Blueprints Clinical Cases in Medicine, Second Edition offers third- and fourth-year medical students valuable preparation for clerkships and the USMLE Steps 2 and 3. The book features 60 clinical cases, 10 new to this edition and 50 revised and updated from the first edition. Each case consists of a clinical vignette followed by thought questions and discussion, and ends with a question-and-answer review and a listing of suggested additional reading. A question-and-answer section at the end of the book contains 100 USMLE-format multiple-choice questions and detailed answer explanations.
Covering the entire spectrum of women’s healthcare , Berek & Novak’s Gynecology, 16th Edition, provides definitive information and guidance for trainees and practicing physicians. A newly streamlined design and brilliant, full-color illustrations highlight must-know content on principles of practice and initial assessment, including relevant basic science; preventive and primary care for women; and methods of diagnosis and management in general gynecology, operative gynecology, urogynecology and pelvic reconstructive surgery, early pregnancy issues, reproductive endocrinology, and gynecologic oncology.
This book focuses on practical applications for using adult and embryonic stem cells in the pharmaceutical development process. It emphasizes new technologies to help overcome the bottlenecks in developing stem cells as therapeutic agents. A key reference for professionals working in stem cell science, it presents the general principles and methodologies in stem cell research and covers topics such as derivitization and characterization of stem cells, stem cell culture and maintenance, stem cell engineering, applications of high-throughput screening, and stem cell genetic modification with their use for drug delivery.
Derived from the bestselling Berek & Novak’s Gynecology, this concise, easily accessible reference presents essential information in gynecology in a highly readable, fully illustrated format. Berek & Novak’s Gynecology Essentials includes the most clinically relevant chapters, tables, and figures from the larger text, carefully compiled and edited by Dr. Berek and ideally suited for residents, nurse practitioners, physician assistants, midwives, and other healthcare providers.
Deploying the scientific method in cybersecurity today is a common-sense approach that is a tough topic in the field of cybersecurity. While most publications in the field emphasize that scientific principles are necessary, there are very few, if any, guides that uncover these principles.This book will give readers practical tools for cybersecurity. It examines the path of developing cybersecurity foundations while taking into account uncertain data. Extensive examples demonstrate how to deploy cybersecurity to sort our day-to-day problems. Using Science in Cybersecurity is intended for advanced undergraduate and graduate students, researchers and practitioners in the fields of cybersecurity, information security, and science of cybersecurity.
The two-volume Encyclopedia of Supramolecular Chemistry offers authoritative, centralized information on a rapidly expanding interdisciplinary field. User-friendly and high-quality articles parse the latest supramolecular advancements and methods in the areas of chemistry, biochemistry, biology, environmental and materials science and engineering, physics, computer science, and applied mathematics. Designed for specialists and students alike, the set covers the fundamentals of supramolecular chemistry and sets the standard for relevant future research.
