This book examines the role of social networks in the formation of identity among sophists, philosophers and Christians in the early Roman Empire. Membership in each category was established and evaluated socially as well as discursively. From clashes over admission to classrooms and communion to construction of the group's history, integration into the social fabric of the community served as both an index of identity and a medium through which contests over status and authority were conducted. The juxtaposition of patterns of belonging in Second Sophistic and early Christian circles reveals a shared repertoire of technologies of self-definition, authorization and institutionalization and shows how each group manipulated and adapted those strategies to its own needs. This approach provides a more rounded view of the Second Sophistic and places the early Christian formation of 'orthodoxy' in a fresh context.
The KRAS oncogene is believed to be the most common single nucleotide variant oncogene in human cancer. Historically, efforts to target KRAS and the other RAS GTPases have struggled. More recently, efforts have focused on identifying and exploiting features unique to specific oncogenic mutations. This has led to the first FDA approval for a RAS targeted therapy. This new agent is a covalent inhibitor that reacts with the cysteine residue created by a codon 12 glycine to cysteine (G12C) mutation within KRAS. Mutant-specific strategies may also exist for other KRAS single nucleotide variants, and recent studies provide examples and mechanisms.
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.