Kevin Guilfoile’s riveting follow-up to Cast of Shadows (“spellbinding”—Chicago Tribune; “a masterpiece of intelligent plotting”—Salon) centers on an extraordinary young woman’s race to find her father’s killer and to free herself from the cross fire of a centuries-old civil war in which she has unknowingly become ensnared. In 530 B.C., a mysterious ship appeared off the rainy shores of Croton, in what is now Italy. After three days the skies finally cleared and a man disembarked to address the curious and frightened crowd that had gathered along the wet sands. He called himself Pythagoras. Exactly what he said that day is unknown, but a thousand men and women abandoned their lives and families to follow him. They became a community. A school. A cult dedicated to the search for a mathematical theory of everything. Although Pythagoras would die years later, following a bloody purge, his disciples would influence Western philosophy, science, and mathematics for all time. Chicago, the present day. Canada Gold, a girl both gifted and burdened by uncanny mental abilities, is putting her skills to questionable use in the casinos and courthouses of Las Vegas when she finds herself drawn back to the city in which her father, the renowned composer Solomon Gold, was killed while composing his magnum opus. Beautiful, brilliant, troubled, Canada has never heard of the Thousand, a clandestine group of powerful individuals safeguarding and exploiting the secret teachings of Pythagoras. But as she struggles to understand her father’s unsolved murder, she finds herself caught in the violence erupting between members of the fractured ancient cult while she is relentlessly pursued by those who want to use her, those who want to kill her, and the one person who wants to save her. In an irresistibly ambitious novel that fuses historical fact with contemporary suspense, Kevin Guilfoile delivers an erudite, propulsively entertaining thriller that seamlessly traverses the realms of math, science, music, and philosophy. The Thousand is ringing confirmation of Guilfoile’s enormous talent. From the Hardcover edition.
Neurotrauma: A Comprehensive Textbook on Traumatic Brain Injury and Spinal Cord Injury aims to bring together the latest clinical practice and research in the filed of two forms of trauma to the central nervous system: namely traumatic brain injury (TBI) and spinal cord injury (SCI). Nationally, more 1.9 million Americans sustain a traumatic brain injury annually. In parallel, there are an estimate of 12,000 new cases of SCI in the United States annually. In addition, approximately 1.2 million people live with paralysis due to SCI. In recent years, dramatic advancements in the field have resulted in much improved outcomes for patients and higher standards of care. This volume details the latest research and clinical practice in the treatment of neurotrauma, in a comprehensive but easy-to-follow format. Neurotrauma is a valuable resource for any clinician involved in caring for TBI and SCI patients, clinical research professionals, researchers, medical and graduate students, and nurse specialists.
The Human Journey offers a truly concise yet satisfyingly full history of the world from ancient times to the present. The book’s scope, as the title implies, is the whole story of humanity, in planetary context. Its themes include not only the great questions of the humanities—nature versus nurture, the history and meaning of human variation, the sources of wealth and causes of revolution—but also the major transformations in human history: agriculture, cities, iron, writing, universal religions, global trade, industrialization, popular government, justice, and equality. In each conceptually rich chapter, Kevin Reilly concentrates on a single important period and theme, sustaining a focused narrative and analytical perspective. Free of either a confined, limiting focus or a mandatory laundry list of topics, this book begins with our most important questions and searches all of our past for answers. Well-grounded in the latest scholarship, this is not a fill-in-the-blanks text, but world history in a grand humanistic tradition. An instructor’s manual includes questions for classroom discussion, substance exam questions, evaluative questions, critical thinking questions, and multiple choice questions, also available in a test-bank format. .
