“Ingenious . . . Mary B is a tribute not just to [Jane] Austen but to defiant women of any era.”—USA Today The overlooked middle sister in Pride and Prejudice casts off her prim exterior and takes center stage in this fresh retelling of the classic novel. NAMED ONE OF THE BEST BOOKS OF THE YEAR BY REAL SIMPLE What is to be done with Mary Bennet? She possesses neither the beauty of her eldest sister, Jane, nor the high-spirited wit of second-born Lizzy. Even compared to her frivolous younger siblings, Kitty and Lydia, Mary knows she is lacking in the ways that matter for single, not-so-well-to-do women in nineteenth-century England who must secure their futures through the finding of a husband. As her sisters wed, one by one, Mary pictures herself growing old, a spinster with no estate to run or children to mind, dependent on the charity of others. At least she has the silent rebellion and secret pleasures of reading and writing to keep her company. But even her fictional creations are no match for the scandal, tragedy, and romance that eventually visit Mary’s own life. In Mary B, readers are transported beyond the center of the ballroom to discover that wallflowers are sometimes the most intriguing guests at the party. Beneath Mary’s plain appearance and bookish demeanor simmers an inner life brimming with passion, humor, and imagination—and a voice that demands to be heard. Set before, during, and after the events of Pride and Prejudice, Katherine J. Chen’s vividly original debut novel pays homage to a beloved classic while envisioning a life that is difficult to achieve in any era: that of a truly independent woman. Praise for Mary B “Charming and smart . . . a heedless downhill pleasure—plush, ironic and illuminating.”—Newsday “Watching [Mary] come into her own is a delight.”—People “A new, wholly original perspective on the classic . . . This is the ultimate Austen adaptation for our time.”—Real Simple “The best part about Mary’s star turn is that it bears little relation to the fates of her sisters. She’s a simmering, churning, smart woman determined to concoct an independent life.”—The Washington Post
“This is not your grandmother’s St. Joan. . . . If every generation gets the Joan it deserves, ours could do worse than an ass-kicking, avenging angel fighting simply for the right to fight.”—The New York Times Book Review “It is as if Chen has crept inside a statue and breathed a soul into it, re-creating Joan of Arc as a woman for our time.”—Hilary Mantel, #1 New York Times bestselling author of the Booker Prize winner Wolf Hall “A secular reimagining and feminist celebration of the life of Joan of Arc that transforms the legendary saint into a flawed yet undeniable young woman.”—USA Today 1412. France is mired in a losing war against England. Its people are starving. Its king is in hiding. From this chaos emerges a teenage girl who will turn the tide of battle and lead the French to victory, becoming an unlikely hero whose name will echo across the centuries. In Katherine J. Chen’s hands, the myth and legend of Joan of Arc is transformed into a flesh-and-blood young woman: reckless, steel-willed, and brilliant. This meticulously researched novel is a sweeping narrative of her life, from a childhood steeped in both joy and violence, to her meteoric rise to fame at the head of the French army, where she navigates the perils of the battlefield and the equally treacherous politics of the royal court. Many are threatened by a woman who leads, and Joan draws wrath and suspicion from all corners, while her first taste of fame and glory leaves her vulnerable to her own powerful ambition. With unforgettably vivid characters, transporting settings, and action-packed storytelling, Joan is a thrilling epic, a triumph of historical fiction, as well as a feminist celebration of one remarkable—and remarkably real—woman who left an indelible mark on history.
The Doctor of Nursing Practice Project, A Framework for Success, Fourth Edition guides students and faculty in the DNP project process. With a primary focus on delivering key information on planning, implementing, and evaluating a project, the text also emphasizes the impact that DNP-prepared nurses and well-developed DNP projects have in shaping the future of nursing. The Fourth Edition focuses on the evolution of the DNP degree by featuring AACN taskforce updates and reorganized content about the clinical scholar and practice scholarship. With chapters devoted to formulating a meaningful DNP project, from selecting appropriate project team members to the importance of communicating and disseminating the results of the project appropriately, it serves as a comprehensive guide for students and faculty alike.
Immune escape and inflammation are now recognized as hallmarks of tumor onset and progression. Myeloid-derived suppressor cells (MDSC), a heterogeneous population of immature myeloid cells that are present in virtually all patients and mice with advanced cancer, are a major contributor to immune escape through their inhibition of innate and adaptive antitumor immunity. Immature myeloid cells with the phenotype of MDSC are present in low levels in healthy individuals; however, chronic inflammation perturbs normal myelopoiesis and mobilizes MDSC, thereby facilitating tumor growth. This chapter reviews the experimental and patient findings that identified MDSC as an immune suppressive cell population mediating tumor immune escape, the phenotypic characteristics and heterogeneity of MDSC from cancer patients and mice, the diversity of mechanisms used by MDSC to facilitate tumor progression and metastasis, the pro-inflammatory mediators that drive the induction and accumulation of MDSC, and therapeutic approaches that have been developed to reduce MDSC levels and/or impair MDSC function.
