This book discusses the general concept and applications of rapid tooling technologies and introduces the use of incremental forming for the development of rapid sheet tools. Methods and techniques for tool design and development are discussed, considering their manufacture using incremental forming and complementary processes. The mechanical and thermal performance of sheet metal tools is analyzed. Finally, possible applications are introduced, with the description of some case study examples.
Refugees and their protection have started to be a part of daily conversation in recent years. New flows from Africa to Europe, new crisis in Asia and in the Americas, and record numbers since the Second World War, for instance, have paved the way for news reports in the media, political discourses on the topic and debates on how to actually protect these persons. In a world scenario of increasingly (i) closed borders, (ii) association of migration to security issues, (iii) lack of political will to ascertain human rights and (iv) disregard for migration as a right in se, the challenges on and for refugees’ protection have been progressing; as have the need for international protection of persons fleeing well-founded fear of persecution due to their race, religion, nationality, political opinion or membership to a social group, i.e. refugees. Regional approaches and national practices gain relevance, especially if they can be seen as good practices, even if not without flaws. “What are the main challenges and opportunities regarding Refugee Protection in Latin America and in Brazil? The book offers a very convincing response. The essays by Liliana Jubilut reflect rigorous academic research and years of practical experience on supporting asylum seekers and refugees. The author is certainly one of the most influential scholars in Brazil working in the Forced Migration field, and the essays provide a comprehensive view of Refugee Protection in Brazil and Latin America”. – Gabriel Gualano de Godoy, PhD, UNHCR Chief of Mission in the Dominican Republic and former Head of UNHCR Protection Unit in Brazil. “This book shed clear lights on the development of refugee protection in Latin America for the years to come. Liliana Jubilut is already a leading scholar on refugee protection in Latin America and her articles reflect a long myriad of issues related to refugee protection, since status determination, resettlement, local integration and the remarkable humanitarian visas for the Syrian refugees. She shows the developments and setbacks and recover the most important developments since the Cartagena Declaration with a sharp eye and historical perspective. This book will soon become an essential bibliography for anyone trying to understand the particular and innovative refugee protection initiatives in this troubled but generous region”. – Wellington Pereira Carneiro, PhD, UNHCR Senior Official (having worked in Brazil and Colombia for UNHCR and in Panama prior to joining the UN)
This book presents an innovative analysis that relates informational structure, syntax and morphology in Quechua. It provides a minimalist account of the relationship between focus, topic, evidentiality and other left-peripheral features and sentence-internal constituents marked with suffixes that have been previously considered of a pragmatic nature. Intervention effects show that these relationships are also of a syntactic nature. The analysis is extended to morphological markers that appear on polarity sensitive items and wh-words. The book also provides a brief overview of the main characteristics of Quechua syntax as well as additional bibliographical information.
American trypanosomiasis is a widespread protozoal infection that affects the poorest and the most disadvantaged populations in the developing world. There is a lack of effective, affordable, and safe medicines for its treatment, mainly due to the low investment in R&D by the pharmaceutical industry. One alternative approach for the development of new drugs is the identification of bioactive natural compounds, which are particularly important for their structural diversity and their potential as novel pharmacophores. In this chapter, an overview of the investigations concerning the trypanocidal activity of plants, published over the period (2000–2010), will be presented. Either medicinal plants or isolated compounds will be considered. Data will be discussed under a critical point of view in relation with the challenge that implicates a drug discovery process from natural sources. The review will be focused on analyzing those published data dealing with the identification of new lead structures aimed at “bringing a drug to market.”
This book provides some regional aspects considered by manufacturing firms in their decisions to gain competitiveness and have effects on the performance of their supply chains (SC). Some of the main aspects considered are: government's policies, fixed costs, the availability and quality of infrastructure services. This book also discusses the risks for the SC; based on a perception approach, some aspects studied are: demand, suppliers and production processes and how these are related to other elements of the SC. The authors use structural modeling to analyze the evaluation of some manufacturing practices and their impact on customer service satisfaction, agility and flexibility of the SC. The context of this study is immersed in the Mexican manufacturing industry of exportation, also known as maquiladora industry of Ciudad Juarez, México. This borderland is among the top 10 manufacturing Mexican cities. World class industries are located in this region and have been recognized around the world for their competitiveness and high performance. Therefore, the methods and results exposed in this book may be valuable and useful for readers and researchers of the SC worldwide.
This is a reference handbook for young researchers exploring gene and cell therapy. Gene therapy could be defined as a set of strategies modifying gene expression or correcting mutant/defective genes through the administration of DNA (or RNA) to cells, in order to treat disease. Important advances like the discovery of RNA interference, the completion of the Human Genome project or the development of induced pluripotent stem cells (iPSc) and the basics of gene therapy are covered. This is a great book for students, teachers, biomedical researchers delving into gene/cell therapy or researchers borrowing skills from this scientific field.
This book discusses the general concept and applications of rapid tooling technologies and introduces the use of incremental forming for the development of rapid sheet tools. Methods and techniques for tool design and development are discussed, considering their manufacture using incremental forming and complementary processes. The mechanical and thermal performance of sheet metal tools is analyzed. Finally, possible applications are introduced, with the description of some case study examples.
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