The metal-catalyzed amination of aryl and alkenyl electrophiles has developed into a widely used methodology for the synthesis of natural products, active pharmaceutical ingredients, agricultural chemicals, and materials for molecular electronics. Copper catalysts promote the coupling of a wide range of nitrogen nucleophiles, including amines, amides, and heteroaromatic nitrogen compounds with aryl and alkenyl halides. The reactivity profile of copper catalysts is complementary to that of palladium catalysts in many cases. Copper catalysts are highly effective with less nucleophilic nitrogen nucleophiles, such as amides and azoles, whereas palladium catalysts are more effective with more nucleophilic amine nucleophiles. Copper is an attractive alternative to palladium due to its significantly lower cost. In addition, high activity palladium catalysts require expensive and often air-sensitive ligands, whereas the modern copper systems use relatively stable and inexpensive diamine or amino acid ligands. Copper-catalyzed C N coupling reactions are tolerant of a wide range of functional groups and have been applied to the synthesis of a variety of complex natural products. Significant work has also been done to understand the mechanism of these reactions. Current mechanistic understanding of these methodologies is covered in this monograph. The contents of the book are taken from the comprehensive review of the topic in the Organic Reactions series. Optimal experimental conditions for the amination of aryl and alkenyl halides with all classes of nitrogen nucleophiles are presented. Specific experimental procedures from the literature are provided for the major classes of copper-catalyzed C N coupling reactions. A tabular survey of all examples of Cu-catalyzed arylation and alkenylation of nitrogen nucleophiles is presented in 35 tables organized by nitrogen nucleophile and electrophilic coupling partner. The literature is covered through December 2015 and provides 300 recent citations to supplement the 680 citations of the original hardbound chapter. These latest literature references have been collected in separate sections according to the sequence of the tables in the tabular survey section. In each of the sections, the individual citations have been arranged in alphabetic order of the author names. Copper-Catalyzed Amination of Aryl and Alkenyl Electrophiles is intended to provide organic chemists with an accessible, but detailed, introduction to this important class of transformations.
Swarming species such as flocks of birds or schools of fish exhibit fascinating collective behaviors during migration and predator avoidance. Similarly, engineered multi-agent dynamic systems such as groups of autonomous ground, underwater, or air vehicles (“vehicle swarms”) exhibit sophisticated collective behaviors while maneuvering. In this book we show how to model and control a wide range of such multi-agent dynamic systems and analyze their collective behavior using both stability theoretic and simulation-based approaches. In particular, we investigate problems such as group aggregation, social foraging, formation control, swarm tracking, distributed agreement, and engineering optimization inspired by swarm behavior.
One of the world's leading experts on genetics unravels one of the most important breakthroughs in modern science and medicine. IIf our genes are, to a great extent, our destiny, then what would happen if mankind could engineer and alter the very essence of our DNA coding? Millions might be spared the devastating effects of hereditary disease or the challenges of disability, whether it was the pain of sickle-cell anemia to the ravages of Huntington’s disease. But this power to “play God” also raises major ethical questions and poses threats for potential misuse. For decades, these questions have lived exclusively in the realm of science fiction, but as Kevin Davies powerfully reveals in his new book, this is all about to change. Engrossing and page-turning, Editing Humanity takes readers inside the fascinating world of a new gene editing technology called CRISPR, a high-powered genetic toolkit that enables scientists to not only engineer but to edit the DNA of any organism down to the individual building blocks of the genetic code. Davies introduces readers to arguably the most profound scientific breakthrough of our time. He tracks the scientists on the front lines of its research to the patients whose powerful stories bring the narrative movingly to human scale. Though the birth of the “CRISPR babies” in China made international news, there is much more to the story of CRISPR than headlines seemingly ripped from science fiction. In Editing Humanity, Davies sheds light on the implications that this new technology can have on our everyday lives and in the lives of generations to come.
