Haley and 3-M plan to kill The Termagant, but at a movie house, a clown opens fire, kills two people, and leaves an enigmatic note-What Would J Do? Thus begins an endgame rooted in 1635, conflating the psychotic Lomi; a killing machine named Übeltäter; natural philosopher Marin Mersenne; movie icon James Cagney; and the prime numbers series. Meanwhile, The Termagant leaves a prophetic note-Your demises shall be my right hand's gift, but how shall I do it? Asked and answered. Soon, serial killer La Bohème begins murdering women, cutting out a section of cheek, and also leaving a note-She's so perfect now, my chef-d'oeuvre. As the clown shootings escalate, Haley and 3-M engage in a battle at Kings Dominion, then learn a massacre to be seen by millions is being planned. But as they hunt the killers, the beasts decide to target their families, stoking Willi's long repressed savagery. After deducing The Termagant's identity, she hides her discovery, then confronts the killer on her own.
Maxine Kordell's high school reunion is marred when al-Qaeda hijacks her plane, a female gang accosts her, her friend Marty Blair is murdered, and she's threatened by a drug cartel, coyotes, and the police. Joined by Mena Harling and Willi Mayers, 3-M investigate, but are almost killed while in custody. Haley joins them, but events intrude involving lost Francisco Goya paintings, a Jim Bowie silver hoard, Sherlock Holmes, Pope Pius XII, The Cluster, a list compiled by former Vice President Aldrich Fellerson implicating The Vatican in war crimes, and a plan for hiding the list devised by Holmes. So Pope John Paul II brings the foursome to Rome, where they're caught in a feud between two cardinals and become targets of the Mafia. 3-M and Haley soon learn their foes include four professional assassins. Aided by born again Christian/Sherlockian Nora Kelly, they find a letter from Holmes, pursue the treasures and list, then Max must face Marty's killer, whose lethality may exceed her own.
Life hasn't been kind to Haley. In his early 30's, a database developer, and once a covert CIA operative, he has an alter ego who emerges when violence threatens. A half Irish, half Jewish orphan, he retreated to a workaholic existence after his wife died in an accident. Then Haley met Montana-born Episcopalian, Willi Mayers, a master at verbal jousting, able to eat enormous quantities of food without gaining weight. As they develop a Cultural Landscapes System for the National Park Service, a cryptic note appears with the message 3912. More notes appear, and Haley's formerly submissive alter ego becomes aggressive. In Montana, Haley tries to effect a rapprochement between Willi and her father, only to return home to face a personal tragedy that frees his alter ego to take vengeance on a merciless killer. His future with Willi at stake, Haley must confront a violent adversary from his past, while deciphering the true meaning and intent of the notes.
Born again Christian Nora Kelly is warned to stop matching real world events to Tribulation prophecies. After Nora turns to 3-M and Haley, she's attacked, a colleague is murdered, then she's kidnapped and brainwashed by Triantologists, who coerce her to renounce Christ. After Nora is rescued from an armed bastion, psychiatrist Marilyn Swiss helps her recover, and Nora learns she's caught up in a conflict conflating an ancient Greek cult-the KOTT, with Moses, the Mormons, Doc Holliday, Frank Sinatra, Don Rickles, and Marilyn Monroe. Nora then uncloaks a plot to discredit Christianity and Judaism, using a false claim that Revelation's prophecy of 144,000 Jews coming to Christ is untrue. Pursuing leads in Chicago and Atlanta, Nora's team encounter assassins Flotilla and Duet, then deduce the deft hand of an old enemy-The Tracer. When Nora finally confronts a malevolence she deems Satanic, she must test her faith by deciding whether to turn the other cheek, or exact a violent retribution.
Mena Harling learns shoddy maintenance caused ThriftJet crashes, one in which her brother died. Then a whistleblower is murdered, a note left by his corpse-Too risky to fly; deny that, you'll die; I'll watch your tears dry; your last sigh's my high. Aether. And TOETIFTSA, who desecrated Nora Kelly's church, continues killing Christians, leaving a note-Christian fundamentalism is not a righteous pursuit. So Maxine Kordell, Nora, Willi Mayers, and Haley join Mena. When Aether murders Cluster members, The Tracer asks for help, and reveals The Cluster killed Will Rogers, Amelia Earhart, and Glenn Miller. Then Aether attacks Dulles Airport and other iconic aerospace sites, as TOETIFTSA causes the crash of a plane carrying Christians, then tries to murder Nora. So Mena seeks help from a notorious serial killer, a psychiatrist living in Italy, who will profile Aether if the team agrees to a favor. Finally, events push Mena to become the determined protector of certain sociopaths just rewards.
