Kenichi Shimada's Books

Biological DNA Sensor

Chapter 10. DNA Damage Responses in Atherosclerosis

By: Kenichi Shimada,Timothy R. Crother,Moshe Arditi

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Biological DNA Sensor

Chapter 10. DNA Damage Responses in Atherosclerosis

By: Kenichi Shimada,Timothy R. Crother,Moshe Arditi

DNA damage exists in all cellular organisms. While DNA damage is distinguished from mutation, mutation can result from unrepaired DNA. While most DNA damage can be repaired, such repair systems are not 100% efficient. Un-repaired DNA damage accumulates in non-replicating cells, such as neurons or myocytes of adult mammals, and can cause aging. DNA damage can be subdivided into two types: (1) endogenous damage caused by reactive oxygen species (ROS) that are derived from metabolic byproducts and (2) exogenous damage caused by radiation (UV, X-ray, gamma), hydrolysis, plant toxins, and viruses. Current data suggest that increased oxidative stress is a major characteristic of hypercholesterolemia-induced atherosclerosis and that oxidative stress is most likely associated with DNA damage in the development of cholesterol-induced plaques. This chapter critically addresses the extent to which the DNA damage, the sensing of it, and DNA damage repair are involved in the pathogenesis of atherosclerosis.

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Elsevier Inc. Chapters

Published Date

ISBN 10

0128068833

ISBN 13

9780128068830

Process Technology for Semiconductor Lasers

Crystal Growth and Microprocesses

By: Kenichi Iga,Susumu Kinoshita

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Process Technology for Semiconductor Lasers

Crystal Growth and Microprocesses

By: Kenichi Iga,Susumu Kinoshita

A description of the design principles, seen mainly from the fabrication point of view. Following a review of the historical development and of the materials used in lasing at short to long wavelengths, the book goes on to discuss the basic design principles for semiconductor-laser devices and the epitaxy for laser production. One entire chapter is devoted to the technology of liquid-phase epitaxy, while another treats vapor-phase and beam epitaxies. The whole is rounded off with mode-control techniques and an introduction to surface-emitting lasers.

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181

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3642795765

ISBN 13

9783642795763

Kinetically Controlled Stepwise Syntheses of a Heterometallic Complex and a Tetrahedral Chiral-at-Metal Complex

By: Kenichi Endo

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Kinetically Controlled Stepwise Syntheses of a Heterometallic Complex and a Tetrahedral Chiral-at-Metal Complex

By: Kenichi Endo

This book describes novel synthetic methodologies for two kinds of structurally elaborate metal complexes: a heterometallic complex and a tetrahedral chiral-at-metal complex. The book provides the tools and inspiration to chemists for development of metal complexes with wide structural diversity than had previously been possible. For each of the two topics, existing synthetic methods for similar compounds are discussed first, and then new strategies are presented, followed by the demonstration of the synthesis of novel compounds supported by experimental results. Both of the final products in this research, a Co–Ni heterometallic complex covered in the first topic and a tetrahedral chiral-at-metal complex in the second one are difficult to obtain by using common synthetic methods for thermodynamic reasons. This research achieved highly selective syntheses of these compounds using newly designed strategies that enable precise kinetic control. Such an approach will be useful for synthesizing other new metal complexes. Since the last century, organic chemistry has flourished with the development of a variety of synthetic techniques that make precise kinetic control possible. Coordination chemistry of 3d or main-group transition metals has been mainly based on simple one-step reactions that yield only thermodynamic products. The publication of this book helps pave the way to kinetically controlled precise syntheses of various metal complexes.

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Springer Nature

Published Date

ISBN 10

9811611637

ISBN 13

9789811611636

Book's by Kenichi Shimada

Biological DNA Sensor

Biological DNA Sensor

Process Technology for Semiconductor Lasers

Process Technology for Semiconductor Lasers

Kinetically Controlled Stepwise Syntheses of a Heterometallic Complex and a Tetrahedral Chiral-at-Metal Complex

Kinetically Controlled Stepwise Syntheses of a Heterometallic Complex and a Tetrahedral Chiral-at-Metal Complex

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