This book describes the current state of the art for simulating paint shop applications, their advantages and limitations, as well as corresponding high-performance computing (HPC) methods utilized in this domain. The authors provide a comprehensive introduction to fluid simulations, corresponding optimization methods from the HPC domain, as well as industrial paint shop applications. They showcase how the complexity of these applications bring corresponding fluid simulation methods to their limits and how these shortcomings can be overcome by employing HPC methods. To that end, this book covers various optimization techniques for three individual fluid simulation techniques, namely grid-based methods, volumetric decomposition methods, and particle-based methods.
The second edition of this bestseller provides a practical and accessible introduction to the main concepts, foundation, and applications of Bayesian networks. This edition contains a new chapter on Bayesian network classifiers and a new section on object-oriented Bayesian networks, along with new applications and case studies. It includes a new section that addresses foundational problems with causal discovery and Markov blanket discovery and a new section that covers methods of evaluating causal discovery programs. The book also offers more coverage on the uses of causal interventions to understand and reason with causal Bayesian networks. Supplemental materials are available on the book's website.
How organisations listen, learn, and adapt to their environment drives success and long-term sustainability. This book focuses on internal stakeholders and how employers can use the voice of their people to improve decision-making, innovation, and performance. It is about why listening to employees matters and how to do it well. Leading the Listening Organisation reveals not just the practices and processes that underpin effective listening but also the leadership characteristics and mindsets necessary to create resilient organisations that feel fair to work in, where people want to speak up, and where new ideas can flourish. It is based on extensive international research with leaders across over 500 organisations before, during, and after the pandemic. The authors bring decades of international experience and expertise in communicating with employees across public, private, and third sector organisations. Rich in practical tools, processes, and working frameworks and brought to life with case studies and insights from leaders and communicators, this book provides a complete guide to understanding the barriers to, and implementation plans for, leading a listening organisation. This comprehensive guide will resonate with leadership, internal communications, human resources, and organisational development professionals.
Toxicological Effects of Veterinary Medicinal Products in Humans is the first definitive guide to discuss the adverse effects of veterinary medicinal products in humans. The chapters focus on occupational safety and consumer issues and examine the circumstances under which exposure is likely to occur. To be in context, it reviews this against the background of adverse health effects from other sources in the veterinary and farming professions. The book examines adverse drug effects reported to regulatory agencies (mainly the FDAÆs Center for Veterinary Medicine) and then considers a series of individual drugs, including antibiotics, anaesthetics and organophosphorus compounds. The chapters also discuss the fundamental aspects of regulatory issues relating to safety assessment, and examine the manner in which user safety is assessed prior to authorisation/approval and what measures can be taken after authorisation/approval in the light of findings from pharmacovigilance activities. There is growing concern over the issue of antimicrobial resistance and the contribution made by veterinary medicinal products. This too is addressed along with the significance to human health and measures that can be taken to mitigate the effects (if any) of the use of antibiotics in animals e.g. prudent use measures. The book will be an essential resource for medical practitioners in hospitals and general practice, pharmaceutical industry scientists, analysts, regulators and risk managers.
What makes you the way you are--and what makes each of us different from everyone else? In Innate, leading neuroscientist and popular science blogger Kevin Mitchell traces human diversity and individual differences to their deepest level: in the wiring of our brains. Deftly guiding us through important new research, including his own groundbreaking work, he explains how variations in the way our brains develop before birth strongly influence our psychology and behavior throughout our lives, shaping our personality, intelligence, sexuality, and even the way we perceive the world. We all share a genetic program for making a human brain, and the program for making a brain like yours is specifically encoded in your DNA. But, as Mitchell explains, the way that program plays out is affected by random processes of development that manifest uniquely in each person, even identical twins. The key insight of Innate is that the combination of these developmental and genetic variations creates innate differences in how our brains are wired--differences that impact all aspects of our psychology--and this insight promises to transform the way we see the interplay of nature and nurture. Innate also explores the genetic and neural underpinnings of disorders such as autism, schizophrenia, and epilepsy, and how our understanding of these conditions is being revolutionized. In addition, the book examines the social and ethical implications of these ideas and of new technologies that may soon offer the means to predict or manipulate human traits. Compelling and original, Innate will change the way you think about why and how we are who we are."--Provided by the publisher.