Large Language Models (LLMs) have emerged as a cornerstone technology, transforming how we interact with information and redefining the boundaries of artificial intelligence. LLMs offer an unprecedented ability to understand, generate, and interact with human language in an intuitive and insightful manner, leading to transformative applications across domains like content creation, chatbots, search engines, and research tools. While fascinating, the complex workings of LLMs -- their intricate architecture, underlying algorithms, and ethical considerations -- require thorough exploration, creating a need for a comprehensive book on this subject. This book provides an authoritative exploration of the design, training, evolution, and application of LLMs. It begins with an overview of pre-trained language models and Transformer architectures, laying the groundwork for understanding prompt-based learning techniques. Next, it dives into methods for fine-tuning LLMs, integrating reinforcement learning for value alignment, and the convergence of LLMs with computer vision, robotics, and speech processing. The book strongly emphasizes practical applications, detailing real-world use cases such as conversational chatbots, retrieval-augmented generation (RAG), and code generation. These examples are carefully chosen to illustrate the diverse and impactful ways LLMs are being applied in various industries and scenarios. Readers will gain insights into operationalizing and deploying LLMs, from implementing modern tools and libraries to addressing challenges like bias and ethical implications. The book also introduces the cutting-edge realm of multimodal LLMs that can process audio, images, video, and robotic inputs. With hands-on tutorials for applying LLMs to natural language tasks, this thorough guide equips readers with both theoretical knowledge and practical skills for leveraging the full potential of large language models. This comprehensive resource is appropriate for a wide audience: students, researchers and academics in AI or NLP, practicing data scientists, and anyone looking to grasp the essence and intricacies of LLMs.
A comprehensive introduction to machine learning that uses probabilistic models and inference as a unifying approach. Today's Web-enabled deluge of electronic data calls for automated methods of data analysis. Machine learning provides these, developing methods that can automatically detect patterns in data and then use the uncovered patterns to predict future data. This textbook offers a comprehensive and self-contained introduction to the field of machine learning, based on a unified, probabilistic approach. The coverage combines breadth and depth, offering necessary background material on such topics as probability, optimization, and linear algebra as well as discussion of recent developments in the field, including conditional random fields, L1 regularization, and deep learning. The book is written in an informal, accessible style, complete with pseudo-code for the most important algorithms. All topics are copiously illustrated with color images and worked examples drawn from such application domains as biology, text processing, computer vision, and robotics. Rather than providing a cookbook of different heuristic methods, the book stresses a principled model-based approach, often using the language of graphical models to specify models in a concise and intuitive way. Almost all the models described have been implemented in a MATLAB software package—PMTK (probabilistic modeling toolkit)—that is freely available online. The book is suitable for upper-level undergraduates with an introductory-level college math background and beginning graduate students.
Drug Delivery: Advances and Emerging Strategies begins with an overview on drug delivery, setting the stage for detailed discussions on oral, pulmonary, vaginal, ocular, and nasal dedicated sections. Chapters cover colonic, transdermal, transungual, brain, and nose-to-brain delivery, but also focus on vaccine delivery and organ specific delivery routes via the myocardium, kidney, liver, pancreas, buccal, sublingual, and injectable drug delivery systems. The book offers an integrated, up-to-date overview of drug delivery methods, technologies, and approaches, targeting body systems and organs. Researchers and advanced students in pharmaceutical science will benefit from this consolidated outlook. - Discusses advanced drug delivery systems and the most recent research developments - Organizes by body system and target organ - Explores organ physiology and drug flow challenges
This volume includes four lecture courses by Bressan, Serre, Zumbrun and Williams and a Tutorial by Bressan on the Center Manifold Theorem. Bressan introduces the vanishing viscosity approach and clearly explains the building blocks of the theory. Serre focuses on existence and stability for discrete shock profiles. The lectures by Williams and Zumbrun deal with the stability of multidimensional fronts.
