Alzheimer's disease (AD), the most common form of neurodegenerative disorder in the elderly, is characterised pathologically by extracellular amyloid plaques and intracellular neurofibrillary tangles, pathophysiologically by synaptic dysfunction, and clinically by a progressive decline in cognition. Currently, AD has no cure and its prevalence is predicted to triple by 2050 with the rapid increase in the ageing population, unless more effective treatments are developed. Since the publication of the second book volume, the rapid progress in the research fields of AD and dementia continues through the intensive efforts of research scientists worldwide. This third book volume contains 15 chapters, bringing together a presentation of research frontiers in current AD/dementia research. The topics include molecular genetics of AD, gene expression abnormalities in AD progression, presenilins, taupathy in AD, single -induced(neuron gene expression abnormalities in AD, intracellular A neurodegeneration, roles of lipoprotein receptors in AD onset and progression, cholesterol and tau hyperphosphorylation, AD diagnostics and therapeutic strategies, in vivo visualisation of amyloid-like structures, cathepsin B, antiamyloidogenesis and neuroprotection, environmental enrichment, Fragile X mental retardation gene and dementia, category learning in Parkinson's disease, cerebrovascular disease and dementia, and dementia and hypertension. These chapters cover current advances in our understanding of the pathogenic mechanisms underlying AD and dementia, in the diagnosis of early AD and dementia, and in the development of therapeutic agents that target memory-relevant AD pathogenesis. The book will be highly valuable to students and scientists worldwide who are interested in the scientific research progress in AD and dementia.
Metal Powder—Based Additive Manufacturing Highly comprehensive resource covering all key aspects of the current developments of metal powder—based additive manufacturing Metal Powder—Based Additive Manufacturing provides valuable knowledge and critical insights regarding the recent advances in various metal powder—based additive manufacturing techniques. This book also reviews typical powder preparation processes and highlights the significance of metal powder—based additive manufacturing for various industrial applications. The key features covered in this book: A rigorous overview of the underlying theories and practical applications of metal powder—based additive manufacturing techniques, including laser powder bed fusion, electron beam melting, laser-based directed energy deposition, and metal binder jetting. An expansive introduction of each technique and its significance pertaining to the printing processes, metallurgical defects, powder materials, equipment, and the microstructures and mechanical properties of the printed parts. A deep exploration of the preparation processes of metal powders for additive manufacturing and the effects of different processes on the powder properties. Comprehensive case studies of parts printed by metal powder—based additive manufacturing for various industrial applications. By providing extensive coverage of relevant concepts in the field of metal powder—based additive manufacturing, this book highlights its essential role in Industry 4.0 and serves as a valuable resource for scientists, engineers, and students in materials science, powder metallurgy, physics, and chemistry. The rich research experience of the authors in additive manufacturing ensures that the readers are provided with both an in-depth understanding and informative technical guidance of metal powder—based additive manufacturing.
In today's interactive network environment, where various types of organizations are eager to monitor and track Internet use, anonymity is one of the most powerful resources available to counterbalance the threat of unknown spectators and to ensure Internet privacy.Addressing the demand for authoritative information on anonymous Internet usage, Ano
This book provides an account of multivariate reduced-rank regression, a tool of multivariate analysis that enjoys a broad array of applications. In addition to a historical review of the topic, its connection to other widely used statistical methods, such as multivariate analysis of variance (MANOVA), discriminant analysis, principal components, canonical correlation analysis, and errors-in-variables models, is also discussed. This new edition incorporates Big Data methodology and its applications, as well as high-dimensional reduced-rank regression, generalized reduced-rank regression with complex data, and sparse and low-rank regression methods. Each chapter contains developments of basic theoretical results, as well as details on computational procedures, illustrated with numerical examples drawn from disciplines such as biochemistry, genetics, marketing, and finance. This book is designed for advanced students, practitioners, and researchers, who may deal with moderate and high-dimensional multivariate data. Because regression is one of the most popular statistical methods, the multivariate regression analysis tools described should provide a natural way of looking at large (both cross-sectional and chronological) data sets. This book can be assigned in seminar-type courses taken by advanced graduate students in statistics, machine learning, econometrics, business, and engineering.
