Larry N. Martin's Books

Iron and Blood

By: Gail Z. Martin,Larry N. Martin

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New Pittsburgh, 1898 – a crucible of invention and intrigue. Born from the ashes of devastating fire, flood and earthquake, the city is ruled by the shadow government of The Oligarchy. In the swarming streets, people of a hundred nations drudge to feed the engines of progress, while in the abandoned tunnels beneath the city, supernatural creatures hide from the light, emerging only to feed. Jake Desmet and Rick Brand travel the world to secure treasures and unusual items for the collections of wealthy patrons, accompanied by Jake’s cousin, Veronique LeClerque. But when their latest commission leads to Jake’s father’s murder, the three friends are drawn into a conspiracy where dark magic, industrial sabotage and the monsters that prey on the night will ultimately threaten not just New Pittsburgh, but the whole world.

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Page Count

453

Publisher

Solaris

Published Date

ISBN 10

1849979170

ISBN 13

9781849979177

Solar Flare

Solarpunk Stories

By: Sharon Lee,David Keener,Anthony W. Eichenlaub,Sarena Ulibarri,Jason Palmatier,Lauren C. Teffeau,S.C. Butler,Devan Barlow,Chaz Brenchley,Liam Hogan,Nicole Givens Kurtz,Christopher R. Muscato,Rhondi Salsitz,Ember Randall,Gail Z. Martin,Larry N. Martin,Steve Miller,Kristine Smith,Anthony Lowe

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Here Comes the Sun! Rising temperatures, melting glaciers, violent storms, and excessive heat. The future seems bleak...but there are signs of hope. In Solar Flare, we ask you to step into a world where we have managed to mitigate or even reverse the disastrous effects of climate change and our own destruction of our world. Race down the depleted waterway of the Mississippi in a solar-, wind-, and water-powered boat. Sail through the skies in a floating hydroponic dirigible. Skim along a solar-powered road in order to expose a corporation’s secret. Hover weightless in space in a last-ditch effort to repair an umbrella-like solar collector. Or cower in a shelter as fire rages outside...only to emerge and discover the rebirth such fire can bring. Experience all of this and more in these seventeen solarpunk stories brought to you by today’s hottest authors, including David Keener, Anthony W. Eichenlaub, Sarena Ulibarri, Jason Palmatier, Lauren C. Teffeau, S.C. Butler, Devan Barlow, Chaz Brenchley, Liam Hogan, Nicole Givens Kurtz, Christopher R. Muscato, Rhondi Salsitz, Ember Randall, Gail Z. Martin & Larry N. Martin, Sharon Lee & Steve Miller, Kristine Smith, and Anthony Lowe. Time to turn the tide and dream of a better future.

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Page Count

333

Publisher

Jabberwocky Literary Agency, Inc.

Published Date

ISBN 10

1940709555

ISBN 13

9781940709550

Alien Artifacts

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What might we run into as we expand beyond Earth and into the stars? As we explore our own solar system and beyond, it seems inevitable that we’ll run into aliens ... and what they’ve left behind. Alien artifacts: what might they reveal about us as we try to unlock their secrets? What might they reveal about the universe? In this anthology, nineteen of today’s leading science fiction and fantasy authors explore how discovering long lost relics of alien civilizations might change humanity. Join Walter H. Hunt, Julie Novakova, David Farland, Angela Penrose, S.C. Butler, Gail Z. Martin & Larry N. Martin, Juliet E. McKenna, Sharon Lee & Steve Miller, Andrija Popovic, Jacey Bedford, Sofie Bird, James Van Pelt, Gini Koch, Anthony Lowe, Jennifer Dunne, Coral Moore, Daniel J. Davis, C.S. Friedman, and Seanan McGuire as they discover the stars and the secrets they may hold—both dark and deadly and awe-inspiring.

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432

Publisher

Jabberwocky Literary Agency, Inc.

