Toxicology is the study of the adverse effects of chemical, physical, or biological agents on people, animals, and the environment. Toxicologists are trained to investigate, interpret, and communicate the nature of those effects. Over the last ten years the subject of toxicology has changed dramatically, moving from a discipline which was once firmly wedded to traditional methods to one which is keen to embrace the innovative techniques emerging from the developing fields of cell culture and molecular biology. There is an acute need for this to be reflected in a paradigm shift which takes advantage of the opportunities offered by modern developments in the life sciences, including new in vitro and in silico approaches, alternative whole organism (non-mammalian) models and the exploitation of ‘omics methods, high throughput screening (HTS) techniques and molecular imaging technologies. This concise, accessible introduction to the field includes the very latest concepts and methodologies. It provides MSc, PhD and final year undergraduate students in pharmacy, biomedical and life sciences, as well as individuals starting out in the cosmetics, consumer products, pharmaceutical and testing industries, with everything they need to know to get to grips with the fast moving field of toxicology and the current approaches used in the risk assessment of drugs and chemicals.
Films possess virtually unlimited power for crafting broad interpretations of American history. Nineteenth-century America has proven especially conducive to Hollywood imaginations, producing indelible images like the plight of Davy Crockett and the defenders of the Alamo, Pickett’s doomed charge at Gettysburg, the proliferation and destruction of plantation slavery in the American South, Custer’s fateful decision to divide his forces at Little Big Horn, and the onset of immigration and industrialization that saw Old World lifestyles and customs dissolve amid rapidly changing environments. Balancing historical nuance with passion for cinematic narratives, Writing History with Lightning confronts how movies about nineteenth-century America influence the ways in which mass audiences remember, understand, and envision the nation’s past. In these twenty-six essays—divided by the editors into sections on topics like frontiers, slavery, the Civil War, the Lost Cause, and the West—notable historians engage with films and the historical events they ostensibly depict. Instead of just separating fact from fiction, the essays contemplate the extent to which movies generate and promulgate collective memories of American history. Along with new takes on familiar classics like Young Mr. Lincoln and They Died with Their Boots On, the volume covers several films released in recent years, including The Revenant, 12 Years a Slave, The Birth of a Nation, Free State of Jones, and The Hateful Eight. The authors address Hollywood epics like The Alamo and Amistad, arguing that these movies flatten the historical record to promote nationalist visions. The contributors also examine overlooked films like Hester Street and Daughters of the Dust, considering their portraits of marginalized communities as transformative perspectives on American culture. By surveying films about nineteenth-century America, Writing History with Lightning analyzes how movies create popular understandings of American history and why those interpretations change over time.
Once Eleanor walked out of the house there was a glimmer of hope for Stanley and his children. He realized why there was such a rift between him and the family. Something he felt he had to remedy. Being down and out, there was a lot for him to do before he could focus on anything other than survival. Candice had been through a rough patch. But she couldn’t sit back and relax. With her new baby, she had even more responsibilities. Feeling alone in the world, she had to carry on with life.
Ladies of the Canyons is the true story of remarkable women who left the security and comforts of genteel Victorian society and journeyed to the American Southwest in search of a wider view of themselves and their world. Educated, restless, and inquisitive, Natalie Curtis, Carol Stanley, Alice Klauber, and Mary Cabot Wheelwright were plucky, intrepid women whose lives were transformed in the first decades of the twentieth century by the people and the landscape of the American Southwest. Part of an influential circle of women that included Louisa Wade Wetherill, Alice Corbin Henderson, Mabel Dodge Luhan, Mary Austin, and Willa Cather, these ladies imagined and created a new home territory, a new society, and a new identity for themselves and for the women who would follow them. Their adventures were shared with the likes of Theodore Roosevelt and Robert Henri, Edgar Hewett and Charles Lummis, Chief Tawakwaptiwa of the Hopi, and Hostiin Klah of the Navajo. Their journeys took them to Monument Valley and Rainbow Bridge, into Canyon de Chelly, and across the high mesas of the Hopi, down through the Grand Canyon, and over the red desert of the Four Corners, to the pueblos along the Rio Grande and the villages in the mountains between Santa Fe and Taos. Although their stories converge in the outback of the American Southwest, the saga of Ladies of the Canyons is also the tale of Boston’s Brahmins, the Greenwich Village avant-garde, the birth of American modern art, and Santa Fe’s art and literary colony. Ladies of the Canyons is the story of New Women stepping boldly into the New World of inconspicuous success, ambitious failure, and the personal challenges experienced by women and men during the emergence of the Modern Age.
Once Eleanor walked out of the house there was a glimmer of hope for Stanley and his children. He realized why there was such a rift between him and the family. Something he felt he had to remedy. Being down and out, there was a lot for him to do before he could focus on anything other than survival. Candice had been through a rough patch. But she couldn’t sit back and relax. With her new baby, she had even more responsibilities. Feeling alone in the world, she had to carry on with life.
