This book is for people who want to learn probability and statistics quickly. It brings together many of the main ideas in modern statistics in one place. The book is suitable for students and researchers in statistics, computer science, data mining and machine learning. This book covers a much wider range of topics than a typical introductory text on mathematical statistics. It includes modern topics like nonparametric curve estimation, bootstrapping and classification, topics that are usually relegated to follow-up courses. The reader is assumed to know calculus and a little linear algebra. No previous knowledge of probability and statistics is required. The text can be used at the advanced undergraduate and graduate level. Larry Wasserman is Professor of Statistics at Carnegie Mellon University. He is also a member of the Center for Automated Learning and Discovery in the School of Computer Science. His research areas include nonparametric inference, asymptotic theory, causality, and applications to astrophysics, bioinformatics, and genetics. He is the 1999 winner of the Committee of Presidents of Statistical Societies Presidents' Award and the 2002 winner of the Centre de recherches mathematiques de Montreal–Statistical Society of Canada Prize in Statistics. He is Associate Editor of The Journal of the American Statistical Association and The Annals of Statistics. He is a fellow of the American Statistical Association and of the Institute of Mathematical Statistics.
In choosing between moral alternatives -- choosing between various forms of ethical action -- we typically make calculations of the following kind, using the principle of transitivity: A is better than B; B is better than C; therefore A is better than C. Larry Temkin shows is that if we want to continue making plausible judgments, we cannot continue to make these assumptions.
A Malone Novel. In this latest thriller featuring the intrepid Los Angeles PI, Malone gets reacquainted with some old friends and meets new enemies in a troubling case that threatens to shake the City of Angels to its core. An aspiring investigative reporter, Piper Lang has her cornflower blue eyes set on becoming more than just another pretty face in the newsroom of a major L.A. newspaper. She also has somebody sending her death threats and threatening to rearrange her lovely face if she keeps snooping into the goings on at a secretive Los Angeles-based female empowerment and entrepreneurial training group. It seems the shadowy company is operating with impunity like a multi-level marketing scheme that one of Lang’s sources claims is only a front for a dangerous sex cult. Malone’s job is to keep the attractive and vivacious Piper healthy until she breaks the biggest story of her career. But after her primary source is almost murdered by two tough guys, Malone’s professional skills are put to the test in a deadly game–a game that may cost Malone and Piper Lang their lives. When it seems clear Malone may be outgunned this time, series favorite L.A.P.D. detective Jaime Reyes comes to the rescue to provide backup. From the mansions of Bel Air to the film studios of Tinseltown, Malone will need to watch his step as he and Piper unravel a exploitative sex-cult. In L.A., all that glitters isn’t always gold.
New York Times #1 bestselling author Larry Schweikart, armed with previously unseen sources from Ronald Reagan’s Presidential Library, uncovers the most important president of the 20th century and details the life and policies of a man who still remains dear to the hearts of Americans. From his time as a lifeguard in Illinois to a sports announcer to a rising actor to a labor union leader, then finally governor of California in the tumultuous 1960s and ultimately President, Reagan’s life is told as it has never been before.
This book is intended to be a textbook for students of water resources engineering and management. It is an introduction to methods used in hydrosystems for upper level undergraduate and graduate students. The material can be presented to students with no background in operations research and with only an undergraduate background in hydrology and hydraulics. A major focus is to bring together the use of economics, operations research, probability and statistics with the use of hydrology, hydraulics, and water resources for the analysis, design, operation, and management of various types of water projects. This book is an excellent reference for engineers, water resource planners, water resource systems analysts, and water managers. This book is concerned with the mathematical modeling of problems in water project design, analysis, operation, and management. The quantitative methods include: (a) the simulation of various hydrologic and hydraulic processes; (b) the use of operations research, probability and statistics, and economics. Rarely have these methods been integrated in a systematic framework in a single book like Hydrosystems Engineering and Management. An extensive number of example problems are presented for ease in understanding the material. In addition, a large number of end-of-chapter problems are provided for use in homework assignments.