Explores the science behind the brain's ability to act like a predictive machine, describing how today's computers and businesses are being developed with the same predictive capacities in order to better anticipate customer needs and prevent potential problems.
The latest edition of this in-depth look at athletic injuries of the shoulder has been updated to feature 16 new chapters, additional illustrations and algorithms, an added focus on arthroscopic treatments, and pearls that highlight key information. Additional contributing authors give you a fresh spin on new and old topics from rehabilitation exercises to special coverage of female athletes, pediatrics, and golfers. This book offers coverage of arthroscopy, total joint replacement, instability, football, tennis, swimming, and gymnastic injuries, rotator cuff injuries, and much, much more! The large range of topics covered in this text ensures that it’s a great resource for orthopaedists, physical therapists, athletic trainers, and primary care physicians. Presents a multidisciplinary approach to the care of the shoulder, combining contributions from the leaders in the field of orthopedic surgery, physical therapy, and athletic training. Demonstrates which exercises your patients should perform in order to decrease their chance of injury or increase strength following an injury through illustrated exercises for rehabilitation and injury prevention. Illustrates how the shoulder is affected during activity of certain sports with a variety of tables and graphs. Covers a large range of topics including all shoulder injuries to be sufficiently comprehensive for both orthopaedists and physical therapists/athletic trainers. Features 16 new chapters, including Internal Impingement, Bankarts: Open vs. Arthroscopy, Adhesive Capsulitis of the Shoulder, Cervicogenic Shoulder Pain, Proprioception: Testing and Treatment, and more. Details current surgical and rehabilitation information for all aspects of shoulder pathology to keep you up-to-date. Organizes topics into different sections on anatomy, biomechanics, surgery, and rehabilitation for ease of reference.
A very hot topic at the 2010 AASLD meeting, hepatic encephalopathy is being brought to the Clinics in Liver Disease for the very first time by top experts, Dr. Mullen and Dr. Prakash. Authors have written articles that fully discuss the clinical aspects of hepatic encephalopathy (HE). Articles presented include History, Nomenclature and Classification; Theories involved in the pathogenesis of HE; Clinical Assessment and utility of clinical scales for semi-quantification of Overt HE; Assessment of Minimal HE( with emphasis on computerized psychometric tests); Brain Imaging and HE; Management of Overt HE; Management of Minimal HE; Nutritional Interventions for HE; TIPS and HE; Liver Transplantation and Reversibility of HE; Minimal HE and Driving; and HE and Quality of Life.
This book describes methods and tools that empower information providers to build and maintain knowledge graphs, including those for manual, semi-automatic, and automatic construction; implementation; and validation and verification of semantic annotations and their integration into knowledge graphs. It also presents lifecycle-based approaches for semi-automatic and automatic curation of these graphs, such as approaches for assessment, error correction, and enrichment of knowledge graphs with other static and dynamic resources. Chapter 1 defines knowledge graphs, focusing on the impact of various approaches rather than mathematical precision. Chapter 2 details how knowledge graphs are built, implemented, maintained, and deployed. Chapter 3 then introduces relevant application layers that can be built on top of such knowledge graphs, and explains how inference can be used to define views on such graphs, making it a useful resource for open and service-oriented dialog systems. Chapter 4 discusses applications of knowledge graph technologies for e-tourism and use cases for other verticals. Lastly, Chapter 5 provides a summary and sketches directions for future work. The additional appendix introduces an abstract syntax and semantics for domain specifications that are used to adapt schema.org to specific domains and tasks. To illustrate the practical use of the approaches presented, the book discusses several pilots with a focus on conversational interfaces, describing how to exploit knowledge graphs for e-marketing and e-commerce. It is intended for advanced professionals and researchers requiring a brief introduction to knowledge graphs and their implementation.
The phrase "teaching for social justice" is often used, but not always explained. What does it look like to teach for social justice? What are the implications for anti-oppressive teaching across different areas of the curriculum? Drawing on his own experiences teaching diverse grades and subjects, leading author and educator Kevin Kumashiro examines various aspects of anti-oppressive teaching and learning in six different subject areas. Celebrating 10 years as a go-to resource for K-12 teachers and teacher educators, this third edition of the bestselling Against Common Sense features: • A new introduction that addresses the increased challenges of anti-oppressive teaching in an era of teacher evaluations, standardization and ever-increasing accountability. • End of chapter teacher responses that provide subject-specific examples of what anti-oppressive teaching really looks like in the classroom. • End of chapter questions for reflection that will enhance comprehension and help readers translate abstract ideas into classroom practice. • Additional readings and resources to inspire students to further their social justice education. Compelling and accessible, Against Common Sense continues to offer readers the tools they need to begin teaching against their common sense assumptions and toward social justice.
