Advancing the science of medicine by targeting a disease more precisely with treatment specific to each patient relies on access to that patient's genomics information and the ability to process massive amounts of genomics data quickly. Although genomics data is becoming a critical source for precision medicine, it is expected to create an expanding data ecosystem. Therefore, hospitals, genome centers, medical research centers, and other clinical institutes need to explore new methods of storing, accessing, securing, managing, sharing, and analyzing significant amounts of data. Healthcare and life sciences organizations that are running data-intensive genomics workloads on an IT infrastructure that lacks scalability, flexibility, performance, management, and cognitive capabilities also need to modernize and transform their infrastructure to support current and future requirements. IBM® offers an integrated solution for genomics that is based on composable infrastructure. This solution enables administrators to build an IT environment in a way that disaggregates the underlying compute, storage, and network resources. Such a composable building block based solution for genomics addresses the most complex data management aspect and allows organizations to store, access, manage, and share huge volumes of genome sequencing data. IBM SpectrumTM Scale is software-defined storage that is used to manage storage and provide massive scale, a global namespace, and high-performance data access with many enterprise features. IBM Spectrum ScaleTM is used in clustered environments, provides unified access to data via file protocols (POSIX, NFS, and SMB) and object protocols (Swift and S3), and supports analytic workloads via HDFS connectors. Deploying IBM Spectrum Scale and IBM Elastic StorageTM Server (IBM ESS) as a composable storage building block in a Genomics Next Generation Sequencing deployment offers key benefits of performance, scalability, analytics, and collaboration via multiple protocols. This IBM RedpaperTM publication describes a composable solution with detailed architecture definitions for storage, compute, and networking services for genomics next generation sequencing that enable solution architects to benefit from tried-and-tested deployments, to quickly plan and design an end-to-end infrastructure deployment. The preferred practices and fully tested recommendations described in this paper are derived from running GATK Best Practices work flow from the Broad Institute. The scenarios provide all that is required, including ready-to-use configuration and tuning templates for the different building blocks (compute, network, and storage), that can enable simpler deployment and that can enlarge the level of assurance over the performance for genomics workloads. The solution is designed to be elastic in nature, and the disaggregation of the building blocks allows IT administrators to easily and optimally configure the solution with maximum flexibility. The intended audience for this paper is technical decision makers, IT architects, deployment engineers, and administrators who are working in the healthcare domain and who are working on genomics-based workloads.
High-speed I/O workloads are moving away from the SAN to Ethernet and IBM® Spectrum Scale is pushing the network limits. The IBM Spectrum® Scale team discovered that many infrastructure Ethernet networks that were used for years to support various applications are not designed to provide a high-performance data path concurrently to many clients from many servers. IBM Spectrum Scale is not the first product to use Ethernet for storage access. Technologies, such as Fibre Channel over Ethernet (FCoE), scale out NAS, and IP connected storage (iSCSI and others) use Ethernet though IBM Spectrum Scale as the leader in parallel I/O performance, which provides the best performance and value when used on a high-performance network. This IBM Redpaper publication is based on lessons that were learned in the field by deploying IBM Spectrum Scale on Ethernet and InfiniBand networks. This IBM Redpaper® publication answers several questions, such as, "How can I prepare my network for high performance storage?", "How do I know when I am ready?", and "How can I tell what is wrong?" when deploying IBM Spectrum Scale and IBM Elastic Storage® Server (ESS). This document can help IT architects get the design correct from the beginning of the process. It also can help the IBM Spectrum Scale administrator work effectively with the networking team to quickly resolve issues.
High-speed I/O workloads are moving away from the SAN to Ethernet and IBM® Spectrum Scale is pushing the network limits. The IBM Spectrum® Scale team discovered that many infrastructure Ethernet networks that were used for years to support various applications are not designed to provide a high-performance data path concurrently to many clients from many servers. IBM Spectrum Scale is not the first product to use Ethernet for storage access. Technologies, such as Fibre Channel over Ethernet (FCoE), scale out NAS, and IP connected storage (iSCSI and others) use Ethernet though IBM Spectrum Scale as the leader in parallel I/O performance, which provides the best performance and value when used on a high-performance network. This IBM Redpaper publication is based on lessons that were learned in the field by deploying IBM Spectrum Scale on Ethernet and InfiniBand networks. This IBM Redpaper® publication answers several questions, such as, "How can I prepare my network for high performance storage?", "How do I know when I am ready?", and "How can I tell what is wrong?" when deploying IBM Spectrum Scale and IBM Elastic Storage® Server (ESS). This document can help IT architects get the design correct from the beginning of the process. It also can help the IBM Spectrum Scale administrator work effectively with the networking team to quickly resolve issues.
