Put the world's most well-known kidney reference to work in your practice with the 11th Edition of Brenner & Rector's The Kidney. This two-volume masterwork provides expert, well-illustrated information on everything from basic science and pathophysiology to clinical best practices. Addressing current issues such as new therapies for cardiorenal syndrome, the increased importance of supportive or palliative care in advanced chronic kidney disease, increasing live kidney donation in transplants, and emerging discoveries in stem cell and kidney regeneration, this revised edition prepares you for any clinical challenge you may encounter. - Extensively updated chapters throughout, providing the latest scientific and clinical information from authorities in their respective fields. - Lifespan coverage of kidney health and disease from pre-conception through fetal and infant health, childhood, adulthood, and old age. - Discussions of today's hot topics, including the global increase in acute kidney injury, chronic kidney disease of unknown etiology, cardiovascular disease and renal disease, and global initiatives for alternatives in areas with limited facilities for dialysis or transplant. - New Key Points that represent either new findings or "pearls" of information that are not widely known or understood. - New Clinical Relevance boxes that highlight the information you must know during a patient visit, such as pertinent physiology or pathophysiology. - Hundreds of full-color, high-quality photographs as well as carefully chosen figures, algorithms, and tables that illustrate essential concepts, nuances of clinical presentation and technique, and clinical decision making. - A new editor who is a world-renowned expert in global health and nephrology care in underserved populations, Dr. Valerie A. Luyckx from University of Zürich. - Board review-style questions to help you prepare for certification or recertification. - Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices
A strategic requirement is something an organisation sets out to achieve; it could be the long-term vision the organisation sets itself, the key business condition for a specific project to be a success or a business strategy to achieve a goal. A set of strategic requirements defines the goals, strategies and tactics that organisations need to put in place to give them direction and impetus. Business analysts and consultants have to understand strategic requirements to know where projects can deliver business benefits and where not. The ability of the analyst to interview, gather, analyse, model and present strategic requirements is key to success. The primary tool consultants and business analysts use for communication is talking; but, if you cannot present all that incredible information back to your client effectively, it is hard for them and you to get to grips quickly enough with what is going on. Being able to present a model is really powerful because it provides a visual format and structure on one page to reason about those strategic requirements. Dr Karl A. Cox offers a process, guidelines and ideas - that have been tried and tested in practice - for conducting interviews and shows you how to rapidly turn interview findings into strategic requirements models all on one page, to present to your clients, customers, team and / or supervisors.
Authored by two leading investigators, this book presents a thorough and authoritative overview of this multifaceted field of science. Pathogenic bacteria have been evolving and spreading resistance to diverse classes of antibiotics. As a result, we risk losing our ability to control and treat infectious diseases. Understanding antibiotic resistance, therefore, is becoming increasingly essential for a broad audience of healthcare professionals, biomedical and public health researchers, students, and policymakers. The authors answer questions such as: What is resistance? How does it emerge? How do common human activities contribute to resistance? What can we do about it? How can we strengthen our “first lines of defense” against resistance? Are there better ways to discover new antibiotics? What unique issues are associated with MRSA and viral influenza? In addition to defining and evaluating one of the most important emerging threats to public health, the authors explain what can be done to minimize risks to public health, and to preserve and extend the effectiveness of existing and new antibiotics.
Serving as both a student textbook and a professional reference/handbook, this volume explores the statistical methods of examining time intervals between successive state transitions or events. Examples include: survival rates of patients in medical studies, unemployment periods in economic studies, or the period of time it takes a criminal to break the law after his release in a criminological study. The authors illustrate the entire research path required in the application of event-history analysis, from the initial problems of recording event-oriented data to the specific questions of data organization, to the concrete application of available program packages and the interpretation of the obtained results. Event History Analysis: * makes didactically accessible the inclusion of covariates in semi-parametric and parametric regression models based upon concrete examples * presents the unabbreviated close relationship underlying statistical theory * details parameter-free methods of analysis of event-history data and the possibilities of their graphical presentation * discusses specific problems of multi-state and multi-episode models * introduces time-varying covariates and the question of unobserved population heterogeneity * demonstrates, through examples, how to implement hypotheses tests and how to choose the right model.
