Heterogeneity, or mixtures, are ubiquitous in genetics. Even for data as simple as mono-genic diseases, populations are a mixture of affected and unaffected individuals. Still, most statistical genetic association analyses, designed to map genes for diseases and other genetic traits, ignore this phenomenon. In this book, we document methods that incorporate heterogeneity into the design and analysis of genetic and genomic association data. Among the key qualities of our developed statistics is that they include mixture parameters as part of the statistic, a unique component for tests of association. A critical feature of this work is the inclusion of at least one heterogeneity parameter when performing statistical power and sample size calculations for tests of genetic association. We anticipate that this book will be useful to researchers who want to estimate heterogeneity in their data, develop or apply genetic association statistics where heterogeneity exists, and accurately evaluate statistical power and sample size for genetic association through the application of robust experimental design.
In this collection of essays, Seyoon Kim analyses the structure and function of 1 Thess 1-3, which leads to a new reading of 1 Thessalonians. He devotes several essays to a comprehensive exposition of Paul's gospel for the Thessalonians by fully unfolding several summaries of the gospel in the epistle, by detecting and analysing various Son of Man sayings of Jesus that are alluded to or echoed in it, and by a thorough discussion of the unity and continuity of Paul's gospel between this early epistle and his later epistles. This exposition is augmented by a new observation of Paul's doctrine of justification in 2 Thess 1-2 and a new explanation of to katέχov and o katέχwv (2 Thess 2:3-8).
Digital Literacy and Digital Inclusion: Information Policy and the Public Library examines the interrelationships between digital literacy, digital inclusion, and public policy, emphasizing the impacts of these policy decisions on the ability of individuals and communities to successfully participate in the information society. This book is the first detailed consideration of digital literacy and digital inclusion as policy problems and as core issues in information policy and libraries. The unique features of this book include drawing together the key themes and findings from the discourse on digital literacy and digital inclusion widely spread among many fields; analyzing digital literacy and digital inclusion as policy issues, both being driven and regulated by policy; building on a wealth of original research conducted by the authors using different quantitative and qualitative data collection approaches on four different continents when analyzing these issues, providing unique examples, case studies, and perspectives; using information behavior theory to provide important insights about these issues at individual, community, and political levels; providing recommendations to inform practice in libraries and help libraries to frame their advocacy for public policies that support literacy and inclusion; and providing policy recommendations to improve the creation and implementation of policy instruments that promote digital literacy and digital inclusion. The authors of this book have been involved in this research for many years, and their experience provides a broad view across the literature, inherent problems, and national perspectives. This breadth allows this book to offer comprehensive policy recommendations, solutions, and best practices for an area that is fragmented in discourse, practice, and policy.
On Lake Michigan's North Shore, an extraordinary group of cosmopolitan and wealthy clients commissioned havens from the city's bustle during the Gilded Age.
The book provides a thorough treatment of the roles of women as authors, scribes, booklenders, and patrons of early Christian literature, and of the ways in which the representation of female figures was contested in the process of copying early Christian texts.
Susan Nye Hutchison (1790-1867) was one of many teachers to venture south across the Mason-Dixon Line in the Second Great Awakening. From 1815 to 1841, she kept journals about her career, family life, and encounters with slavery. Drawing on these journals and hundreds of other documents, Kim Tolley uses Hutchison's life to explore the significance of education in transforming American society in the early national period. Tolley examines the roles of ambitious, educated women like Hutchison who became teachers for economic, spiritual, and professional reasons. During this era, working women faced significant struggles when balancing career ambitions with social conventions about female domesticity. Hutchison's eventual position as head of a respected southern academy was as close to equity as any woman could achieve in any field. By recounting Hutchison's experiences--from praying with slaves and free blacks in the streets of Raleigh and establishing an independent school in Georgia to defying North Carolina law by teaching slaves to read--Tolley offers a rich microhistory of an antebellum teacher. Hutchison's story reveals broad social and cultural shifts and opens an important window onto the world of women's work in southern education.