Advancing the science of medicine by targeting a disease more precisely with treatment specific to each patient relies on access to that patient's genomics information and the ability to process massive amounts of genomics data quickly. Although genomics data is becoming a critical source for precision medicine, it is expected to create an expanding data ecosystem. Therefore, hospitals, genome centers, medical research centers, and other clinical institutes need to explore new methods of storing, accessing, securing, managing, sharing, and analyzing significant amounts of data. Healthcare and life sciences organizations that are running data-intensive genomics workloads on an IT infrastructure that lacks scalability, flexibility, performance, management, and cognitive capabilities also need to modernize and transform their infrastructure to support current and future requirements. IBM® offers an integrated solution for genomics that is based on composable infrastructure. This solution enables administrators to build an IT environment in a way that disaggregates the underlying compute, storage, and network resources. Such a composable building block based solution for genomics addresses the most complex data management aspect and allows organizations to store, access, manage, and share huge volumes of genome sequencing data. IBM SpectrumTM Scale is software-defined storage that is used to manage storage and provide massive scale, a global namespace, and high-performance data access with many enterprise features. IBM Spectrum ScaleTM is used in clustered environments, provides unified access to data via file protocols (POSIX, NFS, and SMB) and object protocols (Swift and S3), and supports analytic workloads via HDFS connectors. Deploying IBM Spectrum Scale and IBM Elastic StorageTM Server (IBM ESS) as a composable storage building block in a Genomics Next Generation Sequencing deployment offers key benefits of performance, scalability, analytics, and collaboration via multiple protocols. This IBM RedpaperTM publication describes a composable solution with detailed architecture definitions for storage, compute, and networking services for genomics next generation sequencing that enable solution architects to benefit from tried-and-tested deployments, to quickly plan and design an end-to-end infrastructure deployment. The preferred practices and fully tested recommendations described in this paper are derived from running GATK Best Practices work flow from the Broad Institute. The scenarios provide all that is required, including ready-to-use configuration and tuning templates for the different building blocks (compute, network, and storage), that can enable simpler deployment and that can enlarge the level of assurance over the performance for genomics workloads. The solution is designed to be elastic in nature, and the disaggregation of the building blocks allows IT administrators to easily and optimally configure the solution with maximum flexibility. The intended audience for this paper is technical decision makers, IT architects, deployment engineers, and administrators who are working in the healthcare domain and who are working on genomics-based workloads.
This book is a study of compassion as a global project from Biafra to Live Aid. Kevin O'Sullivan explains how and why NGOs became the primary conduits of popular concern for the global poor between the late 1960s and the mid-1980s and shows how this shaped the West's relationship with the post-colonial world. Drawing on case studies from Britain, Canada and Ireland, as well as archival material from governments and international organisations, he sheds new light on how the legacies of empire were re-packaged and re-purposed for the post-colonial era, and how a liberal definition of benevolence, rooted in charity, justice, development and rights became the dominant expression of solidarity with the Third World. In doing so, the book provides a unique insight into the social, cultural and ideological foundations of global civil society. It reveals why this period provided such fertile ground for the emergence of NGOs and offers a fresh interpretation of how individuals in the West encountered the outside world.
Kevin William Grant examines the cognitive processes that produce metaphors in psychotherapy. The "I-Ching Task" is the measure of metaphor production applied in this research inquiry. Two cognitive processes are hypothesized to be necessary for the production of a metaphor. The first hypothesized cognitive process is sensory-imaginal processing, where attention is concentrated into one's internal experiencing and sensory awareness to form sensory impressions or sensory images. The second type of processing is called integration-synthesis processing, and this is hypothesized to work in parallel with sensory-imaginal processing. Integration-synthesis processing functions to combine conflicting or contradictory elements into an integrated whole. Metaphor is the meeting point of these processes, and all of them are important in the production of metaphor in psychotherapy. Revised and updated from the first edition published in 1991.