Drs. Cohen, Powderly and Opal, three of the most-respected names in infectious disease medicine, lead a diverse team of international contributors to bring you the latest knowledge and best practices. Extensively updated, the fourth edition includes brand-new information on advances in diagnosis of infection; Hepatitis C; managing resistant bacterial infections; and many other timely topics. An abundance of photographs and illustrations; a practical, clinically-focused style; highly-templated organization; and robust interactive content combine to make this clinician-friendly resource the fastest and best place to find all of the authoritative, current information you need. - Hundreds of full-color photographs and figures provide unparalleled visual guidance. - Consistent chapter organization and colorful layouts make for quick searches. - Clinically-focused guidance from "Practice Points" demonstrates how to diagnose and treat complicated problems encountered in practice. - The "Syndromes by Body System", "HIV and AIDS", and "International Medicine" sections are designed to reflect how practicing specialists think when faced with a patient. - Sweeping updates include new or revised chapters on: - Hepatitis C and antivirals - Fungal infection and newer antifungals - Microbiome and infectious diseases as well as advances in diagnosis of infection; Clostridium difficile epidemiology; infection control in the ICU setting; Chlamydia trachomatis infection; acquired syndromes associated with autoantibodies to cytokines;; management of multidrug resistant pathogens; probiotics, polymyxins, and the pathway to developing new antibiotics - HIV including HIV and aging, antiretroviral therapy in developing countries, and cure for HIV. - Online Antimicrobial pharmacokinetics mannequin, as well an all new HIV medicine mannequin are a useful visual source of treatment information
Movement Disorders in Childhood, Third Edition provides the most up-to-date information on the diseases and disorders that affect motor control, an important area of specialization within child neurology. In this new edition, each chapter has been fully revised to include all of the latest scientific and therapeutic advances. Updates include new insights in motor development, control, goal-directed and habitual behaviors, classifications of movements and their complex and integrated circuitry. The authors also discuss developments in pathophysiologic mechanisms, immunology and metabolic disorders. New chapters include coverage of genetics of movement disorders and movement disorders in psychiatric conditions.Appendices include an updated and revised drug index and genetic search strategy. An updated Companion website hosts selected educational videos to help diagnose movement disorders. - Provides the only current reference specifically focused on childhood movement disorders - Investigates the underlying etiologies and mechanisms of these disorders - Revised and updated with new materials and a more disease-oriented approach - Contains new chapters on the genetics of movement disorders and movement disorders in psychiatric conditions - Includes new videos of instructive and unusual childhood movement disorders
A one-stop, comprehensive, and thoroughly updated resource for students, professors, and researchers alike Thoroughly revised and updated, the Third Edition of Supramolecular Chemistry delivers a comprehensive and integrated approach to this rapidly evolving and quickly expanding field. Distinguished professors and authors Jonathan Steed and Jerry Atwood provide readers with a broad and exhaustive resource that assumes little in the way of prior knowledge of supramolecular chemistry. Extensive new content on cutting edge research throughout the field including molecular machines and the mechanical bond, mechanochemistry, halogen bonding, and crystal nucleation accompanies full-color imagery and study problems designed to help students understand and apply the principles introduced within the book. Additional material is provided in the supplementary online resources, including solutions to the student exercises and PowerPoint slides of the figures in the book. Supramolecular Chemistry, Third Edition also includes: The latest research and developments reported over the last decade A unique “key references” system that highlights crucial reviews and primary literature A description of key experimental techniques included in accessible “boxes” for the non-expert Exercises and problems for students, complete with online solutions Full-color illustrations and imagery designed to facilitate learning and retention of the key concepts and state-of-the art of the field Perfect for undergraduate and postgraduate students taking courses on supramolecular chemistry, the Third Edition of Supramolecular Chemistry also belongs on the bookshelves of all researchers in this, and any closely related, fields. Academics, in particular postdoctoral students and professors, will benefit significantly from this text.
This book aims to provide a fundamental grasp of graphene-based materials (GAMs) and their adsorption process. The effect of diverse process parameters, including pH, temperature, agitation, competing ions, etc., on the adsorption performance of GAMs as well as their recent and relevant applications in biomedical fields, are discussed. The current challenges and future outlook have been addressed as an independent chapter, and the recyclability of these adsorbent materials has also been covered. Features: Focuses on graphene-based materials as adsorbents to remove contaminants from wastewater. Includes detailed computational and statistical analyses and cost comparison points. Compares the performance of graphene-based materials as adsorbents in the context of various other reported adsorbents, including other 2D materials, such as WS2 and BN. Provides fundamental comprehension of the graphene-based materials’ adsorption process. Discusses the recyclable nature of graphene-based materials, as well as approaches used. This book has been aimed at graduate students and researchers in wastewater treatment, environmental, materials, and chemical engineering.
This new volume substantially updates the original pyridazines volume which was published in 1973. Announcing the latest volume in the successful and prominent Chemistry of Heterocyclic Compounds Series.
