Now in its 10th edition, Sleisenger and Fordtran?s Gastrointestinal and Liver Disease remains your indispensable source for definitive, state-of-the-art answers on every aspect of gastroenterology and hepatology. Overcome your most complex clinical challenges and make optimal use of the newest techniques, technologies, and treatments?with superb guidance from hundreds of world-renowned authorities. Meticulous updates throughout include the latest approaches and improvements in gastrointestinal and liver disease diagnosis and therapy as well as hundreds of images and 35 new procedural videos. "..one of the most valuable clinical resources in the dynamic field of gastroenterology and hepatology." Reviewed by Brindusa Diaconu on behalf of the Journal of Gastrointestinal and Liver Diseases, July 2015 "..an engaging, educational yet clinically orientated textbook which is relevant to modern clinical practice." Reviewed by Dr Harry Brown on behalf of glycosmedia.com, April 2015 "I can personally attest to the remarkable advances that have been made, as I was author of the chapter on eosinophilic gastroenteritis in the second edition of the textbook, and reading the same chapter in the tenth edition underscores the important advances that have been made in our understanding of the molecular basis as well as the pathophysiology of this and related disorders." Foreword by Norton J. Greenberger, MD Boston, Massachusetts, June 2015 Consult this title on your favorite e-reader. Get the essential gastroenterology information you need from one authoritative source with an outstanding global reputation for excellence. Zero in on the key information you need to know with a consistent, full-color chapter design. Stay up to date with emerging and challenging topics: enteric microbiota and probiotics; fecal microbiota transplantation; Clostridium difficile colitis; and factitious gastrointestinal diseases. Incorporate the latest findings and improvements in care for liver disease patients—from diagnosis and treatment through post-treatment strategies and management of complications. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and videos from the book on a variety of devices.
DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 10th edition has garnered universal acclaim as the world’s definitive, standard-setting oncology reference. More than 400 respected luminaries explore today’s most effective strategies for managing every type of cancer by stage of presentation - discussing the role of all appropriate therapeutic modalities as well as combined-modality treatments. This multidisciplinary approach will help your cancer team collaboratively face the toughest clinical challenges and provide the best possible care for every cancer patient. Access the complete contents online or on your mobile device, with quarterly updates reflecting late-breaking developments in cancer care, free for the first year on LWW Health Library. Take full advantage of the latest advances with brand-new chapters on Hallmarks of Cancer, Molecular Methods in Cancer, Oncogenic Viruses, Cancer Screening, and new sections on Genetic testing and counseling for cancer, plus comprehensive updates throughout – including coverage of the newest biologic therapies. Make optimal, well-coordinated use of all appropriate therapies with balanced, multidisciplinary advice from a surgeon, a medical oncologist, and a radiation oncologist in each major treatment chapter. Review the latest molecular biology knowledge for each type of cancer and its implications for improved management. Make the best decisions on cancer screening and prevention, palliative care, supportive oncology, and quality-of-life issues
Intersubjective Processes and the Unconscious looks at how the minds of the therapist and the patient interact with each other in a profound and unconscious way: a concept first described by Freud. This book expands Freud’s ideas further and examines how these have been greatly elaborated by contributions from the Kleinian School as well as from the work of Bion. It explores how, together, patient and therapist co-create a narrative through these unconscious intersubjective processes. Topics of discussion include: the unconscious dimensions of intersubjective processes an historical overview of Freudian, Kleinian and Bionian contributions an integrated theory of the nature of unconscious intersubjective processes the central importance of dreaming in intersubjective processes the clinical implications of this intersubjective model The author offers in-depth clinical examples and case vignettes to illustrate the application of these principles when working with trauma, countertransference dreams and supervision. As such, this book will be invaluable to all psychoanalysts and psychotherapists interested in the topic of intersubjectivity as well as those who want to learn more about the interactional dimensions of Freud, Klein and Bion.