Haley, suicidal after Willi's death, joins a CIA mission, then finds her alive in the hands of slavers. As both face death, his alter ego returns to kill her captors. Then past events intrude. Valen, a Gnostic, forges a letter in Jesus' name, then Cesare Borgia adapts it. Centuries later, the letter involves John McCone, J. Edgar Hoover, four U.S. Presidents, Judy Garland, and Haley's CIA mentor, George Durell. In 2000, Pope John Paul II receives the letter, then asks the U.S. for help. But The Order Of The Gnostic Cross, Church Of Triantology, and Raven H2O have their own plans, as does female spy Jasus al-Mara, who enlists the aid of al-Qaeda terrorist Karbala. Meanwhile, the shadowy Cluster pulls everyone's strings, the unknown Termagant plots to destroy TGC, and a monster carves TINPLUFORPLE on the torsos of little girls. When a letter from George Durell surfaces, Haley and Willi again face violent foes, but this time they have help-serial killers Maxine Kordell and Mena Harling.
Haley-database developer, CIA operative, and a multiple personality-is engaged to Willi Mayers. His violent past makes her return home, where her father is murdered. Haley's alter ego emerges, but, when Haley shows an assassin mercy, his other self ends their arrangement. The twosome begin work on a Tribulation Tracking System, funded by a televangelist. On the team is Patricia Candor, a born again Christian. Seeing her faith makes agnostic Willi open to Christ, a decision atheist Haley frets about. When the team is attacked, Willi can't defend herself, so Haley sends her to the CIA's Farm. Then, outside events intrude. Women are abducted and churches are defiled by a cryptic message. Willi concludes the abductions are guided by Revelations' Seal, Trumpet, and Vial judgments. After an Al Qaeda operative recruits MS-13 to explode IEDs at a school, Willi renounces God and plans to execute all involved. Haley must now deal with two mass murderers and a woman he no longer trusts.
3 billion years ago, an alien evolution experiment began, then they ended the age of dinosaurs to protect that experiment. Later, they performed three human makeovers-Jesus Of Nazareth, Galileo, and a 72 year old man named Sam. In 2016, a spacecraft lands in Virginia carrying Sam-now The Emissary-who reveals an hypothesis to be tested-Science as an organizing principle is compatible with species survivability and longevity. With Sam is BC. who appears as a platinum rod, a wooden staff, a Border Collie, and a giant tarantula. Sam explains the experiment is threatened by religious fundamentalism, so to usher in an Age Of Science, Sam confronts a variety of believers and unbelievers. But superstition is hard to overcome, and when fanatics attempt to assassinate them, BC wreaks havoc. Then Sam reveals an unimpeachable witness, whose testimony rocks the world. But the aliens have a hidden motive, one that forces humanity to confront an unworldly terror that threatens their very existence.
In New York City, database developers Haley and Willi foil an attempt to blow up the Manhattan Bridge. Home again, in Centreville, Virginia, a snobbish waiter brings out Willi's darker side, so Haley insists she see a psychiatrist. Then, outside events intrude. A serial killer is murdering pedophiles. A second killer is eliminating famous people who escaped justice, leaving behind a cryptic note-To the determined protector of my just reward. A third killer is murdering parents and daughters, then leaving bizarre notes citing songs about Bill. A hostile takeover of their employer is underway, using The Stroller, an assassin, to ensure the sale. Nora Kelly, an evangelical friend presumed dead in the Sudan, returns, mysteriously saved by Raven H2O, a security contractor known for its ruthlessness. When friends are killed, the twosome are drawn into the tangled web of serial murders, and Haley must deal with the distinct possibility Willi may be one of the killers.
