Updated and revised, The Essentials of Computer Organization and Architecture, Third Edition is a comprehensive resource that addresses all of the necessary organization and architecture topics, yet is appropriate for the one-term course.
How to identify optimal phase II trial designs Providing a practical guide containing the information needed to make crucial decisions regarding phase II trial designs, A Practical Guide to Designing Phase II Trials in Oncology sets forth specific points for consideration between the statistician and clinician when designing a phase II trial, including issues such as how the treatment works, choice of outcome measure and randomization, and considering both academic and industry perspectives. A comprehensive and systematic library of available phase II trial designs is included, saving time otherwise spent considering multiple manuscripts, and real-life practical examples of using this approach to design phase II trials in cancer are given. A Practical Guide to Designing Phase II Trials in Oncology: Offers a structured and practical approach to phase II trial design Considers trial design from both an academic and industry perspective Includes a structured library of available phase II trial designs Is relevant to both clinical and statistical researchers at all levels Includes real life examples of applying this approach For those new to trial design, A Practical Guide to Designing Phase II Trials in Oncology will be a unique and practical learning tool, providing an introduction to the concepts behind informed decision making in phase II trials. For more experienced practitioners, the book will offer an overview of new, less familiar approaches to phase II trial design, providing alternative options to those which they may have previously used.
Through the centuries, at the heart of Catholic moral theology is a fundamental question: How do we behave responsibly in the face of moral uncertainty? Attempts to resolve problems of everyday life led to the growth of a variety of moral systems, one of which emerged in the early 17th century and was known as "probabilism." This method of solving difficult moral cases allowed the believer to rely upon a view that was judged defensible in terms of its arguments or the authorities behind it, even if the opposite opinion was supported by stronger arguments or more authorities. The theologian Juan Caramuel, a Spanish Cistercian monk whom Alphonso Liguori famously characterized as "the prince of laxists," has been regarded as one of the more extreme—and notorious—proponents of probabilism. As the only full-length English study of Caramuel's theological method, Defending Probabilism seeks to reappraise Caramuel's legacy, claiming that his model of moral thinking, if better understood, can actually be of help to the Church today. Considered one of the most erudite theologians of his age, a scientist and scholar who published works on everything from astronomy and architecture to printing and Gregorian chant, Caramuel strove throughout his life to understand probabilism's theological and philosophical foundations as part of his broader analysis of the nature of human knowledge. In applying Caramuel's legacy to our own time, Defending Probabilism calls for a reconsideration of the value of provisional moral knowledge. Fleming's study shows that history matters, and that to attain any position on moral certitude is a difficult and painstaking process.
Unlike monks and nuns, clergy have hitherto been sidelined in accounts of the Middle Ages, but they played an important role in medieval society. This first broad-ranging study in English of the secular clergy examines how ordination provided a framework for clerical life cycles and outlines the influence exerted on secular clergy by monastic ideals before tracing typical career paths for clerics. Concentrating on northern France, England and Germany in the period c.800–c.1200, Julia Barrow explores how entry into the clergy usually occurred in childhood, with parents making decisions for their sons, although other relatives, chiefly clerical uncles, were also influential. By comparing two main types of family structure, Barrow supplies an explanation of why Gregorian reformers faced little serious opposition in demanding an end to clerical marriage in the eleventh and twelfth centuries. Changes in educational provision c.1100 also help to explain growing social and geographical mobility among clerics.
Step back in time and experience the grandeur and romance of a previous era as Harlequin® Historical brings you three new full-length titles in one collection! This boxset includes: THE WALLFLOWER'S LAST CHANCE SEASON Least Likely to Wed by Julia Justiss (Regency) When impoverished Eliza helps an older viscount after he falls at a ball, his son Giles is suspicious she’s out to wed his widowed father! But it’s Giles who actually sets her heart racing… BETROTHED IN HASTE TO THE EARL by Liz Tyner (Regency) Following two troubled courtships, Marianna has sworn off romance. Until Adam, the handsome Earl of Rockwell, is misdirected to her bedchamber after a soiree, and she’s compromised into a hasty betrothal! THE WARRIOR'S RELUCTANT WIFE The Warriors of Wales by Lissa Morgan (Medieval) Widow Rhianon had hoped to never be bound to a man again. But to seal an alliance, she’s forced to marry Peredur. Only ruling with her new husband is revealing some unexpected desires…
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