Advancing the science of medicine by targeting a disease more precisely with treatment specific to each patient relies on access to that patient's genomics information and the ability to process massive amounts of genomics data quickly. Although genomics data is becoming a critical source for precision medicine, it is expected to create an expanding data ecosystem. Therefore, hospitals, genome centers, medical research centers, and other clinical institutes need to explore new methods of storing, accessing, securing, managing, sharing, and analyzing significant amounts of data. Healthcare and life sciences organizations that are running data-intensive genomics workloads on an IT infrastructure that lacks scalability, flexibility, performance, management, and cognitive capabilities also need to modernize and transform their infrastructure to support current and future requirements. IBM® offers an integrated solution for genomics that is based on composable infrastructure. This solution enables administrators to build an IT environment in a way that disaggregates the underlying compute, storage, and network resources. Such a composable building block based solution for genomics addresses the most complex data management aspect and allows organizations to store, access, manage, and share huge volumes of genome sequencing data. IBM SpectrumTM Scale is software-defined storage that is used to manage storage and provide massive scale, a global namespace, and high-performance data access with many enterprise features. IBM Spectrum ScaleTM is used in clustered environments, provides unified access to data via file protocols (POSIX, NFS, and SMB) and object protocols (Swift and S3), and supports analytic workloads via HDFS connectors. Deploying IBM Spectrum Scale and IBM Elastic StorageTM Server (IBM ESS) as a composable storage building block in a Genomics Next Generation Sequencing deployment offers key benefits of performance, scalability, analytics, and collaboration via multiple protocols. This IBM RedpaperTM publication describes a composable solution with detailed architecture definitions for storage, compute, and networking services for genomics next generation sequencing that enable solution architects to benefit from tried-and-tested deployments, to quickly plan and design an end-to-end infrastructure deployment. The preferred practices and fully tested recommendations described in this paper are derived from running GATK Best Practices work flow from the Broad Institute. The scenarios provide all that is required, including ready-to-use configuration and tuning templates for the different building blocks (compute, network, and storage), that can enable simpler deployment and that can enlarge the level of assurance over the performance for genomics workloads. The solution is designed to be elastic in nature, and the disaggregation of the building blocks allows IT administrators to easily and optimally configure the solution with maximum flexibility. The intended audience for this paper is technical decision makers, IT architects, deployment engineers, and administrators who are working in the healthcare domain and who are working on genomics-based workloads.
This book provides holistic guidance and proposes practical frameworks to navigate complex learning environments in the rapidly evolving climate, and an environment to facilitate effective learning and knowledge transfer, while advocating a shift in the learning culture, and culture of learning, in varying contexts. It serves well for varying and cross-disciplinary clusters of individuals, particularly for academics, senior management of higher education institutions, and senior leaders of corporate organizations. This book equips readers with a deeper understanding of the evolving and dynamic issues that need to be addressed in the higher education context; to handle multifaceted situations in the process of engaging University students to be nurtured as future global leaders and knowledge workers.
This book serves as an essential intervention where the innovative, evidence based and contemporary teaching, learning approaches, strategies and learning support systems to be incorporated in the learning process are presented, supported with findings. It addresses the complex challenges and limitations in practice supported with evidence, hence providing possible approaches to address them. It also addresses an interesting scope of topics that are both contemporary and essential to almost all academics that have a high responsibility to nurture, develop, train and equip learners both at the undergraduate and post-graduate levels at the university with the relevant skills and competencies.
This book presents strategies and practices for facilitating effective learning for mainland Chinese students in western based education – regarding e.g. the choice of instructional techniques, attention to students’ cultural dislocation aspects, comfort, familiarity, and ease of knowledge transfer. It embeds innovativeness at a conceptual level, and argues for a holistic and “engaged” approach to learning effectiveness for mainland Chinese students.
Businesses must stay agile and be responsive to the complexities and disruptions brought about by digital transformation. The recent pandemic has also accelerated business digitization. Packed with insights and strategies, this book breaks down the roadmap to organizational success into core areas. It explains how companies can adapt, prepare, and optimize their business performance through strategic positioning, business sustainability, and crisis management. Rajaram describes strategic positioning as a mix of strategies for organizations to gain competitive advantage and ensure long-term success. He also talks about business sustainability and explores how organizations need to re-innovate their approaches to tap into opportunities created by the rapid changing customer needs and evolving environmental interventions. The book also illustrates how companies can navigate out of a crisis successfully. This book will be an excellent, essential guide for leaders, practitioners, and anyone who is formulating effective organizational strategies.
Translation of an Epic level Malayalam Historical Novel, panning 100 Years of a Region’s Struggles for Political Independence and Social Justice, Captured Through the Lives of Over 100 Real and Imagined Characters
Translation of an Epic level Malayalam Historical Novel, panning 100 Years of a Region’s Struggles for Political Independence and Social Justice, Captured Through the Lives of Over 100 Real and Imagined Characters
In this era of rapid urbanisation, the provincial stories are forgotten. The provincial way of life is now limited to the literature. Only through creative imagination can we retrieve the provincial histories, otherwise lost forever. Thakshankunnu Swaroopam represents a sentimental blend of history, myths, and traditions. It reflects the lives of those who lived during a certain period in time, though not in existence anymore, through its interactions at various dimensions of politics, culture, and humanity. It shows the social renaissance movements and India’s freedom struggle defining its contours. That life is what Thakshankunnu Swaroopam has sought to capture for the generations to follow. A symbol of the bygone era. A tombstone. Review: “This is the story of people who lived at Thakshankunnu, situated in the Malabar region of present Kerala. The rich descriptions of villages, cities, romance, strife, and litigations combine to elevate this novel to an epic status. The novelist has succeeded in providing a distinct personality and individuality to Thakshankunnu, through the experiences of the people who lived there during its nearly a century-long era of social and political transformation. Here is another novel written entirely from the ambience of Kerala.” Prof. MGS Narayanan, Former Head, the Department of History, Calicut University, and former Chairman, the Indian Council of Historical Research. Awards received by the Malayalam version: Vayalar Award—2016, Kerala Sahitya Academy Award, Vaikom Chandrasekharan Nair Award, Bashir Award, Cherukad Award, Habeeb Valappat Award, Katharangam Award, Bhasha Institute Award, Abu Dhabi Malayali Samajam Award, P Kunhiraman Nair Award, Balyakalasakhi Award, Vidhya Vibhushan Award, Souhruda Sahithya Award, Namitham Award—2017
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