On the basis of a theologically grounded understanding of the nature of persons and the self, Jack O. Balswick, Pamela Ebstyne King and Kevin S. Reimer present a model of human development that ranges across all of life's stages. This revised second edition engages new research from evolutionary psychology, developmental neuroscience and positive psychology.
This Second Edition of the book explains, with precision and clarity, the basic concepts, theories and practices of international financial management. As international transactions form an integral part of economic activities in the modern globalized economic environment, practising managers need to know the fundamentals of international finance. And this book, written by Professor S. Kevin, who has a rich and long experience in teaching international finance, eminently fulfils this need. The book begins with an explanation of the exchange rate mechanism of foreign currencies, factors influencing exchange rate fluctuations, and the trading mechanism in foreign exchange markets. As currency forwards, futures, options and swaps are the instruments of currency derivatives used as hedging and speculative tools, the book goes on to give a detailed description of the use of currency derivatives for hedging as well as speculative functions. It contains an analysis of international financial institutions and their functioning, the participants and instruments of global financial markets where international funds are raised, the many uses of international funds in the form of portfolio investments, and direct investments in host countries. The book is primarily intended as a text for postgraduate students of commerce and management, chartered accountancy (CA) and chartered financial analysis (CFA). It would also be of immense value to practising professionals in the field of international finance. KEY FEATURES • Illustrates the concepts with the help of examples, figures and tables. • Clearly explains risk management tools and techniques. • Discusses the role of international financial institutions in the global financial market. • Is a handy text for self-study. ADDITIONS IN SECOND EDITION • Exchange rates have been revised to current levels • Two new chapters on ‘International Projects and Portfolios’ and ‘ Practices and Problems of International Financial Management’ have been added
The ability to regulate cell volume in the face of osmotic challenge is one of the most fundamental of cellular homeostatic mechanisms. Cellular and Molecular Physiology of Cell Volume Regulation is an integrated collection of articles describing key aspects of cell volume control. The book has been organized around concepts and cellular/molecular processes rather than around mechanisms of volume regulation in specific cell types in order to make it more accessible to a multidisciplinary audience of students, instructors, and researchers.
Buy a new version of this textbook and receive access to the Connected eBook on CasebookConnect, including: lifetime access to the online ebook with highlight, annotation, and search capabilities, plus an outline tool and other helpful resources. Connected eBooks provide what you need most to be successful in your law school classes. A student-friendly casebook for the new generation of health lawyers in an evolving legal landscape, The Law of American Health Care emphasizes lightly, carefully edited primary source excerpts, plain-language exposition, focused comprehension questions, and problems for concept application. It introduces key themes and uses them as a conceptual anchor so when the law inevitably changes, students have tools to nimbly move forward. These themes include: federalism; individual rights; fiduciary relationships; the administrative state; markets and regulation; and equity and distribution. The book engages topics in-depth, to give students a comprehensive understanding of the most important features of health care law and hands-on experience working through cutting-edge issues. New to the 3rd Edition: Current debates about government power among public health officials, legislatures, judges, and other state actors, including issues arising from the COVID-19 pandemic Public insurance materials reorganized so students can better absorb Medicare/Medicaid and apply lessons of the pandemic and litigation over various issues Solidification of ACA reforms, including surprise billing legislation and changes in the exchange subsidies that attempted to fill the Medicaid coverage gap Consolidated health care business organization materials New/revised materials and new cases in tax exempt entities and health care fraud/abuse, state action doctrine, and discrimination in healthcare/health insurance (including history of attempts to address health care discrimination, 1964 Civil Rights Act Title VI, ADA, HIPAA portability, ACA guaranteed issue, renewal, community rating, and Section 1557) Government enforcement’s more aggressive approach to labor issues Dobbs v. Jackson Women’s Health and ensuing state law chaos and federal/state conflicts Increased use of digital health care tools and telehealth driven by the pandemic Right-to-try movement and other features of biomedical research that became more relevant during the pandemic Benefits for instructors and students: Practice-oriented approach immerses students in primary source materials that include judicial opinions as well as statutory, regulatory, advisory, and empirical sources used in practice Focused on needs of