Once upon a time there was a mean, dying GOP chairman who had a brilliant scheme to assure that his man would retain the office of president of the United States of America. And the only man who could pull off this elaborate plan was a celebrated Hollywood director. Add to the mix a left-coast gumshoe named Broz who is trapped among cover-ups, undercover work, and his own morality, a cast of bicoastal desperate characters, and the stage is set for a powerful D.C./L.A. production. From Edgar award winning author Larry Beinhart, Wag the Dog was the most brilliant political satire of the last decade. It was made into a classic film by Barry Levinson, and, fortunately, is now back in print.
In a media landscape dominated by advocacy news networks pushing competing points of view, how can the average person uncover the truth about any particular issue? This book will show you how to separate the facts from the agenda-driven spin and selective presentation often used by such news sources as Fox and MSNBC. The author describes the goals of advocacy journalism—i.e., journalism that transparently advocates a biased worldview—and shows that it has been a part of our history since the 1700s. He assesses the role of talk radio, cable news networks, and the more recent phenomena of special-interest blogs, websites, and citizen journalists in creating the current media climate. While conceding that advocacy journalism is undoubtedly popular and has some positive aspects, the author also points out its many negative features. Perhaps the most important of these is its polarizing effect on society. Skewed will give readers the tools to critique the media, to see both sides of any issue, and to become better informed citizens and voters.
Inflation has revolutionized cosmology primarily because it has eliminated the dependence of cosmological modelling on initial conditions. Thus inflationary cosmology is able to account for the present universe starting from a wide range of initial conditions. This volume reviews the presents state of subject. Each chapter consists of a brief introduction followed by reprints of important papers. Experts in the field are also provided with a unifying view point.
Considered the definitive source in its field for over 35 years, Endocrinology: Adult and Pediatric, has been thoroughly updated to reflect today's recent advances in adult and pediatric endocrinology. Unique perspectives from a team of trusted, world-renowned experts ensure this medical reference book remains the most highly-regarded text in the field. Make the best clinical decisions with an enhanced emphasis on evidence-based practice and expert opinions on treatment strategies. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. Locate information quickly, while still getting the complete coverage you expect. Now in full color, with special design treatment for at-a-glance pediatric content, helping to distinguish the pediatric content. Expanded coverage for key topics such as pediatric endocrinology and obesity mechanisms and treatment, in addition to today's hot topics in endocrinology, including endocrine disruptors, bariatric surgery, androgen deficiency, genetic causes of obesity, endocrine rhythms, and the use of tyrosine kinase inhibitors in thyroid cancer. New content addressing the latest advances in testosterone and estrogen replacement, as well as the new causes of calcium and phosphate disorders, new molecular causes of endocrine cancers, new genetic causes of reproductive disorders, and more. Updated clinical guidelines for diabetes, lipid disorders, obesity management, osteoporosis, and more, as well as essential treatment updates for the medical management of acromegaly, Cushing's Disease, hypercalcemia, and diabetes mellitus. New Key Points provide snapshots of what to expect in each chapter, or serve as a refresher of what you just read. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and videos from the book on a variety of devices.
“Trumbo emerges from this well-rounded biography as a larger-than-life figure, not unlike the characters he scripted for the screen.” —Publishers Weekly James Dalton Trumbo is widely recognized as a screenwriter, playwright, and author, but he is also remembered as one of the Hollywood Ten who opposed the House Un-American Activities Committee. Refusing to answer questions about his prior involvement with the Communist Party, Trumbo sacrificed a successful career in Hollywood to stand up for his rights and defend political freedom. In Dalton Trumbo, Larry Ceplair and Christopher Trumbo present their extensive research on the famed writer, detailing his work; his membership in the Communist Party; his long campaign against censorship during the domestic cold war; his ten-month prison sentence for contempt of Congress; and his thirteen-year struggle to break the blacklist. The blacklist ended for Trumbo in 1960, when he received screen credits for Exodus and Spartacus. Just before his death, he received a long-delayed Academy Award for The Brave One, and in 1993, he was posthumously given another for Roman Holiday. This comprehensive biography, which includes excerpts of Trumbo’s letters, notes, and other writings, also provides insights into the notable people with whom Trumbo worked, including Stanley Kubrick, Otto Preminger, and Kirk Douglas, and a fascinating look at the life of one of Hollywood’s most prominent screenwriters and his battle against persecution.
