Jean Bodin was a figure of great importance in European intellectual history, known as a jurist, associate of kings and courtiers in sixteenth-century France, and author of influential works in the fields of constitutional and social thought, historical writing, witchcraft, and a great deal else besides. Best known for his contribution to formulating the modern doctrine of sovereignty, Bodin was a scholar of exceptional range, whose works provoked controversy in his own time and have continued to do so down the centuries. Hugh Trevor-Roper described him as 'the Aristotle, the Montesquieu of the sixteenth century, the prophet of comparative history, of political theory, of the philosophy of law, of the quantitative theory of money, and of so much else'. Much has been written on Bodin and his ideas, but in this new intellectual biography, Howell A. Lloyd presents the first rounded treatment of the thinker and his times, his writings (major and minor), and his ideas in their contemporary context, as well as in that of broader intellectual traditions.
Neuropeptides and peptide hormones represent the largest class of chemical messengers that transmit information from one cell to another. In this review, several decades of research on peptides in cell-cell signaling are summarized, with a focus on neuropeptide discovery, biosynthesis, and function. In addition to covering the well-studied aspects of neuropeptides, emerging concepts are discussed, including classical versus non-classical neuropeptides and direct versus indirect neuropeptides. Other potential functions for peptides in intercellular and intracellular signaling are also discussed.
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