Equine sarcoids (ES) and equine malignant melanoma (EMM) are among the tumors affecting horses diagnosed most frequently. Both cutaneous neoplasms can be a significant cause of economic losses, morbidity and mortality in the animals. The treatment of equine skin cancer can be challenging and established, evidence-based therapies resulting in sustained tumor regression are rare. The pentacyclic, lupane-type triterpenes betulinic acid (BA) and betulin can be isolated from many botanical sources, predominantly from the bark of white birch and plane trees. In addition to various biological properties, they have gained attention mainly due to their anticancer features. Within the framework of the current PhD project, the compounds BA, BA derivative NVX-207, and betulin derivative betulinyl-bis-sulfamate were assessed in various in vitro and in vivo studies for their potential as a topical therapy for ES and EMM. In conclusion, the results generated from cell culture experiments, skin permeation assays and studies in the target species are promising. Further advancement of the investigational medicinal products studied herein could lead to an effective topical and marketable, novel drug which helps to relieve suffering and, consequently, improve the welfare of equine skin cancer patients.
This book examines the late sixteenth- and early seventeenth-century engagement with a crucial part of Britain's past, the period between the withdrawal of the Roman legions and the Norman Conquest. A number of early modern plays suggest an underlying continuity, an essential English identity linked to the land and impervious to change. This book considers the extent to which ideas about early modern English and British national, religious, and political identities were rooted in cultural constructions of the pre-Conquest past.
Advances in cytogenetics continue to crop up in wonderful ways, and we know exponentially more about chromosomes now than mere decades ago. Likewise, the necessary skills in offering genetic counseling continue to evolve. This new edition of Chromosome Abnormalities in Genetic Counseling offers a practical, up-to-date guide for the genetic counselor to marshal cytogenetic data and analysis clearly and effectively to families.
An exploration of the importation of French political thought into England during the last decades of Elizabeth's reign. The French Religious Wars generated a large body of political propaganda from the Huguenots, the Politiques (a Huguenot-Catholic confederacy) and the Catholic League. Dr. Parmelee discusses how, in the last decades of the reign ofElizabeth I some 130 translated documents were imported into England, most of them - originating from the Politiques, written in support of the Protestant Henry of Navarre's accession to the French throne-advocating religious tolerance as a way to peace. She argues that while most English political thinkers did not openly embrace or articulate the absolutist ideas often expressed in these writings, they had a wide impact on political discourse in the lateElizabethan period. They were useful against foreign enemies, Catholic recusants and Presbyterians, but particularly, in a time of fear of civil war engendered by an unsettled succession, they helped to establish an intellectualclimate conducive to the later development of Stuart absolutism. Dr. Lisa Ferraro Parmelee teaches in the Department of History at Villanova University.
Introducing the newest comprehensive reference designed specifically for the growing specialty of hospital-based pediatrics. This comprehensive new reference not only brings you the most up-to-date, evidence-based approaches to hospital-based pediatric care, but also covers issues related to staffing a unit; financial, legal and ethical topics, and how a hospitalist program communicates and relates to its referring providers and consulting staff. You'll find it a vital addition to the shelf of anyone who cares for pediatric patients in the hospital. Implement today's best evidence and literature based approaches for a full range of clinical challenges. Easily locate information relevant to your particular areas of interest with comprehensively organized, highly formatted coverage. Make clinical decisions efficiently thanks to numerous diagnostic and therapeutic algorithms. See dermatologic conditions and physical signs and symptoms. Benefit from the experience of editors from two powerhouse institutions - Children's Hospital of Philadelphia and Children's Hospital of Boston.
Harwell Harris would have been pleased with Lisa Germany's book. . . . The quality of the man permeates the work. It is honest, forthright architecture. It is void of tricks. It uses simple materials in an unself-conscious manner. It places priorities on the user. The emphasis on plan in his practice is the thread that takes us from project to project as Germany weaves the Harris tale."--Ray Kappe, FAIA, Journal of the Society of Architectural Historians
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