Immune escape and inflammation are now recognized as hallmarks of tumor onset and progression. Myeloid-derived suppressor cells (MDSC), a heterogeneous population of immature myeloid cells that are present in virtually all patients and mice with advanced cancer, are a major contributor to immune escape through their inhibition of innate and adaptive antitumor immunity. Immature myeloid cells with the phenotype of MDSC are present in low levels in healthy individuals; however, chronic inflammation perturbs normal myelopoiesis and mobilizes MDSC, thereby facilitating tumor growth. This chapter reviews the experimental and patient findings that identified MDSC as an immune suppressive cell population mediating tumor immune escape, the phenotypic characteristics and heterogeneity of MDSC from cancer patients and mice, the diversity of mechanisms used by MDSC to facilitate tumor progression and metastasis, the pro-inflammatory mediators that drive the induction and accumulation of MDSC, and therapeutic approaches that have been developed to reduce MDSC levels and/or impair MDSC function.
In 1907 the U.S. Congress created a joint commission to investigate what many Americans saw as a national crisis: an unprecedented number of immigrants flowing into the United States. Experts—women and men trained in the new field of social science—fanned out across the country to collect data on these fresh arrivals. The trove of information they amassed shaped how Americans thought about immigrants, themselves, and the nation’s place in the world. Katherine Benton-Cohen argues that the Dillingham Commission’s legacy continues to inform the ways that U.S. policy addresses questions raised by immigration, over a century later. Within a decade of its launch, almost all of the commission’s recommendations—including a literacy test, a quota system based on national origin, the continuation of Asian exclusion, and greater federal oversight of immigration policy—were implemented into law. Inventing the Immigration Problem describes the labyrinthine bureaucracy, broad administrative authority, and quantitative record-keeping that followed in the wake of these regulations. Their implementation marks a final turn away from an immigration policy motivated by executive-branch concerns over foreign policy and toward one dictated by domestic labor politics. The Dillingham Commission—which remains the largest immigration study ever conducted in the United States—reflects its particular moment in time when mass immigration, the birth of modern social science, and an aggressive foreign policy fostered a newly robust and optimistic notion of federal power. Its quintessentially Progressive formulation of America’s immigration problem, and its recommendations, endure today in almost every component of immigration policy, control, and enforcement.
“Are you an American, or are you not?” This was the question Harry Wheeler, sheriff of Cochise County, Arizona, used to choose his targets in one of the most remarkable vigilante actions ever carried out on U.S. soil. And this is the question at the heart of Katherine Benton-Cohen’s provocative history, which ties that seemingly remote corner of the country to one of America’s central concerns: the historical creation of racial boundaries. It was in Cochise County that the Earps and Clantons fought, Geronimo surrendered, and Wheeler led the infamous Bisbee Deportation, and it is where private militias patrol for undocumented migrants today. These dramatic events animate the rich story of the Arizona borderlands, where people of nearly every nationality—drawn by “free” land or by jobs in the copper mines—grappled with questions of race and national identity. Benton-Cohen explores the daily lives and shifting racial boundaries between groups as disparate as Apache resistance fighters, Chinese merchants, Mexican-American homesteaders, Midwestern dry farmers, Mormon polygamists, Serbian miners, New York mine managers, and Anglo women reformers. Racial categories once blurry grew sharper as industrial mining dominated the region. Ideas about home, family, work and wages, manhood and womanhood all shaped how people thought about race. Mexicans were legally white, but were they suitable marriage partners for “Americans”? Why were Italian miners described as living “as no white man can”? By showing the multiple possibilities for racial meanings in America, Benton-Cohen’s insightful and informative work challenges our assumptions about race and national identity.
In 1919 the Soviet government directed Ludwig Martens to open a trade bureau in New York. Before his deportation two years later, Martens had established contact with nearly one thousand American firms and conducted trade in the face of a stiff Allied embargo. His work planted the seeds for growing commercial ties between the U.S. and the U.S.S.R. throughout the 1920s. Because the United States did not recognize the Soviet Union until 1933, historians have viewed the early Soviet–American relationship as an ideological stand-off. Katherine Siegel, drawing on public, private, and corporate documents as well as newly opened Soviet archives, paints a different picture. She finds that business ties flourished between 1923 and 1930, American sales to the Soviets grew twentyfold and American firms supplied Russians with more than a fourth of their imports. American businesses were only too eager to tap into huge Soviet markets. Under the Soviets' New Economic Policy and first Five Year Plan, American firms invested in the U.S.S.R. and sold technical processes, provided consulting services, built factories, and trained Soviet engineers in the U.S. Most significantly, Siegel shows, this commercial relationship encouraged policy shifts at the highest levels of the U.S. government. Thus when Franklin D. Roosevelt opened diplomatic relations with Russia, he was building on ties that had been carefully constructed over the previous fifteen years. Siegel's study makes an important contribution to a new understanding of early Soviet-American relations.
This is the first book to analyze the evolution of the Roman amphitheatre as an architectural form. Katherine Welch addresses the critical period in the history of this building type: its origins and dissemination under the Republic, from the third to first centuries BC; its monumentalization as an architectural form under Augustus; and its canonization as a building type with the Colosseum (AD 80). The study then shifts focus to the reception of the amphitheatre in the Greek East, a part of the Empire deeply fractured about the new realities of Roman rule.