Imperial-Time-Order is an engagingly written critical study on a persistent historical way of thinking in modern China. Defined as normalization of unification and moralization of time, Qian suggests, the imperial-time-order signifies a temporal structure of empire that has continued to shape the way modern China developed itself conceptually. Weaving together intellectual debates with literary and media representations of imperial history since the late Qing period, ranging from novels, stage plays, films, to television series, Qian traces the different temporalities of each period and takes “time” as the analytical node by which issues of empire, nation, family, morality, individual and collective subjectivity are constructed and contested.
Natural Polyphenols from Wood: Tannin and Lignin – An Industrial Perspective is a detailed guide to the sourcing and processing of tannin and lignin for valuable advanced applications across areas such as fuels, chemicals, drugs, and food. Drawing on the latest academic research and patent literature, this book provides strong practical understanding of the use of these valuable materials in novel industrial applications. This book introduces natural polyphenols from wood and the fundamental aspects of carbon management within the tree. In-depth presentation of extraction and characterization methods is followed by an extensive coverage of practical and industrial applications of wood polyphenols. This is an essential resource for researchers and advanced students working with lignin or tannin, and across biopolymer science, biomass, wood chemistry, paper, wood adhesives, polymer materials, renewable resources, and biotechnology. It also supports industrial R&D and scientists working with wood polyphenols or bio-based polymers. - This book re-evaluates wood polyphenols from an industrial perspective, revealing the latest techniques and drawing on patent literature. - It addresses fundamental issues of wood polyphenols, such as carbon cycle, wood fractionation, structure, and properties. - It offers a comprehensive review of practical applications, including lignin depolymerization, wood reconstruction, fuels, chemicals, drugs, and food.
This book covers recent developments in correlated data analysis. It utilizes the class of dispersion models as marginal components in the formulation of joint models for correlated data. This enables the book to cover a broader range of data types than the traditional generalized linear models. The reader is provided with a systematic treatment for the topic of estimating functions, and both generalized estimating equations (GEE) and quadratic inference functions (QIF) are studied as special cases. In addition to the discussions on marginal models and mixed-effects models, this book covers new topics on joint regression analysis based on Gaussian copulas.
This unique compendium focuses on the acquisition and analysis of social media data. The approaches concern both the data-intensive characteristics and graphical structures of social media. The book addresses the critical problems in social media analysis, which representatively cover its lifecycle.The must-have volume is an excellent reference text for professionals, researchers, academics and graduate students in AI and databases.
Radar scattering and imaging of rough surfaces is an active interdisciplinary area of research with many practical applications in fields such as mineral and resource exploration, ocean and physical oceanography, military and national defense, planetary exploration, city planning and land use, environmental science, and many more. By focusing on the most advanced analytical and numerical modeling and describing both forward and inverse modeling, Radar Scattering and Imaging of Rough Surfaces: Modeling and Applications with MATLAB® connects the scattering process to imaging techniques by vivid examples through numerical and experimental demonstrations and provides computer codes and practical uses. This book is unique in its simultaneous treatment of radar scattering and imaging. Key Features Bridges physical modeling with simulation for resolving radar imaging problems (the first comprehensive work to do so) Provides excellent basic and advanced information for microwave remote-sensing professionals in various fields of science and engineering Covers most advanced analytical and numerical modeling for both backscattering and bistatic scattering Includes MATLAB® codes useful not only for academics but also for radar engineers and scientists to develop tools applicable in different areas of earth studies Covering both the theoretical and the practical, Radar Scattering and Imaging of Rough Surfaces: Modeling and Applications with MATLAB® is an invaluable resource for professionals and students using remote sensing to study and explain the Earth and its processes. University and research institutes, electrical and radar engineers, remote-sensing image users, application software developers, students, and academics alike will benefit from this book. The author, Kun-Shan Chen, is an internationally known and respected engineer and scientist and an expert in the field of electromagnetic modeling.