From Oreos, Jell-O, raisins, and milk to amusement parks, retail centers, ATMs, and mutual funds, the case studies presented in Marketing Research That Pays Off offer you insight into how actual companies have used market research to successfully solve marketing problems. Editor Larry Percy has collected a series of cases from consumer, service, and industrial marketing executives that provides a problem/solution look at how to address major marketing issues with marketing research. The studies presented cover such topics as communications issues, new product introduction, brand equity, brand positioning, and sales analysis. Because they represent successful applications of marketing research to challenging questions, these cases offer a number of specific lessons. Throughout, Marketing Research That Pays Off shows you how to: use the right sample for reliable data reduce the time needed for traditionally multi-phased research avoid the pitfalls of short-term effects in tracking data deal with multinational research use attitude measures to help interpret sales data involve marketing management to ensure acceptance of results make effective use of small budgets The format of each chapter allows the authors to pose a question or present a particular marketing problem and then take you step-by-step through the solution. Actual problems solved include how to improve upon a successful campaign, revitalize a failing retail center, avoid misunderstanding in conducting multinational research, use scanner data to help understand the package goods market, avoid being mislead by short-term effects in tracking data, learn what aspects of a package attract attention and what they communicate, and how to effectively reach both children and their parents with one message--all on a small budget. It is the unique problem/solution approach to marketing research that makes Marketing Research That Pays Off especially valuable to all marketing research professionals and beginner- to mid-level marketing managers. In addition, the book's easy-to-read presentation of case studies makes it approachable and useful as a companion text for classes in marketing and marketing research.
In the quest for quality, software developers have long focused on improving the internal architecture of their products. Larry L. Constantine--who originally created structured design to effect such improvement--now joins with well-known consultant Lucy A. D. Lockwood to turn the focus of software development to the external architecture. In this book, they present the models and methods of a revolutionary approach to software that will help programmers deliver more usable software--software that will enable users to accomplish their tasks with greater ease and efficiency. Recognizing usability as the key to successful software, Constantine and Lockwood provide concrete tools and techniques that programmers can employ to meet that end. Much more than just another set of rules for good user-interface design, this book guides readers through a systematic software development process. This process, called usage-centered design, weaves together two major threads in software development methods: use cases (also used with UML) and essential modeling. With numerous examples and case studies of both conventional and specialized software applications, the authors illustrate what has been shown in practice to work and what has proved to be of greatest practical value. Highlights Presents a streamlined process for developing highly usable software Describes practical methods and models successfully implemented in industry Complements modern development practices, including the Unified Process and other object-oriented software engineering approaches
This book provides a fresh look at the way the United States is choosing to deal with some of the serious or persistent youth offenders: by transferring juvenile offenders to adult courts. For more than 20 years now, the attitude in some jurisdictions has been "if you're old enough to do the crime, you're old enough to do the time." After two decades of applying this increasingly punitive mindset to juvenile offenders, it is possible to see the actual consequences of transferring more and younger offenders to adult courts. In Do the Crime, Do the Time: Juvenile Criminals and Adult Justice in the American Court System, the authors apply their decades of experience, both in the practical world and from unique research perspectives, to shed light on the influence of public opinion and the political forces that shape juvenile justice policy in the United States. The book provides a fresh look at the way the United States is choosing to deal with some of the serious or persistent juvenile offenders, utilizing real-life examples and cases to draw connections between transfer policies and individual outcomes.