In this “forensic, unflinching, devastating work of historical recovery” (Sathnam Sanghera), Bud Dajo—an American atrocity bigger than Wounded Knee or My Lai, yet today largely forgotten—is revealed, thanks to the rediscovery of a single photograph. In March 1906, American soldiers on the island of Jolo in the southern Philippines surrounded and killed 1000 local men, women, and children, known as Moros, on top of an extinct volcano. The so-called ‘Battle of Bud Dajo’ was hailed as a triumph over an implacable band of dangerous savages, a “brilliant feat of arms” according to President Theodore Roosevelt. Some contemporaries, including W.E.B. Du Bois and Mark Twain, saw the massacre for what it was, but they were the exception and the U.S. military authorities successfully managed to bury the story. Despite the fact that the slaughter of Moros had been captured on camera, the memory of the massacre soon disappeared from the historical record. In Massacre in the Clouds, Kim A. Wagner meticulously recovers the history of a forgotten atrocity and the remarkable photograph that exposed its grim logic. His vivid, unsparing account of the massacre—which claimed hundreds more lives than Wounded Knee and My Lai combined—reveals the extent to which practices of colonial warfare and violence, derived from European imperialism, were fully embraced by Americans with catastrophic results.
This unique first-of-its-kind resource provides practical coverage of the design and implementation of frequency measurement receivers, which aid in identifying unknown signals. The technologies used in frequency measurement interferometry-based on-delay lines and filters are explored in this book. Practitioners also find concrete examples of microwave photonics implementations. The designs and concepts that cover conventional photonic instantaneous frequency measurement (IFM) circuits are explained. This book provides details on new designs for microwave photonic circuits and reconfigurable frequency measurement (RFM) circuits using diodes and MicroElectroMechanical Systems (MEMS). This book explains the many diverse applications of frequency measurement that are used in defense, radar, and communications. The instrumentation used to perform frequency measurements is explained, including the use of block analysis for network and spectrum analyzers and calibration techniques. Readers learn the advantages of using frequency measurement based on microwave/RF techniques, including immunity to electromagnetic interference, low loss, compatibility with fiber signal distribution, and parallel processing signals. Moreover, readers gain insight into the future of frequency measurement receivers. The book examines both the underpinnings and the implementation of frequency measurement receivers using many diverse technological platforms.
A Westerner writing about Istanbul “comes up against the Orient as a European or American first, as an individual second,” writes Edward Said. The American writers gathered in this collection are approached from the willed double perspective advocated by Said: as historically and culturally positioned observers and as individuals. Looking at texts by writers who do not necessarily define themselves as Orientalists, Kim Fortuny broadens the possible ways of thinking about this complex, idiosyncratic city of the world. In addition, the author’s close critical readings of the works of eight American writers who came to Istanbul and wrote about it offer a transnational approach to American writing that urges a loosening of a collective, national grip on literature as a product of place. This volume will be an invaluable addition to the history of literature.
This book introduces the physical principles behind levitation with superconductors, and includes many examples of practical magnetic levitation demonstrations using superconducting phenomena. It features more than twenty examples of magnetic levitation in liquid nitrogen using high temperature superconductors and permanent magnets, all invented by the author. The book includes the demonstration of suspension phenomenon induced by magnetic flux pinning as well as magnetic levitation by the Meissner effect. It shows how superconducting magnetic levitation and suspension phenomena fire the imagination and provide scientific insight and inspiration. This book will be a useful experimental guide and teaching resource for those working on superconductivity, and a fascinating text for undergraduate and graduate students.
High-Density Integrated Electrocortical Neural Interfaces provides a basic understanding, design strategies and implementation applications for electrocortical neural interfaces with a focus on integrated circuit design technologies. A wide variety of topics associated with the design and application of electrocortical neural implants are covered in this book. Written by leading experts in the field— Dr. Sohmyung Ha, Dr. Chul Kim, Dr. Patrick P. Mercier and Dr. Gert Cauwenberghs —the book discusses basic principles and practical design strategies of electrocorticography, electrode interfaces, signal acquisition, power delivery, data communication, and stimulation. In addition, an overview and critical review of the state-of-the-art research is included. These methodologies present a path towards the development of minimally invasive brain-computer interfaces capable of resolving microscale neural activity with wide-ranging coverage across the cortical surface. - Written by leading researchers in electrocorticography in brain-computer interfaces - Offers a unique focus on neural interface circuit design, from electrode to interface, circuit, powering, communication and encapsulation - Covers the newest ECoG interface systems and electrode interfaces for ECoG and biopotential sensing
There are references to clothing throughout Paul's letters, and the metaphor constitutes a significant aspect of his theology. The imagery appears several times in his letters: clothing with Christ (Gal 3:27; Rom 13:14), clothing with the new man (Col 3:9-10; Eph 4:22-24), and clothing with the resurrection body (1 Cor 15:49, 50-54; 2Cor 5:1-4). In order to understand the background to this use of the clothing metaphor, Jung Hoon Kim examines similar imagery in the Old Testament, 1 and 2 Enoch, the Apocalypse of Moses, Philo, rabbinic literature, Joseph and Aseneth, the Hymn of the Pearl, and Apuleius's Metamorphoses. He also discusses the Roman custom of clothing and the baptismal praxis of the ancient church. Kim concludes that Paul's metaphor suggests the life and glory of the image of God, which were lost by Adam, have been restored by baptism in Christ, and will go on to be consummated at the parousia.