This book describes the technical problems and solutions for automatically recognizing and parsing a medical image into multiple objects, structures, or anatomies. It gives all the key methods, including state-of- the-art approaches based on machine learning, for recognizing or detecting, parsing or segmenting, a cohort of anatomical structures from a medical image. Written by top experts in Medical Imaging, this book is ideal for university researchers and industry practitioners in medical imaging who want a complete reference on key methods, algorithms and applications in medical image recognition, segmentation and parsing of multiple objects. Learn: - Research challenges and problems in medical image recognition, segmentation and parsing of multiple objects - Methods and theories for medical image recognition, segmentation and parsing of multiple objects - Efficient and effective machine learning solutions based on big datasets - Selected applications of medical image parsing using proven algorithms - Provides a comprehensive overview of state-of-the-art research on medical image recognition, segmentation, and parsing of multiple objects - Presents efficient and effective approaches based on machine learning paradigms to leverage the anatomical context in the medical images, best exemplified by large datasets - Includes algorithms for recognizing and parsing of known anatomies for practical applications
The main properties that make carbon nanotubes (CNTs) a promising technology for many future applications are: extremely high strength, low mass density, linear elastic behavior, almost perfect geometrical structure, and nanometer scale structure. Also, CNTs can conduct electricity better than copper and transmit heat better than diamonds. Therefore, they are bound to find a wide, and possibly revolutionary use in all fields of engineering. The interest in CNTs and their potential use in a wide range of commercial applications; such as nanoelectronics, quantum wire interconnects, field emission devices, composites, chemical sensors, biosensors, detectors, etc.; have rapidly increased in the last two decades. However, the performance of any CNT-based nanostructure is dependent on the mechanical properties of constituent CNTs. Therefore, it is crucial to know the mechanical behavior of individual CNTs such as their vibration frequencies, buckling loads, and deformations under different loadings. This title is dedicated to the vibration, buckling and impact behavior of CNTs, along with theory for carbon nanosensors, like the Bubnov-Galerkin and the Petrov-Galerkin methods, the Bresse-Timoshenko and the Donnell shell theory.
This book, written by three generations of rankings academics with considerable experience from three very different regions of the globe, lifts the lid on the real impact of higher education ranking systems (HERS) on universities and their stakeholders. It critically analyses the criteria that make up the ‘Big Three’ global ranking systems and, using interviews with senior administrators, academics and managers, discusses their impact on universities from four very different continents. Higher education continues to be dominated by a reputational hierarchy of institutions that sustains and is reinforced by HERS. Despite all the opinions and arguments about the legitimacy of the rankings as a construct, it seems experts agree that they are here to stay. The question, therefore, seems to be less about whether or not universities should be compared and ranked, but the manner in which this is undertaken. Delivering a fresh perspective on global rankings, this book summarizes the development of HERS and provides a critical evaluation of the effects of HERS on four different major regions – South Africa, the Arab region, South East Asia, and Australia. It will appeal to any academic, student, university administrator or governing body interested in or affected by global higher education ranking systems.
The traditional Chinese city is undergoing an identity crisis. With the rapid development taking place, there is growing conflict between this new building and the existing urban heritage. An appropriate approach, both in design and in legislation, is urgently needed to deal with this problem. Furthermore, although Chinese cities have a remarkably long history, existing methods of urban form study in China are either descriptive or loosely structured, whereas a comprehensive methodology is necessary to 'read' Chinese urban forms in a consistent way, and thus inform designers and policy-makers. Chinese Urban Design targets these problems and offers an analytic and conceptual framework for both urban investigation and consequent design. Firstly summarising traditional urban design principles and how Chinese cities have transformed over time, it then introduces and offers a theoretic ground and scientific methodology for understanding the evolution of urban forms, initially developed in western countries. It demonstrates the theoretic model via real cases - from the city of Nanjing - and establishes a direct link between understanding of urban forms and design development. By providing a cross-cultural investigation on the theories and methods of urban typology and morphology, this book aims to suggest best future practice for urban design in China. It explores how urban designers and local policy-makers can produce culturally responsive designs and how they might better understand the formation and transformation of the built environment in which their creations sit. It also looks at how local residents' lifestyle, culture and demands might be reflected and respected in design process.