Written and edited by leading physicians, Breastfeeding: A Guide for the Medical Profession, 9th Edition, offers comprehensive, dependable information and guidance in this multifaceted field. Award-winning author and co-founder of the Academy of Breastfeeding Medicine, Dr. Ruth Lawrence, and her son, Dr. Rob Lawrence, ensure that you're brought fully up to date on everything from basic data on the anatomical, physiological, biochemical, nutritional, immunological, and psychological aspects of human lactation, to the problems of clinical management of breastfeeding—all in a highly readable, easily accessible desk reference. - Helps you make appropriate drug recommendations, treat conditions associated with breastfeeding, and provide thoughtful guidance to the breastfeeding mother according to her circumstances, problems, and lifestyle. - Includes numerous charts and tables throughout, with an emphasis on the scientific, chemical, and physiological underpinnings of breastfeeding. Appendices contain additional charts and tables, including the complete collection of clinical protocols on breastfeeding and human milk from the Academy of Breastfeeding Medicine. - Features new chapters on breast conditions and their management in the breastfeeding mother, breastfeeding and chest-feeding for LGBTQ+ families, breastfeeding during disasters, and establishing a breastfeeding practice or academic department. - Provides significant updates on physiology and biochemistry of lactation; medications and herbal preparations in breast milk; transmission of infectious disease through breast milk; allergy and its relationship with breastfeeding, exposure, and avoidance; premature infants and breastfeeding; and practical management of the mother-infant nursing couple. - Offers authoritative and fresh perspectives from new associate editors: neonatologist Dr. Larry Noble, obstetrician Dr. Alison Stuebe, and pediatrician and lactation specialist Dr. Casey Rosen-Carole. - Covers patient-centered counseling, the cellular composition of human breast milk, microbiota of the breast and human milk, and the multifunctional roles of human milk oligosaccharides (HMOs). - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
This book is a collection of papers by leading contemporary psychoanalysts who comment on the continuing important relevance of Freud's (1911) paper, Formulations on the Two Principles of Mental Functioning. The contributors gathered here represent current European, Latin American, and North American perspectives that elaborate the continuing value of Two Principles for present-day psychoanalytic thinking. Each author examines Freud's paper through a personal lens that is coloured by the psychoanalytic culture from which he or she comes. In each instance, the writers' chapters demonstrate the heuristic value of Two Principles for twenty-first century psychoanalytic theory and technique. A common thread that runs through all the chapters is the view that this brief paper by Freud, which he humbly introduced by stating, "The deficiencies of this short paper, which is preparatory rather than expository ...", is a masterpiece that contains within it the seeds of much of his later writing. The distinction he draws between the pleasure principle and the reality principle are profound and raise questions that still preoccupy analysis today.
Apoptosis is the regulated form of cell death. It is a complex process defined by a set of characteristic morphological and biochemical features that involves the active participation of affected cells in a self-destruction cascade. This programmed cell death plays a critical role in physiological functions such as cell deletion during embryonic development, balancing cell number in continuously renewing tissues and immune system development. Additionally, a dysregulation of apoptosis is underlying in numerous pathological situations such as Parkinson, Alzheimer's disease and cancer.A number of studies have pointed out an association between consumption of fruits and vegetables, and certain beverages such as tea and wine, which are rich in polyphenols, with reduced risk of chronic diseases, including cancer. Apoptosis is also the regulatory mechanism involved in the removal of unnecessary cells during development and in tissue homeostasis in a wide range of organisms from insects to mammals. This book deals with cell apoptosis regulation and environmental factors.
Handbook of Radiosurgery in CNS Disease is a concise and practical manual offering radiation oncology, neurology, and neurosurgery residents, trainees, fellows, and clinicians up-to-date information on the role of radiosurgery within the overall context of CNS disease management. The emphasis is on decision making and the evaluation of radiosurgery as a viable option among the suite of potentially applicable treatments, including frame-based systems, non-invasive body immobilization, and image-guided targeting. The book examines radiosurgery as a treatment modality for various CNS pathologies, discussing relevant radiobiology, current technology, and the technical aspects of specific procedures. Chapters organized by pathology provide practical coverage of clinical evaluations, patient selection and management decision-making, and relevant points in radiosurgical applications for the entity under discussion. Pertinent cases are presented to demonstrate the process for each treatment paradigm. A unique collaboration of editors with an international reputation for excellence in radiation oncology, vascular neurosurgery, and neurosurgical oncology will offer insights into the role of radiosurgery in the entire central nervous system (i.e. both brain and spine). Handbook of Radiosurgery in CNS Disease features: Practical focus on key clinical issues in radiosurgery of CNS disease: patient selection, radiosurgery in context with other modalities, pitfalls Coverage of cranial and extracranial disease Relevant cases illustrate discussion of each treatment paradigm Outstanding editorial team Concise format makes for an easy review or quick reference, in contrast to large texts
This fully updated sixth edition of the international bestseller Research Methods in Education covers the whole range of methods currently employed by educational research at all stages. It is divided into five main parts: the context of educational research; planning educational research; styles of educational research; strategies for data collection and researching; and data analysis. The book also contains references to a comprehensive dedicated website of accompanying materials. The sixth edition includes new material on: complexity theory, ethics, sampling and sensitive educational research experimental research, questionnaire design and administration with practical guidance qualitative and quantitative data analysis, with practical examples internet based research. Research Methods in Education is essential reading for the professional researcher and continues to be the standard text for students and lecturers in educational research. To access the dedicated website of accompanying materials, please visit: www.routledge.com/textbooks/9780415368780.
