws.
This work provides access to approximately 5,000 reviews of English-language mathematical books published in North America. Included are works on mathematics, science, philosophy, and education appearing in the periodical literature from 1800 to 1940. It covers materials not reviewed in Book Review Index and Book Review Digest. It predates Mathematical Reviews, which first appeared in 1940. Books on all aspects of mathematics are included. There are subject, reviewer, and title indexes.
Brennan, Canning & McDowell cover both the theory and practice of global business-to-business (b2b) marketing from a European perspective, illuminating the subject with a wide range of learning features and case studies. New to the 5th edition: Coverage throughout of digital transformation and social responsibility in business markets ‘Scenario’ boxes which provide reflective decision-based situations for students to think through, helping them prepare for future roles. Examples and case studies covering ethics and bribery, circular economy, machine learning, artificial intelligence and blockchain to reflect developments in the b2b marketing environment Further and updated company content, including brands such as Barry Callebaut, Embraer, Flokk, Givaudan, ING, Ingersoll Rand and Pret-a-Manger Updated online resources, including author-selected SAGE journal articles and videos supporting each chapter.
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