The United States Constitution promised a More Perfect Union. It’s a shame no one bothered to write a more perfect Constitution—one that didn’t trigger more than two centuries of arguments about what the darn thing actually says. Until now. Perfection is at hand. A new, improved Constitution is here. And you are holding it. But first, some historical context: In the eighteenth century, a lawyer named James Madison gathered his friends in Philadelphia and, over four long months, wrote four short pages: the Constitution of the United States of America. Not bad. In the nineteenth century, a president named Abraham Lincoln freed an entire people from the flaws in that Constitution by signing the Emancipation Proclamation. Pretty impressive. And in the twentieth century, a doctor at the Bethesda Naval Hospital delivered a baby—but not just any baby. Because in the twenty-first century, that baby would become a man, that man would become a patriot, and that patriot would rescue a country . . . by single-handedly rewriting that Constitution. Why? We think of our Constitution as the painstakingly designed blueprint drawn up by, in Thomas Jefferson’s words, an “assembly of demigods” who laid the foundation for the sturdiest republic ever created. The truth is, it was no blueprint at all but an Etch A Sketch, a haphazard series of blunders, shaken clean and redrawn countless times during a summer of petty debates, drunken ramblings, and desperate compromise—as much the product of an “assembly of demigods” as a confederacy of dunces. No wonder George Washington wished it “had been made more perfect.” No wonder Benjamin Franklin stomached it only “with all its faults.” The Constitution they wrote is a hot mess. For starters, it doesn’t mention slavery, or democracy, or even Facebook; it plays favorites among the states; it has typos, smudges, and misspellings; and its Preamble, its most famous passage, was written by a man with a peg leg. Which, if you think about it, gives our Constitution hardly a leg to stand on. [Pause for laughter.] Now stop laughing. Because you hold in your hands no mere book, but the most important document of our time. Its creator, Daily Show writer Kevin Bleyer, paid every price, bore every burden, and saved every receipt in his quest to assure the salvation of our nation’s founding charter. He flew to Greece, the birthplace of democracy. He bused to Philly, the home of independence. He went toe-to-toe (face-to-face) with Scalia. He added nightly confabs with James Madison to his daily consultations with Jon Stewart. He tracked down not one but two John Hancocks—to make his version twice as official. He even read the Constitution of the United States. So prepare yourselves, fellow patriots, for the most significant literary event of the twenty-first, twentieth, nineteenth, and latter part of the eighteenth centuries. Me the People won’t just form a More Perfect Union. It will save America. Praise for Me the People “I would rather read a constitution written by Kevin Bleyer than by the sharpest minds in the country.”—Jon Stewart “Bleyer takes a red pencil to democracy’s most hallowed laundry list. . . . Uproarious and fascinating.”—Reader’s Digest “I knew James Madison. James Madison was a friend of mine. Mr. Bleyer, you are no James Madison. But you sure are a heck of a lot more fun.”—Pulitzer Prize–winning historian Doris Kearns Goodwin, author of the #1 New York Times bestseller Team of Rivals
The Spatial Language of Time presents a crosslinguistically valid state-of-the-art analysis of space-to-time metaphors, using data mostly from English and Wolof (Africa) but additionally from Japanese and other languages. Metaphors are analyzed in terms of their most direct motivation by basic human experiences (Grady 1997a; Lakoff & Johnson 1980). This motivation explains the crosslinguistic appearance of certain metaphors, but does not say anything about temporal metaphor systems that deviate from the types documented here. Indeed, we observe interesting culture- and language-specific metaphor phenomena. Refining earlier treatments of temporal metaphor and adapting to temporal experience Levinson’s (2003) idea of frames of reference, the author proposes a contrast between perspective-neutral and perspective-specific frames of reference in temporal metaphor that has important crosslinguistic ramifications for the temporal semantics of FRONT/BEHIND expressions. This book refines the cognitive-linguistic approach to temporal metaphor by analyzing the extensive temporal structure in what has been considered the source domain of space, and showing how temporal metaphors can be better understood by downplaying the space-time dichotomy and analyzing metaphor structure in terms of conceptual frames. This book is of interest to linguists, psychologists, anthropologists, philosophers, and others who may have wondered about relationships between space and time.
