The monograph provides a detailed and comprehensive presentation of the rich and beautiful theory of unilateral variational analysis in infinite dimensions. It is divided into two volumes named Part I and Part II. Starting with the convergence of sets and the semilimits and semicontinuities of multimappings, the first volume develops the theories of tangent cones, of subdifferentials, of convexity and duality in locally convex spaces, of extended mean value inequalities in absence of differentiability, of metric regularity, of constrained optimization problems.The second volume is devoted to special classes of non-smooth functions and sets. It expands the theory of subsmooth functions and sets, of semiconvex functions and multimappings, of primal lower regular functions, of singularities of non-smooth mappings, of prox-regular functions and sets in general spaces, of differentiability of projection mapping and others for prox-regular sets. Both volumes I and II contain, for each chapter, extensive comments covering related developments and historical comments.Connected area fields of the material are: optimization, optimal control, variational inequalities, differential inclusions, mechanics, economics. The book is intended for PhD students, researchers, and practitioners using unilateral variational analysis tools.
This book constitutes the refereed proceedings of the 8th International Conference on Model Driven Engineering Languages and Systems (formerly the UML series of conferences), MoDELS 2005, held in Montego Bay, Jamaica, in October 2005. The 52 revised full papers and 2 keynote abstracts presented were carefully reviewed and selected from an initial submission of 215 abstracts and 166 papers. The papers are organized in topical sections on process modelling, product families and reuse, state/behavioral modeling, aspects, design strategies, model transformations, model refactoring, quality control, MDA automation, UML 2.0, industrial experience, crosscutting concerns, modeling strategies, as well as a recapitulatory section on workshops, tutorials and panels.
The authors show how the pharmaceutical industry faces the development of dermal drugs and provide the only book of its kind that describes how the industry develops and selects dermal drugs, complete with the challenges and opportunities of the field. Delivery of drugs through the skin has been an attractive and challenging area for research, and advances in modern technologies have resulted in a larger number of drugs being delivered transdermally, including conventional hydrophobic small molecule drugs, hydrophilic drugs and macromolecules. Offering the perspective from the industrial side of selection and development of drugs, the primary audience is geared towards the pharmaceutical industry but can also offer valuable information to clinicians, compounding pharmacists, and similarly pharmacy students. Dermal Drug Selection and Development covers the scientific gaps that exist in terms of dermal pharmacokinetics and the resulting uncertainty by clinicians when choosing a drug candidate.
This monograph elucidates common legal principles underlying the use of juridical powers. It addresses both public law and private law, and examines both the common law and the civil law. It aims to provide a theory of how Western law regulates the situations in which we hold legal powers, not for ourselves, but for and on behalf of others. It does this by elucidating the justificatory principles that are attracted in those situations. These principles include that other-regarding powers can only properly be used for the purposes for which they were granted; that they should not be used when the holder is in a conflict of self-interest and duty, or a conflict of duty and duty; and that the holder is presumptively accountable for any profits extracted from the other-regarding role. These principles stand behind the detailed legal rules that govern these relationships in multiple legal systems and in multiple public and private settings. In private law this includes the powers of trustees, corporate directors, agents and mandataries; in public law it includes all powers held for public purposes, whether they be held by the Prime Minister, by a police officer, or by a judge.
In the early modern period, the term ‘enthusiasm’ was a smear word used to discredit the dissenters of the radical Reformation as dangerous religious fanatics. In England, the term gained prominence from the Civil War period and throughout the eighteenth century. Anglican ministers and the proponents of the Enlightenment used it more widely against Paracelsian chemists, experimental philosophers, religious dissenters and divines, astrologers or anyone claiming superior knowledge. But who exactly were these enthusiasts? What did they believe in and what impact did they have on their contemporaries? This book concentrates on the notorious case of the French Prophets as the epitome of religious enthusiasm in early Enlightenment England. Based on new archival research, it retraces the formation, development and evolution of their movement and sheds new light on key contemporary issues such as millenarianism, censorship and the press, blasphemy, dissent and toleration, and madness.
How to Find Out About the Victorian Period: A Guide to Sources of Information focuses on the Victorian period of Great Britain. The book first discusses the study of the Victorian period and general guides to the literature. The use of books, periodical articles, theses, and bibliographies in the study of this period in British history is emphasized. The text underscores the value of Victorian periodicals and newspapers in the study of the Victorian period. Guides to special collections and source materials on this period are discussed. These include guides to collection of books and manuscripts, libraries and their collections, archives and manuscripts, and government publications. The book also presents guides to the study of the Victorian church. These include encyclopedias and dictionaries, biographical works, and theses. Guides on the kind of education, development of science, visual arts, music, and literature of the Victorian period are also described. The text is a fine reference for readers who are interested in British history, particularly the Victorian era.
Drugs for the Heart presents highly portable, up-to-date information on every drug class used to treat cardiovascular disease. Drs. Lionel H. Opie and Bernard J. Gersh put the latest dosages, interactions, indications and contraindications, side effects, and more at your fingertips, equipping you to make effective clinical decisions on behalf of your patients. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Quickly check when to use each drug for any condition with the popular "Which Drug for Which Disease" chapter. Get expert advice from the practice-proven experience of two well-known editors who represent the best possible combination of clinical and research expertise in cardiovascular therapeutics. Expedite your reference with summaries of each drug class at the end of chapters. Carry it with you anywhere thanks to a highly compact, pocket-sized format. Navigate the latest pharmacologic advances through coverage of the newest drugs and drug classes, as well as all the latest clinical trial results and evidence used to treat heart disease. Effectively manage comorbid diseases. Apply international insights into cardiac drugs, thanks to new global contributors. Visualize key pharmacologic and physiologic actions thanks to dynamic new full-color drawings. Access the complete contents online at Expert Consult, with regular online updates posted by leading cardiologist, Dr. Opie.
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