This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. - Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France - 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology - Includes the major toxins of both basic and clinical interest are described in depth - Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology - Evolutionary and functional aspects of bacterial toxins evaluated and summarized - Toxin applications in cell biology presented - Therapy (cancer therapy, dystonias) discussed - Vaccines (native and genetically engineered vaccines) featured - Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.
This volume of interdisciplinary essays brings together leading academics from the fields of history, economic history, politics and sociology to review and take forward a series of debates on the role of culture in social explanation. The book is aimed at those involved in cultural studies, but is particularly concerned with the relationship between the economic and the cultural. The contributors suggest that the boundaries of production and consumption are themselves cultural constructs, formed by changing conceptions of economic and cultural explanation, but offer very different approaches to resolving the problems created by this.
The discovery and treatment of insanity remains one of the most debated and discussed issues in social history. Focusing on the second half of the nineteenth century, The Politics of Madness provides a new perspective on this important topic, based on research drawn from both local and national material. Within a social and cultural history of the English political and class order, it presents a fresh appraisal of the significance of the asylum in the decades following the creation of a national asylum system in 1845. Arguing that the new asylums provided a meeting place for different social interests and aspirations, the text asserts that this then marked a transition in provincial power relations from the landed interests to the new coalition of professional, commercial and populist groups, which gained control of the public asylums at the end of the period surveyed.
Feminist interpretation has become one of the important text-centered literary methods in biblical interpretation. It challenges the authority, canonicity, veracity, and normativity of the biblical text due to its patriarchal-androcentric orientation. Feminist readers ask how far the patriarchal texts in the Bible can be authoritative and normative in articulating the theology and practices of the church. The author responds to these important questions both sympathetically and critically and considers whether they might have universal significance. He provides a lucid and thorough examination of the hermeneutical methodologies and presuppositions that lie behind many of the leading proponents of feminist readings of the Old Testament. The author asks whether Eve is unnecessarily accused by the traditional readers or is completely liberated by modern feminist readers.
New communication technologies have changed the world of mental health professionals and their patients. This practical handbook guides readers through the new practice arenas.
Although sports and athletics provide a nearly universal social context for the learning of such cherished values as courage, honesty, discipline, communal efforts, and the pursuit of excellence, little attention has been devoted to the philosophy of this important element in human life. In a fascinating survey of the philosophic dimensions of sports and athletics, the author delves into a variety of topics, including game and play theory, play-forms and game principles in history, existentialism and sports, the popularity of sports, its educational values, the function of ethics and moral values, and the role of competition, violence and aggression, self discovery, spirituality, and joy. He also considers recurrent problems such as corruption, the excessive emphasis on winning, and the exploitation of student athletes and suggests specific ways of preserving perspective and integrity. -- From publisher's description.
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