Introducing the most dramatically revised edition of Harrison's ever! Now with NEW bonus DVD with 37 chapters and more than 500 brand new images and video clips! MORE THAN TRUSTED, BEYOND ESSENTIAL . . . The #1 selling medical textbook worldwide, Harrison's has defined internal medicine for millions of clinicians and students. The new Seventeenth Edition retains Harrison's acclaimed balance of pathobiology, cardinal signs and manifestations of disease, and best approaches to patient management, yet has been massively updated to give you an innovative array of bold new features and content. If ever there was one must-have resource for clinicians and students - this is it! UNMATCHED EXPERTISE AT YOUR FINGERTIPS As an unprecedented amount of medical information bombards you and your patients, where do you go to sort it out and make sense of it all? When your patients request clarification on something they've “printed off” where do you turn for expert explanations? The same trusted resource physicians and students have turned to for over fifty years: Harrison's Principles of Internal Medicine. Now more than ever, trust Harrison's to filter and clarify the exploding knowledge base, to highlight the breakthroughs, and to deliver a clear, balanced distillation of the best and most current information on which to base clinical decisions. THE MOST EXCITING AND EXTENSIVELY REVISED EDITION EVER! Here are just a few of the reasons why the new 17th Edition of Harrison's is the best edition yet: Bonus companion DVD featuring: 37 new “e-chapters”; over 500 brand-new radiological, laboratory, and clinical images, including complete atlases; state-of-the-art video clips; an Image Bank of nearly all the illustrations contained in the parent text, and much more Expanded, modernized illustration program with more than 800 brand-new, additional illustrations-a 60% increase over the previous edition Dozens of brand new chapters on vital topics in medical education and clinical practice: Global Issues in Medicine: Patient Safety and Health Quality; Health Disparities: Atlas of EKGs; Clinical Management of Obesity: Atlas of Hematology: Atlases of Chest, Neurological, and Cardiovascular Radiology, and much more! Also included a complete new Section on biological foundations and emerging clinical applications of regenerative medicine! Brand new, reader-friendly text design optimizes the full-color format An expanded, innovative focus on global health NEW Global Advisory Board comprised of 11 prominent medical experts from Asia, India, Europe, and South America Revision of the popular On Line Learning Center, which offers more skill-sharpening self-assessment questions and answers, plus additional case studies for helping you apply Harrison's content to the daily care of patients Harrison's related products are available in a full suite of formats to meet all your educational and clinical needs. Harrison's Practice of Medicine is a complete database of more than 700 clinical topics formatted for use at the point of care. The Harrison's Manual of Medicine is one of the most popular and heavily used handbook-sized resources in internal medicine. The Harrison's Self-Assessment and Board Review features more than 1000 board-type cases and questions and highlights the use of Harrison's as a great board prep resouce.
SPECIAL OFFER! SAVE WHEN YOU PURCHASE HARRISON’S PRINCIPLES OF INTERNAL MEDICINE, 19e ALONG WITH THE COMPANION BOARD REVIEW BOOK! This dollar-saving Harrison’s bundle includes two great resources: Harrison’s Principles of Internal Medicine, Nineteenth Edition Through six decades, no resource has matched the authority, esteemed scholarship, and scientific rigor of Harrison's Principles of Internal Medicine. Capturing the countless advances and developments across the full span of medicine, the 19th edition of Harrison’s provides a complete update of essential content related to disease pathogenesis, clinical trials, current diagnostic methods and imaging approaches, evidence-based practice guidelines, and established and newly approved treatment methods. Here are just a few of the outstanding features of the Nineteenth Edition: •Presented in two volumes: Volume 1 is devoted to foundational principles, cardinal manifestations of disease and approach to differential diagnosis; Volume 2 covers disease pathogenesis and treatment •NEW chapters on important topics such as Men’s Health, The Impact of Global Warming on Infectious Diseases, Fatigue, and many more •Critical updates in management and therapeutics in Hepatitis, Coronary Artery Disease, Ebola