Many political commentators, both liberal and conservative, have argued that the 1980s were a period of fundamental conservative change. Some of them believe that the changes have been so important that the 1980s should be seen as a watershed period in American political history as significant as the 1930s. Schwab argues here that politics and policy have not fundamentally changed in a conservative direction, but have actually moved in the opposite direction. This book is a timely and comprehensive analysis of the Reagan years, of interest to all readers interested in politics and national policy.
pH Deregulation as the Eleventh Hallmark of Cancer presents key concepts about pH deregulation in a concise and straight-forward manner. The book discusses topics such as pH regulation and metabolism, sodium hydrogen exchanger, monocarboxylate transporter, V-ATPase proton pump, carbonic anhydrases, and voltage gated sodium channels. In addition, it covers clinical and therapeutic implications and future perspectives. This is a valuable resource for researchers, oncologists, students and members of the biomedical and medical fields who want to learn more about the role of pH deregulation in cancer treatment. pH deregulation can improve the outcome of classical treatments without adding toxicity to them, and the book shows that treating the pH peculiarities of cancer is simple and can be performed with existing drugs. Based on the classification of tumor malignancy in ten hallmarks, the authors put pH deregulation at the spotlight and separated from metabolic reprogramming due to its impact on all other hallmarks, proposing it as an additional characteristic to evaluate and fight cancer. Proposes that pH deregulation should be considered as an independent hallmark of cancer from metabolic reprogramming due to its impact on all other hallmarks (based on seminal work of Hanahan and Weinberg) Explains basic issues of cancer pH deregulation and its consequences in a simple and concise manner Discusses the subject from the start with very elementary concepts on pH and pH regulation to help readers understand key concepts without proper background Presents key concepts through original illustrations and table for easy comprehension
This book vividly illustrates the history of business in the United States from the point of view of the enterprising men and women who made it happen. Ever since the first colonists landed in the New World, Americans have forged ahead in their quest to make good on promises of capitalism and independence. Weaving stirring narrative with economic analysis, this historical deep dive recounts the successes and failures of some of the most iconic business people to grace our history books--from the founding of our country to the present day. In American Entrepreneur, you’ll learn about how: Eli Whitney changed the shape of the American business landscape; the Civil War impacted the economy, and how it was renewed by the subsequent dominance of Andrew Carnegie and J. P. Morgan; Asa Candler, W. K. Kellogg, Henry Ford, and J.C. Penney led the rise of the consumer marketplace; and Warren Buffett’s, Michael Milken’s, and Martha Stewart’s experience in the “New Economy” in the 1990s--and how that economy continues today. It is an adventure to start a business, and the greatest risk takers in that adventure are entrepreneurs. This is the epic story of America’s entrepreneurs and how they created the economy we enjoy today.
This volume constitutes the refereed proceedings of the 12th International Workshop on Languages and Compilers for Parallel Computing, LCPC'99, held in La Jolla, CA, USA in August 1999. The 27 revised full papers and 14 posters presented have gone through two rounds of selection and reviewing. The volume offers topical sections on Java, low-level transformations, data distribution, high-level transformations, models, array analysis, language support, and compiler design and cost analysis.
Completely updated for its Third Edition, this book is a comprehensive review of the topics on the American Board of Surgery In-Training Examination (ABSITE), the certifying exam, and recertification exams. Chapters are co-authored by residents and attending physicians at the Hospital of the University of Pennsylvania and integrate basic science with clinical practice. More than 300 illustrations complement the text. This edition's Table of Contents has been reorganized to match the current exam. The Key Concept summaries have been expanded and moved to the front of each chapter. Additional diagrams and tables have been included for quicker review.
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