This framework document provides a pragmatic approach for designing representative studies and developing uniform sampling guidelines to support estimates of morbidity that are explicitly linked to exposure to land-based contaminants from small-scale artisanal gold mining activities. A primary goal is to support environmental burden of disease evaluations, which attempt to attribute health outcomes to specific sources of pollution. The guidelines provide recommendations on the most appropriate and cost-effective sampling and analysis methods to ensure the collection of representative population-level data, sample size recommendations for each contaminant and environmental media, biological sampling data, household survey data, and health outcome data. This framework focuses on small-scale artisanal gold mining (ASGM) activities that are known to use and generate mercury (Hg) as well as other metals, such as arsenic (As) and lead (Pb), depending on the specific ores being mined. A particular concern with Hg is the conversion to methylmercury (MeHg) in aquatic environments, leading to bioaccumulation and biomagnification in fish that may be locally consumed. Exposure to Hg, MeHg, and Pb are strongly associated with neurodevelopmental health outcomes in children. Exposure to Hg and MeHg are also associated with neurological illnesses in adults. Exposures to Pb are associated with renal outcomes in children and adults, and cardiovascular outcomes in adults. Exposure to As are associated with neurodevelopmental health outcomes in children, arsenicosis and skin disorders in children and adults, and potential cancers in adults, including skin, bladder, and lung. The primary objective of this framework is to guide research to assess the relationship between environmental contamination, exposures, and health outcomes related to a subset of contaminants originating from ASGM activities for particularly vulnerable populations (such as children) and the general population within a single household in the vicinity of ASGM sites in low- and medium-income countries. To achieve this objective, biomonitoring and health outcome data are linked to household survey and environmental data (for example, soil, dust, water, agricultural products, fish) at the individual level from an exposed population compared to individuals from an unexposed (reference) population. Data on exposures and health outcomes in the same individual across a representative set of individuals is required to support an understanding of the potential impact of ASGM activities on local populations. These guidelines can also assist in building local capacity to conduct environmental assessments following a consistent methodology to facilitate comparability across ASGM sites in different geographic areas. Sampling strategies and methods are prioritized given information needs, resource availability, and other constraints or considerations. The framework includes a number of supporting appendixes that provide additional resources and references on relevant topics.
This document includes a pragmatic framework for designing representative studies and developing uniform sampling guidelines to support estimates of morbidity that are explicitly linked to exposure to land-based contaminants from used lead acid battery recycling (ULAB) activities. A primary goal is to support environmental burden of disease evaluations, which attempt to attribute health outcomes to specific sources of pollution. The guidelines provide recommendations on the most appropriate and cost-effective sampling and analysis methods to ensure the collection of representative population-level data, sample size recommendations for each contaminant and environmental media, biological sampling data, household survey data, and health outcome data. These guidelines focus on small-scale ULABs that are known to generate significant amounts of lead waste through the smelting process, as well as other metals including arsenic and cadmium. A primary concern with lead exposure is the documented association with neurodevelopmental outcomes in children as demonstrated by statistically significant reduced performance on a variety of cognitive tests. These associations are evident even in the youngest children, and toxicological and epidemiologic data indicate these effects have no threshold. Other potential exposures include arsenic and cadmium, and exposure to these contaminants is also associated with neurodevelopmental outcomes in children, as well as arsenicosis; bladder, lung, and skin cancers; and renal outcomes. The primary objective of this document is to guide research to assess the relationship between environmental contamination, exposures, and health outcomes related to a subset of contaminants originating from ULAB activities for particularly vulnerable populations (such as children) and the general population within a single household in the vicinity of ULAB sites in low- and middle-income countries. To achieve this objective, biomonitoring and health outcome data are linked to household survey and environmental data (for example, soil, dust, water, and agricultural products) at the individual level from an exposed population compared to individuals from an unexposed (reference) population. Data on exposures and health outcomes in the same individual, across a representative set of individuals, is required to support an understanding of the potential impact of ULAB activities on local populations. The guidelines can also assist in building local capacity toconduct environmental assessments following a consistent methodology to facilitate comparability across ULAB sites in different geographic areas. Sampling strategies and methods are prioritized given information needs, resource availability, and other constraints or considerations. The document includes a number of supporting appendixes that provide additional resources and references on relevant topics. Data obtained following these recommendations can be used to support consistent, comparable, and standardized community risk and health impact assessments at contaminated sites in low- and middle-income countries. These data can also be used to support economic analyses and risk management decision-making for evaluating site cleanup and risk mitigation options in the most cost-effective and efficient manner. Following these recommendations will facilitate comparisons and meta-analyses across studies by standardizing data collection efforts at the community level.
Spanning the entire history of the city of Rome from Iron Age village to modern metropolis, this is the first book to take the long view of the Eternal City as an urban organism. Three thousand years old and counting, Rome has thrived almost from the start on self-reference, supplementing the everyday concerns of urban management and planning by projecting its own past onto the city of the moment. This is a study of the urban processes by which Rome's people and leaders, both as custodians of its illustrious past and as agents of its expansive power, have shaped and conditioned its urban fabric by manipulating geography and organizing space; planning infrastructure; designing and presiding over mythmaking, ritual, and stagecraft; controlling resident and transient populations; and exploiting Rome's standing as a seat of global power and a religious capital.