Der Abt und seine Bauern. Territorialisierung als Prozess in Salem vom Spten Mittelalter bis zum Dreiigjhrigen Krieg Die Studie ber die reichsunmittelbare Zisterzienserabtei Salem erffnet neue Einsichten ber grundlegende politische Entwicklungen in der Frhen Neuzeit. Sie beleuchtet die Mglichkeiten und die Grenzen kirchlicher Herrschaft und weist auf breiter Quellengrundlage den dauerhaften politischen Einfluss der Bauernschaft nach. In der untersuchten Periode von 1473 bis 1637 festigte die Abtei ihre politische Herrschaft ber Land und Leute. Im Zuge der Territorialisierung verdichtete sie verschiedene Herrschaftsrechte in ihrer Hand und schloss das Herrschaftsgebiet ab. Dies wurde auf zwei Ebenen erreicht: Erstens wurden die Grenzen des Territoriums gegen Auen eindeutig definiert - in rumlich-physischer, rechtlicher und symbolischer Hinsicht. Zweitens wurden die Untertanen vollstndig in das eigene Territorium integriert. Diesen Prozess kann man jedoch nicht einfach als Staatsbildung von "oben" - durch die Aktivitten der bte - charakterisieren. Deren Herrschaft wurde zwar gestrkt und zentralisiert, aber durchaus nicht vornehmlich auf Kosten der Bauernschaft. Deren materielle Bedrfnisse und Interessen wurden aufgegriffen, so dass gtliche Vergleiche zustande kamen. Das Beispiel Salem zeigt das Moment politischer Inklusion auf einer breiten sozialen Basis. Durch kleinteiliges Agieren und auf dem Wege direkter Kommunikation brachten sich die kommunalen Entscheidungstrger aus der Bauernschaft wirkungsvoll ein. So entwickelte sich die Herrschaft in der Abtei aufgrund interaktiver Prozesse fort. Wir begegnen also in der Arbeit vielseitigen Aushandlungsprozessen, bei denen sowohl wechselnde Bndnisse und ungleiche Partnerschaften als auch das Prinzip der Gegenseitigkeit sowie direkte Kooperation zwischen sozialen Gruppen mitwirkten. Dieses Primat des Verhandlungsprinzips brachte wechselseitige Vorteile, nicht weil die sozialen Gruppen von vornherein gemeinsame Interessen hatten, sondern da sich Kommunikationskanle ffneten und Konflikte abschwchten. Die Kommunikation im Territorium lief ber zwei zentrale Institutionen, das "Sidelgericht," und das "Verhr." Diese beiden Krperschaften vermochten es, nicht nur Konflikte zu dmpfen und diverse soziale Gruppen zu integrieren, sondern auch deren Anliegen zu bercksichtigen, und hier lag das Fundament der bemerkenswerten politischen und sozialen Stabilitt in Salem. So ist dieses kleine Territorium ein Beispiel dafr, wie ein erfolgreiches Gemeinwesen vorgeht, wie es stndig neue Ziele entwickelt und sich dabei selbst erhlt. Durch diese Forschungsarbeit ber Salem werden die Potenziale und Grenzen der Staatsbildung im Reich grundlegend beleuchtet, sie zeigt auf, wie die Beziehungen zwischen Herren und Untertanen in der Frhen Neuzeit miteinander verflochten waren.
What was childhood like in ancient Greece? What activities and games did Greek children embrace? How were they schooled and what religious and ceremonial rites of passage were key to their development? These fascinating questions and many more are answered in this groundbreaking book--the first English-language study to feature and discuss imagery and artifacts relating to childhood in ancient Greece.Coming of Age in Ancient Greece shows that the Greeks were the first culture to represent children and their activities naturalistically in their art. Here we learn about depictions of children in myth as well as life, from infancy to adolescence. This beautifully illustrated book features such archaeological artifacts as toys and gaming pieces alongside images of them in use by children on ancient vases, coins, terracotta figurines, bronze and stone sculpture, and marble grave monuments. Essays by eminent scholars in the fields of Greek social history, literature, archaeology, anthropology, and art history discuss a wide range of topics, including the burgeoning role of childhood studies in interdisciplinary studies; the status of children in Greek culture; the evolution of attitudes toward children from the Bronze Age to the Hellenistic period as documented by literature and art; the relationships of fathers and sons and mothers and daughters; and the roles of cult practice and death in a child's existence.This delightful book illuminates what is most universal and specific about childhood in ancient Greece and examines childhood's effects on Greek life and culture, the foundation on which Western civilization has been based.
Filled with updated information, equations, tables, figures, and citations, Environmental Investigation and Remediation: 1,4-Dioxane and Other Solvent Stabilizers, Second Edition provides the full range of information on 1,4-dioxane. It offers passive and active remediation strategies and treatment technologies for 1,4-dioxane in groundwater and provides the technical resources to help readers choose the best methods for their particular situation. This new edition includes all new information on remediation costs and reflects the latest research in the field. It includes new practical case studies to illustrate the concepts presented, including 1,4-dioxane occurrence in Long Island and the Cape Fear watershed in North Carolina. Features: Fully updated throughout to reflect the most recent research on 1,4-dioxane Describes the nature and extent of 1,4-dioxane releases, their regulation, and their remediation in a variety of geologic settings Examines 1,4-dioxane analytical chemistry, its many industrial uses, and 1,4-dioxane occurrence as a byproduct in production of many products Provides ample site data for recent and relevant remediation case studies, and a review of the widely varying regulatory landscape for 1,4-dioxane cleanup levels and drinking water limits Discusses the importance of accounting for contaminant archeology in investigating contaminated sites, and leveraging solvent stabilizers in forensic investigations While written primarily for practicing professionals, such as environmental consultants and attorneys, water utility engineers, and laboratory managers, the book will also appeal to researchers and academics as well. This new edition serves as a highly useful reference on the occurrence, sampling and analysis, and remedial investigation and design for 1,4-dioxane and related contaminants.
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