Modern biological databases comprise not only data, but also sophisticated query facilities and bioinformatics data analysis tools. This book provides an exploration through the world of Bioinformatics Database Systems. The book summarizes the popular and innovative bioinformatics repositories currently available, including popular primary genetic and protein sequence databases, phylogenetic databases, structure and pathway databases, microarray databases and boutique databases. It also explores the data quality and information integration issues currently involved with managing bioinformatics databases, including data quality issues that have been observed, and efforts in the data cleaning field. Biological data integration issues are also covered in-depth, and the book demonstrates how data integration can create new repositories to address the needs of the biological communities. It also presents typical data integration architectures employed in current bioinformatics databases. The latter part of the book covers biological data mining and biological data processing approaches using cloud-based technologies. General data mining approaches are discussed, as well as specific data mining methodologies that have been successfully deployed in biological data mining applications. Two biological data mining case studies are also included to illustrate how data, query, and analysis methods are integrated into user-friendly systems. Aimed at researchers and developers of bioinformatics database systems, the book is also useful as a supplementary textbook for a one-semester upper-level undergraduate course, or an introductory graduate bioinformatics course. About the Authors Kevin Byron is a PhD candidate in the Department of Computer Science at the New Jersey Institute of Technology. Katherine G. Herbert is Associate Professor of Computer Science at Montclair State University. Jason T.L. Wang is Professor of Bioinformatics and Computer Science at the New Jersey Institute of Technology.
**Selected for Doody's Core Titles® 2024 in Dentistry** Comprehensive, cutting-edge content addresses contemporary orthodontic practice! Orthodontics: Current Principles and Techniques, 7th Edition provides an evidence-based approach to orthodontic diagnosis, treatment planning, and clinical techniques, including esthetics, genetics, temporary anchorage devices, aligners, technology-assisted biomechanics, and much more. New to this edition are seven chapters, covering topics like AI, maxillary expansion in adults, Class II correctors, and autotransplantation. Newly authored chapters on orthognathic surgery and the craniofacial team, the periodontal-orthodontic interface, interdisciplinary treatment, and accelerated tooth movement, among others, address current perspectives. The 7th edition comes with access to an enhanced eBook version, which includes videos and additional visuals to show concepts difficult to explain with words alone. Readers can also find additional, online-only chapters and a fully searchable version of the text. Respected editors Lee Graber, Katherine Vig, and Greg Huang are joined by new editor Pádhraig Fleming, along with expert contributors from around the world. This text provides the most current and comprehensive collection of orthodontic knowledge, making it the go-to book for orthodontic residents and practitioners! - Comprehensive coverage provides a one-stop resource for the field of orthodontics, including foundational theory and the latest on the materials and techniques used in today's practice. - Experienced, renowned editors lead a team of expert, international contributors to provide the most authoritative clinical practice and supporting science from the best and brightest in the industry. - More than 3,400 images include a mixture of radiographs, full-color clinical photos, and anatomic or schematic line drawings, showing examples of treatment, techniques, and outcomes. - Detailed, illustrated case studies show the decision-making process, highlighting the consequences of various treatment techniques over time. - Extensive references make it easy to look up the latest in orthodontic research and evidence-based information, and all references also appear online. - Enhanced ebook, included with every print purchase, features a fully searchable version of the text and bonus online-only chapters, instructional videos, and more. - NEW! Seven chapters cover topics such as AI, maxillary expansion in adults, Class II correctors, and autotransplantation. Newly authored chapters on aligners, orthognathic surgery, the periodontal-orthodontic interface, interdisciplinary and computer-assisted treatment, temporary anchorage devices, and accelerated tooth movement, among others, address current perspectives. - UPDATED! Relevant literature and evidence-based practices are featured throughout the text. - NEW! Additional photos and illustrations visually reinforce key concepts and procedures.