Overcome the toughest clinical challenges in nephrology with the new 9th edition of Brenner/Rector’s The Kidney! A brand-new editorial team of Drs. Maarten W. Taal, Glenn M. Chertow, Philip A. Marsden, Karl Skorecki, Alan S. L. Yu, and Barry M. Brenner,, together with a diverse list of international contributors bring you the latest knowledge and best practices on every front in nephrology worldwide. Brand-new sections on Global Considerations in Nephrology and Pediatric Nephrology, as well as new chapters on recent clinical trials, cardiovascular and renal risk prediction in chronic kidney disease, identification of genetic causes of kidney disease, and many others, keep you at the forefront of this rapidly growing, ever-changing specialty. Brenner/Rector remains the go-to resource for practicing and training nephrologists and internists who wish to master basic science, pathophysiology, and clinical best practices. Broaden your knowledge base with expert, dependable, comprehensive answers for every stage of your career from the most comprehensive, definitive clinical reference in the field! Prepare for certification or recertification with a review of the basic science that underpins clinical nephrology as well as a comprehensive selection of the most important bibliographical sources in nephrology. Visually grasp and better understand critical information with the aid of over 700 full-color high-quality photographs as well as carefully chosen figures, algorithms, and tables to illustrate essential concepts, nuances of clinical presentation and technique, and decision making. Get internationally diverse, trusted guidance and perspectives from a team of well-respected global contributors, all of whom are at the top and the cutting edge of your field. A new editorial team headed by Dr. Taal and hand-picked by Dr. Brenner ensures the ongoing adherence to previous standards of excellence. Access information quickly thanks to a new, reorganized format and supplemental figures, tables, additional references, and expanded discussions. Keep current with the rapid development of care and research worldwide. A new section, "Global Considerations", focuses on regions outside Europe and North America. Leading experts from Latin America, Africa, Near and Middle East, Indian Subcontinent, Far East, Oceania and Australia present their expert insights into specific conditions, as well as progress and challenges in the development of the specialty. Improve therapy and outcomes for children with renal disease. New to this edition, "Pediatric Nephrology" addresses renal pathologies that usually present in childhood and covers topics such as Maturation of Kidney Structure and Function; Fluid; Electrolyte and Acid-Base Disorders in Children; Diseases of the Kidney and Urinary Tract in Children; Dialysis in Children; and Kidney Transplantation in Children. Stay up to date with all the latest clinical information including recent clinical trials, genetic causes of kidney disease, and cardiovascular and renal risk prediction in chronic kidney disease.
Comprehensive discussion of QTL mapping concepts and theory Detailed instructions on the use of the R/qtl software, the most featured and flexible software for QTL mapping Two case studies illustrate QTL analysis in its entirety
A hands-on introduction to the theoretical and computational aspects of linear algebra using Mathematica® Many topics in linear algebra are simple, yet computationally intensive, and computer algebra systems such as Mathematica® are essential not only for learning to apply the concepts to computationally challenging problems, but also for visualizing many of the geometric aspects within this field of study. Principles of Linear Algebra with Mathematica uniquely bridges the gap between beginning linear algebra and computational linear algebra that is often encountered in applied settings, and the commands required to solve complex and computationally challenging problems using Mathematica are provided. The book begins with an introduction to the commands and programming guidelines for working with Mathematica. Next, the authors explore linear systems of equations and matrices, applications of linear systems and matrices, determinants, inverses, and Cramer's rule. Basic linear algebra topics, such as vectors, dot product, cross product, and vector projection are explored, as well as a unique variety of more advanced topics including rotations in space, 'rolling' a circle along a curve, and the TNB Frame. Subsequent chapters feature coverage of linear transformations from Rn to Rm, the geometry of linear and affine transformations, with an exploration of their effect on arclength, area, and volume, least squares fits, and pseudoinverses. Mathematica is used to enhance concepts and is seamlessly integrated throughout the book through symbolic manipulations, numerical computations, graphics in two and three dimensions, animations, and programming. Each section concludes with standard problems in addition to problems that were specifically designed to be solved with Mathematica, allowing readers to test their comprehension of the presented material. All related Mathematica code is available on a corresponding website, along with solutions to problems and additional topical resources. Extensively class-tested to ensure an accessible presentation, Principles of Linear Algebra with Mathematica is an excellent book for courses on linear algebra at the undergraduate level. The book is also an ideal reference for students and professionals who would like to gain a further understanding of the use of Mathematica to solve linear algebra problems.
One of the many important skills a business analyst needs in requirements discovery is the ability to effectively plan, conduct and manage a set of interviews to get the requirements right, be they strategic, operational or IT-oriented. In Strategic Requirements Analysis Dr Karl A. Cox offers a process, guidelines and ideas - that have been tried a
A strategic requirement is something an organisation sets out to achieve; it could be the long-term vision the organisation sets itself, the key business condition for a specific project to be a success or a business strategy to achieve a goal. A set of strategic requirements defines the goals, strategies and tactics that organisations need to put in place to give them direction and impetus. Business analysts and consultants have to understand strategic requirements to know where projects can deliver business benefits and where not. The ability of the analyst to interview, gather, analyse, model and present strategic requirements is key to success. The primary tool consultants and business analysts use for communication is talking; but, if you cannot present all that incredible information back to your client effectively, it is hard for them and you to get to grips quickly enough with what is going on. Being able to present a model is really powerful because it provides a visual format and structure on one page to reason about those strategic requirements. Dr Karl A. Cox offers a process, guidelines and ideas - that have been tried and tested in practice - for conducting interviews and shows you how to rapidly turn interview findings into strategic requirements models all on one page, to present to your clients, customers, team and / or supervisors.
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