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Development of Isatin as CNS Agents: Anticonvulsant Activity

By: Kiran Gangarapu

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DESIGN, SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF NEW INDOLE DERIVATIVES AS ANTICANCER AGENTS

By: GANGARAPU KIRAN

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Development of Isatin as CNS Agents: Anticonvulsant Activity

By: Kiran Gangarapu

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DESIGN, SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF NEW INDOLE DERIVATIVES AS ANTICANCER AGENTS

By: GANGARAPU KIRAN

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Development of Isatin as CNS Agents: Anticonvulsant Activity

By: Kiran Gangarapu

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Development of Isatin as CNS Agents: Anticonvulsant Activity

By: Kiran Gangarapu

The present study was aimed at synthesizing isatin-5-sulphonamide derivatives are prepared by chlorosulphonation of isatin to prepare isatin-5-sulphonic acid chloride and it is subjected to reaction with different amines or anilines to form respective sulphonamide derivatives. The new compounds were characterized based on spectral (FT-IR, NMR and Mass) analysis. All the test compounds showed CNS depression while studying the gross behavioral changes. All the test compounds exhibited reduction in locomotor activity. Compound IIIf (R = p-toluidino) showed more reduction in the locomotor activity among all the test compounds. Compounds IIId, IIIc, IIIb, IIIa were next in the order of reduction of locomotor activity. The compounds were evaluated for anticonvulsant activity against maximum electric shock induced and Pentylenetetrazol (PTZ) induced seizures in mice using phenytoin as a standard.

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Page Count

57

Publisher

Anchor Academic Publishing (aap_verlag)

Published Date

ISBN 10

3954892790

ISBN 13

9783954892792

DESIGN, SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF NEW INDOLE DERIVATIVES AS ANTICANCER AGENTS

By: GANGARAPU KIRAN

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DESIGN, SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF NEW INDOLE DERIVATIVES AS ANTICANCER AGENTS

By: GANGARAPU KIRAN

The book describes the design of novel indole derivatives for the possible development of anticancer and chemopreventive agents.

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Page Count

218

Publisher

Lulu.com

Published Date

ISBN 10

0359044425

ISBN 13

9780359044429

Development of Isatin as CNS Agents: Anticonvulsant Activity

By: Kiran Gangarapu

Write a review Read reviews

Take a Quiz Solve Book Puzzle

Development of Isatin as CNS Agents: Anticonvulsant Activity

By: Kiran Gangarapu

The present study was aimed at synthesizing isatin-5-sulphonamide derivatives are prepared by chlorosulphonation of isatin to prepare isatin-5-sulphonic acid chloride and it is subjected to reaction with different amines or anilines to form respective sulphonamide derivatives. The new compounds were characterized based on spectral (FT-IR, NMR and Mass) analysis. All the test compounds showed CNS depression while studying the gross behavioral changes. All the test compounds exhibited reduction in locomotor activity. Compound IIIf (R = p-toluidino) showed more reduction in the locomotor activity among all the test compounds. Compounds IIId, IIIc, IIIb, IIIa were next in the order of reduction of locomotor activity. The compounds were evaluated for anticonvulsant activity against maximum electric shock induced and Pentylenetetrazol (PTZ) induced seizures in mice using phenytoin as a standard.

Average ratings

N/A

5

0%

4

0%

3

0%

2

0%

1

0%

Solve jigsaw puzzle

Age

Page Count

57

Publisher

Anchor Academic Publishing (aap_verlag)

Published Date

ISBN 10

3954892790

ISBN 13

9783954892792

DESIGN, SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF NEW INDOLE DERIVATIVES AS ANTICANCER AGENTS

By: GANGARAPU KIRAN

Write a review Read reviews

Take a Quiz Solve Book Puzzle

DESIGN, SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF NEW INDOLE DERIVATIVES AS ANTICANCER AGENTS

By: GANGARAPU KIRAN

The book describes the design of novel indole derivatives for the possible development of anticancer and chemopreventive agents.

Average ratings

N/A

5

0%

4

0%

3

0%

2

0%

1

0%

Solve jigsaw puzzle

Age

Page Count

218

Publisher

Lulu.com

Published Date

ISBN 10

0359044425

ISBN 13

9780359044429

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