Evolution is the single unifying principle of biology and core to everything in the life sciences. More than a century of work by scientists from across the biological spectrum has produced a detailed history of life across the phyla and explained the mechanisms by which new species form. This textbook covers both this history and the mechanisms of speciation; it also aims to provide students with the background needed to read the research literature on evolution. Students will therefore learn about cladistics, molecular phylogenies, the molecular-genetical basis of evolutionary change including the important role of protein networks, symbionts and holobionts, together with the core principles of developmental biology. The book also includes introductory appendices that provide background knowledge on, for example, the diversity of life today, fossils, the geology of Earth and the history of evolutionary thought. Key Features Summarizes the origins of life and the evolution of the eukaryotic cell and of Urbilateria, the last common ancestor of invertebrates and vertebrates. Reviews the history of life across the phyla based on the fossil record and computational phylogenetics. Explains evo-devo and the generation of anatomical novelties. Illustrates the roles of small populations, genetic drift, mutation and selection in speciation. Documents human evolution using the fossil record and evidence of dispersal across the world leading to the emergence of modern humans.
This groundbreaking core textbook offers a comprehensive overview of different approaches to the causes, assessment and treatment of psychological disorders. The book includes important diagnostic frameworks, including the new DSM-5-TR, ICD-11 and PDM, but also widens the scope of coverage beyond mainstream psychiatric models to include psychological, biological, historical, sociocultural and therapeutic approaches. Contemporary and well-balanced, this book provides an even-handed and holistic foundation, allowing students to develop a strong critical mindset while retaining a robust research-driven orientation. This new edition: - features an innovative structure organized by presenting problem, examining each in a broad context of traditional psychiatric and alternative approaches - is grounded in lived experience of disorder: shining a spot-light on service-users through 'Case Examples' scenarios and 'Lived Experience' perspective pieces - Supports student learning and critical thinking through engaging 'Controversial Question' and 'In Depth' features - Features an attractive new layout and plenty of colour illustrations - Is supported by impressive online support features including lecture slides, a test bank, instructor manual, video library, student study questions, self-test quizzes, flashcard activities and more. Now thoroughly updated to include the latest developments in research and clinical practice, along with enhanced in-text and online pedagogy to support instructors and learners, this book is ideal for undergraduate and graduate students on abnormal psychology, psychopathology, mental health or clinical psychology courses.
A wide range of chemical products (especially fine chemicals) are important for a healthy and enjoyable modern life; therefore efficient syntheses of these materials are essential. Traditional stoichiometric processes need to be replaced by modern catalytical methods in the change to sustainable chemistry and the production of lower amounts of waste. This book summarizes the wide variety of catalytic methods that have been developed and applied on an industrial scale in recent years to fulfill this goal. The synthesis of compound classes such as pharmaceuticals, agrochemicals, flavoring, and fragrance compounds as well as food additives such as vitamins exemplify the use of these modern catalytic methods in the modern chemical industry.
Second Edition features the latest tools for uncovering thegenetic basis of human disease The Second Edition of this landmark publication bringstogether a team of leading experts in the field to thoroughlyupdate the publication. Readers will discover the tremendousadvances made in human genetics in the seven years that haveelapsed since the First Edition. Once again, the editorshave assembled a comprehensive introduction to the strategies,designs, and methods of analysis for the discovery of genes incommon and genetically complex traits. The growing social, legal,and ethical issues surrounding the field are thoroughly examined aswell. Rather than focusing on technical details or particularmethodologies, the editors take a broader approach that emphasizesconcepts and experimental design. Readers familiar with theFirst Edition will find new and cutting-edge materialincorporated into the text: Updated presentations of bioinformatics, multiple comparisons,sample size requirements, parametric linkage analysis, case-controland family-based approaches, and genomic screening New methods for analysis of gene-gene and gene-environmentinteractions A completely rewritten and updated chapter on determininggenetic components of disease New chapters covering molecular genomic approaches such asmicroarray and SAGE analyses using single nucleotide polymorphism(SNP) and cDNA expression data, as well as quantitative trait loci(QTL) mapping The editors, two of the world's leading genetic epidemiologists,have ensured that each chapter adheres to a consistent and highstandard. Each one includes all-new discussion questions andpractical examples. Chapter summaries highlight key points, and alist of references for each chapter opens the door to furtherinvestigation of specific topics. Molecular biologists, human geneticists, geneticepidemiologists, and clinical and pharmaceutical researchers willfind the Second Edition a helpful guide to understanding thegenetic basis of human disease, with its new tools for detectingrisk factors and discovering treatment strategies.