Although the compass was first invented by the Chinese about 2,500 years ago, it’s gone on to help give direction to the entire world! The introduction of the compass lead to many other advancements in science and navigation, including reliable maps, the system of latitude and longitude, and GPS. You may even have a compass app on your phone! Readers will travel to ancient China to witness the invention of the compass as a fortune-telling item and learn how it eventually became used as a navigational tool. The text also explains how the compass spread to the rest of the world, and how it has helped shape our modern lives.
This primer introduces the theory of self-assembly of block polymers, most notably self-consistent field theory (SCFT). Block polymer self-assembly is a fascinating and highly interdisciplinary topic. This primer can be read at several levels, depending on what readers want to get out of it. Readers who want an overview of self-assembly in block polymer and what SCFT says about the process can read Chapters 1-3 and skip to Chapter 7 to see the open questions. If the reader is further interested in the output of SCFT calculations but not how those outputs are generated, they should read Chapter 6 as well. But if the reader wants to learn how to do the SCFT calculations themselves, Chapters 4 and 5 offer an accessible introduction to the theory and numerical methods, providing an excellent entry point into the literature. This primer includes data that the authors have computed using SCFT. All calculations use the open-source software package Polymer Self-Consistent Field (PSCF), developed by David Morse at the University of Minnesota. Take breaks from reading to watch ten “Insider Q&A” videos included throughout, which offer additional insight from experts in the field, such as An-Chang Shi, Chinedum O. Osuji, Frank S. Bates, Christopher M. Bates, Glenn H. Fredrickson, and Lisa Hall. Furthermore, this primer includes multiple features to aid and enhance readers’ learning. “That’s a Wrap” summarizes key concepts at the end of each chapter, while “Read These Next” suggests references that may interest further reading. A pop-up glossary ensures readers have definitions as needed throughout the primer.
High-temperature Solid Oxide Fuel Cells, Second Edition, explores the growing interest in fuel cells as a sustainable source of energy. The text brings the topic of green energy front and center, illustrating the need for new books that provide comprehensive and practical information on specific types of fuel cells and their applications. This landmark volume on solid oxide fuel cells contains contributions from experts of international repute, and provides a single source of the latest knowledge on this topic. - A single source for all the latest information on solid oxide fuel cells and their applications - Illustrates the need for new, more comprehensive books and study on the topic - Explores the growing interest in fuel cells as viable, sustainable sources of energy
The tropical plant family Pandanaceae comprises three genera, Freycinetia, Pandanus and Sararanga. One-hundred and fourteen genera and 226 species of fungi were found on dead leaves of Pandanaceae collected in Australia, Brunei Darussalam, Fiji, Hawaii, Hong Kong, Malaysia, Mauritius, Nepal, New Zealand, Niue, Philippines, Seychelles, Vanuatu and Vietnam. Taxonomic issues within each fungus genus are discussed and reference made to preceding work. All species are written up with bibliographic details, relevant measurements of the current specimens, known habitat and distribution, collection details, and a discussion on taxonomic conclusions. New taxa (4 genera, 35 species) are fully described and illustrated, each with a plate showing relevant macro- and microscopic details. Keys and/or synoptic tables are provided to all species in 28 genera. In addition, details on almost 700 species of fungi described and recorded worldwide from the Pandanaceae are listed.
In Song-period China (960–1279 CE), masters in the Chan (Japanese Zen) school of Buddhism were presented as sources of religious authority on par with the Buddha, an almost unthinkably lofty status before the rise of Chan. This claim carried great rhetorical power, facilitating Chan’s appeal to Buddhist monastics and powerful patrons alike. But it also raised a challenging question for Chan Buddhists, who insisted that buddhahood properly transcends all worldly marks: By what signs could one recognize a Chan master as a buddha? Discerning Buddhas argues that Chan Buddhists wove together tropes of sovereignty, hospitality, and martial heroism drawn from both Buddhist tradition and China’s cultural heritage to develop a distinctive vision of what it meant for a Chan master to be a buddha in Song-period China. Kevin Buckelew analyzes the ways Chan Buddhists deployed such tropes in ritual, literature, and visual culture in order to stage the comparison of Chan mastery with buddhahood. He examines how they used the concept of buddhahood to work through questions about the ideal Chan master’s authority, agency, and masculinity, in the process rendering buddhahood in terms highly legible to elite Chinese society. Chan Buddhists, Buckelew shows, developed their own “signature” of buddhahood, according to which enlightened Chan masters who truly deserved comparison to the Buddha were supposed to be distinguished from everyone else. By exploring the resulting Chan culture of discernment, which raised fundamental questions about Buddhist authority at a pivotal inflection point in Chinese history, this book offers fresh insight into the place of Buddhism in Chinese society.