Long before Wittgenstein drew attention to its complexities, the concept of play had captured the interest of theorists for millennia. How do games contribute to our knowledge of the world? Wherein lies their universal appeal? Play is usually associated with a certain blitheness and buoyancy - could it nevertheless be argued that playfulness is not quite as innocent as it might seem? Bence Kun draws on Adorno's writings to explore the relation between philosophical play (understood here as imaginative thought as well as experimental expression) and an experience of dread Adorno links to children's first encounter with death. By investigating his less familiar works, some of which have not yet been translated, Kun challenges the received view on Adorno's approach to metaphysics, the role of systematic inquiry and the modern condition. As he has Adorno say, the originary impression of shock at the heart of philosophical reflection can only be fully apprehended through an open-ended and defiantly creative intellectual practice.
Optical Fiber Sensing Technologies/ b Explore foundational and advanced topics in optical fiber sensing technologies In Optical Fiber Sensing Technologies: Principles, Techniques, and Applications, a team of distinguished researchers delivers a comprehensive overview of all critical aspects of optical fiber sensing devices, systems, and technologies. The book moves from the basic principles of the technology to innovation methods and a broad range of applications, including Bragg grating sensing technology, intra-cavity laser gas sensing technology, optical coherence tomography, distributed vibration sensing, and acoustic sensing. The accomplished authors bridge the gap between innovative new research in the field and practical engineering solutions, offering readers an unmatched source of practical, application-ready knowledge. Ideal for anyone seeking to further the boundaries of the science of optical fiber sensing or the technological applications for which these techniques are used, Optical Fiber Sensing Technologies: Principles, Techniques, and Applications also includes: Thorough introductions to optical fiber and optical devices, as well as optical fiber Bragg grating sensing technology Practical discussions of Extrinsic-Fabry-Perot-Interferometer-based optical fiber sensing technology, acoustic sensing technology, and high-temperature sensing technology Comprehensive explorations of assemble free micro-interferometer-based optical fiber sensing technology In-depth examinations of optical fiber intra-cavity laser gas sensing technology Perfect for applied and semiconductor physicists, Optical Fiber Sensing Technologies: Principles, Techniques, and Applications is also an invaluable resource for professionals working in the semiconductor, optical, and sensor industries, as well as materials scientists and engineers for measurement and control.
This book addresses development laws for axial strain and excess pore water pressure in silty clay around subway shield tunnels before and after freezing-thawing when subjected to subway loading, as well as the effect of freezing-thawing on the dynamic parameters of silty clay, including the dynamic modulus and damping ratio, introducing readers to the design and construction of bypasses in subway tunnels with the artificial freezing method. On this basis, it then studies the microstructures of silty clay before and after freezing-thawing cyclic loading by means of scanning electron microscope tests and mercury intrusion porosimetry tests. Lastly, the book presents a numerical simulation of the dynamics of silty clay around subway tunnels before and after thawing. Given its scope, it offers a valuable reference guide for construction researchers and designers alike, as well as senior undergraduate and graduate students at colleges and universities.
This book systematically presents 40 pests, 7 natural pest enemies, and 20 diseases and weeds commonly encountered in sugarcane production, combining clear colour photos with detailed scientific descriptions. It covers a range of related topics, including morphological identification, habits and frequency of occurrence, prevention and control measures, symptom identification, characteristics of infections and epidemics, parasitic (predator) characteristics, ways of utilising natural pest enemies, main species and distribution, fluctuation in the field, and chemical control of weeds. With novel content presented in simple, straightforward language, the book provides a valuable reference guide for scientific researchers, educators and industrial practitioners, as well as students and advisers at agricultural universities.
Computational fluid dynamics (CFD) studies the flow motion in a discretized space. Its basic scale resolved is the mesh size and time step. The CFD algorithm can be constructed through a direct modeling of flow motion in such a space. This book presents the principle of direct modeling for the CFD algorithm development, and the construction unified gas-kinetic scheme (UGKS). The UGKS accurately captures the gas evolution from rarefied to continuum flows. Numerically it provides a continuous spectrum of governing equation in the whole flow regimes.
Principles of Synthetic Aperture Radar Imaging: A System Simulation Approach demonstrates the use of image simulation for SAR. It covers the various applications of SAR (including feature extraction, target classification, and change detection), provides a complete understanding of SAR principles, and illustrates the complete chain of a SAR operati
In this book, the authors cover the recent progress in the synthesis, characterization and application of various multi-layered carbides, carbonitrides and nitrides. Moreover, the processing and development of MXene-based composites are elaborated, focusing on their applications and performances as transparent conductors in environmental remediation and energy storage systems.