Physiology of Sport and Exercise, Eighth Edition With HKPropel Access, continues its legacy as a top physiology textbook and favorite of instructors and students alike. Combining research with extensive visual aids, this resource offers a simple way for students to explore the body’s response to various types and intensities of exercise and sports. Written by a team of distinguished researchers, all past presidents of the American College of Sports Medicine, this eighth edition has been updated based on the most recent standards and guidelines in the field of exercise physiology. The text builds upon the previous edition’s high standards for illustrations, photos, and medical artwork with a refreshed, more sophisticated look to encourage a deep understanding of complex topics. Related multimedia components delivered through HKPropel further enrich the learning experience with 26 animations that offer a dynamic way to experience physiological concepts and 66 audio clips that offer explanations of elaborate physiological processes. Leaders in the field help students connect theoretical and practical concepts in 27 video clips. Various types of online learning activities, key term flash card reviews, and key term quizzes offer interactive opportunities to engage with the content—all of which can be assigned, and progress tracked, by instructors directly through HKPropel. In addition, chapter quizzes (assessments) may also be assigned; these are automatically graded to test comprehension of critical concepts. QR codes throughout the text notify students when complementary digital components are available. Physiology of Sport and Exercise, Eighth Edition, features the following enhancements based on the latest research in the field: Additional information on cellular signaling and molecular adaptations Expanded content on obesity and sports nutrition Reorganized and expanded chapters on energy expenditure and exercise prescription that make the content more accessible to students Extensive updates on important topics, including bioinformatics and big data, reading research articles, molecular mechanisms of increased protein synthesis, muscle cramps, and mitochondrial oxidation Updated Research Perspective sidebars that emphasize emerging findings in the field and a Research Perspectives Finder to help students locate key content quickly As in previous editions, readability and ease of understanding make Physiology of Sport and Exercise different from other physiology resources. Unique learning aids, including chapter-opening outlines and review boxes throughout each chapter, will help students focus on the major concepts addressed. Study questions and a list of key terms at the end of each chapter provide opportunities for recall and self-assessment. A comprehensive glossary and lists of common abbreviations and conversions provide easy reference for students. Physiology of Sport and Exercise has been a pivotal textbook in the field of exercise physiology. Through this edition’s dynamic and interactive learning activities, easy-to-follow layouts, and research-oriented content enriched with visual supplements, students and instructors will find this an invaluable resource for their continued education. Note: A code for accessing HKPropel is not included with this ebook but may be purchased separately.
This text explores community policing - a philosophy and an organizational strategy that expands the traditional police mandate. It broadens the focus of fighting crime to include solving community problems, urging police to form a partnership with the people in the community so average citizens can contribute to the police process in exchange for their support and participation. Now includes a chapter on Community Crime Prevention. Profiles feature community policing programs in various cities, and problem-solving case studies cover special topics. Includes: The Ten Principles of Community Po.
All films with a predominantly or entirely African American cast or that were about African Americans are detailed here. Each entry includes cast and credits, year of release, studio, distributor, type of film (feature, short or documentary) and other production details. In most cases, a brief synopsis of the film or contemporary reviews of it follow. In the appendices, film credits for over 1,850 actors and actresses are provided, along with a listing of film companies.
French Frenzies" is a lively history of French popular music that responds to a real need: how to understand the cultural differences between France and the English speaking countries of Britain and North America? The book is unique in showing how French forms of cultural expression are rooted in social and political tensions that, although shared by other countries, are not generally commented upon in songs with the same degree of clarity. In France, the persistence of strong literary and political traditions continues to nurture an exceptional current of criticism in songs and musical expression.