Deep Network Design for Medical Image Computing: Principles and Applications covers a range of MIC tasks and discusses design principles of these tasks for deep learning approaches in medicine. These include skin disease classification, vertebrae identification and localization, cardiac ultrasound image segmentation, 2D/3D medical image registration for intervention, metal artifact reduction, sparse-view artifact reduction, etc. For each topic, the book provides a deep learning-based solution that takes into account the medical or biological aspect of the problem and how the solution addresses a variety of important questions surrounding architecture, the design of deep learning techniques, when to introduce adversarial learning, and more. This book will help graduate students and researchers develop a better understanding of the deep learning design principles for MIC and to apply them to their medical problems. - Explains design principles of deep learning techniques for MIC - Contains cutting-edge deep learning research on MIC - Covers a broad range of MIC tasks, including the classification, detection, segmentation, registration, reconstruction and synthesis of medical images
The definitive text for medical students and residents in plastic surgery, Grabb and Smith’s Plastic Surgery, Ninth Edition, covers every aspect of this challenging field in up-to-date, easy-to-understand detail. Superb illustrations, convenient key points, and relevant review questions help you develop a deeper understanding of basic principles and prepare effectively for the In-Training Exam (ITE) and other certification exams. Dr. Kevin C. Chung leads a team of expert contributing authors to create a fully revised resource that also serves as a reference for practicing plastic surgeons to refresh knowledge and to enhance competency in various topics. Coverage includes all areas of plastic surgery: basic science, principles and techniques, skin and soft tissue topics, congenital anomalies and pediatric plastic surgery, head and neck surgery, aesthetic surgery, breast surgery, body contouring, hand surgery, and trunk and lower extremity surgery.
The book summarizes the emerging topic about the effects of SMF on biological samples ranging from single molecules, subcellular compartments, and cells to whole organisms, as well as the potential application of SMF in clinical treatment of cancer and other diseases. With the development and growing popularity of modern appliances, including MRI in the hospitals, the potential impact of magnetic fields on human health is invoking increasing concerns. At the same time, SMF has been used in the clinical treatment of tumors and other diseases for decades. However, there are still some reservations and uncertainties about these treatments, which are largely due to the differential biological effects reported in the literature. These experimental inconsistencies are mainly caused by variations such as different magnetic field types, intensities, treatment time as well as biological samples examined. This volume will help clarify some dilemmas in this field and encourage further investigations in order to achieve a better understanding of the biological effects of SMF, aiming for a rational application of SMF in clinical therapy in the near future. The book is useful for scientists doctors, and students who are interested in magnetic fields and life sciences.
Globalisation trends have increased the transnational flows of cultural goods, media products and information, as well as human transnational migration. This publication considers how these developments are leading to greater and more complex patterns of diversity which are transnational and transcultural in nature, functioning across national frontiers and therefore creating new challenges for national policy frameworks, as well as for the role of the Council of Europe in this new transnational policy landscape.