In Lands of Likeness, philosopher, theologian, and poet Kevin Hart utilizes the history of Christian thought and secular philosophy to develop a novel and profound hermeneutics of contemplation. Drawing in particular on the work of Arthur Schopenhauer, Samuel Taylor Coleridge, and Edmund Husserl, Hart traces the development of notions of contemplation in modernity and refines the approaches he finds there. Utilizing his refined approach, Hart trains our attention on modern poems from G. M. Hopkins, Wallace Stevens, A. R. Ammons, Geoffrey Hill and others as sites for a kind of contemplative reading that phenomenology can make precise. Delivered in its original form as the prestigious Gifford Lectures, Lands of Likeness is a revelatory meditation on contemplation for the modern world"--
Large Language Models (LLMs) have emerged as a cornerstone technology, transforming how we interact with information and redefining the boundaries of artificial intelligence. LLMs offer an unprecedented ability to understand, generate, and interact with human language in an intuitive and insightful manner, leading to transformative applications across domains like content creation, chatbots, search engines, and research tools. While fascinating, the complex workings of LLMs -- their intricate architecture, underlying algorithms, and ethical considerations -- require thorough exploration, creating a need for a comprehensive book on this subject. This book provides an authoritative exploration of the design, training, evolution, and application of LLMs. It begins with an overview of pre-trained language models and Transformer architectures, laying the groundwork for understanding prompt-based learning techniques. Next, it dives into methods for fine-tuning LLMs, integrating reinforcement learning for value alignment, and the convergence of LLMs with computer vision, robotics, and speech processing. The book strongly emphasizes practical applications, detailing real-world use cases such as conversational chatbots, retrieval-augmented generation (RAG), and code generation. These examples are carefully chosen to illustrate the diverse and impactful ways LLMs are being applied in various industries and scenarios. Readers will gain insights into operationalizing and deploying LLMs, from implementing modern tools and libraries to addressing challenges like bias and ethical implications. The book also introduces the cutting-edge realm of multimodal LLMs that can process audio, images, video, and robotic inputs. With hands-on tutorials for applying LLMs to natural language tasks, this thorough guide equips readers with both theoretical knowledge and practical skills for leveraging the full potential of large language models. This comprehensive resource is appropriate for a wide audience: students, researchers and academics in AI or NLP, practicing data scientists, and anyone looking to grasp the essence and intricacies of LLMs.
The first book to fully explore the extraordinary covert actions NFL teams are willing to take in order to win. Spies disguised as priests. Secret surveillance of targets’ movements. Radio frequency jamming. Tapped telephones. These might sound like acts of espionage right out of the Cold War or a spy movie—but in fact came straight from the National Football League. In Spies on the Sidelines: The High-Stakes World of NFL Espionage, Kevin Bryant provides the first in-depth investigation of spying in professional football, as well as the countermeasures utilized to defend against these threats. Spanning across all teams and eras, Bryant shines a light on the shady world of NFL reconnaissance—from clandestine photography and hidden draft prospects to listening devices and stolen documents—along with the permissible, if sometimes questionable, spy techniques teams utilize day in and day out to gain an advantage over their opponents. Written by a former Special Agent with decades of experience collecting and safeguarding information for the Department of Defense, Spies on the Sidelines reveals that, behind the game-day action, professional football can be as cloak-and-dagger as American intelligence agencies. This fascinating and expansive compilation of NFL spy anecdotes exposes the extraordinary measures teams are willing to take in order to win.
This book places the study of public support for the arts and culture within the prism of public policy making. It is explicitly comparative in casting cultural policy within a broad sociopolitical and historical framework. Given the complexity of national communities, there has been an absence of comparative analyses that would explain the wide variability in modes of cultural policy as reflections of public cultures and cultural identity. The discussion is internationally focused and interdisciplinary. Mulcahy contextualizes a wide variety of cultural policies and their relation to politics and identity by asking a basic question: who gets their heritage valorized and by whom is this done? The fundamental assumption is that culture is at the heart of public policy as it defines national identity and personal value.
Presents an offbeat revision of the U.S. Constitution that reflects twenty-first century realities and addresses unresolved questions while describing the author's research into ancient Greece's early practices of democracy.