A complete e-Book boxset of the novels in Lesley Thomson's bestselling Detective's Daughter series. Stella Darnell, a cleaner, is the detective's daughter. When her father died, she discovered old case files in his attic while clearing out his house. Now she has devoted herself to solving crimes that were once thought unsolvable, assisted by her friend Jack, a tube driver. Follow Stella and Jack's story with this complete eBook boxset, including books 1–8: The Detective's Daughter Ghost Girl The Detective's Secret The House with No Rooms The Dog Walker The Death Chamber The Playground Murders The Distant Dead The first novel in the series, The Detective's Daughter, became an ebook phenomenon in 2013, staying at number 1 in the digital charts for 3 months. Since then, the series has gone on to sell 800,000 copies worldwide. 'Lesley Thomson is a class above' Ian Rankin 'Stella Darnell is without doubt one of the most orginial characters in British crime fiction'Crime Review
For more than a century, Ghost Ranch has attracted people of enormous energy and creativity to the high desert of northern New Mexico. Occupying twenty-two thousand acres of the Piedra Lumbre basin, this fabled place was the love of artist Georgia O’Keeffe’s life, and her depictions of the landscape catapulted Ghost Ranch to international recognition. Building on the history of the Abiquiu region that she told in Valley of Shining Stone, Ghost Ranch historian Lesley Poling-Kempes now unfolds the story of this celebrated retreat. She traces its transformation from el Rancho de los Brujos, a hideout for legendary outlaws, to a renowned cultural mecca and one of the Southwest’s premier conference centers. First a dude ranch, Ghost Ranch became a magical sanctuary where the veil between heaven and earth seemed almost transparent. Focusing on those who visited from the 1920s and ’30s until the 1990s, Poling-Kempes tells how O’Keeffe and others—from Boston Brahmin Carol Bishop Stanley to paleontologist Edwin H. Colbert, Los Alamos physicists to movie stars—created a unique community that evolved into the institution that is Ghost Ranch today. For this book, Poling-Kempes has drawn on information not available when Valley of Shining Stone was written. The biography of Juan de Dios Gallegos has been enhanced and definitively corrected. The Robert Wood Johnson (of Johnson & Johnson) years at Ghost Ranch are recounted with reminiscences from family members. And the memories of David McAlpin Jr. shed light on how the Princeton circle that included the Packs, the Johnson brothers, the Rockefellers, and the McAlpins ended up as summer neighbors on the high desert of New Mexico. After Arthur Pack’s gift of the ranch to the Presbyterian Church in 1955, Ghost Ranch became a spiritual home for thousands of people still awestruck by the landscape that O’Keeffe so lovingly committed to canvas; yet the care taken to protect Ghost Ranch’s land and character has preserved its sense of intimacy. By relating its remarkable story, Poling-Kempes invites all visitors to better appreciate its place as an honored wilderness—and to help safeguard its future.
From the number one bestseller of The Detective's Daughter. For forty years, someone has got away with murder... Forty years ago, seventeen-year-old Cassie Baker took a shortcut home from a small Cotswolds village, and was never seen again. Twenty years later, Cotswolds police found Cassie's remains while searching for another missing teenager, Bryony Motson. Bryony's body was never found. Now Stella Darnell, cleaner and private detective, has decided to find out what happened to Bryony. She knows her investigation will be dangerous. Because, for too long, someone has got away with murder. Someone who will do anything to keep it that way... PRAISE FOR LESLEY THOMSON: 'In the best traditions of the classic whodunnit, this is Midsomer Murders for grown-ups' Jake Kerridge, SUNDAY EXPRESS. 'Lesley Thomson is a class above' IAN RANKIN. 'Stella Darnell is one of the most original characters in British crime fiction' Joan Smith, SUNDAY TIMES. 'A wonderfully eerie setting, unique characters and a chilling plot' ELLY GRIFFITHS. 'Clever, credible and memorable' LITERARY REVIEW. 'Gloriously well-written... Thomson creates a rich and sinister world that is utterly unique' WILLIAM SHAW.
