Our understanding of the biological bases to the autistic spectrum disorders (ASDs) is advancing rapidly. Over 80 genetic conditions have now been reported in people who have also been diagnosed with ASDs. Many of these conditions have specific implications for the presenting phenotype and for treatment, management, and intervention. If the basis to the presenting behavioural phenotype is not identified, this can result in a sub-optimal level of care, complications, or even permanent damage. Kenneth J. Aitken shows that the notion of a single condition known as 'autism' is no longer tenable, and challenges current trends in the diagnosis and management of these behaviours as a homogenous group by drawing on recent research into brain function, genetics, epidemiology and neurology. This volume explains the biology and genetics of ASD, and provides clinicians and researchers with a comprehensive summary of each genetic factor including the research that links it to ASD, diagnosis and treatment issues, and related animal models, as well as detailing relevant professional organisations and avenues for further research. An A-Z of Genetic Factors in Autism is an essential resource for a wide range of researchers, clinical professionals and students interested in autism spectrum disorders, including clinical and educational psychologists, dieticians, psychiatrists, and neurologists.
First published in 1977. This book ascertains what sources Shakespeare used for the plots of his plays and discusses the use he made of them; and secondly illustrates how his general reading is woven into the texture of his work. Few Elizabethan dramatists took such pains as Shakespeare in the collection of source-material. Frequently the sources were apparently incompatible, but Shakespeare's ability to combine a chronicle play, one or two prose chronicles, two poems and a pastoral romance without any sense of incongruity, was masterly. The plays are examined in approximately chronological order and Shakespeare's developing skill becomes evident.
Provides a highly engaging, richly contextualized account of the residency system in all its dimensions and analyzes the mutual relationship between residency education and patient care in America.
Presents a new collection of accounts from actual undertakers--including tales of slapstick humor, wild coincidences, and touching moments--that highlight the lighter side of death.
There is an increasing need to construct engineering structures in the Arctic seas. The requirement is principally generated by the oil and gas industry, because of the substantial reserves that are known to exist offshore in the Beaufort Sea, the Caspian Sea, the Barents Sea, the Pacific Ocean off the coast of Sakhalin, the Canadian Arctic, and almost certainly elsewhere. Structures have to withstand the severe environmental forces generated by sea ice, a subject that is developing rapidly but is still far from completely understood. Underwater pipelines have to be safe against ice gouging and strudel scour, but also have to be constructed safely and economically. The social and human environment has to be understood and respected.This important book intentionally takes a broad view, and vividly accounts for the many and often subtle interactions between the different factors. It is illustrated by case studies of actual projects.
Presents a unique approach to selecting and assembling disparate pieces of information to produce a general understanding of a threat. The Atypical Signal Analysis and Processing schema identifies atypical behavior potentially related to terror activity; puts it into context; generates and tests hypotheses; and focuses analysts' attention on the most significant findings. A supporting conceptual architecture and specific techniques for identifying and analyzing out-of-the-ordinary information are also described.
Known for shedding light on the link between the courts, public policy, and the political environment, Judicial Process in America offers you a clear but comprehensive overview of today’s American judiciary. Considering the courts from every level, the authors thoroughly cover judges, lawyers, litigants, and the variables at play in judicial decision-making. The highly anticipated Eleventh Edition offers updated coverage of recent Supreme Court rulings, including same-sex marriage and health care subsidies; the effect of three women justices on the Court's patterns of decision; and the policy-making role of state tribunals as they consider an increasing number of state programs and policies.
The latest edition of Williams Textbook of Endocrinology edited by Drs. Shlomo Melmed, Kenneth S. Polonsky, P. Reed Larsen, and Henry M. Kronenberg, helps you diagnose and treat your patients effectively with up-to-the minute, practical know-how on all endocrine system disorders. Comprehensive yet accessible, this extensively revised 12th Edition updates you on diabetes, metabolic syndrome, obesity, thyroid disease, testicular disorders, and much more so you can provide your patients with the most successful treatments. Find scientific insight and clinical data interwoven in every chapter, reflecting advances in both areas of this constantly changing discipline, and presented in a truly accessible format. You’ll also access valuable contributions from a dynamic list of expert authors and nearly 2.000 full-color images to help you with every diagnosis. This title has everything you need to manage any and all the clinical endocrinopathies you may encounter. Rely on the one reference that integrates rapidly evolving basic and clinical science in a cohesive, user-friendly format, definitively addresses every topic in the field, and has remained a standard for more than half a century. Update your know-how and skills to diagnose and treat your patients most effectively with exhaustively revised content on diabetes, metabolic disease, thyroid cancer, fertility problems, testicular problems, weight issues, and much more. Apply reliable guidance on endocrine conditions of growing interest like hypothyroidism and testicular disorders, with dedicated new chapters that expound on the latest research findings. Overcome any clinical challenge with comprehensive and easy-to-use coverage of everything from hormone activity, diagnostic techniques, imaging modalities, and molecular genetics, to total care of the patient. Apply the latest practices with guidance from expert authors who contribute fresh perspectives on every topic.