Virus Disease, Multiple Sclerosis, Diabetes, Hypertension, Deep Vein Thrombosis and Pulmonary Embolism, Acute and Chronic Kidney Disease, Inflammatory Bowel Disease, Lipoprotein Disorders, HIV and AIDS, and more. •Increased number of the popular Harrison’s clinical algorithms; clinically relevant radiographic examples spanning hundreds of diseases; clinical-pathological images in full color; crystal clear, full color drawings and illustrations and helpful tables and summary lists that make clinical application of the content faster than ever •Access to outstanding multi-media resources including practical videos demonstrating essential bedside procedures, physical examination techniques, endoscopic findings, cardiovascular findings, and more The package also includes..... Harrison’s Principles of Internal Medicine Self-Assessment and Board Review Based on the content of Harrison’s Principles of Internal Medicine, Nineteenth Edition, this full-color study aid is essential for Internal Medicine Board certification or recertification/maintenance of certification, or as a refresher for any internal medicine examination. Reflecting the accuracy, currency, and wide scope of Harrison’s, this complete review of internal medicine delivers more than 1,000 extremely challenging review questions, many of which utilize realistic patient scenarios, including radiographic and pathologic images. Each question is accompanied by explanations for correct and incorrect answers. These explanations -- which are derived from and cross-referenced to Harrison’s Principles of Internal Medicine, Nineteenth Edition – are one of the most effective ways to learn and teach internal medicine. They are designed to bolster your understanding of pathophysiology, epidemiology, differential diagnosis, clinical decision making, and therapeutics. You will also find a beautiful full-color atlas.
The most trusted textbook in medicine -- featuring the acclaimed Harrison's multimedia download with 57 additional chapters and exclusive video and tutorials Now presented in TWO VOLUMES As reviwed by JAMA: "With the 18th edition, Harrison's Principles of Internal Medicine retains its standing as a definitive clinical reference and remains an outstanding foundation for any physician or physician-in-training. In many regards, Harrison’s remains synonymous not just with internal medicine but with medicine in general. The editors of the 18th edition have skillfully balanced tradition with the desire and need for innovation. The result is a book that remains as fundamental to current medical practice as the first edition was in 1949." --JAMA Extensively revised and expanded by the world’s leading physicians, Harrison’s Principles of Internal Medicine, 18e continues to set the standard as the pinnacle of current medical knowledge and practice, offering the definitive review of disease mechanisms and management. CURRENT All chapters have been completely updated to reflect the latest knowledge and evidence, and important new chapters have been added, including: "Systems Biology in Health and Disease," "The Human Microbiome," "The Biology of Aging," and "Neuropsychiatric Illnesses in War Veterans." CONNECTED Harrison's covers more global aspects of medicine than any other textbook, and features such chapters as "Global Issues in Medicine," by Jim Yong Kim, Paul Farmer, and Joseph Rhatigan, and new to the 18th edition, "Primary Care in Low and Middle Income Countries." COMPREHENSIVE No other resource delivers coverage of disease mechanisms and management like Harrison's, including world-renowned chapters on HIV/AIDS, STEMI and non-STEMI myocardial infarction, cancer biology, multiple sclerosis, and diabetes. The Harrison’s Multimedia Download— Better Than Ever! The Harrison’s multimedia download has been expanded to include an extensive video demonstration of the neurological physical examination, and video tutorials on how to perform essential clinical procedures, including: Thoracentesis Abdominal Paracentesis Endotracheal Intubation Central Venous Catheter Placement 57 additional chapters and more than 2,000 images make the companion download an essential part of every physician's education, practice, and lifelong learning. The download also features PowerPoint presentations from fifty chapters to facilitate classroom lectures, and a free trial subscription to AccessMedicine.com (including Harrison's Online). Harrison’s 18e is proud to present a tribute to longtime editor, Eugene Braunwald, MD for his outstanding and continuing contributions to medical knowledge and practice.