Published Date

ISBN 10

1940709091

ISBN 13

9781940709093

Parasiticide Screening

Volume 2: In Vitro and In Vivo Tests with Relevant Parasite Rearing and Host Infection/Infestation Methods

By: Alan A. Marchiondo,Larry R. Cruthers,Josephus J. Fourie

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Parasiticide Screening

Volume 2: In Vitro and In Vivo Tests with Relevant Parasite Rearing and Host Infection/Infestation Methods

By: Alan A. Marchiondo,Larry R. Cruthers,Josephus J. Fourie

Parasiticide Discovery: In Vitro and In Vivo Tests with Relevant Parasite Rearing and Host Infection/Infestation Methods, Volume Two presents valuable screening methods that have led to the discovery of the majority of parasiticides commercialized in the animal health industry. As much of the knowledge of parasiticide discovery methods is being lost in the animal health industry as seasoned parasitologists retire, this book serves to preserve valuable methods that have led to the discovery of the majority of parasiticides commercialized in animal health, also giving insights into the in vitro and in vivo methods used to identify the parasiticide activity of compounds. - Addresses current issues of resistance, along with combination uses for resistant parasites - Presents useful, authoritative information (chemical, pharmaceutical, clinical, etc.) for the pyrantel family of compounds - Includes a discussion on screening methods in combination therapies - Provides cutting-edge material for an evolving area of scientific discussion - Includes in vitro and in vivo screens and parasite maintenance and culture methods

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Page Count

724

Publisher

Academic Press

Published Date

ISBN 10

0128165782

ISBN 13

9780128165782

Prostate Cancer Metabolism

From Biochemistry to Therapeutics

By: Tomas Koltai,Stephan J. Reshkin,Fatima Baltazar,Larry Fliegel

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Prostate Cancer Metabolism

From Biochemistry to Therapeutics

By: Tomas Koltai,Stephan J. Reshkin,Fatima Baltazar,Larry Fliegel

Prostate Cancer Metabolism: From Biochemistry to Therapeutics shows the peculiarities of prostate cancer metabolism, emphasizing the targetable aspects – that have not been considered in conventional treatment protocols. The book specifically addresses treatment of the castration-resistant stage of prostate cancer proposing many repurposed drugs and nutraceuticals to complement, not replace, standard therapies. The large body of evidence supporting these concepts makes them deserving of further research and well-designed clinical trials. It discusses lipid, cholesterol, glutamine, and glucose metabolisms and their impact on prostate cancer. Additionally, it explains how current established drugs can be repurposed to improve treatment outcomes. The concepts set out in the book, that deal with cancer at the cellular/molecular level, help identify new avenues of research and treatments to pursue that do not affect well-being whilst offer consistent benefits. Since most practicing physicians have not studied basic biochemistry since medical school, each chapter begins with a brief review of the topic to facilitate an understanding of the metabolically-oriented approach to targeting prostate cancer. Conventional treatments are not discussed here since they are covered in textbooks and specialized updates that abound in the medical literature. It is a valuable resource for cancer researchers, oncologists, clinicians and members of biomedical field who want to learn more about prostate cancer metabolism and how to apply recent findings in the field to bedside. - Explains the basic aspects of prostate cancer metabolism, including its biochemistry which has a pivotal role in clinical practice - Discusses new drugs and nutraceuticals with a metabolism-centered approach - Offers practical bedside approach in combination with molecular and biochemical fundamentals to help readers identify and provide the best treatment to their patients

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Page Count

418

Publisher

Academic Press

Published Date

ISBN 10

032390551X

ISBN 13

9780323905510

Privileged Structures in Drug Discovery

Medicinal Chemistry and Synthesis

By: Larry Yet

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Privileged Structures in Drug Discovery

Medicinal Chemistry and Synthesis

By: Larry Yet

A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—includes an historical perspective on the topic, presents a practical compendium to privileged structures, and offers an informed perspective on the future direction for the field. The book describes the up-to-date and state-of-the-art methods of organic synthesis that describe the use of privileged structures that are of most interest. Chapters included information on benzodiazepines, 1,4-dihydropyridines, biaryls, 4-(hetero)arylpiperidines, spiropiperidines, 2-aminopyrimidines, 2-aminothiazoles, 2-(hetero)arylindoles, tetrahydroisoquinolines, 2,2-dimethylbenzopyrans, hydroxamates, and bicyclic pyridines containing ring-junction nitrogen as privileged scaffolds in medicinal chemistry. Numerous, illustrative case studies document the current use of the privileged structures in the discovery of drugs. This important volume: Describes the drug compounds that have successfully made it to the marketplace and the chemistry associated with them Offers the experience from an author who has worked in many therapeutic areas of medicinal chemistry Details many of the recent developments in organic chemistry that prepare target molecules Includes a wealth of medicinal chemistry case studies that clearly illustrate the use of privileged structures Designed for use by industrial medicinal chemists and process chemists, academic organic and medicinal chemists, as well as chemistry students and faculty, Privileged Structures in Drug Discovery offers a current guide to organic synthesis methods to access the privileged structures of interest, and contains medicinal chemistry case studies that document their application.