Endocrinology: Adult and Pediatric: Reproductive Endocrinology is a new eBook from the same experts responsible for the highly acclaimed two-volume Endocrinology clinical reference book. It puts all of the latest advances in adult and pediatric reproductive endocrinology at your fingertips, instantly accessible on your favorite eReader - so you can give your patients the benefit of today’s best know-how. Stay abreast of the newest knowledge in reproductive endocrinology, including endocrinology of sexual behavior and gender identity; genetic pathways that control gonadal development and sex differentiation; management of PCOS and hirsutism; management of male androgen deficiency; management of gynecomastia; and much more. Effectively review the causes and management of precocious or delayed puberty. Count on all the authority that has made Endocrinology, 6th Edition, edited by leading endocrinologists Drs. Jameson and DeGroot, the go-to clinical reference for endocrinologists worldwide. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices.
Cynical news hounds, grumbling editors, snooping television newscasters, inquisitive foreign correspondents, probing newsreel cameramen, and a host of others--all can be found in this reference work to Hollywood's version of journalism: from the early one-reelers to modern fare, over a thousand silent and sound films can be found. Each entry includes title, date of release, distributor, director, screenwriter, and major cast members. These credits are followed by a brief plot summary and analysis, cross-references and other information. The book is arranged alphabetically, and includes a preface, introduction, bibliography, a list of abbreviations, appendices, and an index of names. The detailed introduction covers an historical survey of the topic, with numerous film examples. The work also includes a selection of stills from various films.
This systematically organized collection evaluates the effectiveness of prescription drugs and considers complex dermatological conditions that may require multiple approaches, providing guidance for appropriate selection, initiation, and follow-up of drug therapy. Covers treatments for psoriasis ranging from coal tar, anthralin, and phototherap
Take an irreverent, chronological romp through the 2012 campaign. Laugh at the convention that ignored its candidate, but gave a standing ovation to an empty chair. Learn why PACs were more Clark Kent, than super. Enjoy the thrill of victory and the agony of defeat. Political experience, a legal background and an appetite for alliteration, propel this journey.
Larry Elder calls them like he sees them. And in this collection of some of his best columns, he wields his pen against anyone who doesn’t. Welfare, the Iran nuclear deal, Ferguson, the Republican primaries and the ascendancy of Donald Trump: Elder takes on a breadth of controversial issues. His incisive wit cuts right to the heart of hypocrisy in public discourse, particularly that of the left -- which taps into its “moral” outrage when it’s politically expedient and becomes curiously docile when it’s not. “The truth will not set you free if delivered without hope,” he writes in one column, quoting his late mother. Though he’s not hopeful about certain politicians, Elder is fundamentally optimistic about the American people: He believes in their power to overcome almost any circumstance -- if only government would stop telling them they can’t.
The essays included in this volume present Larry W. Hurtado's steadfast analysis of the earliest Christian manuscripts. In these chapters, Hurtado considers not only standard text-critical issues which seek to uncover an earliest possible version of a text, but also the very manuscripts that are available to us. As one of the pre-eminent scholars of the field, Hurtado examines often overlooked 2nd and 3rd century artefacts, which are among the earliest manuscripts available, drawing fascinating conclusions about the features of early Christianity. Divided into two halves, the first part of the volume addresses text-critical and text-historical issues about the textual transmission of various New Testament writings. The second part looks at manuscripts as physical and visual artefacts themselves, exploring the metadata and sociology of their context and the nature of their first readers, for the light cast upon early Christianity. Whilst these essays are presented together here as a republished collection, Hurtado has made several updates across the collection to draw them together and to reflect on the developing nature of the issues that they address since they were first written.
Larry Sitsky, professor emeritus at The Australian National University, is an internationally known composer, pianist, scholar, and teacher. His books are fundamental reference works on subjects such as Australian piano music, the 20th-century avant-garde, the piano music of Anton Rubinstein, the early 20th-century Russian avant-garde, and the classical reproducing piano roll. The Compleat Busoni is the result of Sitsky’s lifelong focus on the composer Ferruccio Busoni. Over three volumes, Sitsky surveys Busoni’s vast output, provides an ending to the unfinished opera Dr. Faust, and presents definitive realisations of the Fantasia Contrappuntistica in two-piano and orchestral versions. New insights into Busoni’s style and aesthetics are an integral aspect of this work.