Microneedles explores the design, fabrication and use of microneedles for drug and vaccine delivery. This book discusses the contemporary status of the field, describing several areas in detail, including the distinct types of microneedles (dissolving, solid, coted, hollow and hydrogel-forming). The anatomy of the eye is also described to facilitate an understanding of microneedle-assisted ocular drug delivery. Finally, the book provides a detailed discussion of microneedle use in the field of diagnostics, with a chapter dedicated to the mathematical modeling of microneedle-mediated drug delivery. As microneedles can be used by research scientists in academia and in industry, this book will be ideal for regulatory scientists and graduate students who find the topic relevant to their area of study. - Provides information for the design and fabrication of microneedles - Discusses choice of materials, fabrication protocol, sterilization protocol and characterization - Supplies the most up-to-date research on all aspects of microneedles
Modern Labor Economics: Theory and Public Policy, now in its fourteenth edition, continues to be the leading text for one-semester courses in labor economics at the undergraduate and graduate levels. It offers a thorough overview of the modern theory of labor market behavior and reveals how this theory is used to analyze public policy. Designed for students who may not have extensive backgrounds in economics, the text balances theoretical coverage with examples of practical applications that allow students to see concepts in action. The authors believe that showing students the social implications of the concepts discussed in the course will enhance their motivation to learn. Consequently, this text presents numerous examples of policy decisions that have been affected by the ever-shifting labor market. This new edition continues to offer the following: a balance of relevant, contemporary examples coverage of the current economic climate an introduction to basic methodological techniques and problems tools for review and further study This fourteenth edition presents updated data throughout and a wealth of new examples, such as the impact of COVID-19 lockdowns, gig work, nudges, monopsony power in the technology industry, and the effect of machine learning on inequality. Supplementary materials for students and instructors are available on the book’s companion website.
An advanced book for researchers and graduate students working in machine learning and statistics who want to learn about deep learning, Bayesian inference, generative models, and decision making under uncertainty. An advanced counterpart to Probabilistic Machine Learning: An Introduction, this high-level textbook provides researchers and graduate students detailed coverage of cutting-edge topics in machine learning, including deep generative modeling, graphical models, Bayesian inference, reinforcement learning, and causality. This volume puts deep learning into a larger statistical context and unifies approaches based on deep learning with ones based on probabilistic modeling and inference. With contributions from top scientists and domain experts from places such as Google, DeepMind, Amazon, Purdue University, NYU, and the University of Washington, this rigorous book is essential to understanding the vital issues in machine learning. Covers generation of high dimensional outputs, such as images, text, and graphs Discusses methods for discovering insights about data, based on latent variable models Considers training and testing under different distributions Explores how to use probabilistic models and inference for causal inference and decision making Features online Python code accompaniment
This issue of Neuroimaging Clinics of North America focuses on Plaque Imaging. Articles will include: 3D carotid plaque MR imaging, Analysis of multi-contrast carotid plaque MR imaging, Incorporating carotid plaque imaging into routine clinical carotid MRA, PET-CT imaging to assess future cardiovascular risk, Utility of combining PET and MR imaging of carotid plaque, 3D carotid plaque ultrasound, Contrast-enhanced carotid plaque ultrasound, Detection of vulnerable plaque in patients with “cryptogenic stroke, Measuring plaque burden in secondary prevention of asymptomatic patients with known carotid stenosis, Plaque imaging in primary prevention of cardiovascular disease, Plaque imaging to decide on optimal treatment: medical versus CEA versus CAS, Clinical perspective of carotid plaque imaging, and more!
In the last decade there has been an explosion of interest in viral therapies for cancer. Viral agents have been developed that are harmless to normal tissues but selectively able to kill cancer cells. These agents have been endowed with additional selectivity and potency through genetic manipulation. Increasingly these viruses are undergoing evaluation in clinical trials, both as single agents and in combination with standard chemotherapy and radiotherapy. This book provides a comprehensive yet succinct overview of the current status of viral therapy of cancer. Chapters coherently present the advances made with individual agents and review the biological and clinical background to a range of viral therapies: structured to proceed from basic science at the bench to the patient’s bedside, they give an up-to-date and realistic evaluation of a therapy’s potential utility for the cancer patient. Presents state of the art knowledge on how viruses can be, and have been, used in novel therapeutic approaches for the treatment of cancer Describes the use of viruses as oncolytic agents, killing cells directly Editors are experts in the field, with experience of both laboratory and clinical research Viral Therapy of Cancer is essential reading for both basic scientists and clinicians with an interest in viral therapy and gene therapy.