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Page Count

562

Publisher

John Wiley & Sons

Published Date

ISBN 10

1118686357

ISBN 13

9781118686355

Applied Clinical Pharmacokinetics 3/E

By: Larry A. Bauer

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Applied Clinical Pharmacokinetics 3/E

By: Larry A. Bauer

The most current, hands-on book in the field, Applied Clinical Pharmacokinetics The perfect textbook for pharmacy students learning the clinical application of pharmacokinetics, which is the mathematical tools for modifying doages. Students like that each chapter includes sample problems throughout the chapter, with a ton of practice problems at the end. Answers for the practice problems are in the back, but not detailed like the sample problems) *Changes in the 3/e includes: *All chapters updated and revised, as needed, including critical new references *Antibiotic individualization and monitoring sections increases use of pharmacodynamic parameters (Cmax/MIC, AUC24/MIC, Time above MIC) in addition to pharmacokinetic parameters to adjust dosages *Anticonvulsants section includes 5 new agents (Fosphenytoin, Lamotrigine, Levetiracetam, Oxcarbazepine, Eslicarbazepine) *Immunosuppressants section includes 1 new agent (Sirolimus), About the Book Text focuses on the latest standardized techniques and approaches to patient-specific dosing and provides up-to-date information on more recently moniotored drugs. Features Clear, useful coverage of drug dosing and drug monitoring Clear and concise summary of pharmacokinetic and pharmacodynamic concepts Practical help with calculations and equations Focus on the latest standardized techniques and approaches to patient-specific dosing Up-to-date information on more recently monitored drugs Essential information on drug dosing in special populations, including patients with renal and hepatic disease, obesity, and congestive heart failure All the information practitioners need on drug categories such as antibiotics, cardiovascular agents, anticonvulsants, and immunosuppressants Full coverage of drugs such as Aminoglycosides, Vancomycin, Digoxin, Phenytoin, Carbamazepine, Theophylline, Cyclosporine, Tacrolimus, and Lithium Student friendly approach to teaching pharmacokinetics--sample problems embedded into the text to allow for students to apply what they are learing. .

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Page Count

881

Publisher

McGraw Hill Professional

Published Date

ISBN 10

007179459X

ISBN 13

9780071794596

Endocrinology: Adult and Pediatric E-Book

By: J. Larry Jameson,Leslie J. De Groot

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Endocrinology: Adult and Pediatric E-Book

By: J. Larry Jameson,Leslie J. De Groot

Considered the definitive source in its field for over 35 years, Endocrinology: Adult and Pediatric, has been thoroughly updated to reflect today's recent advances in adult and pediatric endocrinology. Unique perspectives from a team of trusted, world-renowned experts ensure this medical reference book remains the most highly-regarded text in the field. Make the best clinical decisions with an enhanced emphasis on evidence-based practice and expert opinions on treatment strategies. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. Locate information quickly, while still getting the complete coverage you expect. Now in full color, with special design treatment for at-a-glance pediatric content, helping to distinguish the pediatric content. Expanded coverage for key topics such as pediatric endocrinology and obesity mechanisms and treatment, in addition to today's hot topics in endocrinology, including endocrine disruptors, bariatric surgery, androgen deficiency, genetic causes of obesity, endocrine rhythms, and the use of tyrosine kinase inhibitors in thyroid cancer. New content addressing the latest advances in testosterone and estrogen replacement, as well as the new causes of calcium and phosphate disorders, new molecular causes of endocrine cancers, new genetic causes of reproductive disorders, and more. Updated clinical guidelines for diabetes, lipid disorders, obesity management, osteoporosis, and more, as well as essential treatment updates for the medical management of acromegaly, Cushing's Disease, hypercalcemia, and diabetes mellitus. New Key Points provide snapshots of what to expect in each chapter, or serve as a refresher of what you just read. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and videos from the book on a variety of devices.

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Page Count

3707

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

032332195X

ISBN 13

9780323321952

Book's by Larry N. Martin

Iron and Blood

Iron and Blood

Solar Flare

Solar Flare

Alien Artifacts

Alien Artifacts

Parasiticide Screening

Parasiticide Screening

Prostate Cancer Metabolism

Prostate Cancer Metabolism

Privileged Structures in Drug Discovery

Privileged Structures in Drug Discovery

Applied Clinical Pharmacokinetics 3/E

Applied Clinical Pharmacokinetics 3/E

Endocrinology: Adult and Pediatric E-Book

Endocrinology: Adult and Pediatric E-Book

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