International Student Mobility presents an autoethnographic study, which follows a group of non-English speaking international students from Taiwan during a period of study in Australia. The study examines the ways in which the students’ sense of identity shifts over time, and why this happens. Hsieh engages Pierre Bourdieu’s notions of capital, habitus and field to develop an understanding of complexity of identity movements and asks to what extent the students see themselves as culturally and linguistically ‘international’, both during their time abroad and upon their return home. Perfect for researchers and advanced students interested in international higher education, International Student Mobility is also an insightful read for those investigating the experiences of Chinese-speaking international students.
This book presents a time-delay approach to the analysis and synthesis of networked control systems (NCSs) under communication constraints. Differently from other approaches, the time-delay approach to NCSs allows communication delays to be larger than the sampling intervals in the presence of scheduling protocols. The book starts from a comprehensive introduction to three main approaches to sampled-data and networked control. It then focuses on time-delay approach, and the modelling of the closed-loop systems in the form of time-delay system. It presents discontinuous (in time) Lyapunov functional constructions that are efficient for NCSs in the presence of communications delays. Further, it highlights time-delay approaches developed to model and analyze NCSs under communication constraints, with a particular focus on dynamic quantization, round-robin, try-once-discard and stochastic protocols. The results are first presented for the continuous-time NCSs and then extended to discrete-time NCSs. Discussing recent developments in Lyapunov-based analysis of NCSs under communication constraints, the book is a valuable resource for researchers interested in sampled-data and networked control, and time-delay systems, as well as for graduate students in automatic control and systems theory.
Draw the best portraits with form and spirit. Drawing techniques from a master! Mau-Kun Yim learned to draw as the Old Masters did and believes that to render the essence of life in portrait drawing, one must continue to pursue the old ways. This philosophy and methodology relies on a holistic approach to observation, analysis and critical-thinking honed through time and patience. • Start with a solid foundation - Classical bust drawing is a must. These lessons aid in constructing volume in your drawing and introduce concepts of structure. • Move on to sketching - The best way to train your observation skills. Anatomy, value and state of mind are the focus of these lessons. • 12 step-by-step tutorials put it all together - Form and spirit combine along with more clearly defined details to bring life and dimension to your portraits. • An extensive gallery of beautifully and classically executed portraits, figures, sketches and busts serves as inspiration.
Ranging from Los Angeles to Havana to the Bronx to the U.S.-Mexico border and from klezmer to hip hop to Latin rock, this groundbreaking book injects popular music into contemporary debates over American identity. Josh Kun, a MacArthur "Genius" Fellow, insists that America is not a single chorus of many voices folded into one, but rather various republics of sound that represent multiple stories of racial and ethnic difference. To this end he covers a range of music and listeners to evoke the ways that popular sounds have expanded our idea of American culture and American identity. Artists as diverse as The Weavers, Café Tacuba, Mickey Katz, Rahsaan Roland Kirk, Bessie Smith, and Ozomatli reveal that the song of America is endlessly hybrid, heterogeneous, and enriching—a source of comfort and strength for populations who have been taught that their lives do not matter. Kun melds studies of individual musicians with studies of painters such as Jean-Michel Basquiat and of writers such as Walt Whitman, James Baldwin, and Langston Hughes. There is no history of race in the Americas that is not a history of popular music, Kun claims. Inviting readers to listen closely and critically, Audiotopia forges a new understanding of sound that will stoke debates about music, race, identity, and culture for many years to come.
This endearing, giftable guidebook by Korean bestseller Dr. Rhee reflects on the wisdom he’s learned during his life: how to forgive, persevere, and stop the rat race, plus the joys of living simply and the power of ordinary happiness. He explores his relationships with his wife, children, and grandchildren, and how to stay whole as your body naturally ages. If You’re Going to Live to 100 is a meditation on aging contently and finding peace and humor in everyday life.