This book was written to provide consolation, in particularly, to the millions in Christ Jesus and others who are profoundly sickened, frustrated, irritated, broken-hearted about the immoral actions and fifthly languages of Donald J. Trump, both before and after becoming president of the United States of America, who has managed to avoid justice due to him through the help of cunning, clever, scheming, devious, and disingenuous attorneys of his own nature.
Interviewing in a Changing World offers students the broadest coverage of interviewing available today by including several unique interview situations. Students begin to develop a better understanding of how to utilize strong interviewing skills in several different settings, as this text demonstrates that interviewing techniques differ in accordance with varying situations and contexts. The Second Edition covers employment contexts such as job interviews, persuasive interviews, performance and appraisal interviews, as well as media interviews on radio, television, newspapers, and political reporting. There are two full chapters on research, including interviewing skills needed for both qualitative and quantitative research. The book covers several unique interviewing situations that are on the cutting edge of communication research with an interview with a professional from the field and multiple sidebars on related theoretical and applied issues within each chapter.
In the field of law enforcement in the United States, it is essential to know the contemporary problems being faced and combine that knowledge with empirical research and theoretical reasoning to arrive at best practices and an understanding of policing. Policing in America, Eighth Edition, provides a thorough analysis of the key issues in policing today, and offers an issues-oriented discussion focusing on critical concerns such as personnel systems, organization and management, operations, discretion, use of force, culture and behavior, ethics and deviance, civil liability, and police-community relations. A critical assessment of police history and the role politics played in the development of American police institutions is also addressed, as well as globalization, terrorism, and homeland security. This new edition not only offers updated research and examples, it also incorporates more ways for the reader to connect to the content through learning objectives, discussion questions, and "Myths and Realities of Policing" boxes. Video and Internet links provide additional coverage of important issues. With completely revised and updated chapters, Policing in America, Eighth Edition provides an up-to-date examination of what to expect as a police officer in America.
The community is more than an abstract object of theoretical inquiry. It is also a place where people live. It is difficult to determine where community research and theory merge, because the community is a unique place where theory and the real world come together. Local conditions change and new research techniques emerge. In the second edition of The Community in Urban Society, the authors solve this problem by distilling the historic and foundational theories of community, applying traditional approaches (typology, ecology, systems theory, and conflict theory) to current conditions, and exploring new and relevant theories that impact todays communities. The latest edition also examines recent and emerging technologies that facilitate examination and evaluation of the modern community condition. Updated coverage includes topics such as New Urbanism, modern network analysis methods, the urban political economy approach to community, the growth machine approach, GIS mapping, recent holistic studies, cyberspace communities, and up-to-date discussions of community indicator studies, quality of life, community power, and regime politics.
There are many strategy books available in the marketplace for today’s student or business professional; most of them view strategy from the 10,000 foot level, while Strategic Thinking looks at this important business topic through a different lens. Written from the perspective of a manager, this book builds on theories of managerial and organizational cognition that have had a powerful influence on many business fields over the last two decades. As other books on business policy and strategy cover a broad range of topics, models, frameworks, and theories, the unique feature of this book is that it covers all this, but also focuses on how managers of business firms understand their business environments, assess and marshal their firms’ resources, and strive for advantage in the competitive marketplace. It examines the economic, structural, and managerial explanations for firm performance. Offering professors and business people who are intrigued by the ideas introduced in Peter Senge’s books ways to apply those ideas and principles in the classroom and in the companies in which they work, the book puts managers front and center.
This book was sponsored by the U.S. Air Force Academy Space Mission Analysis and Design Program with support from program offices at the Air Force Space and Missile Systems Center, the National Reconnaissance Office, the U.S. Department of Transportation, and organizations within the National Aeronautics and Space Administration.
