The description by Graham Hughes of the ?antiphospholipid syndrome? or Hughes Syndrome is one of the medical landmarks of the 20th century.There is something of a fashion in science to play down ?clinical? discoveries as being somehow less ground-breaking than ?basic? laboratory based observations.Here is a disease, a medical discovery, which should turn such fashions around. In a series of brilliant clinical observations, Dr Hughes, not only pieced together what is now clearly a common and important disease, but also, with his team, set up the blood tests and treatment guidelines, which are used world-wide.Kay Thackray describes the condition as a patient, providing a clear practical guide to living life.
The description by Graham Hughes of the ?antiphospholipid syndrome? or Hughes Syndrome is one of the medical landmarks of the 20th century.There is something of a fashion in science to play down ?clinical? discoveries as being somehow less ground-breaking than ?basic? laboratory based observations.Here is a disease, a medical discovery, which should turn such fashions around. In a series of brilliant clinical observations, Dr Hughes, not only pieced together what is now clearly a common and important disease, but also, with his team, set up the blood tests and treatment guidelines, which are used world-wide.Kay Thackray describes the condition as a patient, providing a clear practical guide to living life.
This fascinating study examines the rise of American molecular biology to disciplinary dominance, focusing on the period between 1930 and the elucidation of DNA structure in the mid 1950s. Research undertaken during this period, with its focus on genetic structure and function, endowed scientists with then unprecedented power over life. By viewing the new biology as both a scientific and cultural enterprise, Lily E. Kay shows that the growth of molecular biology was a result of systematic efforts by key scientists and their sponsors to direct the development of biological research toward a shared vision of science and society. She analyzes the motivations and mechanisms empowering this vision by focusing on two key institutions: Caltech and its sponsor, the Rockefeller Foundation. Her study explores a number of vital, sometimes controversial topics, among them the role of private power centers in shaping scientific agenda, and the political dimensions of "pure" research. It also advances a sobering argument: the cognitive and social groundwork for genetic engineering and human genome projects was laid by the American architects of molecular biology during these early decades of the project. This book will be of interest to molecular biologists, historians, sociologists, and the general reader alike.
Motivated by the maximal subgroup problem of the finite classical groups the authors begin the classification of imprimitive irreducible modules of finite quasisimple groups over algebraically closed fields K. A module of a group G over K is imprimitive, if it is induced from a module of a proper subgroup of G. The authors obtain their strongest results when char(K)=0, although much of their analysis carries over into positive characteristic. If G is a finite quasisimple group of Lie type, they prove that an imprimitive irreducible KG-module is Harish-Chandra induced. This being true for \rm char(K) different from the defining characteristic of G, the authors specialize to the case char(K)=0 and apply Harish-Chandra philosophy to classify irreducible Harish-Chandra induced modules in terms of Harish-Chandra series, as well as in terms of Lusztig series. The authors determine the asymptotic proportion of the irreducible imprimitive KG-modules, when G runs through a series groups of fixed (twisted) Lie type. One of the surprising outcomes of their investigations is the fact that these proportions tend to 1, if the Lie rank of the groups tends to infinity. For exceptional groups G of Lie type of small rank, and for sporadic groups G, the authors determine all irreducible imprimitive KG-modules for arbitrary characteristic of K.
During the early part of the 20th century farming in America was transformed from a pre-industrial to an industrial activity. This book explores the modernization of the 1920s, which saw farmers adopt not just new technology, but also the financial cultural & ideological apparatus of industrialism.
Hughes Syndrome is now recognised as a major 'new' disease. It has been described by colleague Dr Josep Font of Barcelona, as, "one of the two new diseases (with AIDS) of the 20th century." The messages are simple. Blood clots can cause untold damage. The tendency to 'sticky blood' found in Hughes Syndrome can be diagnosed by simple blood tests. The use of medicines, some as simple as aspirin, can protect against the clotting tendency. Kay Thackray here provides just the sort of clear guidance patients with Hughes Syndrome need. Coming from a patient, and coming straight from the heart, I believe that the lessons provided by this book are beyond value. - Munther A Khamashta MD FRCP Consultant Physician, Lupus Unit ST THOMAS' HOSPITAL, LONDON
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