Comprehensive resource detailing the latest advances in microwave and wireless sensors implemented in planar technology Planar Microwave Sensors is an authoritative resource on the subject, discussing the main relevant sensing strategies, working principles, and applications on the basis of the authors’ own experience and background, while also highlighting the most relevant contributions to the topic reported by international research groups. The authors provide an overview of planar microwave sensors grouped by chapters according to their working principle. In each chapter, the working principle is explained in detail and the specific sensor design strategies are discussed, including validation examples at both simulation and experimental level. The most suited applications in each case are also reported. The necessary theory and analysis for sensor design are further provided, with special emphasis on performance improvement (i.e., sensitivity and resolution optimization, dynamic range, etc.). Lastly, the work covers a number of applications, from material characterization to biosensing, including motion control sensors, microfluidic sensors, industrial sensors, and more. Sample topics covered in the work include: Non-resonant and resonant sensors, reflective-mode and transmission-mode sensors, single-ended and differential sensors, and contact and contactless sensors Design guidelines for sensor performance optimization and analytical methods to retrieve the variables of interest from the measured sensor responses Radiofrequency identification (RFID) sensor types, prospective applications, and materials/technologies towards “green sensors” implementation Comparisons between different technologies for sensing and the advantages and limitations of microwave sensors, particularly planar sensors Engineers and qualified professionals involved in sensor technologies, along with undergraduate and graduate students in related programs of study, can harness the valuable information inside Planar Microwave Sensors to gain complete foundational knowledge on the subject and stay up to date on the latest research and developments in the field.
How Genes Influence Behavior 2e takes a personal and lively approach to the study of behavioral genetics, providing an up-to-date and accessible introduction to a variety of approaches and their application to a wide range of disorders, and modeling a critical approach to both methods and results. This second edition includes additional biology content to help students understand the biological foundations of the field, while maintaining an appropriate focus on the main issues of relevance to psychology students; updates coverage of genomic technologies and their applications; and covers a wider range of disorders, including autism spectrum disorder, eating disorders, and intellectual disability. A new final chapter guides students through a range of quantitative approaches using worked examples that relate directly to cases and examples used earlier in the text, and addresses current issues arising from debates around reproducibility. The online resources that accompany this book include: For students *Multiple choice questions for students to check their threshold knowledge *Data sets for students to manipulate, so that they can apply what they have learned For lecturers *Figures and tables from the book, ready to download
Since its first edition over 60 years ago, Rockwood and Wilkins’ Fractures in Children has been the go-to reference for treating a wide range of fractures in children and adolescents. The landmark tenth edition continues this tradition with the addition of four associate editors, a refreshed mix of contributors, and fully revised content throughout, bringing you fully up to date with today’s techniques and technologies in fractures in pediatric orthopaedics. Drs. Peter M. Waters, David L. Skaggs, John M. Flynn, Lindsay Andras, Donald S. Bae, Keith D. Baldwin, and Jonathan G. Schoenecker lead a team of experts who ensure that the most up-to-date information is presented in a comprehensive yet easy to digest manner.
Asymmetric synthesis has become a major aspect of modern organic chemistry. The stereochemical properties of an organic compound are often essential to its bioactivity, and the need for stereochemically pure pharmaceutical products is a key example of the importance of stereochemical control in organic synthesis. However, achieving high levels of stereoselectivity in the synthesis of complex natural products represents a considerable intellectual and practical challenge for chemists. Written from a synthetic organic chemistry perspective, this text provides a practical overview of the field, illustrating a wide range of transformations that can be achieved. The book captures the latest advances in asymmetric catalysis with emphasis placed on non-enzymatic methods. Topics covered include: Reduction of alkenes, ketones and imines Nucleophilic addition to carbonyl compounds Catalytic carbon-carbon bond forming reactions Catalytic reactions involving metal carbenoids Conjugate addition reactions Catalysis in Asymmetric Synthesis bridges the gap between undergraduate and advanced level textbooks and provides a convenient point of entry to the primary literature for the experienced synthetic organic chemist.