Dr. Larry Poland’s book, Chasm: Crossing the Divide Between Hollywood and People of Faith, explores the century-old warfare between the world of entertainment and mainstream Americans, those “flyovers” between Hollywood and New York. It is filled with fascinating first-person stories exposing the conflicts over excess, entitlement, morality, God, faith, and intrinsic value. Dr. Poland’s three decades in Hollywood as a consultant on the faith community informs his analysis. Stunning stories from inside the industry are told with insight and good humor. Biting criticisms of those on both sides of the divide end with a call to build trust and goodwill.
Principles and Practice of Pediatric Infectious Disease provides the comprehensive and actionable coverage you need to understand, diagnose, and manage the ever-changing, high-risk clinical problems caused by pediatric infectious diseases. With new chapters, expanded and updated coverage, and increased worldwide perspectives, this authoritative medical reference offers the latest need-to-know information in an easily-accessible, high-yield format for quick answers and fast, effective intervention! Spend less time searching thanks to a consistent, easily-accessible format featuring revised high-yield information boxes, highlighted key points, and an abundance of detailed illustrations and at-a-glance tables. Be prepared for the unexpected! A veritable "who's who" of global authorities provides practical knowledge to effectively diagnose and manage almost any infectious disease you may encounter. Quickly look up the answers you need by clinical presentation, pathogen, or type of host. Get expanded coverage for all types of infectious diseases including new chapters on infection related to pets and exotic animals, and tickborne infections. Apply the latest recommendations and treatments for emerging and re-emerging diseases including the H1N1 virus.
Hybrid Intelligent Systems summarizes the strengths and weaknesses of five intelligent technologies: fuzzy logic, genetic algorithms, case-based reasoning, neural networks and expert systems, reviewing the status and significance of research into their integration. Engineering and scientific examples and case studies are used to illustrate principles and application development techniques. The reader will gain a clear idea of the current status of hybrid intelligent systems and discover how to choose and develop appropriate applications. The book is based on a thorough literature search of recent publications on research and development in hybrid intelligent systems; the resulting 50-page reference section of the book is invaluable. The book starts with a summary of the five major intelligent technologies and of the issues in and current status of research into them. Each subsequent chapter presents a detailed discussion of a different combination of intelligent technologies, along with examples and case studies. Four chapters contain detailed case studies of working hybrid systems. The book enables the reader to: Describe the important concepts, strengths and limitations of each technology; Recognize and analyze potential problems with the application of hybrid systems; Choose appropriate hybrid intelligent solutions; Understand how applications are designed with any of the approaches covered; Choose appropriate commercial development shells or tools. An invaluable reference source for those who wish to apply intelligent systems techniques to their own problems.
A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—includes an historical perspective on the topic, presents a practical compendium to privileged structures, and offers an informed perspective on the future direction for the field. The book describes the up-to-date and state-of-the-art methods of organic synthesis that describe the use of privileged structures that are of most interest. Chapters included information on benzodiazepines, 1,4-dihydropyridines, biaryls, 4-(hetero)arylpiperidines, spiropiperidines, 2-aminopyrimidines, 2-aminothiazoles, 2-(hetero)arylindoles, tetrahydroisoquinolines, 2,2-dimethylbenzopyrans, hydroxamates, and bicyclic pyridines containing ring-junction nitrogen as privileged scaffolds in medicinal chemistry. Numerous, illustrative case studies document the current use of the privileged structures in the discovery of drugs. This important volume: Describes the drug compounds that have successfully made it to the marketplace and the chemistry associated with them Offers the experience from an author who has worked in many therapeutic areas of medicinal chemistry Details many of the recent developments in organic chemistry that prepare target molecules Includes a wealth of medicinal chemistry case studies that clearly illustrate the use of privileged structures Designed for use by industrial medicinal chemists and process chemists, academic organic and medicinal chemists, as well as chemistry students and faculty, Privileged Structures in Drug Discovery offers a current guide to organic synthesis methods to access the privileged structures of interest, and contains medicinal chemistry case studies that document their application.
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