A social history of British civilian life in the months following the declaration of the end of the second world war. On the 8th of May in 1945 British Prime Minister Winston Churchill finally announced to waiting crowds that the Allies had accepted the unconditional surrender of Nazi Germany and that the war in Europe was over. For the next two days, people around the world celebrated. But the “slow outbreak of peace” that gradually dawned across the world in the summer of 1945 was fraught with difficulties and violence. Beginning with the signing of the German surrender to the Western Allies in Reims on 7 May, The Summer of ’45 is a “people’s history” which gathers voices from all levels of society and from all corners of the globe to explore four months that would dictate the order of the world for decades to come. Quoting from generals, world statesmen, infantrymen, prisoners of war, journalists, civilians and neutral onlookers, this book presents the memories of the men and women who danced alongside Princesses Elizabeth and Margaret outside Buckingham Palace on the first night of peace; the reactions of the vanquished and those faced with rebuilding a shattered Europe; the often overlooked story of the “forgotten army” still battling against the Japanese in the East; the election of Clement Attlee’s reforming Labour government; the beginnings of what would become the Iron Curtain; and testimony from the first victims of nuclear warfare in Hiroshima and Nagasaki. Combining archive sources and original interviews with living witnesses, The Summer of ’45 reveals the lingering trauma of the war and the new challenges brought by peacetime.
Biomedical Natural Language Processing is a comprehensive tour through the classic and current work in the field. It discusses all subjects from both a rule-based and a machine learning approach, and also describes each subject from the perspective of both biological science and clinical medicine. The intended audience is readers who already have a background in natural language processing, but a clear introduction makes it accessible to readers from the fields of bioinformatics and computational biology, as well. The book is suitable as a reference, as well as a text for advanced courses in biomedical natural language processing and text mining.
This complete chronological record of the Victoria Crosses awarded to British and Commonwealth soldiers during the Anglo-Zulu and Boer wars is an essential work of reference for everyone with a special interest in these major conflicts in southern Africa fought at the height of the British empire. The British army was severely tested in its battles against the Zulu kingdom and the Boer states, and the 107 Victoria Crosses that were awarded testify to the intensity of the fighting and the bravery and self-sacrifice of the soldiers concerned. The book celebrates their extraordinary exploits in action at famous locations like Isandlwana, Rorke’s Drift, Ladysmith, Colenso and Mafeking where, under fire, they had to draw on exceptional reserves of courage. Each entry gives the name and rank of the VC holder and the date and location of the action in which the VC was earned. The episodes themselves are described, in vivid detail. Information is also provided on the subsequent career of the VC recipients, the location of their medals and their place of burial.
Technological advances in hardware and software provide powerful tools with the potential to design interfaces that are powerful and easy to use. Yet, the frustrations and convoluted "work-arounds" often encountered make it clear that there is substantial room for improvement. Drawn from more than 60 years of combined experience studying, implement
For those who come from a Christian background, the idea of Sabbath rest may be unfamiliar territory (although it has become better known recently through a string of self-help books on the subject), but, in our hectic, stress-filled world, it is needed now more than ever and offers tremendous physical and spiritual benefits for all who are willing to put it into practice. At a time in which many are feeling a greater need for God and giving church attendance higher priority, Pastor Morgan had provided a well researched and accurate account of the roots of Sunday observance to assist those who want to place their faith on a solid biblical foundation. --Jack Blanco, author and retired professor of theology.
This book examines comparatively how the writing of history has been used to 'legitimate' the nation-state against socialist, communist and catholic internationalism in the modern era.
This is the first fully comprehensive survey and analysis of masted structures and covers examples that have evolved during the past three decades. Masted Structures are one of the most interesting developments in post-war architecture resulting from a combination of technology, structural engineering theory and a collaboration between architects and engineers. This is an essential guide for architects to the structural and constructional implications of masted forms in relation to space enclosure, patterns of loading and use of differing materials and techniques. This useful volume will enable architects and engineers to understand the origins, development and nature of masted structures and will provide a stimulating basis for future design.
Over the past two centuries, many aspects of criminal behavior have been investigated. Finding this information and making sense of it all is difficult when many studies would appear to offer contradictory findings. The Handbook of Crime Correlates collects in one source the summary analysis of crime research worldwide. It provides over 400 tables that divide crime research into nine broad categories: Pervasiveness and intra-offending relationships Demographic factors Ecological and macroeconomic factors Family and peer factors Institutional factors Behavioral and personality factors Cognitive factors Biological factors Crime victimization and fear of crime Within these broad categories, tables identify regions of the world and how separate variables are or are not positively or negatively associated with criminal behavior. Criminal behavior is broken down into separate offending categories of violent crime, property crime, drug offenses, sex offenses, delinquency, general and adult offenses, and recidivism. Accompanying each table is a description of what each table indicates in terms of the positive or negative association of specific variables with specific types of crime by region. This book should serve as a valuable resource for criminal justice personnel and academics in the social and life sciences interested in criminal behavior.
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