Food engineering has become increasingly important in the food industry over the years, as food engineers play a key role in developing new food products and improved manufacturing processes. While other textbooks have covered some aspects of this emerging field, this is the first applications-oriented handbook to cover food engineering processes and manufacturing techniques. A major portion of Handbook of Food Engineering Practice is devoted to defining and explaining essential food operations such as pumping systems, food preservation, and sterilization, as well as freezing and drying. Membranes and evaporator systems and packaging materials and their properties are examined as well. The handbook provides information on how to design accelerated storage studies and determine the temperature tolerance of foods, both of which are important in predicting shelf life. The book also examines the importance of physical and rheological properties of foods, with a special look at the rheology of dough and the design of processing systems for the manufacture of dough. The final third of the book provides useful supporting material that applies to all of the previously discussed unit operations, including cost/profit analysis methods, simulation procedures, sanitary guidelines, and process controller design. The book also includes a survey of food chemistry, a critical area of science for food engineers.
The definitive endodontics reference, Cohen’s Pathways of the Pulp is known for its comprehensive coverage of leading-edge information, materials, and techniques. It examines all aspects of endodontic care, from preparing the clinician and patient for endodontic treatment to the role the endodontist can play in the treatment of traumatic injuries and to the procedures used in the treatment of pediatric and older patients. Not only does Hargreaves and Cohen’s 10th edition add five chapters on hot new topics, it also includes online access! As an Expert Consult title, Cohen’s Pathways of the Pulp lets you search the entire contents of the book on your computer, and includes five online chapters not available in the printed text, plus videos, a searchable image collection, and more. For evidence-based endodontics research and treatment, this is your one-stop resource!
Already the recipient of extraordinary critical acclaim, this magisterial book provides a landmark account of American medical education in the twentieth century, concluding with a call for the reformation of a system currently handicapped by managed care and by narrow, self-centered professional interests. Kenneth M. Ludmerer describes the evolution of American medical education from 1910, when a muck-raking report on medical diploma mills spurred the reform and expansion of medical schools, to the current era of managed care, when commercial interests once more have come to the fore, compromising the training of the nation's future doctors. Ludmerer portrays the experience of learning medicine from the perspective of students, house officers, faculty, administrators, and patients, and he traces the immense impact on academic medical centers of outside factors such as World War II, the National Institutes of Health, private medical insurance, and Medicare and Medicaid. Most notably, the book explores the very real threats to medical education in the current environment of managed care, viewing these developments not as a catastrophe but as a challenge to make many long overdue changes in medical education and medical practice. Panoramic in scope, meticulously researched, brilliantly argued, and engagingly written, Time to Heal is both a stunning work of scholarship and a courageous critique of modern medical education. The definitive book on the subject, it provides an indispensable framework for making informed choices about the future of medical education and health care in America.
This issue of Medical Clinics of North America provides the latest essential updates on thyroid disorders and diseases. Topics covered include the following: thyroid synthesis and physiology; hyperthyroidism; hypothyroidism; thyroid nodules; goiter; differentiated thyroid cancer; subacute, silent, and postpartum thyroiditis; thyroid and pregnancy; thyroid and the elderly; medications and thyroid hormones; thyroid and the heart; thyroid and lipids; and Graves’ ophthalmology.
Now in a fully revised Fourth Edition, Modern Epidemiology remains the gold standard text in this complex and evolving field. This edition continues to provide comprehensive coverage of the principles and methods for the design, analysis, and interpretation of epidemiologic research. Featuring a new format allowing space for margin notes, this edition • Reflects both the conceptual development of this evolving science and the increasing role that epidemiology plays in improving public health and medicine. • Features new coverage of methods such as agent-based modeling, quasi-experimental designs, mediation analysis, and causal modeling. • Updates coverage of methods such as concepts of interaction, bias analysis, and time-varying designs and analysis. • Continues to cover the full breadth of epidemiologic methods and concepts, including epidemiologic measures of occurrence and effect, study designs, validity, precision, statistical interference, field methods, surveillance, ecologic designs, and use of secondary data sources. • Includes data analysis topics such as Bayesian analysis, probabilistic bias analysis, time-to-event analysis, and an extensive overview of modern regression methods including logistic and survival regression, splines, longitudinal and cluster-correlated/hierarchical data analysis, propensity scores and other scoring methods, and marginal structural models. • Summarizes the history, specialized aspects, and future directions of topical areas, including among others social epidemiology, infectious disease epidemiology, genetic and molecular epidemiology, psychiatric epidemiology, injury and violence epidemiology, and pharmacoepidemiology.