Wiley is proud to announce the publication of the first ever broad-based textbook introduction to Bioinformatics and Functional Genomics by a trained biologist, experienced researcher, and award-winning instructor. In this new text, author Jonathan Pevsner, winner of the 2001 Johns Hopkins University "Teacher of the Year" award, explains problem-solving using bioinformatic approaches using real examples such as breast cancer, HIV-1, and retinal-binding protein throughout. His book includes 375 figures and over 170 tables. Each chapter includes: Problems, discussion of Pitfalls, Boxes explaining key techniques and math/stats principles, Summary, Recommended Reading list, and URLs for freely available software. The text is suitable for professionals and students at every level, including those with little to no background in computer science.
This book is a guide to concepts and practice in numerical algebraic geometry ? the solution of systems of polynomial equations by numerical methods. Through numerous examples, the authors show how to apply the well-received and widely used open-source Bertini software package to compute solutions, including a detailed manual on syntax and usage options. The authors also maintain a complementary web page where readers can find supplementary materials and Bertini input files. Numerically Solving Polynomial Systems with Bertini approaches numerical algebraic geometry from a user's point of view with numerous examples of how Bertini is applicable to polynomial systems. It treats the fundamental task of solving a given polynomial system and describes the latest advances in the field, including algorithms for intersecting and projecting algebraic sets, methods for treating singular sets, the nascent field of real numerical algebraic geometry, and applications to large polynomial systems arising from differential equations. Those who wish to solve polynomial systems can start gently by finding isolated solutions to small systems, advance rapidly to using algorithms for finding positive-dimensional solution sets (curves, surfaces, etc.), and learn how to use parallel computers on large problems. These techniques are of interest to engineers and scientists in fields where polynomial equations arise, including robotics, control theory, economics, physics, numerical PDEs, and computational chemistry.
Anion recognition plays a critical role in a range of biological processes, and a variety of receptors and carriers can be found throughout the natural world. Chemists working in the area of supramolecular chemistry have created a range of anion receptors, drawing inspiration from nature as well as their own inventive processes. This book traces the origins of anion recognition chemistry as a unique sub-field in supramolecular chemistry while illustrating the basic approaches currently being used to effect receptor design. The combination of biological overview and summary of current synthetic approaches provides a coverage that is both comprehensive and comprehensible. First, the authors detail the key design motifs that have been used to generate synthetic receptors and which are likely to provide the basis for further developments. They also highlight briefly some of the features that are present in naturally occurring anion recognition and transport systems and summarise the applications of anion recognition chemistry. Providing as it does a detailed review for practitioners in the field and a concise introduction to the topic for newcomers, Anion Receptor Chemistry reflects the current state of the art. Fully referenced and illustrated in colour, it is a welcome addition to the literature.
Part of the highly regarded Biopsy Interpretation Series, this fully revised volume is your definitive guide to mastering biopsy pathology interpretation for prostate cancer care. Biopsy Interpretation of the Prostate, 6th Edition, provides superbly illustrated guidance from a top expert in the field, guiding you through the best utilization of H&E microscopy as well as the latest immunohistochemical markers in order to deliver accurate, reliable diagnoses. Hundreds of full-color illustrations depict the full range of benign and malignant prostatic entities.