Comprehensive, cutting-edge content prepares you for today's orthodontics! Orthodontics: Current Principles and Techniques: 1st South Asia Edition provides evidence-based coverage of orthodontic diagnosis, planning strategies, and treatment protocols, including esthetics, genetics, temporary anchorage devices, aligners, technology-assisted biomechanics, and much more. From respected editors Lee Graber, Robert Vanarsdall, Katherine Vig, and Greg Huang, along with a veritable Who's Who of expert contributors, this classic reference has a concise, no-nonsense approach to treatment that makes it the go-to book for orthodontic residents and practitioners - Comprehensive coverage provides a one-stop resource for the field of orthodontics, including foundational theory and the latest on the materials and techniques used in today's practice. - Experienced, renowned editors lead a team of expert, international contributors, bringing the most authoritative clinical practice and supporting science from the best and brightest in the industry. - More than 3,400 images include a mixture of radiographs, full-color clinical photos, and anatomic or schematic line drawings, showing examples of treatment, techniques, and outcomes. - Extensive references make it easy to look up the latest in orthodontic research and evidence-based information, and all references also appear online. - Detailed, illustrated case studies show the decision-making process, showing the consequences of various treatment techniques over time
This framework document provides a pragmatic approach for designing representative studies and developing uniform sampling guidelines to support estimates of morbidity that are explicitly linked to exposure to land-based contaminants from small-scale artisanal gold mining activities. A primary goal is to support environmental burden of disease evaluations, which attempt to attribute health outcomes to specific sources of pollution. The guidelines provide recommendations on the most appropriate and cost-effective sampling and analysis methods to ensure the collection of representative population-level data, sample size recommendations for each contaminant and environmental media, biological sampling data, household survey data, and health outcome data. This framework focuses on small-scale artisanal gold mining (ASGM) activities that are known to use and generate mercury (Hg) as well as other metals, such as arsenic (As) and lead (Pb), depending on the specific ores being mined. A particular concern with Hg is the conversion to methylmercury (MeHg) in aquatic environments, leading to bioaccumulation and biomagnification in fish that may be locally consumed. Exposure to Hg, MeHg, and Pb are strongly associated with neurodevelopmental health outcomes in children. Exposure to Hg and MeHg are also associated with neurological illnesses in adults. Exposures to Pb are associated with renal outcomes in children and adults, and cardiovascular outcomes in adults. Exposure to As are associated with neurodevelopmental health outcomes in children, arsenicosis and skin disorders in children and adults, and potential cancers in adults, including skin, bladder, and lung. The primary objective of this framework is to guide research to assess the relationship between environmental contamination, exposures, and health outcomes related to a subset of contaminants originating from ASGM activities for particularly vulnerable populations (such as children) and the general population within a single household in the vicinity of ASGM sites in low- and medium-income countries. To achieve this objective, biomonitoring and health outcome data are linked to household survey and environmental data (for example, soil, dust, water, agricultural products, fish) at the individual level from an exposed population compared to individuals from an unexposed (reference) population. Data on exposures and health outcomes in the same individual across a representative set of individuals is required to support an understanding of the potential impact of ASGM activities on local populations. These guidelines can also assist in building local capacity to conduct environmental assessments following a consistent methodology to facilitate comparability across ASGM sites in different geographic areas. Sampling strategies and methods are prioritized given information needs, resource availability, and other constraints or considerations. The framework includes a number of supporting appendixes that provide additional resources and references on relevant topics.
This widely acclaimed book is a complete, authoritative reference on nutrition and its role in contemporary medicine, dietetics, nursing, public health, and public policy. Distinguished international experts provide in-depth information on historical landmarks in nutrition, specific dietary components, nutrition in integrated biologic systems, nutritional assessment through the life cycle, nutrition in various clinical disorders, and public health and policy issues. Modern Nutrition in Health and Disease, Eleventh Edition, offers coverage of nutrition's role in disease prevention, international nutrition issues, public health concerns, the role of obesity in a variety of chronic illnesses, genetics as it applies to nutrition, and areas of major scientific progress relating nutrition to disease.
This widely acclaimed book is a complete, authoritative reference on nutrition and its role in contemporary medicine, dietetics, nursing, public health, and public policy. Distinguished international experts provide in-depth information on historical landmarks in nutrition, specific dietary components, nutrition in integrated biologic systems, nutritional assessment through the life cycle, nutrition in various clinical disorders, and public health and policy issues. Modern Nutrition in Health and Disease, Eleventh Edition, offers coverage of nutrition's role in disease prevention, international nutrition issues, public health concerns, the role of obesity in a variety of chronic illnesses, genetics as it applies to nutrition, and areas of major scientific progress relating nutrition to disease.