‘Environmental Problem-Solving' presents short excerpts from carefully selected readings, expert commentaries on those readings, assignments, and the best MIT student responses to the assignments and exam questions with excellent student response. The book presents four main models of environmental policy-making: competing theories of environmental ethics; tools for environmental assessment and environmental decision-making; and techniques for public engagement and group decision-making. The book covers the material presented in the semester-long course required of all students enrolled in MIT’s Environmental Policy and Planning Specialization.
In this book, Lawrence J. Brown offers a contemporary perspective on how the mind transforms, and gives meaning to, emotional experience that arises unconsciously in the here-and-now of the clinical hour. Brown surveys the developments in theory and practice that follow from Freud’s original observations and traces this evolution from its conception to contemporary analytic field theory. Brown emphasizes that these unconscious transformational processes occur spontaneously, in the blink of an eye, through the "unconscious work" in which the analyst and patient are engaged. Though unconscious, these processes are accessible and the analyst must train himself to become aware of the subtle ways he is affected by the patient in the clinical moment. By paying attention to one’s reveries, countertransference manifestations and even supposed "wild" or extraneous thoughts, the analyst is able to obtain a glimpse of how his unconscious is transforming the ambient emotions of the session in order to formulate an interpretation. Brown casts a wide theoretical net in his exploration of these transformational processes and builds on the contributions of Freud, Theodor Reik, Bion, Ogden, the Barangers, Cassorla, Civitarese and Ferro. Bion’s theories of alpha function, transformations, dreaming and his clinical emphasis on the present moment are foundational to this book. Brown’s writing is clear and aims to describe the various theoretical ideas as plainly as possible. Detailed clinical material is given in most chapters to illustrate the theoretical perspectives. Brown applies this theory of transformational processes to a variety of topics, including the analyst’s receptivity, countertransference as transformation, the analytic setting, the paintings of J.M.W. Turner, "autistic transformations" and other clinical situations in the analysis of children and adults. Transformational Processes in Clinical Psychoanalysis will be of great interest to all psychoanalysts and psychoanalytic psychotherapists.
Modern Surgical Pathology, 2nd Edition presents today's most complete, current, and practical assistance in evaluating and signing out surgical specimens. Nearly 3,000 high-quality color pathology images provide a crystal-clear basis for comparison to any sample you see under the microscope. Clinical, gross, microscopic, immunohistochemical, and molecular genetic features are integrated as appropriate for all tumors and tumor-like lesions, addressing all of the investigative contexts relevant to formulating an accurate diagnosis. Edited by four leading surgical pathologists - Noel Weidner, MD, Richard J. Cote, MD, Saul Suster, MD and Lawrence M. Weiss, MD - with contributions from more than 70 other experts, Modern Surgical Pathology, 2nd Edition delivers the well-rounded, well-organized, richly illustrated, user-friendly guidance you need to efficiently arrive at confident diagnoses for even the most challenging lesions. Contributions from many leading surgical pathologists give you well-rounded, expert answers to any question that you may face. Clinical, gross, microscopic, immunohistochemical, and molecular genetic features are correlated as appropriate for every type of surgical pathology specimen, addressing all of the investigative contexts relevant to formulating an accurate diagnosis and thereby ensuring a completely accurate surgical report. Nearly 3,000 brand-new, high-quality color pathology images provide a crystal-clear basis for comparison to any specimen you see under the microscope. A completely rewritten section on the female reproductive tract offers many more illustrations of common entities to help you more easily distinguish between tumors and tumor-like lesions. Expanded coverage of non-neoplastic diseases and disorders makes it easier to recognize benign conditions that can mimic malignancy. The latest classification schemes and criteria for malignancy, incorporated throughout, enable you to include the most current gradings in your reports. A new, more consistent organization explores anatomy/histology, gross and microscopic appearance, adjunct techniques, diagnosis, and differential diagnosis for each neoplastic or non-neoplastic lesion, facilitating rapid consultation in the reporting room. An increased number of differential diagnosis and classification tables expedite diagnosis.
