First published in 1998. In June 1831 the New York Magdalen Society published its first annual report. The Society charged that widespread sexual deviation, primarily in the form of prostitution, existed in New York City. The Magdalen Report claimed that approximately ten thousand women earned their livings as public prostitutes, and another ten thousand were “private or part-time prostitutes.” The Magdalen Society’s establishment and the subsequent publication of the Magdalen Report marked the beginning of a crusade in New York City to curtail sexual deviation and this study looks at the changes and reforms that took place.
A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—includes an historical perspective on the topic, presents a practical compendium to privileged structures, and offers an informed perspective on the future direction for the field. The book describes the up-to-date and state-of-the-art methods of organic synthesis that describe the use of privileged structures that are of most interest. Chapters included information on benzodiazepines, 1,4-dihydropyridines, biaryls, 4-(hetero)arylpiperidines, spiropiperidines, 2-aminopyrimidines, 2-aminothiazoles, 2-(hetero)arylindoles, tetrahydroisoquinolines, 2,2-dimethylbenzopyrans, hydroxamates, and bicyclic pyridines containing ring-junction nitrogen as privileged scaffolds in medicinal chemistry. Numerous, illustrative case studies document the current use of the privileged structures in the discovery of drugs. This important volume: Describes the drug compounds that have successfully made it to the marketplace and the chemistry associated with them Offers the experience from an author who has worked in many therapeutic areas of medicinal chemistry Details many of the recent developments in organic chemistry that prepare target molecules Includes a wealth of medicinal chemistry case studies that clearly illustrate the use of privileged structures Designed for use by industrial medicinal chemists and process chemists, academic organic and medicinal chemists, as well as chemistry students and faculty, Privileged Structures in Drug Discovery offers a current guide to organic synthesis methods to access the privileged structures of interest, and contains medicinal chemistry case studies that document their application.
Revised and updated, this 15th anniversary edition of the #1 New York Times bestseller salutes America’s true and proud history. Fifteen years ago, Professors Larry Schweikart and Michael Allen set out to correct the doctrinaire biases that had distorted the way America’s past is taught – and they succeeded. A Patriot’s History of the United States is the definitive objective history of our country, presented honestly and fairly. Schweikart and Allen don’t ignore America’s mistakes through the years. Instead, they put them back in the proper perspective, celebrating the strengths of the men and women who cleared the wilderness, abolished slavery, and rid the world of fascism and communism. Now in this revised fifteenth-anniversary edition, a new generation of readers will learn the truth about America’s discovery, founding, and advancement, from Columbus’s voyage to Trump’s promise to “Make America Great Again.
First published in 1998. In June 1831 the New York Magdalen Society published its first annual report. The Society charged that widespread sexual deviation, primarily in the form of prostitution, existed in New York City. The Magdalen Report claimed that approximately ten thousand women earned their livings as public prostitutes, and another ten thousand were “private or part-time prostitutes.” The Magdalen Society’s establishment and the subsequent publication of the Magdalen Report marked the beginning of a crusade in New York City to curtail sexual deviation and this study looks at the changes and reforms that took place.
From Death to Disney. Larry Watkin won the National Book Award in 1937 for his novel ON BORROWED TIME, about Death imprisoned in an apple tree. From there, after an adventurous stint in the US Navy, he joined the Disney studio, working alongside Walt Disney himself on live-action classics.
The award-winning radio talk-show host presents anecdotes about the hundreds of interesting individuals who have passed through his life, including Jackie Gleason, Elvis, Nixon, Rosanne Barr, Stephen King, and Gore Vidal
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