The novels of Storm Jameson and their depictions of Britain's relationship to Europe around the Second World War represent a crucial departure from the work of her contemporaries. As the first female President of English PEN, Jameson led her country's wartime literary community through turbulent times in history by focusing on European – rather than pointedly British – experiences of war. War, Nation and Europe in the Novels of Storm Jameson is a timely critique situated within the historical and theoretical contexts so fundamental to understanding her work. Presenting previously unpublished archival material that documents her work as an ambassador for British writers during a time of national upheaval, Katherine Cooper reveals how the novelist's pacifism and evolving attitudes to war and peace were underpinned by her overarching vision for the post-war world. Drawing comparisons to the works of Virginia Woolf, Arthur Koestler, Graham Greene and others, this study shows how Jameson's novels gesture towards prevalent internationalist perspectives and reshapes how we view the literary history of the period.
This document includes a pragmatic framework for designing representative studies and developing uniform sampling guidelines to support estimates of morbidity that are explicitly linked to exposure to land-based contaminants from used lead acid battery recycling (ULAB) activities. A primary goal is to support environmental burden of disease evaluations, which attempt to attribute health outcomes to specific sources of pollution. The guidelines provide recommendations on the most appropriate and cost-effective sampling and analysis methods to ensure the collection of representative population-level data, sample size recommendations for each contaminant and environmental media, biological sampling data, household survey data, and health outcome data. These guidelines focus on small-scale ULABs that are known to generate significant amounts of lead waste through the smelting process, as well as other metals including arsenic and cadmium. A primary concern with lead exposure is the documented association with neurodevelopmental outcomes in children as demonstrated by statistically significant reduced performance on a variety of cognitive tests. These associations are evident even in the youngest children, and toxicological and epidemiologic data indicate these effects have no threshold. Other potential exposures include arsenic and cadmium, and exposure to these contaminants is also associated with neurodevelopmental outcomes in children, as well as arsenicosis; bladder, lung, and skin cancers; and renal outcomes. The primary objective of this document is to guide research to assess the relationship between environmental contamination, exposures, and health outcomes related to a subset of contaminants originating from ULAB activities for particularly vulnerable populations (such as children) and the general population within a single household in the vicinity of ULAB sites in low- and middle-income countries. To achieve this objective, biomonitoring and health outcome data are linked to household survey and environmental data (for example, soil, dust, water, and agricultural products) at the individual level from an exposed population compared to individuals from an unexposed (reference) population. Data on exposures and health outcomes in the same individual, across a representative set of individuals, is required to support an understanding of the potential impact of ULAB activities on local populations. The guidelines can also assist in building local capacity toconduct environmental assessments following a consistent methodology to facilitate comparability across ULAB sites in different geographic areas. Sampling strategies and methods are prioritized given information needs, resource availability, and other constraints or considerations. The document includes a number of supporting appendixes that provide additional resources and references on relevant topics. Data obtained following these recommendations can be used to support consistent, comparable, and standardized community risk and health impact assessments at contaminated sites in low- and middle-income countries. These data can also be used to support economic analyses and risk management decision-making for evaluating site cleanup and risk mitigation options in the most cost-effective and efficient manner. Following these recommendations will facilitate comparisons and meta-analyses across studies by standardizing data collection efforts at the community level.
This framework document provides a pragmatic approach for designing representative studies and developing uniform sampling guidelines to support estimates of morbidity that are explicitly linked to exposure to land-based contaminants from small-scale artisanal gold mining activities. A primary goal is to support environmental burden of disease evaluations, which attempt to attribute health outcomes to specific sources of pollution. The guidelines provide recommendations on the most appropriate and cost-effective sampling and analysis methods to ensure the collection of representative population-level data, sample size recommendations for each contaminant and environmental media, biological sampling data, household survey data, and health outcome data. This framework focuses on small-scale artisanal gold mining (ASGM) activities that are known to use and generate mercury (Hg) as well as other metals, such as arsenic (As) and lead (Pb), depending on the specific ores being mined. A particular concern with Hg is the conversion to methylmercury (MeHg) in aquatic environments, leading to bioaccumulation and biomagnification in fish that may be locally consumed. Exposure to Hg, MeHg, and Pb are strongly associated with neurodevelopmental health outcomes in children. Exposure to Hg and MeHg are also associated with neurological illnesses in adults. Exposures to Pb are associated with renal outcomes in children and adults, and cardiovascular outcomes in adults. Exposure to As are associated with neurodevelopmental health outcomes in children, arsenicosis and skin disorders in children and adults, and potential cancers in adults, including skin, bladder, and lung. The primary objective of this framework is to guide research to assess the relationship between environmental contamination, exposures, and health outcomes related to a subset of contaminants originating from ASGM activities for particularly vulnerable populations (such as children) and the general population within a single household in the vicinity of ASGM sites in low- and medium-income countries. To achieve this objective, biomonitoring and health outcome data are linked to household survey and environmental data (for example, soil, dust, water, agricultural products, fish) at the individual level from an exposed population compared to individuals from an unexposed (reference) population. Data on exposures and health outcomes in the same individual across a representative set of individuals is required to support an understanding of the potential impact of ASGM activities on local populations. These guidelines can also assist in building local capacity to conduct environmental assessments following a consistent methodology to facilitate comparability across ASGM sites in different geographic areas. Sampling strategies and methods are prioritized given information needs, resource availability, and other constraints or considerations. The framework includes a number of supporting appendixes that provide additional resources and references on relevant topics.
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.