students practicing health care law in a post-ACA, pandemic-impacted world First health care law casebook to reorient federal law as central authority for health care regulation (as opposed to state or common law) Exploration of two major public insurance programs provided before discussion of private insurance options, intentionally suggesting the increasing primacy of social insurance in the U.S. and underscoring even the most uniform coverage (Medicare) is complex Intro chapter with critical organizing themes and in-depth case studies which are woven throughout other chapters, including more prominent emphasis on equity and distributive justice Text boxes highlight key lessons and help explain/enhance material Directed Questions, hypothetical Problems, and end-of-chapter Capstone Problems support focused reading and clearer synthesis of major issues Manageable length Focused on topics encountered in the day-to-day practice of health law Essential connective narrative without overwhelming notes New co-author with deep health care legislative and regulatory experience
Methods of IT Project Management (Third Edition) is built around the latest version of the Project Management Body of Knowledge (PMBOK) and covers best practices unique to the IT field. It is designed for use in graduate, advanced undergraduate, and professional IT project management courses to prepare students for success in the IT field, and to prepare them to pass the Project Management Professional (PMP) certification exam given by the Project Management Institute (PMI), the world's leading certification in the field of project management. Unlike other project management texts, Methods of IT Project Management follows the IT project life cycle, from overview and initiation to execution, control, and closing. An enterprise-scale IT project (macro-case study) runs through the entire text. Each section presents mini-cases based on the larger case and focuses on new concepts presented in each section. Readers gain practical knowledge of IT project management workflows, at scale, while building technical knowledge and skills required to pass the PMP. Mini-case studies encourage deep retention, prompt rich in-class discussion, and challenge more advanced students and professionals alike. Unique skills covered can be put directly into practice. An appendix presents practice study questions and advice on preparing for and passing the PMP exam. The revised third edition includes expanded coverage of agile system development methodologies, leadership and negotiation skills, and process maturity models.
Essential Study and Employment Skills for Business and Management Students offers a comprehensive, one-stop guide that will equip you with all the necessary skills needed to enhance your success both during university and in your future working environment. It covers all the core areas associated with business and management degrees, and offers a unique focus on employability to ensure that you can translate the skills you acquire into professional practice. This third edition has been fully revised to include a new group activity in each chapter, as well as updated activities throughout to reinforce the skills introduced in each chapter. The content and structure of the book has been updated to focus more effectively on core areas such as the use of quantitative data, and the development of professional skills and employability. With the main focus of the book firmly on active experimentation and reflection, Essential Study and Employment Skills for Business and Management Students remains unparalleled as a resource to support, encourage, and develop business and management students throughout their time at university and beyond. Online Resource Centre: For students: Selected activities from the text (including templates to complete online) Answer guidance on writing style and using a narrative approach Critical incidents log Excel workbook to provide additional support in areas such as constructing pie charts, bar charts, and line charts Information on using Excel in data analysis Web links YouTube channel featuring relevant videos on skills, including interviews with students and graduates that accompany the book For lecturers: PowerPoint slides
An easy-to-navigate, comparative book on state and local government. Very student-friendly and well-organized." —Jane Bryant, John A. Logan College The trusted and proven Governing States and Localities guides students through the contentious environment of state and local politics and focuses on the role that economic and budget pressures play in issues facing state and local governments. With their engaging journalistic writing and crisp storytelling, Kevin B. Smith and Alan Greenblatt employ a comparative approach to explain how and why states and localities are both similar and different. The Seventh Edition is thoroughly updated to account for such major developments as state versus federal conflicts over immigration reform, school shootings, and gun control; the impact of the Donald Trump presidency on intergovernmental relations and issues of central interest to states and localities; and the lingering effects of the Great Recession. A Complete Teaching and Learning Package SAGE coursepacks FREE! Easily import our quality instructor and student resource content into your school’s learning management system (LMS) and save time. Learn more. SAGE edge FREE online resources for students that make learning easier. See how your students benefit.