Kenneth A. Posner spent close to two decades as a Wall Street analyst, tracking the so-called "specialty finance" sector, which included controversial companies such as Countrywide, Fannie Mae, Freddie Mac, CIT, and MasterCard many of which were caught in the subprime mortgage and capital markets crisis of 2007. While extreme volatility is nothing new in finance, the recent downturn caught many off guard, indicating that the traditional approach to decision making had let them down. Introducing a new framework for handling and evaluating extreme risk, Posner draws on years of experience to show how decision makers can best cope with the "Black Swans" of our time. Posner's shrewd assessment combines the classic fundamental research approach of Benjamin Graham and David Dodd with more recent developments in cognitive science, computational theory, and quantitative finance. He outlines a probabilistic approach to decision making that involves forecasting across a range of scenarios, and he explains how to balance confidence, react accurately to fast-breaking information, overcome information overload, zero in on the critical issues, penetrate the information asymmetry shielding corporate executives, and integrate the power of human intuition with sophisticated analytics. Emphasizing the computational resources we already have at our disposal our computers and our minds Posner offers a new track to decision making for analysts, investors, traders, corporate executives, risk managers, regulators, policymakers, journalists, and anyone who faces a world of extreme volatility.
Since 1975, Dr. Kenneth Swaiman's classic text has been the reference of choice for authoritative guidance in pediatric neurology, and the 6th Edition continues this tradition of excellence with thorough revisions that bring you fully up to date with all that's new in the field. Five new sections, 62 new chapters, 4 new editors, and a reconfigured format make this a comprehensive and clearly-written resource for the experienced clinician as well as the physician-in-training. - Nearly 3,000 line drawings, photographs, tables, and boxes highlight the text, clarify key concepts, and make it easy to find information quickly.
This Gold Standard in clinical child neurology presents the entire specialty in the most comprehensive, authoritative, and clearly written fashion. Its clinical focus, along with relevant science, throughout is directed at both the experienced clinician and the physician in training. New editor, Dr. Ferriero brings expertise in neonatal neurology to the Fourth Edition. New chapters: Pathophysiology of Hypoxic Ischemic Encephalopathy, Congenital Disorders of Glycosylation, Pediatric Neurotransmitter Diseases, Neurophysiology of Epilepsy, Genetics of Epilepsy, Pediatric Neurorehabilitation Medicine, Neuropsychopharmacology, Pain and Palliative Care Management, Ethical Issues in Child Neurology
**Selected for Doody's Core Titles® 2024 with "Essential Purchase" designation in Dentistry** Stay up on the latest research and techniques in endodontics with Cohen's Pathways of the Pulp, 12th Edition. Written by a team of internationally renowned experts and trusted for more than 40 years, this definitive guide covers the science, theory, and practice of endodontics. Full color illustrations and detailed radiographs guide readers through each step of endodontic care — from diagnosis and treatment planning to proven techniques for managing pulpal and periapical diseases. This new twelfth edition also boasts the very latest evidence-based research and techniques, reorganized and condensed chapters, plus other features designed to help you locate important information quickly and easily. Complete with access to Expert Consult, it's everything you need to stay ahead in the field of endodontics. - Extensive illustration collection includes over 2,000 full-color photos, line art, and radiographs to clearly demonstrate core concepts and reinforce the essential principles and techniques of endodontics. - Video clips and case studies demonstrate key procedures such as palpation of the masseter muscle, introsseous anesthesia with the X-tip system, dentin hypersensitivity, and more. - Diverse and respected contributor pool includes experts from many national- and international-based dental education programs. - NEW! Updated content and new images incorporate the most recent developments in research and clinical endodontic techniques. - NEW! Additional topics cover pulp biology, pathobiology, diagnosis, treatment planning, pain control, isolation, access, cleaning and shaping, obturation, restoration, assessment of outcomes, emergencies and surgery. Each online topic comes with assigned reading lists, a PowerPoint lecture, written lesson objectives, and example exam questions. - NEW! Compliance with the Commission on Dental Accreditation Curriculum ensures that the needs of all dental programs are met. - NEW! Reorganized sections now divide chapters by those covering clinical endodontics, those covering the biological basis of endodontics, and chapters which detail endodontics in private practice to make content easier for both clinicians and students to navigate. - NEW! Condensed chapters remove unnecessary duplication of content across the text and make the physical text lighter and easier to use.
