These volumes represent the "state-of-the-art" in morphological methods for detection of steroid receptors. In Volume I we have attempted to collect current available methods and experimental approahes which might be useful in solving present enigmas. The background and recent advances presented are intended to stimulate further experimentation and new innovations, and spur clinical trials by all investigators with an interest in steroid hormones, cell biology, and clinical oncology.
A comprehensive review of the literature on steroid hormone receptor immuncytochemistry. It includes the development of the first monoclonal antireceptor antibody and initial procedures designed to localize steroid receptors in situ up to the present. The step-by-step instructions provide easy reading of topics such as tissue handling, processing, and interpretation. This text places particular emphasis on the studies of human material-especially mammary carcinoma. It presents specific details with chapters on estrogen and progesterone receptors in breast malignancies and benign breast disease. Each section of this outstanding book contains comprehensive photomicrographs that illustrate the most salient features discussed. Detailed graphs pertaining to theoretical particulars concerning technology and the relationship between image analysis and endocrine response are also included. This monograph is an excellent resource for all researchers concerned with hormone-dependent tissues, pathologists who have an interest in working with novel techniques for localizing steroid hormone receptors, and oncologists who must use assay results in the treatment of breast cancer.
These volumes represent the "state-of-the-art" in morphological methods for detection of steroid receptors. In Volume I we have attempted to collect current available methods and experimental approahes which might be useful in solving present enigmas. The background and recent advances presented are intended to stimulate further experimentation and new innovations, and spur clinical trials by all investigators with an interest in steroid hormones, cell biology, and clinical oncology.
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