Many animals, including humans, acquire valuable skills and knowledge by copying others. Scientists refer to this as social learning. It is one of the most exciting and rapidly developing areas of behavioral research and sits at the interface of many academic disciplines, including biology, experimental psychology, economics, and cognitive neuroscience. Social Learning provides a comprehensive, practical guide to the research methods of this important emerging field. William Hoppitt and Kevin Laland define the mechanisms thought to underlie social learning and demonstrate how to distinguish them experimentally in the laboratory. They present techniques for detecting and quantifying social learning in nature, including statistical modeling of the spatial distribution of behavior traits. They also describe the latest theory and empirical findings on social learning strategies, and introduce readers to mathematical methods and models used in the study of cultural evolution. This book is an indispensable tool for researchers and an essential primer for students. Provides a comprehensive, practical guide to social learning research Combines theoretical and empirical approaches Describes techniques for the laboratory and the field Covers social learning mechanisms and strategies, statistical modeling techniques for field data, mathematical modeling of cultural evolution, and more
Piped Voices is a story of murder, greed, love, lust, and exploitation, set in a remote underdeveloped Indian village. It is also the story of an extraordinary orphan with a penchant for humor even in the grimmest situation.
Immunocytochemistry of plant cells is the first book exclusively dedicated to this topic. The first and largest portion of the book is concerned with a group of proven protocols and variations on these protocols that might prove useful, many developed or modified in the author's laboratory. The second portion of the book covers the studies that have been published previously on each of the plant organelles. Numerous state of the art micrographs from researchers around the world are included to demonstrate typical results.
Exploring common challenges and unpacking why performance appraisal often fails in organizations, Performance Appraisal and Management uses the latest thinking and research to equip readers with evidence-based tools and strategies for overcoming these obstacles.
A handbook for the study of strategic communication in the fields of politics, diplomacy and civill society. Contains theory, practice and case studies.
This book of text, cases and materials from Asia is designed for scholars and students of constitutional law and comparative constitutional law. The book is divided into 11 chapters, arranged thematically around key ideas and controversies, enabling the reader to work through the major facets of constitutionalism in the region. The book begins with a lengthy introduction that critically examines the study of constitutional orders in 'Asia', highlighting the histories, colonial influences, and cultural particularities extant in the region. This chapter serves both as a provisional orientation towards the major constitutional developments seen in Asia – both unique and shared with other regions – and as a guide to the controversies encountered in the study of constitutional law in Asia. Each of the following chapters is framed by an introductory essay setting out the issues and succinctly highlighting critical perspectives and themes. The approach is one of 'challenge and response', whereby questions of constitutional importance are posed and the reader is then led, by engaging with primary and secondary materials, through the way the various Asian states respond to these questions and challenges. Chapter segments are accompanied by notes, comments and questions to facilitate critical and comparative analysis, as well as recommendations for further reading.The book presents a representative range of Asian materials from jurisdictions including: Bangladesh, China, Hong Kong, India, Japan, Mongolia, Nepal, Pakistan, South Korea, Sri Lanka , Taiwan, Timor-Leste and the 10 ASEAN states.
Designed for graduate, advanced undergraduate, and practitioner project management courses with an information technology focus, Methods of IT Project Management is designed around the Project Management Body of Knowledge (PMBOK), incorporating material from the latest seventh edition while still maintaining the book’s process approach. The text provides students with all the concepts, techniques, artifacts, and methods found in the leading project management reference books and modern development methodologies (agile, hybrid, and traditional), while also conveying practical knowledge that can immediately be applied in real-world settings. Unlike other books in this area, the material is organized according to the sequence of a generic project life cycle—from project selection to initiation, planning, execution, control, and iteration or project closeout. Following this life-cycle approach, as opposed to covering the material by knowledge area or project performance domain, allows new learners to simultaneously study project management concepts and methods as they develop skills they can use immediately during and upon completion of the course. The text’s structure also allows different programs to use the book during real-world student projects.
Since the 1980s, Mexico has alternately served as a model of structural economic reform and as a cautionary example of the limitations associated with market-led development. This book provides a comprehensive, interdisciplinary assessment of the principal economic and social policies adopted by Mexico during the 1980s and 1990s.