This book introduces readers to the development of novel optical biosensors for environmental analysis. Environmental pollution has now become a serious problem, which threatens the health of human beings. Traditional analytical methods have a number of drawbacks, such as the need for professional operators and complicated instruments. After millions of years of evolution, biomolecules can perform various functions with good accuracy and efficiency due to their unique structures, offering a viable alternative to traditional methods. This work focuses on using new biological sensing strategies, e.g. those based on special biomaterials, bio-reactions or living cells, to establish novel biosensors. As these biosensors offer satisfactory optical response performance, they can be used to transform the recognition behavior of specific targets into optical signals and effectively detect target objects.
The book discusses data and energy integrated communication networking technologies, including the latest research contributions in this promising area. It firstly provides an overview of data and energy integrated communication networks (DEINs) and introduces the key techniques for enabling integrated wireless energy transfer (WET) and wireless information transfer (WIT) in the radio frequency (RF) band. It then describes the ubiquitous architecture of DEINs and demonstrates the typical DEIN system and investigates the core issues in both the physical layer and the medium-access-control (MAC) layer in order to coordinate both the WIT and WET in the same RF band. Lastly, the book addresses a number of emerging research topics in the field of DEINs. It promotes joint efforts from both academia and industry to push DEIN a step closer to practical implementation. It is also a valuable resource for students interested in studying cutting-edge techniques in this field.
The book focuses on several skew-normal mixed effects models, and systematically explores statistical inference theories, methods, and applications of parameters of interest. This book is of academic value as it helps to establish a series of statistical inference theories and methods for skew-normal mixed effects models. On the applications side, it provides efficient methods and tools for practical data analysis in various fields including economics, finance, biology and medical science.
Established since 1986 as the definitive text and reference on use of radiation therapy for childhood cancer, Pediatric Radiation Oncology is now in its thoroughly revised and updated Fifth Edition. This edition reviews all significant recent clinical trials—including, for the first time, significant European clinical trials—and provides increased coverage of international and Third World issues. The latest cancer staging guidelines are included. New chapters cover psychosocial aspects of radiotherapy for the child and family and medical management of pain, nausea, nutritional problems, and blood count depression in the child with cancer. This edition also has full-color illustrations throughout. A companion website includes the full text and an image bank.
Molecular Dynamic Simulation: Fundamentals and Applications explains the basic principles of MD simulation and explores its recent developments and roles in advanced modeling approaches. The implementation of MD simulation and its application to various aspects of materials science and engineering including mechanical, thermal, mass transportation, and physical/chemical reaction problems are illustrated. Innovative modeling techniques that apply MD to explore the mechanics of typical nanomaterials and nanostructures and to characterize crystalline, amorphous, and liquid systems are also presented. The rich research experience of the authors in MD simulation will ensure that the readers are provided with both an in-depth understanding of MD simulation and clear technical guidance. - Provides a comprehensive overview of the underlying theories of molecular dynamics (MD) simulation - Presents application-based examples pertaining to a broad range of mechanical, thermal, and mass transport problems - Explores innovative modeling techniques for simulating typical nanomaterials and nanostructures and for characterizing crystalline, amorphous, and liquid systems
This book introduces state-of-the-art models and methods based on the neuroendocrine-immune-inspired approaches in the field of manufacturing control systems. It develops various bio-inspired intelligent approaches for multiple applications in order to efficiently generate production plans and control solutions and agilely deal with the frequent unexpected disturbances at the shop floor level. It also provides an introduction to bio-inspired manufacturing systems with intelligent control structures and the latest technologies. Further, the book describes recent advances in the bio-inspired methodology for a high-level adaptability in manufacturing systems, including the bio-inspired control architecture and the implementation of intelligent and adaptive control approaches based on neuroendocrine-immune mechanisms and hormone-regulation principles. It offers a valuable resource for graduate students, researchers and engineers in the fields of production management, manufacturing system control and related areas. /div
A gyrotron traveling-wave amplifier (gyro-TWT) with the high-power and broad-band capabilities is considered as a turn-on key for next generation high-resolution radar. The book presents the most advanced theory, methods and physics in a gyro-TWT. The most challenging problem of instability competition has been for the first time addressed in a focused and systematic way and reported via concise states and vivid pictures. The book is likely to meet the interest of researchers and engineers in radar and microwave technology, who would like to study the gyro-TWTs and to promote its application in millimeter-wave radars. Chao-Hai Du and Pu-Kun Liu are both professors at Peking University.
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