SPECIAL OFFER! SAVE WHEN YOU PURCHASE HARRISON’S PRINCIPLES OF INTERNAL MEDICINE, 19e ALONG WITH THE COMPANION HARRISON’S MANUAL! This dollar-saving Harrison’s bundle includes these two great resources: Harrison’s Principles of Internal Medicine, Nineteenth Edition Through six decades, no resource has matched the authority, esteemed scholarship, and scientific rigor of Harrison's Principles of Internal Medicine. Capturing the countless advances and developments across the full span of medicine, the 19th edition of Harrison’s provides a complete update of essential content related to disease pathogenesis, clinical trials, current diagnostic methods and imaging approaches, evidence-based practice guidelines, and established and newly approved treatment methods. Here are just a few of the outstanding features of the Nineteenth Edition: •Presented in two volumes: Volume 1 is devoted to foundational principles, cardinal manifestations of disease and approach to differential diagnosis; Volume 2 covers disease pathogenesis and treatment •NEW chapters on important topics such as Men’s Health, The Impact of Global Warming on Infectious Diseases, Fatigue, and many more •Critical updates in management and therapeutics in Hepatitis, Coronary Artery Disease, Ebola Virus Disease, Multiple Sclerosis, Diabetes, Hypertension, Deep Vein Thrombosis and Pulmonary Embolism, Acute and Chronic Kidney Disease, Inflammatory Bowel Disease, Lipoprotein Disorders, HIV and AIDS, and more. •Increased number of the popular Harrison’s clinical algorithms; clinically relevant radiographic examples spanning hundreds of diseases; clinical-pathological images in full color; crystal clear, full color drawings and illustrations and helpful tables and summary lists that make clinical application of the content faster than ever •Access to outstanding multi-media resources including practical videos demonstrating essential bedside procedures, physical examination techniques, endoscopic findings, cardiovascular findings, and more The package also includes..... Harrison’s Manual of Medicine, Nineteenth Edition Harrison’s Manual of Medicine is a concise, bedside resource derived from content found in Harrison’s Principles of Internal Medicine, Nineteenth Edition. Perfect for use at the point of care, the Manual presents clinical information covering key aspects of the diagnosis, clinical manifestations, and treatment of the major diseases that are likely to be encountered in medical practice. Presented in full color and incorporating an efficient blend of succinct text, bullet points, algorithms, and tables Harrison’s Manual of Medicine, Nineteenth Edition covers every area of clinical medicine, including: • Etiology and Epidemiology • Clinically Relevant Pathophysiology • Signs and Symptoms • Differential Diagnosis • Physical and Laboratory Findings • Therapeutics • Practice Guidelines
The landmark guide to internal medicine— updated and streamlined for today’s students and clinicians The only place you can get ALL the great content found in the two print volumes AND the acclaimed DVD in one convenient resource! Through six decades, no resource has matched the authority, esteemed scholarship, and scientific rigor of Harrison’s Principles of Internal Medicine. Capturing the countless advances and developments across the full span of medicine, the new 19th edition of Harrison’s provides a complete update of essential content related to disease pathogenesis, clinical trials, current diagnostic methods and imaging approaches, evidence-based practice guidelines, and established and newly approved treatment methods. Here are just a few of the outstanding features of the new Nineteenth Edition: Content is practically organized around two basic themes: education and clinical practice The teaching and learning sections cover foundational principles, cardinal manifestations of disease and approach to differential diagnosis; the content devoted to clinical practice focuses on disease pathogenesis and treatment NEW chapters on important topics such as Men’s Health, The Impact of Global Warming on Infectious Diseases, Fatigue, and many more Critical updates in management and therapeutics in Hepatitis, Coronary Artery Disease, Ebola Virus Disease, Multiple Sclerosis, Diabetes, Hypertension, Deep Vein Thrombosis and Pulmonary Embolism, Acute and Chronic Kidney Disease, Inflammatory Bowel Disease, Lipoprotein Disorders, HIV and AIDS, and more. Increased number of the popular Harrison’s clinical algorithms; clinically relevant radiographic examples spanning hundreds of diseases; clinical-pathological images in full color; crystal clear, full color drawings and illustrations and helpful tables and summary lists that make clinical application of the content faster than ever Outstanding multi-media resources including practical videos demonstrating essential bedside procedures, physical examination techniques, endoscopic findings, cardiovascular findings, are available for easy download Supporting the renowned coverage are supplemental resources that reflect and assist modern medical practice: more than 1,000 full-color photographs to aid visual recognition skills, hundreds of state-of-the-art radiographs, from plain film to 3D CT to PET Scans; beautiful illustrations that bring applied anatomy and processes to life; the renowned Harrison’s patient-care algorithms, essential summary tables, and practical demonstrative videos. In addition, several digital atlases highlight noninvasive imaging, percutaneous revascularization, gastrointestinal