Scientific arguments—and indeed arguments in most disciplines—depend on visuals and other nontextual elements; however, most models of argumentation typically neglect these important resources. In Assembling Arguments, Jonathan Buehl offers a concentrated study of scientific argumentation that is sensitive to both the historical and theoretical possibilities of multimodal persuasion as it advances two related claims. First, rhetorical theory—when augmented with methods for reading nonverbal representations—can provide the analytical tools needed to understand and appreciate multimodal scientific arguments. Second, science—an inherently multimodal enterprise—offers ideal subjects for developing general theories of multimodal rhetoric applicable across fields. In developing these claims, Buehl offers a comprehensive account of scientific persuasion as a multimodal process and develops a simple but productive framework for analyzing and teaching multimodal argumentation. Comprising five case studies, the book provides detailed treatments of argumentation in specific technological and historical contexts: argumentation before World War I, when images circulated by hand and by post; argumentation during the mid-twentieth century, when computers were beginning to bolster scientific inquiry but images remained hand-crafted products; and argumentation at the turn of the twenty-first century—an era of digital revolutions and digital fraud. Each study examines the rhetorical problems and strategies of specific scientists to investigate key issues regarding visualization and argument: 1) establishing new instruments as reliable sources of visual evidence; 2) creating novel arguments from reliable visual evidence; 3) creating novel arguments with unreliable visual evidence; 4) preserving the credibility of visualization practices; and 5) creating multimodal artifacts before and in the era of digital circulation. Given the growing enterprise of rhetorical studies and the field's contributions to communication practices in all disciplines, rhetoricians need a comprehensive rhetoric of science—one that accounts for the multimodal arguments that change our relation to reality. Assembling Arguments argues that such rhetoric should enable the interpretation of visual scientific arguments and improve science-writing instruction.
This book covers fundamental aspects in the preparation of polymeric in-situ, stimuli-responsive hydrogels; the properties, characterization, chemistry, and fabrication of these hydrogels is detailed, helping the reader to select the most appropriate material and design for the desired application. The book goes on to review applications in ophthalmic drug delivery, covering in vitro and in vivo models, animal models, preclinical testing, patents and more. Stimuli-responsive Hydrogels for Ophthalmic Drug Delivery is a must-have reference for researchers and academics in the fields of materials science, biomaterials, pharmacology and polymer science, with an interest in clinical aspects of hydrogel design and application. - Provides step-by-step coverage for engineering in-situ and stimuli-responsive hydrogels, from design, characterization, and toxicity considerations to fabrication, process optimization, and drug release kinetics - Utilizes an interdisciplinary approach, bringing together authors from pharmacology, polymer science, and medical backgrounds - Details the advantages and challenges of using stimuli-responsive hydrogels for ophthalmic drug delivery, with a focus on clinical translation
Weeds are rarely considered a priority despite the fact that all active farmers know that the majority of their variable costs and time are devoted to eradicating them. Even most crop losses due to pests can be traced directly back to weeds, which harbor the pests as secondary hosts. In the Molecular Biology of Weed Control, Jonathan Gressel focuses attention upon the tools of molecular biology that can be used effectively in the science of weed control. Always keeping his perspective congruent with that of the working farmer, Gressel explains how weed biologists and ecologists are beginning to use recently developed tools to control intransigent weed species in modern as well as less developed areas of the world. With his usual candor, Gressel evaluates past efforts, while also exploring future prospects for replacing chemical herbicides with genetic engineering, to improve a crop's ability to compete against its feral cousins for light, nutrients, and water. Like much of Gressel's work, this book should be mandatory reading for all agriculturists and plant scientists, so that they employ and encourage what is truly effective and efficient in meeting one of this century's most critical challenges: maximizing agricultural productivity.
This book documents the history of pi from the dawn of mathematical time to the present. One of the beauties of the literature on pi is that it allows for the inclusion of very modern, yet accessible, mathematics. The articles on pi collected herein fall into various classes. First and foremost there is a selection from the mathematical and computational literature of four millennia. There is also a variety of historical studies on the cultural significance of the number. Additionally, there is a selection of pieces that are anecdotal, fanciful, or simply amusing. For this new edition, the authors have updated the original material while adding new material of historical and cultural interest. There is a substantial exposition of the recent history of the computation of digits of pi, a discussion of the normality of the distribution of the digits, and new translations of works by Viete and Huygen.
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