This book covers conventional clinical treatment methods for handling bone, cartilage, and related disorders along with their limitations and highlights the current state of the art of tissue engineering as an alternative for regenerating such defective tissue. Potential biomimetic scaffolding materials and their development, desired properties, modifications, and optimizations are described. The design and advancement in fabrication, characterization, properties, and biological functions of scaffolds, their integration with stem cells, and various bioreactor systems for tissue regeneration are presented. It further reviews in vitro and in vivo (pre-clinical) assessments of tissue constructs, involved translational challenges, and strategies in various stages of neo-tissue production. Features: Discusses the key aspects of generating engineered bone, cartilage, and associated tissues through tissue engineering approach Describes multiple engineering principles, and processes involved in the various stages of developing biomaterials and scaffolds Covers integration of stem cells with scaffolds, including assessment of tissue grafts, and translational strategy Explores key factors influencing tissue graft generation in bioreactors and challenges involved in various stages Includes several exercises including review questions and numerical problems for better understanding of the subject This book is aimed at researchers, students, and professionals in biomedical engineering, tissue engineering, stem cells, biomaterials, and orthopaedics.
The application of metal cutting fluids is an integral part of industrial machining operations. Minimum quantity lubrication (MQL) is the latest form of cutting fluid application method currently used by several manufacturing organizations. This book consolidates all the available knowledge in terms of the application of different processes as well as materials in a concise fashion in one reference resource. Sustainable Machining Using MQL Application of Cutting Fluids offers a detailed discussion of the MQL mechanism in cutting fluid applications. It highlights the influence of MQL parameters on different workpiece materials and provides sound explanations along with photographs for all technical reasonings. The book presents the usage of both micro and nano cutting fluids in machining for sustainability while it also captures the knowledge in the field including the recent research outputs, as it illustrates a comprehensive coverage of MQL practical application. This book should be on the bookshelf of industrial engineers, those working in production and manufacturing, process designers, tool material designers, cutting tool designers, and quality specialists. Researchers, senior undergraduate students, and graduate students will also find this book full of very helpful reference information.
The book covers various methods of characterization of advanced materials commonly used in engineering including understanding of the working principle and applicability of devices. It explores the techniques implemented for advanced materials like superalloys, thin films, powders, nanocomposites, polymers, shape memory alloys, high entropy alloys, and so on. Major instruments covered include X-ray diffraction, near-field scanning optical microscopy Raman, X-ray photospectroscopy, ultraviolet-visible-near-infrared spectrosphotometer, Fourier-transform infrared spectroscopy, differential scanning calorimeter, profilometer, and thermogravimetric analysis. Features: Covers material characterization techniques and the development of advanced characterization technology Includes multiple length scale characterization approaches for a large variety of materials, from nano- to micron-scale, as well as their constraints Discusses advanced material characterization technology in the microstructural and property characterization fields Reviews both practical and theoretical explanations of approaches for characterizing microstructure and properties Offers fundamentals, basic instrumentation details, experimental approaches, analyses, and applications with case studies This book is aimed at graduate students and researchers in materials science and engineering.
The second volume of the book-Protein-Protein Interactions (PPIs) provides an overview of various protein-protein interactions (PPIs) that are involved in various human diseases including cancer, neurodegenerative diseases, immune diseases, and inflammation. It summarizes the structure and ligand-based drug designing approaches for the discovery of small molecules that can inhibit PPIs in these diseases. The book discusses different computational and experimental tools that are used to determine the anomalous interactions underlying the diseases. Lastly, it also reviews the classical interactions between pathogens and hosts that are responsible for the pathophysiology of infectious diseases.
Unknown to most people, there are innumerable microbial species that accomplish vital ecosystem functions while residing in a suspended state in the troposphere or resting on crop canopies. These microbial species, if utilized properly, can improve agriculture. At the same time, harmful microbes can also devastate crops easily. This new book, Microbiology of the Agricultural Sky, explores a number of microbes present in the agrarian sky and details their identities, roles in nature, and usefulness to crops as well as other biotic factors. The volume first provides an introduction that details the historical aspects of microbes relating to their discovery and identification of their role in agrarian ecosystems. The book then gives detailed explanations of microbes in the atmosphere, with information on the general distribution, spread distance, and intercontinental migration of microbes in the atmosphere. It discusses aeolian dust microbes above agrarian regions and the role of aerial microbes in nutrient dynamics. The book also explains the functions of microbes that reside on crop canopies and the importance of the plant‘s phyllosphere. It looks at microbial flora and how a region‘s bio-geochemical functions affect crops. Also discussed is the role of aerial microbes in inducing epidemics and pandemics among different crops. The final chapter details farm procedures that can be adopted in the outfield and in animal houses and how they impact atmospheric microbes. Key features: Highlights the relevance of the agrarian sky and its microbial component, detailing the wide range of functions that microbes accomplish in the aerospace Presents a timeline of discoveries about aeromicrobiology and the agrarian sky Discusses aerial microbes on crop canopies and their influence on plant pathogens, including beneficial nutrients, need for crop protection, etc. Looks at the microbiology of the agrarian sky and the spread of crop diseases locally and via the intercontinental migration of microbes Discusses farm procedures and their impact on microbes in the troposphere and the agricultural fields beneath it This first-of-its-kind book provides extensive information on microorganisms that can be traced in the agrarian sky and their relevance to agriculture. The easy-to-read style of the book makes it suitable for farmers, agricultural science professors, students, and researchers. It will be useful for farm specialists dealing with airborne diseases, GHG emissions, and agronomic procedures as well.
Natural Products as Anticancer Agents introduces the different types of natural products that have been used for cancer treatment. Divided into four parts, covering anticancer agents derived from terrestrial plants, anticancer agents derived from the marine environment, and anticancer agents derived from microorganisms, as well as evaluation of new anticancer agents, each part includes discussion of the properties, synthesis/extraction, storage, mechanism of action, and usage of the molecules. Discussion of the future prospects in anticancer natural products—including several new trends and an indication of where research in this area is likely to go in the future—is also included. - Assists in the identification of risk factors associated with the drug development process - Includes process diagrams detailing the procedure for the isolation and purification of molecules - Covers cost-effective green approaches in the development of anticancer drugs
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