Lila M Gierasch's Books

Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell

By: Lila M Gierasch,Arthur L Horwich,Christine Slingsby,Sue Wickner,David Agard

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Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell

By: Lila M Gierasch,Arthur L Horwich,Christine Slingsby,Sue Wickner,David Agard

This unique volume reviews the beautiful architectures and varying mechanical actions of the set of specialized cellular proteins called molecular chaperones, which provide essential kinetic assistance to processes of protein folding and unfolding in the cell. Ranging from multisubunit ring-shaped chaperonin and Hsp100 machines that use their central cavities to bind and compartmentalize action on proteins, to machines that use other topologies of recognition — binding cellular proteins in an archway or at the surface of a 'clamp' or at the surface of a globular assembly — the structures show us the ways and means the cell has devised to assist its major effectors, proteins, to reach and maintain their unique active forms, as well as, when required, to disrupt protein structure in order to remodel or degrade. Each type of chaperone is beautifully illustrated by X-ray and EM structure determinations at near- atomic level resolution and described by a leader in the study of the respective family. The beauty of what Mother Nature has devised to accomplish essential assisting actions for proteins in vivo is fully appreciable.

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Age

Page Count

328

Publisher

World Scientific

Published Date

ISBN 10

9814749346

ISBN 13

9789814749343

Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell

By: Lila M Gierasch,Arthur L Horwich,Christine Slingsby,Sue Wickner,David Agard

Write a review Read reviews Take a Quiz Solve Book Puzzle

Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell

By: Lila M Gierasch,Arthur L Horwich,Christine Slingsby,Sue Wickner,David Agard

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

328

Publisher

World Scientific

Published Date

ISBN 10

9814749346

ISBN 13

9789814749343

Structure and Action of Molecular Chaperones

Machines that Assist Protein Folding in the Cell

By: Lila M. Gierasch,Arthur Horwich,Christine Slingsby,Sue Wickner,David Agard

Write a review Read reviews Take a Quiz Solve Book Puzzle

Structure and Action of Molecular Chaperones

Machines that Assist Protein Folding in the Cell

By: Lila M. Gierasch,Arthur Horwich,Christine Slingsby,Sue Wickner,David Agard

This unique volume reviews the beautiful architectures and varying mechanical actions of the set of specialized cellular proteins called molecular chaperones, which provide essential kinetic assistance to processes of protein folding and unfolding in the cell. Ranging from multisubunit ring-shaped chaperonin and Hsp100 machines that use their central cavities to bind and compartmentalize action on proteins, to machines that use other topologies of recognition -- binding cellular proteins in an archway or at the surface of a "clamp" or at the surface of a globular assembly -- the structures show us the ways and means the cell has devised to assist its major effectors, proteins, to reach and maintain their unique active forms, as well as, when required, to disrupt protein structure in order to remodel or degrade. Each type of chaperone is beautifully illustrated by X-ray and EM structure determinations at near- atomic level resolution and described by a leader in the study of the respective family. The beauty of what Mother Nature has devised to accomplish essential assisting actions for proteins in vivo is fully appreciable.

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Solve jigsaw puzzle

Age

Page Count

319

Publisher

World Scientific Publishing Company

Published Date

ISBN 10

981474932X

ISBN 13

9789814749329

Book's by Lila M Gierasch

Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell

Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell

Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell

Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell

Structure and Action of Molecular Chaperones

Structure and Action of Molecular Chaperones

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