Skin lymphomas are relatively rare and can be easily misdiagnosed as psoriasis or dermatitis. These lymphomas can be fatal. Consequently, those in training in dermatology and pathology need to have a good understanding of the clinical presentations and the pathological correlates of this challenging disease. This updated edition provides: A full-colour illustrated text and atlas that combines pathology with clinical features and treatment updated nomenclature according to WHO/EORTC and WHO classifications Images to expand the diagnostic potential Cases to enhance the scope for teaching and learning
Introduction and scope -- State of the art and current practice -- Laboratory testing program -- Field evaluations of CLSM -- Conclusions and suggested research -- References -- Appendices.
The metal-catalyzed amination of aryl and alkenyl electrophiles has developed into a widely used methodology for the synthesis of natural products, active pharmaceutical ingredients, agricultural chemicals, and materials for molecular electronics. Copper catalysts promote the coupling of a wide range of nitrogen nucleophiles, including amines, amides, and heteroaromatic nitrogen compounds with aryl and alkenyl halides. The reactivity profile of copper catalysts is complementary to that of palladium catalysts in many cases. Copper catalysts are highly effective with less nucleophilic nitrogen nucleophiles, such as amides and azoles, whereas palladium catalysts are more effective with more nucleophilic amine nucleophiles. Copper is an attractive alternative to palladium due to its significantly lower cost. In addition, high activity palladium catalysts require expensive and often air-sensitive ligands, whereas the modern copper systems use relatively stable and inexpensive diamine or amino acid ligands. Copper-catalyzed C N coupling reactions are tolerant of a wide range of functional groups and have been applied to the synthesis of a variety of complex natural products. Significant work has also been done to understand the mechanism of these reactions. Current mechanistic understanding of these methodologies is covered in this monograph. The contents of the book are taken from the comprehensive review of the topic in the Organic Reactions series. Optimal experimental conditions for the amination of aryl and alkenyl halides with all classes of nitrogen nucleophiles are presented. Specific experimental procedures from the literature are provided for the major classes of copper-catalyzed C N coupling reactions. A tabular survey of all examples of Cu-catalyzed arylation and alkenylation of nitrogen nucleophiles is presented in 35 tables organized by nitrogen nucleophile and electrophilic coupling partner. The literature is covered through December 2015 and provides 300 recent citations to supplement the 680 citations of the original hardbound chapter. These latest literature references have been collected in separate sections according to the sequence of the tables in the tabular survey section. In each of the sections, the individual citations have been arranged in alphabetic order of the author names. Copper-Catalyzed Amination of Aryl and Alkenyl Electrophiles is intended to provide organic chemists with an accessible, but detailed, introduction to this important class of transformations.
Critical Race Theory provides a framework for exploring racism in society, taking into account the role of institutions and drawing on the experiences of those affected. Applied to the world of sport, this framework can reveal the underlying social mores and institutionalised prejudices that have helped perpetuate those racial stereotypes particular to sport, and those that permeate broader society. In this groundbreaking sociological investigation, Kevin Hylton takes on the controversial subject of racial attitudes in sport and beyond. With sport as his primary focus, Hylton unpacks the central concepts of ‘race’, ethnicity, social constructionism and racialisation, and helps the reader navigate the complicated issues and debates that surround the study of ‘race’ in sport. Containing rigorous and insightful analysis throughout, the book explores key topics such as: the origins, applications and terminology of Critical Race Theory the meaning of ‘whiteness’ the media, sport and racism anti-racism and sport genetics and scientific racism. The contested concepts that define the subject of ‘race’ in sport present a constant challenge for academics, policy makers and practitioners in the development of their ideas, policies and interventions. This innovative and challenging book is essential reading for anybody looking to fully understand this important subject.
Earth Materials Earth materials encompass the minerals, rocks, soil and water that constitute our planet and the physical, chemical and biological processes that produce them. Since the expansion of computer technology in the last two decades of the twentieth century, many universities have compressed or eliminated individual course offerings such as mineralogy, optical mineralogy, igneous petrology, sedimentology and metamorphic petrology and replaced them with Earth materials courses. Earth materials courses have become an essential curricular component in the fields of geology, geoscience, Earth science, and many related areas of study. This textbook is designed to address the needs of a one- or two-semester Earth materials course, as well as individuals who want or need an expanded background in minerals, rocks, soils and water resources. Earth Materials, Second Edition, provides: Comprehensive descriptive analysis of Earth materials Color graphics and insightful text in a logical integrated format Field examples and regional relationships with graphics that illustrate concepts discussed Examples of how concepts discussed can be used to address real world issues Contemporary references from current scientific journals related to developments in Earth materials research Summative discussions of how Earth materials are interrelated with other science and non-science fields of study Additional resources, including detailed descriptions of major rock-forming minerals and keys for identifying minerals using macroscopic and/or optical methods, are available online at www.wiley.com/go/hefferan/earthmaterials Earth Materials, Second Edition, is an innovative, visually appealing, informative and readable textbook that addresses the full spectrum of Earth materials.