For more than 65 years, Williams Textbook of Endocrinology has been the gold standard in the field, delivering authoritative guidance on every aspect of adult and pediatric endocrine system disorders. The 13th Edition has been thoroughly updated by Drs. Shlomo Melmed, Kenneth S. Polonsky, P. Reed Larsen, and Henry M. Kronenberg, to bring you state-of-the-art coverage of diabetes, metabolic syndrome, obesity, thyroid disease, testicular disorders, and much more, all designed to help you provide optimal care to every patient. Bridging the gap between basic science and clinical information, it is an essential, relevant resource for endocrinologists, endocrine surgeons, gynecologists, internists, and pediatricians - any clinician who needs the most reliable coverage available on the diverse features across the spectrum of endocrine disease. Obtain a better understanding of both scientific insight and clinical data from the classic reference that delivers the current information you need in a highly illustrated, user-friendly format. Stay up to date with expanded discussions of autoimmune thyroid diseases, mechanisms, and the appropriate treatment of the ophthalmopathy of Graves' disease; a new section on the interpretation of fine needle aspiration results in patients with thyroid nodules; and new coverage of when and when not to use radioiodine in the treatment of patients with thyroid cancer. Update your knowledge and skills with all-new chapters on Genetics of Endocrine Disease, Endocrinology of Population Health, and Laboratory Techniques for Recognition of Endocrine Disorders. Confidently manage any clinical endocrinopathy you may encounter thanks to new information on recent FDA-approved drugs for pituitary disorders, a new focus on pediatrics, and new content on diabetes, obesity, and appetite control. Benefit from the expertise of dynamic new contributors who offer fresh perspectives throughout.
Find the latest evidence-based research and clinical treatments! Cohen's Pathways of the Pulp, 11th Edition covers the science, theory, and practice of endondontics with chapters written by internationally renowned experts. Full-color illustrations and detailed radiographs guide you through each step of endodontic care - from diagnosis and treatment planning to proven techniques for managing pulpal and periapical diseases. New to the print edition are seven new chapters, and the eBook version adds three more. As an Expert Consult title, Cohen's Pathways of the Pulp lets you search the entire contents of the book on your desktop or mobile device, and includes videos, case studies, and more. Edited by noted specialists Kenneth Hargreaves and Louis Berman, this book is the definitive resource in endodontics! Print version of the text includes 27 comprehensive chapters and meets the CODA requirements for endodontic dental education. EBook version of the text consists of 30 searchable chapters, including the 27 chapters in the print version, and features videos, PowerPoint® slides, review questions, case studies, and more; this expanded version makes it easy to find clinical answers quickly, and meets the needs of students, clinicians, and residents in endodontics. Videos and animations demonstrate key procedures such as palpation of the masseter muscle, introsseous anesthesia with the X-tipT system, dentin hypersensitivity, indirect ultrasound, palpation of the temporomandibular joint, and ultrasonic settling. Over 2,000 illustrations include full-color photos and line art, along with a wide range of radiographs, clearly demonstrating core concepts and reinforcing the essential principles and techniques of endodontics. NEW co-editor Dr. Louis H. Berman joins lead editor Dr. Kenneth M. Hargreaves for this edition, and a respected team of contributors includes experts from many U.S.-based dental education programs, as well as programs in Canada, the U.K., Norway, Sweden, France, Germany, Italy, and Switzerland. NEW chapter organization reflects the chronology of endodontic treatment with three comprehensive sections: Clinical Endodontics, focusing on core clinical concepts, and Biological Basis of Endodontics and Endodontics in Clinical Practice, both with information that advanced students, endodontic residents, and clinicians need to know. NEW! Three chapters are available in the eBook: Understanding and Managing the Anxious Patient, Endodontic Records and Legal Responsibilities, and Endodontic Practice Management. NEW Radiographic Interpretation chapter clarifies the diagnostic process with coverage of imaging modalities, diagnostic tasks, three-dimensional imaging, cone beam computed tomography, intra- or post-operative assessment of endodontic treatment complications, and more. NEW Pain Control chapter addresses the management of acute endodontic pain with coverage of local anesthesia for restorative dentistry and endodontics, along with nonnarcotic analgesics and therapeutic recommendations. NEW Evaluation of Outcomes chapter helps you achieve optimal treatment outcomes with information on topics such as the reasons for evaluating outcomes, outcome measurements for endodontic