In March 2006 the Bush administration released its National Security Strategy (NSS), as required by Congress under the Goldwater-Nichols Dept. of Defense Reorganization Act of 1986. The authors of this essay analyzing the NSS maintain that this latest iteration of the national security strategy again disappoints -- it fails to offer a realistic plan with achievable goals to safeguard American interests, contradicts the actual policies & actions of the administration, & reveals an absence of introspection & lessons learned from the mistakes of the first term.
Neonatal and Infant Dermatology is a unique comprehensive and heavily illustrated reference on the dermatologic diseases of newborns and infants. It includes discussions of common and uncommon conditions seen in infants at birth and in the first few months of life. With over 600 superb photographs of normal and abnormal skin conditions including images of rare conditions, this easily accessible resource is essential for pediatricians, neonatologists, and dermatologists as well as other healthcare professionals involved in the diagnosis and treatment of dermatologic diseases in infants and newborns. - Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. - Get the depth of coverage you need to effectively diagnose skin conditions in neonates and infants. - Expedite effective differential diagnoses with guidance from algorithms, lists, text, boxes and supporting images. - Benefit from the experience of over 60 contributors from around the world lead by Drs. Lawrence F. Eichenfield and Ilona J. Frieden, two of the most important names in the fields of dermatology and pediatrics. - Glean all essential, up-to-date, need-to-know information with new chapters on Papulosquamous and Lichenoid Disorders, Acneiform and Sweat-gland disorders and two individual chapters on Vascular Malformations and Vascular Tumors. - See what to expect and how to proceed with new, high-quality illustrations and photos that provide even more visual examples of abnormal and normal conditions. - Take it with you anywhere! Access the full text, image library, and more online at Expert Consult.
This updated edition of Stroke: Pathophysiology, Diagnosis, and Management delivers convenient access to the latest research findings and management approaches for cerebrovascular disease. Picking up from where J. P. Mohr and colleagues left off, a new team of editors — Drs. Grotta, Albers, Broderick, Kasner, Lo, Mendelow, Sacco, and Wong — head the sixth edition of this classic text, which is authored by the world’s foremost stroke experts. Comprehensive, expert clinical guidance enables you to recognize the clinical manifestations of stroke, use the latest laboratory and imaging studies to arrive at a diagnosis, and generate an effective medical and surgical treatment plan. Abundant full-color CT images and pathology slides help you make efficient and accurate diagnoses. Data from late-breaking endovascular trials equips you with recent findings. Includes comprehensive coverage of advances in molecular biology of cell death; risk factors and prevention; advances in diagnostics and stroke imaging; and therapeutic options, including a thorough review of thrombolytic agents and emerging data for endovascular therapy. Features brand-new chapters on Intracellular Signaling: Mediators and Protective Responses; The Neurovascular Unit and Responses to Ischemia; Mechanisms of Cerebral Hemorrhage; Stroke Related to Surgery and Other Procedures; Cryptogenic Stroke; and Interventions to Improve Recovery after Stroke. Highlights new information on genetic risk factors; primary prevention of stroke; infectious diseases and stroke; recovery interventions such as robotics, brain stimulation, and telerehabilitation; and trial design. Details advances in diagnostic tests, such as ultrasound, computed tomography (including CT angiography and CT perfusion), MRI (including MR perfusion techniques), and angiography. Includes extracted and highlighted evidence levels. Expert Consult eBook version included with print purchase. This enhanced eBook experience allows you to search all of the text, figures, and references on a variety of devices. The content can also be downloaded to tablets and smart phones for offline use.