This comprehensive introduction to schizophrenia is an ideal starting point for students. It covers the theoretical foundations of different perspectives of schizophrenia, including medical, evolutionary and social, to give readers a solid grounding and then discusses the various forms of treatments and the arguments surrounding each perspective.
Toxicological Effects of Veterinary Medicinal Products in Humans is the first definitive guide to discuss the adverse effects of veterinary medicinal products in humans. The chapters focus on occupational safety and consumer issues and examine the circumstances under which exposure is likely to occur. To be in context, it reviews this against the background of adverse health effects from other sources in the veterinary and farming professions. The book examines adverse drug effects reported to regulatory agencies (mainly the FDAÆs Center for Veterinary Medicine) and then considers a series of individual drugs, including antibiotics, anaesthetics and organophosphorus compounds. The chapters also discuss the fundamental aspects of regulatory issues relating to safety assessment, and examine the manner in which user safety is assessed prior to authorisation/approval and what measures can be taken after authorisation/approval in the light of findings from pharmacovigilance activities. There is growing concern over the issue of antimicrobial resistance and the contribution made by veterinary medicinal products. This too is addressed along with the significance to human health and measures that can be taken to mitigate the effects (if any) of the use of antibiotics in animals e.g. prudent use measures. The book will be an essential resource for medical practitioners in hospitals and general practice, pharmaceutical industry scientists, analysts, regulators and risk managers.
This volume describes recent research in the field of metalloproteinases (a family of enzymes that can catalyze tissue degradation), in particular their participation in autoimmune diseases such as rheumatoid arthritis, reviewing the latest developments in metalloproteinase inhibitor design and the current status of clinical candidates. This volume is intended not only for those active in research into metalloproteinases but also for those with an interest in inflammatory diseases. Thus it addresses both academic and industrial researchers.
In the last decade there has been an explosion of interest in viral therapies for cancer. Viral agents have been developed that are harmless to normal tissues but selectively able to kill cancer cells. These agents have been endowed with additional selectivity and potency through genetic manipulation. Increasingly these viruses are undergoing evaluation in clinical trials, both as single agents and in combination with standard chemotherapy and radiotherapy. This book provides a comprehensive yet succinct overview of the current status of viral therapy of cancer. Chapters coherently present the advances made with individual agents and review the biological and clinical background to a range of viral therapies: structured to proceed from basic science at the bench to the patient’s bedside, they give an up-to-date and realistic evaluation of a therapy’s potential utility for the cancer patient. Presents state of the art knowledge on how viruses can be, and have been, used in novel therapeutic approaches for the treatment of cancer Describes the use of viruses as oncolytic agents, killing cells directly Editors are experts in the field, with experience of both laboratory and clinical research Viral Therapy of Cancer is essential reading for both basic scientists and clinicians with an interest in viral therapy and gene therapy.
Providing an expert overview of the current structure of health care and how it affects today’s orthopaedic surgeons, Value-Based Health Care in Orthopaedics addresses the healthcare system’s transition from a fee-for-service model to value-based health care. This transition aligns the incentives of all stakeholders, including payers, purchasers, clinicians, and most importantly, patients, by prioritizing health over care, and facilitating competition based on health outcomes and cost. Developed in partnership with the American Academy of Orthopaedic Surgeons (AAOS) and edited by Eric C. Makhni, MD, MBA, FAAOS, Benedict Nwachukwu, MD, MBA, and Kevin J. Bozic, MD, MBA, FAAOS, this unique, authoritative text covers essential information not often covered in medical school or orthopaedic residency training—offering a comprehensive discussion of the principles of value-based health care as applied to orthopaedics.
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