The Latin texts collected by Leon Baudry present the late fifteenth century debate at the University of Louvain over the truth-value of proposi tions about future contingent events, a subject of perennial interest in phil osophy. The theologians held fast to divine predetermination, and the Aristotelians in the Arts Faculty supported the doctrine of free choice based on indeterminism. Although the issues in the debate are still argued in philosophy, this rich collection of the theories and arguments has been neglected. Peter de Rivo and Henry de Zomeren, the principal antagonists, are cited in the recent literature, but only on the basis of slight, mostly second-hand information. The full collection of texts has never before been translated into English (or any other modern language), leaving them inaccessible to the majority of students, or any others who are not equipped to work their way through 450 pages of fifteenth-century scholastic Latin. Apart from their philosophical significance, the texts shed light on late scholastic methods in teaching and disputation, on university politics of the period in relation to the Vatican, the Court of the Duke of Burgundy, and the faculties of other great universities, and on legal procedures both secular and ecclesiastical. The human drama that develops as the debate proceeds should hold the interest of even the non-specialist.
Understanding of memory and learning is one of the major goals of neuroscientists and psychologists. The author first introduces the reader into the current state of knowledge of the mechanisms underlying memory by providing extensive reviews of contemporary results including behavioural approaches and molecular studies. He presents results of his group obtained by analysing elec- trical activity - including single neuron meassures. As a major experimental model the phenomenon of hippocampal long- term potentiation was studied. The so-called quantal analy- sis - a quantitative method - was applied to study mammalian brain plasticity. Short- and long-term synaptic plasticities were registered both in vivo and in vitro mammalian brain preparations. Results show the involvement of mainly presynaptic location in memory, however, the possible involvement of postsynaptic mechanisms is indicated by changes in quantal amplitude as shown by the author.
Leon Cooper's somewhat peripatetic career has resulted in work in quantum field theory, superconductivity, the quantum theory of measurement as well as the mechanisms that underly learning and memory. He has written numerous essays on a variety of subjects as well as a highly regarded introduction to the ideas and methods of physics for non-physicists. Among the many accolades, he has received (some deserved) one he likes specially is the comment of an anonymous reviewer who characterized him as ?a nonsense physicist?.This compilation of papers presents the evolution of his thinking on mechanisms of learning, memory storage and higher brain function. The first half proceeds from early models of memory and synaptic plasticity to a concrete theory that has been put into detailed correspondence with experiment and leads to the very current exploration of the molecular basis for learning and memory storage. The second half outlines his efforts to investigate the properties of neural network systems and to explore to what extent they can be applied to real world problems.In all this collection, hopefully, provides a coherent, no-nonsense, account of a line of research that leads to present investigations into the biological basis for learning and memory storage and the information processing and classification properties of neural systems.
This definitive work, the combined effort of 30 international contributors, provides in-depth discussion of neuropsychological rehabilitation, the consequences of brain injury, fundamentals of recovery, current rehabilitation models, and treatment. Remarkable in the depth of its content, this publication reveals the numerous changes that have occurred over the past decade and the new pathways open to treating TBI. Experts from the United States and Europe detail the consolidation of neuropsychological rehabilitation as an interdisciplinary field with strong clinical and applied roots. The material explores the foundations which support and direct treatment, and it combines those foundations with a vision of the current state of the most innovative methodologies (e.g., gene therapy, post-traumatic sleep disorder intervention, neural transplants).
The Latin texts collected by Leon Baudry present the late fifteenth century debate at the University of Louvain over the truth-value of proposi tions about future contingent events, a subject of perennial interest in phil osophy. The theologians held fast to divine predetermination, and the Aristotelians in the Arts Faculty supported the doctrine of free choice based on indeterminism. Although the issues in the debate are still argued in philosophy, this rich collection of the theories and arguments has been neglected. Peter de Rivo and Henry de Zomeren, the principal antagonists, are cited in the recent literature, but only on the basis of slight, mostly second-hand information. The full collection of texts has never before been translated into English (or any other modern language), leaving them inaccessible to the majority of students, or any others who are not equipped to work their way through 450 pages of fifteenth-century scholastic Latin. Apart from their philosophical significance, the texts shed light on late scholastic methods in teaching and disputation, on university politics of the period in relation to the Vatican, the Court of the Duke of Burgundy, and the faculties of other great universities, and on legal procedures both secular and ecclesiastical. The human drama that develops as the debate proceeds should hold the interest of even the non-specialist.
The authoritative textbook on the principles and practical applications of biopharmaceutics and pharmacokinetics Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics has been the standard textbook in its field for over 40 years. This eighth edition includes recent scientific developments in the field and embodies the collective contribution of experts with deep knowledge and experience in the selected subject areas. Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics, Eighth Edition provides the reader with a fundamental understanding of biopharmaceutics and pharmacokinetics principles that can be applied to patient drug therapy and rational drug product development. Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics, Eighth Edition has been expanded and revised to include advancements in biopharmaceutics and pharmacokinetics. The chapter sequence has been reorganized into four main sections, providing a more logical sequence for students. The textbook starts with fundamental concepts, followed by application of these principles to optimize drug therapy and to the rational development of drug products. Each chapter includes theoretical concepts with practical examples and clinical applications. Frequently asked questions provide a discussion of overall concepts. Features: Expanded and revised chapters to include scientific advances in biopharmaceutics and pharmacokinetics Four main sections providing a natural buildup of knowledge: introduction to biopharmaceutics and pharmacokinetics, fundamentals of biopharmaceutics, pharmacokinetic calculations, clinical pharmacokinetics and pharmacodynamics, and biopharmaceutics and pharmacokinetics in drug product development Additional chapters for this edition include: o Physiological factors related to drug absorption o Approaches to pharmacokinetics and pharmacodynamics calculations o Novel and complex dosage Forms o Clinical Development and Therapeutic Equivalence of Generic Drug and Biosimilar Products o Pharmacokinetics and Pharmacodynamics in Clinical Drug Product Development Additional information on drug therapy, drug product performance, and other related topics Frequently asked questions, practice problems, clinical examples and learning questions
The landmark textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics—now fully updated. Explains how to detect clinical pharmacokinetic problems and apply basic pharmacokinetic principles to solve them Helps you critically evaluate biopharmaceutic studies involving drug product equivalency and unequivalency Chapters have been revised to reflect the latest clinical perspectives on drug performance, bioavailability, bioequivalence, pharmacokinetics, pharmacodynamics, and drug therapy The field’s leading text for more than three decades, Applied Biopharmaceutics & Pharmacokinetics gets you up to speed on the basics of the discipline like no other resource. Practical problems and clinical examples with discussions are integrated within each chapter to help you apply principles to patient care and drug consultation situations. In addition, outstanding pedagogy, including chapter objectives, chapter summaries, and FAQs, plus additional application questions, identify and focus on key concepts. Written by authors who have both academic and clinical experience, Applied Biopharmaceutics & Pharmacokinetics shows you how to use raw data and formulate the pharmacokinetic models and parameters that best describe the process of drug absorption, distribution, and elimination. The book also helps you work with pharmacokinetic and biopharmaceutic parameters to design and evaluate dosage regimens of drugs. In the seventh edition of this must-have interactive learning tool, most of the chapters are updated to reflect our current understanding of complex issues associated with safe and efficacious drug therapy.
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