This book examines how children’s and young adult literature addresses and interrogates the legacies of American school desegregation. Such literature narrates not only the famous battles to implement desegregation in the South, in places like Little Rock, Arkansas, but also more insidious and less visible legacies, such as re-segregation within schools through the mechanism of disability diagnosis. Novelizations of children’s experiences with school desegregation comment upon the politics of getting African-American children access to white schools; but more than this, as school stories, they also comment upon how structural racism operates in the classroom and mutates, over the course of decades, through the pedagogical practices depicted in literature for young readers. Lesley combines approaches from critical race theory, disability studies, and educational philosophy in order to investigate how the educational market simultaneously constrains how racism in schools can be presented to young readers and also provides channels for radical critiques of pedagogy and visions of alternative systems. The volume examines a range of titles, from novels that directly engage the Brown v. Board of Education decision, such as Sharon Draper’s Fire From the Rock and Dorothy Sterling’s Mary Jane, to novels that engage less obvious legacies of desegregation, such as Cynthia Voigt’s Dicey’s Song, Sharon Flake’s Pinned, Virginia Hamilton’s The Planet of Junior Brown, and Louis Sachar’s Holes. This book will be of interest to scholars of American studies, children’s literature, and educational philosophy and history.
They will learn the city's secrets. They will learn who plans to kill... A man has jumped in front of a late night train. Stella Darnell, a cleaner who solves crimes, suspects it's murder. Now she's stirring up the past with questions that no one wants to answer. Jack Harmon, a driver on the Tube, has a new home at the top of an old water tower, with a perfect bird's eye view of London. If he watches through binoculars, he will learn the city's secrets. He will learn who plans to kill... THE DETECTIVE'S DAUGHTER SERIES: The Detective's Daughter. Ghost Girl. The Detective's Secret. The House With No Rooms. The Dog Walker.
North by northwest from old Santa Fe is the winding road to Abiquiu (ah-be-cue'), Ghost Ranch, and el Valle de la Piedra Lumbre, the Valley of Shining Stone: mythical names in a near-mythical place, captured for the ages in the famous paintings of Georgia O'Keeffe. O'Keeffe saw the magic of sandstone cliffs and turquoise skies, but her life and death here are only part of the story. Reading almost like a novel, this book spills over with other legends buried deep in time, just as some of North America's oldest dinosaur bones lie hidden beneath the valley floor. Here are the stories of Pueblo Indians who have claimed this land for generations. Here, too, are Utes, Navajos, Jicarilla Apaches, Hispanos, and Anglos—many lives tangled together, yet also separate and distinct. Underlying these stories is the saga of Ghost Ranch itself, a last living vestige of the Old West ideal of horses, cowboys, and wide-open spaces. Readers will meet a virtual Who's Who of visitors from "dude ranch" days, ranging from such luminaries as Willa Cather, Ansel Adams, and Charles Lindbergh to World War II scientist J. Robert Oppenheimer and his colleagues, who were working on the top-secret atomic bomb in nearby Los Alamos. Moving on through the twentieth century, the book describes struggles to preserve the valley's wild beauty in the face of land development and increased tourism. Just as the Piedra Lumbre landscape has captivated countless wayfarers over hundreds of years, so its stories cast their own spell. Indispensable for travelers, pure pleasure for history buffs and general readers, these pages are a magic carpet to a magic land: Abiquiu, Ghost Ranch, the Valley of Shining Stone.
A saga of immense charm and warmth, with three characters you won't forget. Thea, Anna and Daisy forge an unbreakable friendship through adversity. Thea's loathsome stepbrother is trying to trick her out of her inheritance of her parents' beautiful house in the seaside town of Brighton by means of a Will which Thea believes to be forged. He gives her three months in which to leave. Afterwards she will face destitution. Anna is pregnant and grieving, her explorer fiancé lost at sea. Her violent father drives her from the family home in the back streets of London's Bermondsey and her fiancé's upper-class relatives cruelly reject her. Daisy is in search of independence, running from a man she doesn't want to marry. Together the three girls set up Thea's home as a guest house and embark on a mission to outwit her stepbrother by proving his fraud. In a race against time, nothing will turn out to be quite as it seems.
Brand new from the #1 bestselling author of The Detective's Daughter. Stella and Jack must reawaken the secrets of the past in order to solve the mysteries of the present. January, 1987. In the depths of winter, only joggers and dog walkers brave the Thames towpath after dark. Helen Honeysett, a young newlywed, sets off for an evening run from her riverside cottage and disappears. Twenty-nine years later, Helen's body has never been found. Her husband has asked Stella Darnell, a private detective, and her side-kick Jack Harmon, to find out what happened all those years ago. But when the five households on that desolate stretch of towpath refuse to give up their secrets, Stella and Jack find themselves hunting a killer whose trail has long gone cold.
The mesmerizing sight of Madison standing in his doorway struck Taylor to the core. It was love at first sight. Madison was caught unawares by the way she felt. She was love struck. Taylor was smitten and gladly accepted her invitation to a party. The last day of the year was about to become the first day of a whole new experience for Madison and Taylor. A budding romance that flourished, but not without ups and downs thrown in the mix.