The Development of Children and Adolescents, by Penny Hauser-Cram, J. Kevin Nugent, Kathleen Thies, and John F. Travers, provides an integrated view of child development. Presenting the most pertinent research for each developmental stage and linking this to practical applications in the areas of Parenting, Policy, and Practice, this balanced approach emphasizes the relationship between research and theory and applications. The rich media program, including WileyPLUS with Real Development promotes active learning and allows for increased understanding and comprehension of the course content. Real Development, authored by Nicole Barnes, Ph.D., Montclair State University and Christine Hatchard, Psy.D., Monmouth University, uses authentic video showcasing real families, along with activities and assessments that put students in the place of a professional, to gain an understanding of key concepts. Through the combination of text and media, students are engaged in meaningful learning that deepens and enriches their understanding of developmental concepts. WileyPLUS sold separately from text.
In Imagining Nature Kevin Hutchings combines insights garnered from literary history, poststructuralist theory, and the emerging field of ecological literary studies. He considers William Blake's illuminated poetry in the context of the eighteenth-century model of "nature's economy,' a conceptual paradigm that prefigured modern-day ecological insights, describing all earthly entities as integrated parts of a dynamic, interactive system. Hutchings details Blake's sympathy for – and important suspicions concerning – the burgeoning contemporary fascination with such things as environmental ethics, animal rights, and the various fields of scientific naturalism. By focusing on Blake's concern for the relationship between nature and ideology (including the politics of class, gender, and religion) Hutchings avoids the sentimentalism and misanthropic pitfalls all too often associated with environmental commentary. He articulates a distinctively Blakean perspective on current debates in literary theory and eco-criticism and argues that while Blake's peculiar humanism and profound emphasis upon spiritual concerns have led the majority of his readers to regard his work as patently anti-natural, such a view distorts the central political and aesthetic concerns of Blake's corpus. By showing that Blake's apparent hostility toward the natural world is actually a key aspect of his famous critique of institutionalized authority, Hutchings presents Blake's work as an example of "green Romanticism" in its most sophisticated and socially responsive form.
Readings in Multimedia Computing and Networking captures the broad areas of research and developments in this burgeoning field, distills the key findings, and makes them accessible to professionals, researchers, and students alike. For the first time, the most influential and innovative papers on these topics are presented in a cohesive form, giving shape to the diverse area of multimedia computing. The seminal moments are recorded by a dozen visionaries in the field and each contributing editor provides a context for their area of research by way of a thoughtful, focused chapter introduction. The volume editors, Kevin Jeffay and HongJiang Zhang, offer further incisive interpretations of past and present developments in this area, including those within media and content processing, operating systems, and networking support for multimedia. This book will provide you with a sound understanding of the theoretical and practical issues at work in the field's continuing evolution.* Offers an in-depth look at the technical challenges in multimedia and provides real and potential solutions that promise to expand the role of multimedia in business, entertainment, and education.* Examines in Part One issues at the heart of multimedia processes: the means by which multimedia data are coded, compressed, indexed, retrieved, and otherwise manipulated.* Examines in Part Two the accommodation of these processes by storage systems, operating systems, network protocols, and applications.* Written by leading researchers, the introductions give shape to a field that is continually defining itself and place the key research findings in context to those who need to understand the state-of-the art developments.
A collection of over 150 speeches reflecting a broad range of issues before the American public between 1937 and 1997, organized around sixteen interconnected themes, including civil rights, education, and war.
McGraw-Hill Humanities, Social Sciences & World Languages
Published Date
ISBN 10
0070598339
ISBN 13
9780070598331
Select your Age
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.