The studies collected here are presented to Brunilde Sismondo Ridgway to honor an unusually inspiring and energetic teacher, a dedicated and prolific scholar, and a profoundly humane and caring human being. Bruni's passion for Greek sculpture, her constantly inquiring mind, and her bold questioning of long-accepted positions have sparked many stimulating discussions, often planting the germ of an idea to which students return in their own work. The themes here discussed reflect many of Bruni's scholarly interests. Most are on sculptural topics, but numismatics, architecture, and Iron Age Cyprus are also represented. Discussions focus on interpretations of technique and style, consider single sculptures, groups, and whole monuments, the well known as well as the unusual. University Museum Monograph, 100
Understanding Paul and his conversion to Christianity is imperative for a thorough knowledge of the New Testament. In Paul and the New Perspective Seyoon Kim develops his argument that the origin of Paul's gospel lies in two places his radical conversion at Damascus and his usage of the Jesus tradition in light of Damascus. This new way of looking at Paul further explains how Paul made strong distinctions between the Spirit and the flesh/law, with further implications for his doctrine of justification. A departure from the New Perspective School represented by James D. G. Dunn, Kim's Paul and the New Perspective offers a thorough and extensive argument for the foundation of the gospel that Paul spread in the first century.
- ALL-NEW topics provide updates on infectious diseases, including herpesvirus, equine granulocytic anaplasmosis, and lawsonia infection and proliferative enteropathy; pain diagnosis and multimodal management; management of thoracic and airway trauma, imaging, endoscopy, and other diagnostic procedures for the acute abdomen; and neurologic injury. - 212 concise, NEW chapters include both a succinct guide to diagnosis of disorders and a detailed discussion of therapy. - NEW images demonstrate advances in various imaging techniques. - Thoroughly updated drug appendices, including all-new coverage of drug dosages for donkeys and mules, provide a handy, quick reference for the clinical setting.
Volume 3 Number 1 of The Mystery Fancier contains: "Gene Stratton-Porter: Mistress of the Mini-Mystery," by Jane S. Bakerman, "The Len Deighton Series," by Jeff Banks and Harry Dawson, "Kim Philby, Master Spy in Fact and Fiction," by Theodore P. Dukeshire, "Bouchercon, 1978: IX and Counting," by Donald A. Yates, "The Nero Wolfe Saga, Part XI," by Guy M. Townsend, and "An Index of Books Reviewed in TMF Volume 2," compiled by David H. Doerrer.
Baltimore's unforgettable dining scene of the past is re-visited here in thirty-five now shuttered restaurants that made their mark on this city. Haussner's artwork. Coffey salad at the Pimlico Hotel. Finger bowls at Hutzler's Colonial Tea Room. The bell outside the door at Martick's Restaurant Francais. Details like these made Baltimore's dining scene so unforgettable. Explore the stories behind thirty-five shuttered restaurants that Baltimoreans once loved and remember the meals, the crowds, the owners and the spaces that made these places hot spots. Suzanne Loudermilk and Kit Waskom Pollard share behind-the-scenes tales of what made them tick, why they closed their doors and how they helped make Baltimore a culinary destination.
Although there is broad agreement on the importance of rehabilitation and the need to improve occupational health and vocational rehabilitation in the UK, there is considerable uncertainty about what 'rehabilitation' is, and about its cost-effectiveness, particularly for the common health problems that cause most long-term disability and incapacity. This paper seeks to develop a theoretical and conceptual basis for the rehabilitation of common health problems. Chapters include: traditional rehabilitation and the need for a different approach; illness, disability and incapacity for work; the biopsychosocial model and framework of disability; obstacles to recovery and return to work; clinical and occupational management of common health problems; personal responsibility and motivation; and rehabilitation in a social security context.
