Over the past 30 years many significant advances have been made in the management of a number of disseminated malignant diseases. The prognosis for diseases such as childhood leukaemia, choriocarcinoma and Hodgkin's disease has gradually been transformed as better anti tumour agents have become available and their clinical use has been refined. During the past 10 years the advent of new agents, particularly cisplatin, bleomycin and the podophyllotoxins, has allowed the cure of disseminated testicular tumours. This degree of success has not, however, been achieved in the case of a number of other common cancers. Ovarian carcinoma is tantalisingly chemo-sensitive and although there are long term survivors from disseminated disease, these are only a small proportion of the total. Breast cancer, although "sensitive" to a multitude of drugs appears to have yielded neither survival benefit, nor cure to the efforts of therapists, while tumours such as those of the colon remain stubbornly unresponsive. Against this backcloth it is apparent that additional more selective treatments are needed if further impact is to be made on the problem of cancer. The development of such agents requires the integration of a multidisciplinary effort encompassing the fields of chemistry, biology and medicine. This symposium provided a forum for clinical and preclinical sCientists, where current aspects of cancer treatment were reviewed and approaches to the development of a new generation of more selective anticancer drugs discussed.
The partition of India and the agonies associated with it are still alive in the memory of millions of people. Although the India-Pakistan Partition took place nearly seven decades ago, it is still a lingering reality. It is the indifferent attitude of leaders both from the Congress and the Muslim League that resulted in bifurcating the country. This is well made out from the writings of the leaders of the time. This indifference continued even after 1947. Kashmir got divided and it became a perpetual bone of contention. Sending terrorists across the border is Pakistan's spasmodic habit. Training Indian extremists in violence is its dedicated, continual process. The author affirms that many an unpleasant development would have been avoided had the leaders understood the issues properly and mobilized support from the Indian populace. But the leadership was cynical and failed in understanding the gravity of the situation. Personal interests and egos ruled the roost. However, a few lay Indians know how the partition took place. What was the need for it? Who played the spoilsport in creating Pakistan? This volume, for the better understanding of the readers, reproduces the views of Jinnah, Gandhi, Ambedkar, Rajendra Prasad and G.D. Khosla in this context. This book is a sincere attempt to portray the actual developments that had taken place associated with the Independence of the country and a few afterward results. The Indian government under Nehru failed in resolving many an issue, paving the way for numerous post-Independent challenges that are still continuing. Thus, this book should be an eye opener for the readers, unfurling their mind, grasping the reality in its absolute sense.
K.R. McClay Department of Geology, Royal Holloway and Bedford New College, University of London, Egham, Surrey, England TW20 OEX. Since the first Thrust and Nappe Tectonics Conference in London in 1979 (McClay & Price 1981), and the Toulouse Meeting on Thrusting and Deformation in 1984 (Platt et al. 1986) there have been considerable advances in the study of thrust systems incorporating new field observations, conceptual models, mechanical models, analogue and numerical simulations, together with geophysical studies of thrust belts. Thrust Tectonics 1990 was an International Conference convened by the editor and held at Royal Holloway and Bedford New College, University of London, Egham Surrey, from April 4th until April 7th 1990. There were one hundred and seventy participants from all continents except South America. The conference was generously sponsored by Brasoil U.K. Limited, BP Exploration, Chevron U.K. Limited, Clyde Petroleum, Enterprise Oil, Esso Exploration and Production UK Limited, and Shell U.K. Exploration and Production. One hundred and five contributions were presented at the meeting, - seventy six oral presentations (together with poster displays) and an additional twenty nine posters without oral presentation (McClay 1990, conference abstract volume).
Over the past 30 years many significant advances have been made in the management of a number of disseminated malignant diseases. The prognosis for diseases such as childhood leukaemia, choriocarcinoma and Hodgkin's disease has gradually been transformed as better anti tumour agents have become available and their clinical use has been refined. During the past 10 years the advent of new agents, particularly cisplatin, bleomycin and the podophyllotoxins, has allowed the cure of disseminated testicular tumours. This degree of success has not, however, been achieved in the case of a number of other common cancers. Ovarian carcinoma is tantalisingly chemo-sensitive and although there are long term survivors from disseminated disease, these are only a small proportion of the total. Breast cancer, although "sensitive" to a multitude of drugs appears to have yielded neither survival benefit, nor cure to the efforts of therapists, while tumours such as those of the colon remain stubbornly unresponsive. Against this backcloth it is apparent that additional more selective treatments are needed if further impact is to be made on the problem of cancer. The development of such agents requires the integration of a multidisciplinary effort encompassing the fields of chemistry, biology and medicine. This symposium provided a forum for clinical and preclinical sCientists, where current aspects of cancer treatment were reviewed and approaches to the development of a new generation of more selective anticancer drugs discussed.
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