treatment, and the outcomes of vital pulp therapy procedures, non-surgical root canal treatment, non-surgical retreatment, and surgical retreatment. NEW Root Resorption chapter covers the early detection, diagnosis, and histological features of root resorption, as well as external inflammatory resorption, external cervical resorption, and internal resorption. NEW Iatrogenic Endodontics chapter addresses failed treatment scenarios with key information on the event itself, the etiology, soft and hard tissue implications and symptoms, and treatment options and prognosis; the events include cervico-facial subcutaneous emphysema, sodium hypochlorite accidents, perforations (non-surgical), inferior alveolar nerve injury, surgical, sinus perforation, instrument separation, apical extrusion of obturation materials, and ledge formation. NEW Vital Pulp Therapy chapter provides an overview of new treatment concepts for the preservation of the pulpally involved permanent tooth, covering topics such as the living pulp, pulpal response to caries, procedures for generating reparative dentin, indications and materials for vital pulp therapy, MTA applications, and treatment recommendations. NEW Bleaching chapter addresses procedures that can be utilized during and following endodontic treatment to eliminate or reduce any discoloration issues, reviewing internal and external bleaching procedures and their impact on pulpal health/endodontic treatment - with presentations of cases and clinical protocols.
Do you want to stop forgetting appointments, birthdays, and other important dates? Work more efficiently at your job? Study less and get better grades? Remember the names and faces of people you meet? The good news is that it's all possible. Your Memory will help to expand your memory abilities beyond what you thought possible. Dr. Higbee reveals how simple techniques, like the Link, Loci, Peg, and Phonetic systems, can be incorporated into your everyday life and how you can also use these techniques to learn foreign languages faster than you thought possible, remember details you would have otherwise forgotten, and overcome general absentmindedness. Higbee also includes sections on aging and memory and the latest information on the use of mnemonics.
Aeolian Dust and Dust Deposits explores the entrainment, dispersion, and deposition of aeolian dust and dust deposits, with emphasis on transport and deposition of dust derived by deflation of surface sediments and soils. Topics covered range from the mechanisms of fine-particle formation to dust sources, sinks, and rates of deposition. Dust-transporting wind systems are also discussed, along with the grain size, mineralogy, and chemical composition of aeolian dust. Comprised of nine chapters, this book begins with an overview of the general nature and significance of windborne dust as well as the importance of aeolian dust and loess. The next chapter deals with the mechanisms underlying the formation of fine particles, including glacial grinding, frost and salt weathering, and fluvial comminution. The reader is then introduced to dust entrainment, transport, and deposition, together with dust sources, sinks, and rates of deposition. Subsequent chapters focus on the implications of dust deflation, transport, and deposition; dust deposition in the oceans; and loess distribution and the thickness and morphology of loess deposits. This monograph is written primarily for research workers and advanced students in sedimentology, geomorphology, and Quaternary studies, but is also likely to be of value to soil scientists, meteorologists, planetary geologists, engineers, and others concerned with environmental management.
Solo Vocal Works on Jewish Themes: A Bibliography of Jewish Composers is a comprehensive and annotated compendium of stage, concert, and liturgical compositions written by Jewish composers from every known time period and country. Kenneth Jaffe has amassed nearly 3,000 large-scale musical works for solo voice(s) on Jewish themes, written by Jewish composers. The works include over 400 cantatas, 150 oratorios, almost 300 operas, more than 100 sacred services, 20 symphonies, and more than 350 stage works, including Yiddish theatre, Purim and sacred plays, multi-media pieces, and musical theatre. In addition, original song cycles and liturgical services arranged for a modest to large complement of instruments are also included. The works are organized by composer and subdivided by genre, and each entry is fully annotated, detailing the title, opus, voicing and instrumentation, text source, commission, year completed, year and location of the premiere, the year of publication and the publisher (if any), the location of scores, and the duration of the work. The works are then broken down by theme, such as Biblical themes, works for children, works of the Holocaust or Jewish suffering and persecution, interfaith works, and wedding music. They are then cross-referenced by voice type, arrangement, and by title. A list of libraries and publishing houses of Jewish music rounds out this invaluable reference.
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