When the body of Saga Atsushi, Japan's preeminent connoisseur of ukiyo-e (woodblock prints), is pulled from the ocean off the coast of Tohoku, having apparently committed suicide, the shocked Japanese art world turns out to mourn his death. Among them is Ryohei, an up-and-coming young ukiyo-e scholar and research assistant to Saga's colleague-turned-rival, Professor Nishijima. But a chance encounter with an old friend makes Ryohei wonder if there might be more to Saga's death than meets the eye...
Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases in humans characterized by the loss of photoreceptor cells leading to reduction of the peripheral visual field (known as tunnel vision) and eventually to blindness. N-Methyl-N-nitrosourea (MNU) is an alkylating agent that exhibits its toxicity by transferring its methyl group to nucleobases in nucleic acids. A single systemic administration of MNU causes retinal degeneration in various animal species. The retinal degeneration is highly reproducible, and the photoreceptor cell loss occurs within a week when a suitable dose of MNU is administered. Photoreceptor cell loss occurs via apoptosis, which resembles human RP. Decreased levels of basal autophagy concomitantly occur during the course of apoptosis progression. The time-course progression of the disease, the molecular mechanisms of the disease, and the therapeutic trials against MNU-induced photoreceptor cell apoptosis are described.
This book proposes emergent responsible management as a new tool to address the infinite nature of managerial responsibility and discusses how to bring out activities based on infinite responsibility in organizations. Whereas the concept of responsibility of corporations has been brought to the forefront with increasing recognition of the importance of corporate social responsibility (CSR), its essence has not been fully perceived, which has inevitably resulted in the restrictive feeling associated with organizational CSR activities. This book not only involves theoretical discussion by shedding light on the notions of ‘responsibility’ and ‘emergence’ underpinning the theory of emergent responsible management; it also provides practical insights with several case studies to examine how activities reflecting these fundamental elements have been practiced. In this way, the authors propose corresponding organizational design and process to encourage its continued practice. In addition, the effects of emergent responsible management and how it can be applied to new issues such as fulfilling sustainable development goals (SDGs) are also examined. The book is highly recommended for business practitioners as well as consultants who deal with CSR in everyday practice.
The fundamentals of "supramolecular chemistry" to the latest developments on the subject are covered by this book. It sets out to explain the topic in a relatively easy way. The basic concepts of molecular recognition chemistry are included. Molecules with fascinating shapes and functions such as fullerenes, carbon nanotubes, dendrimers, rotaxane, and catenane, and molecular assemblies are also explained. Thereafter applications of supermolecules to nanotechnology are introduced with many examples of molecular devices. The last part of the book describes biological supermolecules and their mimics. Though simply explained undergraduate and graduate students in Chemistry will be able to use aspects of this work as an advanced textbook.
Der endobronchiale Ultraschall (EBUS) ist eine aufregende Diagnosetechnik. Das Verfahren wird immer weiterentwickelt und hat die Diagnose und das Staging von Lungenkrebs und anderen Thoraxerkrankungen erheblich vereinfacht. Einer der Pioniere der Methode ist Mitautor dieses Fachbuchs, das das notwendige Wissen vermittelt, um endobronchiale Ultraschalluntersuchungen zur Diagnose und zum Staging von Lungenkrebs und anderer Tumoren in der Brusthöhle durchzuführen. Die 2. Auflage von Endobronchial Ultrasonography behandelt alle Standardverfahren sowie die neuesten Entwicklungen und Richtlinien in dem Fachgebiet. Dabei werden zwei gängige Verfahren, Bronchoskopie und Echtzeit-Sonografie, kombiniert. So erhalten Mediziner präzise Biopsien der Lymphknoten und der Organe in der Brusthöhle.
Showcasing the most influential developments, experiments, and architectures impacting the digital, surveillance, automotive, industrial, and medical sciences, this text/reference tracks the evolution and advancement of CVIP technologies - examining methods and algorithms for image analysis, optimization, segmentation, and restoration.
This book summarizes the branch tracing method for bronchoscopic diagnosis. Cytopathological and histopathological diagnoses are essential to making prognoses and selecting appropriate treatment for peripheral pulmonary lesions, notably lung cancer. In order to collect cell and tissue samples from peripheral pulmonary lesions for cytopathological and histopathological diagnoses, exfoliative cytodiagnosis and biopsy under bronchoscopy with endobronchial ultrasonography (EBUS) are currently used worldwide. Bronchial Branch Tracing highlights how to identify the bronchial branches that lead to peripheral pulmonary lesions and offers a valuable guide for all respiratory physicians, as well as surgeons, who frequently perform bronchoscopies, helping them understand the method and improve their technique.
When the body of Saga Atsushi, Japan’s preeminent connoisseur of ukiyo-e (woodblock prints), is pulled from the ocean off the coast of Tohoku, having apparently committed suicide, the shocked Japanese art world turns out to mourn his death. Among them is Ryohei, an up-and-coming young ukiyo-e scholar and research assistant to Saga’s colleague-turned-rival, Professor Nishijima. But a chance encounter with an old friend makes Ryohei wonder if there might be more to Saga’s death than meets the eye…
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