The clinical trial is “the most definitive tool for evaluation of the applicability of clinical research.” It represents “a key research activity with the potential to improve the quality of health care and control costs through careful comparison of alternative treatments” [1]. It has been called on many occasions, “the gold st- dard” against which all other clinical research is measured. Although many clinical trials are of high quality, a careful reader of the medical literature will notice that a large number have deficiencies in design, conduct, analysis, presentation, and/or interpretation of results. Improvements have occurred over the past few decades, but too many trials are still conducted without adequate attention to its fundamental principles. Certainly, numerous studies could have been upgraded if the authors had had a better understanding of the fundamentals. Since the publication of the first edition of this book, a large number of other texts on clinical trials have appeared, most of which are indicated here [2–21]. Several of them, however, discuss only specific issues involved in clinical trials. Additionally, many are no longer current. The purpose of this fourth edition is to update areas in which major progress has been made since the publication of the third edition. We have revised most chapters considerably and added one on ethical issues.
Once a vibrant part of religious life for many Pennsylvania Germans in the eighteenth and nineteenth centuries, Fraktur manuscripts today are primarily studied for their decorative qualities. The Word in the Wilderness takes a different view, probing these documents for what they tell us about the lived religious experiences of the Protestant communities that made and used them and opening avenues for reinterpretation of this well-known, if little understood, set of cultural artifacts. The resplendent illuminated religious manuscripts commonly known as Fraktur have captivated collectors and scholars for generations. Yet fundamental questions about their cultural origins, purpose, and historical significance remain. Alexander Lawrence Ames addresses these by placing Fraktur manuscripts within a “Pietist paradigm,” grounded in an understanding of how their makers viewed “the Word,” or scripture. His analysis combines a sweeping overview of Protestant Christian religious movements in Europe and early America with close analysis of key Pennsylvania devotional manuscripts, revealing novel insights into the religious utility of calligraphy, manuscript illumination, and devotional reading as Protestant spiritual enterprises. Situating the manuscripts in the context of transatlantic religious history, early American spirituality, material culture studies, and the history of book and manuscript production, Ames challenges long-held approaches to Pennsylvania German studies and urges scholars to engage with these texts and with their makers and users on their own terms. Featuring dozens of illustrations, this lively, engaging book will appeal to Fraktur scholars and enthusiasts, historians of early America, and anyone interested in the material culture and spiritual practices of the German-speaking residents of Pennsylvania.
FOUR CONGRESSIONAL MEDALS OF HONOR, THIRTEEN NAVAL CROSSES, SEVENTY-TWO SILVER STARS . . . In four and a half years in Vietnam, the Marines of the Third Reconnaissance Battalion repeatedly penetrated North Vietnamese and Vietcong sanctuaries by foot and by helicopter to find enemy forces, learn the enemy's intentions, and, when possible, bring deadly fire down on his head. Heavily armed, well-camouflaged teams of six and eight men daily exposed themselves to overwhelming enemy forces so that other Marines would have the information necessary to fight the war. It's all here: grueling, tense, and deadly recon patrols; insertions directly into NVA basecamps; last-stand defenses in the wreckage of downed helicopters; pursuit by superior North Vietnamese forces; agonizing deaths of men who valiantly put their lives on the line. NEVER WITHOUT HEROES is the first book to recount the story of a Marine reconnaissance battalion in Vietnam from the day of its arrival to its withdrawal. In Vietnam, Larry Vetter served as a platoon leader in Third Recon Battalion. He supplements his own recollections with Marine Corps records, exhaustive interviews with veterans, and correspondence to capture the bravery, and self-sacrifice of war.
Based on deep consultation of seldom-examined primary sources, this third volume in Richard Lawrence Miller's massive Lincoln biography follows Lincoln's long effort to win a seat in Congress, his activity there, and his return to Illinois--chastened by his Washington experience. Topics include: Lincoln's anti-slavery efforts in Congress; the popularity of his stance against the Mexican War (which, contrary to common belief, didn't significantly harm his political reputation); his support of Zachary Taylor's presidential campaign and his subsequent efforts to win a patronage job from the Taylor White House; his political activities after returning to Illinois; and his generally happy home life with Mary and his sons. Throughout the work, a new portrait emerges of Lincoln as a canny politician, making his own luck by striking swiftly and strongly when opportunities arose.
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