“Exactly what I wanted as a die-hard fan of the novels.” – Comics Alliance For a dark decade, Dracula has ruled the British Empire, unchecked. Now, on the verge of his Tin Jubilee, forces are gathering to challenge his insidious reign. In London, vampire journalist Kate Reed has been summoned to a meeting with the Council of the Seven Days, a secret cabal dedicated to destroying Dracula. Meanwhile, the sinister Lord of Strange Deaths is planning to use the Jubilee celebrations for his own nefarious act of sedition. This album collects together issues #1-5 of Anno Dracula: Seven Days of Mayhem. This all-new adventure written by Kim Newman and drawn by Paul McCaffrey, sees master storyteller Kim Newman’s vast cast of characters explore the terrifying reality of a world ruled by the deadliest vampire of all times. “Compulsory reading… glorious!” – Neil Gaiman
Whilst London prepares to celebrate Prince Dracula’s 10th anniversary, his secret police force, The Grey Men are purging the streets of any and all political malcontents and miscreants, including the Council of Seven Days – an anarchist cell. Meanwhile, vampiric journalist Kate Reed and the surviving members of the Council are now running for the lives following a police raid on their headquarters and are unaware that the Grey Men have secreted one of their own among their dwindling membership. Moreover, Kate’s friend, Penny Churchward – who has been summoned to the Tower of London to be appointed overseer of the Jubilee celebrations, has stumbled into the presence of an ancient, unbelievably-evil, undead vampire legend that rumor has it frightens even Prince Dracula himself…
Probiotics: A Clinical Guide is one of the first books on the market to present current and evidence-based recommendations for primary care providers and gastroenterologists on the use of probiotics as a way to treat specific diseases and disorders. Why you will want Probiotics: A Clinical Guide: Unique focus on the clinical use of probiotics in a wide variety of diseases Comprehensive review of the science behind probiotics and probiotic products In-depth review of current literature for specific diseases or disorders Recommendations of the use of probiotics is supported by evidence-based clinical trials Each chapter includes a table that outlines the exact probiotic organisms and dosages that are the most efficacious A glance at what is inside Probiotics: A Clinical Guide: Basic Physiology Intestinal microecology; stimulating the immune response, nutrients to nourish the organism, role in fermentation and metabolism, and much more... Use in Clinical Medicine Probiotics in children, adult infectious diarrhea, surgical infections, allergic disease, ulcerative colitis, crohn’s disease, liver disease, and more... Probiotics: A Clinical Guide by Dr. Martin Floch & Dr. Adam Kim is a ground-breaking book that will serve as a valuable reference and clinical guide for gastroenterologists, internists, family practitioners, nurse practitioners, and physician assistants.
Computerized medical imaging and image analysis have been the central focus in diagnostic radiology. They provide revolutionarizing tools for visualization of physiology as well as the understanding and quantitative measurement of physiological parameters. This book provides a unique depth of knowledge from the principles to recent advanced methods in medical imaging instrumentation and techniques as well as multidimensional image analysis and classification methods for research, education and applications in computer-aided diagnostic radiology. Internationally renowned researchers and experts in their respective areas provide detailed description of the basic foundation as well as the most recent developments in medical imaging. This book helps readers to understand theoretical and advanced concepts for important research and clinical applications.
Annals of natural disasters have always caused common interest. Scientists and specialists of various domains, teachers, students, post-graduates, journalists .. and merely inquisitive can find useful and didactic information in such annals~ Sad experience of the natural disasters endured gives very important material for humanity. It allows us not only to understand better the phenomenon itself, but also to prepare ourselves for future cataclysms, which our "Mother-Nature" is so rich in. The book by Sergey Soloviev and a group of his collaborators represents a detailed description of tsunami waves and accompanying phenomena in the Mediterranean Sea over a period of approximately four thousand years. Sergey Soloviev, the founder and recognised leader of the Russian scientific school of tsunami researchers, was unable to see the publication of this book, passing away on March 9, 1994. However, his ample experience in investigation and systematisation of tsunami waves for the Pacific area [Soloviev and Go, 1974, 1975; Soloviev, Go and Kim, 1986] has been widely used in compiling this book. The Mediterranean coasts are the cradle of civilisation. Written accounts of past disasters in this region of the Earth are rather numerous and highly reliable. Therefore the results of the tsunami study in the Mediterranean Sea are of specific value both for the scientific community and for humanity at large.
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