Inflammatory cell recruitment requires the concerted action of at least five major sets of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate structures serving as selectin ligands, and certain ectoenzymes. This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future approaches is also provided. The book is of interest to clinicians and scientists from immunology, physiology, cancer research, rheumatology, allergology, infectious diseases, gastroenterology, pulmonology and cardiology.
This book constitutes the refereed proceedings of the 13th International Conference on Advanced Information Systems Engineering, CAiSE 2001, held in Interlaken, Switzerland in June 2001. The 27 revised full papers presented together with three invited papers, three experience reports, and a panel summary were carefully reviewed and selected from a total of 97 submissions. The papers are organized in topical sections on requirements engineering, agent-based approaches, workflow managment, data models and design, reuse and method engineering, XML and information systems integration, evolution, and conceptual modeling.
This book of a renowned political scientist and specialist in political theory fundamentally challenges the new fashion of post-democracy by offering an outlook on ‘neo-democracy’. The political periods are similar to epochs in modern art, where ‘neo’ succeeded Post-impressionism and Post-expressionism. This book reviews the topical debate on postdemocracy and scenarios of decline in democratic theory without the alternative of dictatorship. It discusses criticism of politics in the old and new media and a new culture of protest. It addresses new forms of participation and the dangers of populism and right-wing extremism. It proposes institutional reforms of democracy, of the parliamentary system and the party state, in negotiations of coalition-building, in governmental declarations and for the policy output. The book concludes with a debate of normative models of democracy from ‘Post-democracy’ to ‘Neo-democracy’, models of justice and theories of democratic reform.
Written by experienced authors, this book presents numerous natural everyday products with a high range of structural diversity. Twenty natural products have been arranged in five sections, describing three alkaloids, five colored compounds, three carbohydrates and glycosides, seven terpenoids, and two aromatic compounds. Adopting a highly didactical approach, each chapter features a uniform structure: Background, in-depth information about isolation processes and structural characterization as well as a Q&A section at the end. Alongside the theoretical information many practical hints for the laboratory work are also included. A comprehensive overview of UV-, IR- and NMR-spectroscopy as well as mass-spectrometry for every exemplified compound is provided and the understanding of these methods is supported by concluding questions and exercises. Educating and entertaining, this full-color textbook turns the learning process into a real pleasure, not only for students in natural products chemistry but also experienced professionals.
What can computer simulation contribute to the social sciences? Which of the many approaches to simulation would be best for my social science project? How do I design, carry out and analyse the results from a computer simulation? Interest in social simulation has been growing rapidly worldwide as a result of increasingly powerful hardware and software and also a rising interest in the application of ideas of complexity, evolution, adaptation and chaos in the social sciences. Simulation for the Social Scientist is a practical textbook on the techniques of building computer simulations to assist understanding of social and economic issues and problems. This authoritative book details all the common approaches to social simulation, to provide social scientists with an appreciation of the literature and allow those with some programming skills to create their own simulations. New for this edition: A new chapter on designing multi-agent systems, to support the fact that multi-agent modelling has become the most common approach to simulation New examples and guides to current software Updated throughout to take new approaches into account The book is an essential tool for social scientists in a wide range of fields, particularly sociology, economics, anthropology, geography, organizational theory, political science, social policy, cognitive psychology and cognitive science. It will also appeal to computer scientists interested in distributed artificial intelligence, multi-agent systems and agent technologies.
This book presents the development of modern molecular models for fluids from the interdisciplinary fundamentals of classical and statistical mechanics, of electrodynamics and of quantum mechanics. The concepts and working equations of the various fields are briefly derived and illustrated in the context of understanding the properties of molecular systems. Special emphasis is devoted to the quantum mechanical basis, since this is used throughout in the calculation of the molecular energy of a system. The book is application oriented. It stresses those elements that are essential for practical model development. The fundamentals are then used to derive models for various types of applications. Finally, equation of state models are presented based on quantum chemically based models for the intermolecular potential energy and perturbation theory. The book is suited for graduate courses in chemical and mechanical engineering, physics and chemistry, but may also, by proper selection, be found useful on the undergraduate level.
The book presents the latest findings in experimental plasticity, crystal plasticity, phase transitions, advanced mathematical modeling of finite plasticity and multi-scale modeling. The associated algorithmic treatment is mainly based on finite element formulations for standard (local approach) as well as for non-standard (non-local approach) continua and for pure macroscopic as well as for directly coupled two-scale boundary value problems. Applications in the area of material design/processing are covered, ranging from grain boundary effects in polycrystals and phase transitions to deep-drawing of multiphase steels by directly taking into account random microstructures.
This new edition of the near-legendary textbook by Schlichting and revised by Gersten presents a comprehensive overview of boundary-layer theory and its application to all areas of fluid mechanics, with particular emphasis on the flow past bodies (e.g. aircraft aerodynamics). The new edition features an updated reference list and over 100 additional changes throughout the book, reflecting the latest advances on the subject.
A new edition of the almost legendary textbook by Schlichting completely revised by Klaus Gersten is now available. This book presents a comprehensive overview of boundary-layer theory and its application to all areas of fluid mechanics, with emphasis on the flow past bodies (e.g. aircraft aerodynamics). It contains the latest knowledge of the subject based on a thorough review of the literature over the past 15 years. Yet again, it will be an indispensable source of inexhaustible information for students of fluid mechanics and engineers alike.
This is the first book to extensively and exclusively cover nonconventional yeasts - all yeasts other than S. cerevisiae and S. pombe. In addition to useful background information, the author includes detailed protocols allowing the investigation of basic and applied aspects for a wide range of these organisms. Due to the increasing importance of nonconventional yeasts in biotechnological applications, this book should become the standard reference for both pure and applied scientists working in the fields of microbiology and biochemistry.
Unwanted childlessness affects approximately one in six couples worldwide. - though the exact proportion of the predominant cause of the problem remains controversial, according to the World Health Organization (WHO), in nearly 40% of cases the cause can be attributed to the female, in 20% to the male, in 25% to both, and in 15% the cause remains unknown. Based on these ?gures, the - cidence of male factor infertility in the general population is approximately 7%. The majority of these men, approximately 30%, experience irreversible idiopathic infertility and cannot father children without some form of medical intervention. Male factor infertility, in addition, may be caused by testicular germ cell cancer, which is known to represent the most common cancer among young men, aged 15 to 35 years, in Western industrialized countries. The number of affected men has increased dramatically over the past 50 years. There is now growing evidence that human testicular germ cell cancer originates from fetal germ cells exhibiting an aberrant programme of gene expression, and tumour progression may be favoured by an aberrant Sertoli cell-germ cell communication.
The twentieth century is as remarkable for its world wars as it is for its efforts to outlaw war in international and constitutional law and politics. Japan in the World examines some of these efforts through the life and work of Shidehara Kijuro, who was active as diplomat and statesman between 1896 until his death in 1951. Shidehara is seen as a guiding thread running through the first five decades of the twentieth century. Through the 1920s until the beginning of the 1930s, his foreign policy shaped Japan's place within the community of nations. The positive role Japan played in internation.
First Published in 1989. Tackling the problem of Germany's role in the history of world politics in the nineteenth and twentieth centuries is one of the most interesting tasks of historiography. Furthermore, the relationship between Britain and Germany is of central significance in understanding this role.
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