Couples and families worldwide have a constant electronic connection to others, a fact that is influencing the concerns and issues they bring to therapy. The authors of this resource help mental health practitioners to better deal with concerns such as online infidelity, online dating, internet addictions, cyber bulling, and many more by introducing the Couple and Family Technology (CFT) framework, a multi-theoretical approach that doesn’t require clinicians to change their preferred clinical approach. The CFT framework acknowledges the ways in which couples navigate their relationship with technology and a partner simultaneously, and it attends to, and in some cases incorporates the role of technology in therapeutic ways. Included in the authors’ discussion of how different technologies affect relationships is • a survey of what individuals’ motivations of usage are • an examination of the specific issues that emerge in treatment • a study of the risks particularly relevant to intimate relationships, and • an introduction of the first-ever technology-based genogram. They also examine technological usage across different developmental points in a couple’s lifespan, with attention given throughout to people from various cultural backgrounds. Along with the CFT framework, the authors also introduce a new discipline of family research: Couple and Family Technology. This discipline integrates three broad perspectives in family science and helps therapists maintain a systemic focus in assessing and treating couples where issues of the Internet and new media are problematic. Online resources can be accessed by purchasers of the book and include videos, additional case studies, glossary, and forms.
A tumour suppressor gene is a gene that reduces the probability that a cell in a multicellular organism will turn into a tumor cell. A mutation or deletion of such a gene will increase the probability of the formation of a tumor. Unlike oncogenes, tumor suppressor genes generally follow the 'two-hit hypothesis', which implies that both alleles that code for a particular gene must be affected before an effect is manifested. This is due to the fact that if only one allele for the gene is damaged, the second can still produce the correct protein. However, there are cases where mutations in only one allele will cause an effect. A notable example is the gene that codes for p53. Tumor suppressor genes, or more precisely, the proteins for which they code, either have a dampening or repressive effect on the regulation of the cell cycle or promote apoptosis, and sometimes do both. This book presents new and important research from throughout the world.
Biophotonic diagnostics/biomedical spectroscopy can revolutionise the medical environment by providing a responsive and objective diagnostic environment. This book aims to explain the fundamentals of the physical techniques used combined with the particular requirements of analysing medical/clinical samples as a resource for any interested party. In addition, it will show the potential of this field for the future of medical science and act as a driver for translation across many different biological problems/questions.
The growing demand for the detection of trace analytes, such as drugs, biomarkers, environmental pollutants, and explosives, in different fields including on-site healthcare monitoring, disease diagnostics, environmental monitoring, and homeland security has driven the development of high-performance sensors to tackle real-world problems. Self-assembly of nanoparticles mediated by macrocyclic molecules provides a facile method to fabricate nanosubstrates with precise interparticle spacings, leading to very strong and reproducible signals. This introductory book is designed to offer fundamental insights into the nanosensing platforms based on macrocycle-functionalised nanoparticles, including their synthesis and functionalisation, host–guest chemistry, and optical spectroscopies. It also explores potential applications of these nanosensing platforms in biological and chemical sensing.
“Ingenious . . . Mary B is a tribute not just to [Jane] Austen but to defiant women of any era.”—USA Today The overlooked middle sister in Pride and Prejudice casts off her prim exterior and takes center stage in this fresh retelling of the classic novel. NAMED ONE OF THE BEST BOOKS OF THE YEAR BY REAL SIMPLE What is to be done with Mary Bennet? She possesses neither the beauty of her eldest sister, Jane, nor the high-spirited wit of second-born Lizzy. Even compared to her frivolous younger siblings, Kitty and Lydia, Mary knows she is lacking in the ways that matter for single, not-so-well-to-do women in nineteenth-century England who must secure their futures through the finding of a husband. As her sisters wed, one by one, Mary pictures herself growing old, a spinster with no estate to run or children to mind, dependent on the charity of others. At least she has the silent rebellion and secret pleasures of reading and writing to keep her company. But even her fictional creations are no match for the scandal, tragedy, and romance that eventually visit Mary’s own life. In Mary B, readers are transported beyond the center of the ballroom to discover that wallflowers are sometimes the most intriguing guests at the party. Beneath Mary’s plain appearance and bookish demeanor simmers an inner life brimming with passion, humor, and imagination—and a voice that demands to be heard. Set before, during, and after the events of Pride and Prejudice, Katherine J. Chen’s vividly original debut novel pays homage to a beloved classic while envisioning a life that is difficult to achieve in any era: that of a truly independent woman. Praise for Mary B “Charming and smart . . . a heedless downhill pleasure—plush, ironic and illuminating.”—Newsday “Watching [Mary] come into her own is a delight.”—People “A new, wholly original perspective on the classic . . . This is the ultimate Austen adaptation for our time.”—Real Simple “The best part about Mary’s star turn is that it bears little relation to the fates of her sisters. She’s a simmering, churning, smart woman determined to concoct an independent life.”—The Washington Post
Journal of Katherine Mansfield' is one of the great classics of 20th century literature. Compiled by her husband John Middleton Murry soon after she died and published in 1927, it consists of fragments of diary entries, unposted letters, and scraps of writing.
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