This relatively nontechnical book is the first account of the history of statistics from the Fisher revolution to the computer revolution. It sketches the careers, and highlights some of the work, of 65 people, most of them statisticians. What gives the book its special character is its emphasis on the author's interaction with these people and the inclusion of many personal anecdotes. Combined, these portraits provide an amazing fly-on-the-wall view of statistics during the period in question. The stress is on ideas and technical material is held to a minimum. Thus the book is accessible to anyone with at least an elementary background in statistics.
This second, much enlarged edition by Lehmann and Casella of Lehmann's classic text on point estimation maintains the outlook and general style of the first edition. All of the topics are updated, while an entirely new chapter on Bayesian and hierarchical Bayesian approaches is provided, and there is much new material on simultaneous estimation. Each chapter concludes with a Notes section which contains suggestions for further study. This is a companion volume to the second edition of Lehmann's "Testing Statistical Hypotheses".
Classical statistical theory—hypothesis testing, estimation, and the design of experiments and sample surveys—is mainly the creation of two men: Ronald A. Fisher (1890-1962) and Jerzy Neyman (1894-1981). Their contributions sometimes complemented each other, sometimes occurred in parallel, and, particularly at later stages, often were in strong opposition. The two men would not be pleased to see their names linked in this way, since throughout most of their working lives they detested each other. Nevertheless, they worked on the same problems, and through their combined efforts created a new discipline. This new book by E.L. Lehmann, himself a student of Neyman’s, explores the relationship between Neyman and Fisher, as well as their interactions with other influential statisticians, and the statistical history they helped create together. Lehmann uses direct correspondence and original papers to recreate an historical account of the creation of the Neyman-Pearson Theory as well as Fisher’s dissent, and other important statistical theories.
The third edition of Testing Statistical Hypotheses updates and expands upon the classic graduate text, emphasizing optimality theory for hypothesis testing and confidence sets. The principal additions include a rigorous treatment of large sample optimality, together with the requisite tools. In addition, an introduction to the theory of resampling methods such as the bootstrap is developed. The sections on multiple testing and goodness of fit testing are expanded. The text is suitable for Ph.D. students in statistics and includes over 300 new problems out of a total of more than 760.
Personalized medicine employing patient-based tailor-made therapeutic drugs is taking over treatment paradigms in a variety of ?elds in oncology and the central nervous system. The success of such therapies is mainly dependent on ef?cacious therapeutic drugs and a selective imaging probe for identi?cation of potential responders as well as therapy monitoring for an early bene?t assessment. Molecular imaging (MI) is based on the selective and speci?c interaction of a molecular probe with a biological target which is visualized through nuclear, magnetic resonance, near infrared or other methods. Therefore it is the method of choice for patient selection and therapy monitoring as well as for speci?c e- point monitoring in modern drug development. PET (positron emitting tomography), a nuclear medical imaging modality, is ideally suited to produce three-dimensional images of various targets or processes. The rapidly increasing demand for highly selective probes for MI strongly pushes the development of new PET tracers and PET chemistry. ‘PET chemistry’ can be de?ned as the study of positron-emitting compounds regarding their synthesis, structure, composition, reactivity, nuclear properties and processes and their properties in natural and - natural environments. In practice PET chemistry is strongly in?uenced by the unique properties of the radioisotopes used (e. g. , half-life, che- cal reactivity, etc. ) and integrates scienti?c aspects of nuclear-, organic-, inorganic- and biochemistry.
An important book for theology, ethics, and the church. James H. Cone This book displays all the depth, penetrating insight, and clarity of thinking that have become the hallmarks of Lehmann's writing. It mercilessly and wonderfully exposes the superficiality and frivolousness of many of the arguments surrounding the Decalogue.... Theologically instructive, intellectually satisfying, and spiritually uplifting. Allan Boesak Paul Lehmann was one of the greatest of America's Christian ethicists and one of its most influential teachers. His work has had a profound impact on many persons, especially pastors and lay folk. This final work brings him back to some of his major themes - the relation of the gospel and law, the commitment to a truly human life in this world that is shaped by God's just and loving activity in Jesus Christ, and the need for the gift of discernment to see what it is that makes and keeps human life human.... One does not expect to hear much that is fresh on such worked-over moral issues as abortion and homosexuality, but in these pages Lehmann makes us think afresh and challenges us even on those familiar topics. It is sad to think that we shall hear no more from this deeply Christian and moral thinker. Patrick D. Miller, Princeton Theological Seminary This is vintage Lehmann. His koinonia ethic continues to make enormous sense - not least in South Africa and other transitional situations where people are seeking moral discernment amid complexity and ambiguity in the quest for social justice. This book's development of Lehmann's ethic around the Ten Commandments makes it more than a textbook for students. It is a book for pastors, the laity, and the general public. It is also a wonderful culmination to the work of a great theologian. Charles Villa-Vicencio, University of Cape Town, South Africa
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