In the area of organic chemistry one major challenge we are currently faced with is how to assemble potentially useful molecules in new ways that generate molecular complexity and in sequences that are as efficient as possible. Our efforts in this regard, specifically for the preparation of amino containing compounds incorporating an aromatic ring, are described in this doctoral thesis. We discovered an interesting regioselectivity in an intramolecular Heck reaction, which we studied for a series of substrates that are unbiased in terms of the size of the newly formed ring, where very high levels of selectivity in relation to the new carbon-carbon bond are typically observed. DFT calculations were performed to attempt to shed light on the reaction sequence. This regioselective Heck reaction, combined with the reductive removal of the temporary amino-protecting group, allowed us to synthesize the Sceletium alkaloids: mesembrane, mesembranol and mesembrine.
In September 1861 the men of Company A enlisted for three years in the Union Army during the American Civil War. Initially their regiment was intended to serve on the Eastern Shore of Maryland as Home Guard. On August 16, 1862, those men were discharged after only eleven months of service. Some claim that their discharge was the result of the men's refusal to cross the state line into Eastern Virginia. A Year in the Guard attempts to disprove that claim. The story of Company A begins with their enlistment and encampment in Cambridge, Maryland, and follows them through their participation in the invasion into Eastern Virginia. Their duties and camp life are illustrated through newspapers and personal accounts, while military records suggest that the men in fact did not refuse orders and were honorably discharged. A Year in the Guard is a work that sheds light on a previously unexplored aspect of Delmarva history."--
With a new chapter dedicated to psychosocial and environmental stressors such as racism, climate change, discrimination, collective trauma, and settler colonialism, this fully updated second edition of An Introduction to Stress and Health explains how chronic and acute stress can precipitate changes in the body that exacerbate and contribute to conditions including heart disease, diabetes, and depression. This is the first textbook to blend psychosocial and behavioural neuroscience perspectives, giving you a broad understanding of the immunological, neurochemical, hormonal and growth factor processes that can be influenced by stress. Anisman and Matheson further invite you to consider how different interventions and therapeutic strategies might be used to deal with stress and its consequences on the body. Its lively writing, fascinating case studies and signposts to further reading make this an indispensable guide for postgraduate students taking courses in health psychology, and stress, health, and illness. Hymie Anisman is Professor of Neuroscience at Carleton University. Kimberly Matheson is Research Chair in Culture and Gender Mental Health and Professor of Neuroscience at The Royal Ottawa’s Institute of Mental Health Research and Carleton University.
From the Newbery Honor and Schneider Award-winning author of The War that Saved My Life comes The President's Daughter, a novel about the Roosevelts and perfect for fans of hisorical fiction. ETHEL IS 10 YEARS OLD in 1901 when her family’s life changed forever. Suddenly, Father is not only a famous cowboy, war hero, and politician, but also President Theodore Roosevelt, leader of the United States—and Ethel has a new place to call home. The White House is older and stuffier than Ethel imagined, but there’s never a dull moment with her adventurous family around. Ethel would love to spend every day following Father on horseback rides and scrambles through neighboring Rock Creek Park. Instead, Ethel has to stay at boarding school during the week, where nothing she does feels right and none of the girls seem to like her. Ethel’s parents keep telling her to keep her chin up and be patient, but it’s not easy being the president’s daughter. Ethel wishes she could be as courageous as father and make her family proud. When her fashionable older sister arrives home, Ethel feels new hope. Sister knows the secret of being brave and making friends, and she’s willing to share it. All Ethel needs to do is take one outrageous dare. "[Bradley] makes Ethel a vivid and engaging presence and...[this novel is] a fascinating look at an intriguing world."-Kirkus Reviews "A fascinating story."-Booklist "Loaded with historical details...the novel rings true and the people come to life."-SLJ "Fascinating glimpses of pre-World War I Washington and one of the liveliest families to ever occupy the White House."-The Bulletin
Stress is a physical response to an undesirable situation. Mild stress can result from missing the bus, standing in a long line at the store or getting a parking ticket. Stress can also be severe. Divorce, family problems, an assault, or the death of a loved one, for example, can be devastating. One of the most common sources of both mild and severe stress is work. Stress can be short-term (acute) or long-term (chronic). Acute stress is a reaction to an immediate threat -- either real or perceived. Chronic stress involves situations that aren't short-lived, such as relationship problems, workplace pressures, and financial or health worries. Stress is an unavoidable consequence of life. As Hans Selye (who coined the term as it is currently used) noted, "Without stress, there would be no life". However, just as distress can cause disease, it seems plausible that there are good stresses that promote wellness. Stress is not always necessarily harmful. Winning a race or an election can be just as stressful as losing, or more so, but may trigger very different biological responses. Increased stress results in increased productivity up to a point. This new book deals with the dazzling complexity of this good-bad phenomenon and presents up-to-date research from throughout the world.
Using different disciplinary approaches, this collection of thoughtful and timely selections focuses on integrating issues related to violence and gender. Violence and Gender enables readers to learn about these complex issues so they can work to lessen the occurrence of violence in their personal and professional lives. The introductory section presents a number of theories of violence that ground readers in different theories and reasons for violent behavior. The subsequent sections deal with the topics of gender, youth violence, domestic violence, sexual assault, child abuse, violence and sports, and media representation of violence. Because of its comprehensive coverage of many issues, this book can serve as an excellent resource for sociologists, criminologists, justice administrators, psychologists, therapists, and those involved in social work.
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