After working with his temp for a week, Phillip realized his secretary was not up to scratch. Rae was super efficient and organized. Her prim and proper dress code didn’t appeal to him, but something about her drew him in. Having set his sights on a young woman in the pub, he felt rather confused. He had never been a womanizer but felt caught in the middle by someone he knew, and a complete stranger. Once he got to know the real Raeleen Crompton he realized things would change. Not only in the office, but after hours as well.
Designing and Doing Survey Research is an introduction to the processes and methods of planning and conducting survey research in the real world. Taking a mixed method approach throughout, the book provides step-by-step guidance on: * Designing your research * Ethical issues * Developing your survey questions * Sampling * Budgeting, scheduling and managing your time * Administering your survey * Preparing for data analysis With a focus on the impact of new technologies, this book provides a cutting-edge look at how survey research is conducted today as well as the challenges survey researchers face. Packed full of international examples from various social science disciplines, the book is ideal for students and researchers new to survey research.
A woman lies dead on the ground. A girl watches from the shadows. What did she really see? The summer of 1976 was the hottest in living memory. A lost little girl, dizzied by the head, stumbled upon a deserted museum. She thought she saw a woman lying dead on the ground. But when she opened her eyes, the woman had gone. Forty years later, cleaner and detective Stella Darnell is investigating a suspected murder in the Botanical Gardens at Kew. Working methodically, stain by stain, she is drawn into an obsessive world, and towards a killer who has never been caught... THE DETECTIVE'S DAUGHTER SERIES: The Detective's Daughter. Ghost Girl. The Detective's Secret. The House With No Rooms. The Dog Walker. What people are saying about THE HOUSE WITH NO ROOMS: 'I'd give it 6 stars if it were possible' 'An unsettling, accomplished book by a writer at the top of her game' 'There is a sense of menace, suspense and sadness all interspersed with pockets of humour. So cleverly written' 'Can't put it down, the perfect present
Lesley Thomson at her considerable best - you'll laugh, you'll cry, you'll never guess.' ELLY GRIFFITHS 'Always a treat reading Lesley Thomson.' IAN RANKIN Eighty years of secrets. A body that reveals them all. 1940. At Yew Tree House, recently widowed Adelaide Stride is raising her two daughters alone – but it's not just the threat of German invasion that keeps her up at night. She is surrounded by enemies posing as allies and, while war rages, she grows sure that something terrible is about to happen. 2023. Soon after Stella Darnell begins her holiday at Yew Tree House, a skeleton is found in a pillbox at the bottom of the garden. The bullet hole in the skull tells her that the person was murdered. This triggers the unravelling of a mystery eighty years in the making. Soon, Stella will learn that Adelaide was right to worry – the fighting might have been happening abroad, but the true enemy was always much closer to home... A unique take on the traditional murder mystery from critically acclaimed author, Lesley Thomson, for fans of Elly Griffiths, Val McDermid and Mari Hannah. 'Fiercely unique, it's a whodunnit on an epic scale.' SUN 'Thomson has created a complex mystery full of psychological suspense, worthy of Barbara Vine. She makes you feel the presence of evil.' THE TIMES 'Elegant and spooky... A gripping demonstration that the past is never really the past.' MAIL ON SUNDAY Praise for The Detective's Daughter series: 'Cunningly plotted.' Mick Herron 'One of the most original characters in British crime fiction.' Sunday Times
Gabe and Heath had been friends for a couple of years. They chatted on the phone and had formed a strong bond and a meaningful relationship. Even though they hadn’t met each other they could discuss anything. He kept on pushing to meet with her. After so many years they had still not met for their first cup of coffee. The holidays came and Gabe had a freak accident. His parents rushed him to the hospital. The doctor was so attentive and helpful and sorted out the problem. Only Gabe hadn’t realized who Doctor Winters was. He had noticed everything about her. Her gorgeous figure and the way her hands felt on his skin. She was the most beautiful woman he had ever seen. As Gabe was leaving an ambulance rushed in to the casualties entrance. They called for Doctor Winters by name. She was gone in a flash. Gabe could not believe his luck. He had met his Heath.
This dual biography highlights the human dimensions of the Upper Missouri fur trade. Focusing on two major figures, Alexander Culbertson (1809-1879), trader with the American Fur Company, founder of Fort Benton, and the first white American to live among the Blackfeet Indians, and his wife, Natoyist-Siksina’ (“Holy Snake”) (1825-1893), daughter of Two Suns, the chief of the Blood (Kainah) tribe, Lesley Wischmann shows the great influence this couple had on the region. Culbertson and Natoyist-Siksina’ worked together for thirty years to promote cooperative relations between Native inhabitants and newly arrived white adventurers and played key roles in the Fort Laramie Treaty Conference of 1851 and treaty negotiations with the Blackfeet tribes in 1855. As she tells the story of these “frontier diplomats,” Wischmann also challenges conventional wisdom about the character of fur traders, the nature of the Blackfeet, and the role of Indian women.
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