Spanning the Roaring Twenties, Prohibition and The Great Depression, Pile Driver is set in one of the most colorful periods of United States history. The story of Charles Berthold Fischer reveals hardship, humility and honor. Wrestling honestly in a dishonest era, Fischer, standing but 5'3, simultaneously held middleweight and light heavyweight world titles. Despite national sports figure status, Charlie was never ashamed to declare Butternut, Wisconsin, as his home. A man to whom many taller men looked up, Pile Driver is the untold story of an exceptional individual: Charles Midget Fischer.
The characters in these short stories all have a connection with the fictional town of Menninger, ND, created in the novel The Song Is Ended (2011). Facing adversity, moral conflicts, or just the challenges of living, the characters must find their way in an imperfect world.
Preclinical and Clinical Modulation of Anticancer Drugs focuses on the theoretical and practical approaches to designing and enacting modulation principles. Each class of anticancer drug and the different types of modulators used within each drug class are discussed within individual chapters. The molecular and biochemical rationale for the use of specific modulators is discussed in detail, and preclinical and clinical implications of the data are integrated into each chapter. Mechanisms of drug resistance and the reasons behind circumventing the resistant phenotype are covered. The book will interest cancer chemotherapists, pharmacologists, oncologists, biochemists, and experimental therapeutics researchers, in addition to students studying the principles of drug discovery and protocol design.
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