endoscopy, diagnosis and management of vasculitis, and numerous other issues commonly encountered in clinical practice. Acclaim for Harrison’s: “Covering nearly every possible topic in the field of medicine, the book begins with a phenomenal overview of clinical medicine, discussing important topics such as global medicine, decision-making in clinical practice, the concepts of disease screening and prevention, as well as the importance of medical disorders in specific groups (e.g. women, surgical patients, end of life). The extensive chapters that follow focus on a symptom-based presentation of disease and then illness organized by organ system. Numerous tables, graphs, and figures add further clarity to the text." ...Written by experts in the field, this book is updated with the latest advances in pathophysiology and treatment. It is organized in a way that makes reading from beginning to end a logical journey, yet each chapter can stand alone as a quick reference on a particular topic. “ Doody’s Review Service reviewing the previous edition of Harrison’s
Publisher's Note: There is a new edition of Harrison's Principles of Internal Medicine. The 21st edition contains the most timely and comprehensive updates from the world's top experts. MASTER MODERN MEDICINE! Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible. Essential for practice and education, the landmark 20th Edition features: Thoroughly revised content—covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison’s. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care. State-of-the-art coverage of disease mechanisms: Harrison’s focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison’s summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system’s role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals. All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine—Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine. Important and timely new chapters—such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more—offer the very latest, definitive perspectives on must-know topics in medical education and practice. Updated clinical guidelines, expert opinions, and treatment approaches from world-renowned editors and authors contribute to the accuracy and immediacy of the text material and pres
The Voice of Clinical ReasonHarrison’s Principles of Internal Medicine is the world's most trusted clinical medicine text—and a superb resource for learning the art and science of clinical reasoning. Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine provides the informational foundation you need for the best patient care possible. This new edition is fully updated with timely new chapters and essential updates across the spectrum of internal medicine. Harrison's Principles of Internal Medicine stands as the benchmark for authoritative, practical information on patient care and the pathogenesis and clinical management of symptoms and signs and specific diseases. Written and edited by the world’s top experts in their respective fields, this landmark guide provides the comprehensive, accurate, and essential coverage of the pathogenesis, diagnosis, and treatment of disease. Harrison’s is world-renowned as the most authoritative source for: • Descriptions of disease mechanisms and how the clinician can apply that knowledge for the best patient care and optimal diagnosis and treatment of specific diseases • Clear, concise schemas that facilitate the generation of differential diagnoses to reason efficiently through complex real world clinical cases • The physiologic and epidemiologic basis of signs and symptoms, which are covered through a wealth of unsurpassed expert guidance and linked to the disease-specific chapters that follow • Updated clinical trial results and recommended guidelines • Excellent and extensive visual support, including radiographs, clinical photos, schematics, and high-quality drawings • Coverage of both therapeutic approaches and specific treatment regimens • Practical clinical decision trees and algorithms • Organ-specific sections, with clinically relevant pathophysiology and practical clinical advice on the approach to the patient, strategies towards building a differential diagnosis, outstanding clinical algorithms and diagnostic schema, a wealth of clinical images and diagrams, current clinical guidelines, general and specific approaches to therapy Harrison’s remains the most trusted resource in a world influenced by endless sources of medical information. The most timely and comprehensive updates from the world’s top experts are featured in the 21st edition: • Current coverage of the diagnosis and treatment of diseases, from COVID to dementia to sepsis to multiple sclerosis to lung cancer • Updated content that reflects new approved therapeutics and new practice-changing guidelines and evidence summaries • More than 1000 clinical, pathological, and radiographic photographs, diagnostic and therapeutic decision trees, and clear schematics and diagrams describing pathophysiologic processes • More than a dozen atlases featuring curated collections of visual aspects of diagnosis and management • Complete, updated curation and synthesis of primary medical literature which incorporates current data from major studies and clinical trials • Clinical reasoning resources and helpful disease/presentation schemas • Clinically relevant coverage of disease mechanics and pathophysiology, and related therapeutic mechanisms
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