Jonathan F. Russell's Books

Genetic Steroid Disorders

Chapter 3J. Aromatase Deficiency and Aromatase Excess

By: Jonathan F. Russell,Jenise C. Wong,Melvin M. Grumbach

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Genetic Steroid Disorders

Chapter 3J. Aromatase Deficiency and Aromatase Excess

By: Jonathan F. Russell,Jenise C. Wong,Melvin M. Grumbach

Aromatase is a cytochrome P450 enzyme that catalyzes a critical step in the conversion of androgens (C19 steroids) to estrogens (C18 steroids). Mutations in the aromatase gene (CYP19A1) can result in a lack of aromatase activity and, as a consequence, impairment in estrogen biosynthesis. The functional consequences of this deficiency begin in utero owing to the inability of the placenta to convert androgens to estrogens. This disorder is termed aromatase deficiency (AD). Upon the initial identification of patients with AD, certain clinical findings, such as virilization of the pregnant mother and 46,XX fetus, were easily understood based on the known effects of placental aromatase on the conversion of C19 androgens and androgen precursors to estrogens. However, the discovery that the lack of estrogens in both females and males with AD leads to the absence of a pubertal growth spurt, delayed bone age, delayed epiphyseal fusion, and decreased accrual of bone mass in the male (not only in the female) has transformed our understanding of the role of estrogen on the male skeleton. It is now established that in both females and males, estrogen induces the pubertal growth spurt and mediates epiphyseal fusion. In this chapter we summarize the clinical characteristics, pathophysiology, differential diagnosis, and treatment of human AD. The implications of AD for the clinical use of aromatase inhibitors are reviewed.

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Elsevier Inc. Chapters

Published Date

ISBN 10

0128072873

ISBN 13

9780128072875

The Second Crusade

Extending the Frontiers of Christendom

By: Jonathan Phillips

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The Second Crusade

Extending the Frontiers of Christendom

By: Jonathan Phillips

The Second Crusade (1145-1149) was an extraordinarily bold attempt to overcome unbelievers on no less than three fronts. Crusader armies set out to defeat Muslims in the Holy Land and in Iberia as well as pagans in northeastern Europe. But, to the shock and dismay of a society raised on the triumphant legacy of the First Crusade, only in Iberia did they achieve any success. This book, the first in 140 years devoted to the Second Crusade, fills a major gap in our understanding of the Crusades and their importance in medieval European history. Historian Jonathan Phillips draws on the latest developments in Crusade studies to cast new light on the origins, planning, and execution of the Second Crusade, some of its more radical intentions, and its unprecedented ambition. With original insights into the legacy of the First Crusade and the roles of Pope Eugenius III and King Conrad III of Germany, Phillips offers the definitive work on this neglected Crusade that, despite its failed objectives, exerted a profound impact across Europe and the eastern Mediterranean.

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Page Count

390

Publisher

Yale University Press

Published Date

ISBN 10

0300168365

ISBN 13

9780300168365

Non-Governmental Development Organizations and the Poverty Reduction Agenda

The moral crusaders

By: Jonathan J. Makuwira

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Non-Governmental Development Organizations and the Poverty Reduction Agenda

The moral crusaders

By: Jonathan J. Makuwira

The Non-Governmental Development Organisations (NGDOs) have, over the past two decades, entered centre stage in their active participation in the social, political and economic issues affecting both the developing and developed world. This book offers a highly stimulating and concise summary of the NGDO sector by examining their history and metamorphosis; their influence on the social, political and economic landscapes of the ‘Northern’ and ‘Southern’ governments and societies. The author analyses competing theoretical and conceptual debates not only regarding their contribution to the global social political dynamism but also on the sector’s changing external influence as they try and mitigate poverty in marginalized communities. This book presents NGDOs as multidimensional actors propelled by the desire to make a lasting change but constrained by market-oriented approaches to development and other factors both internal and external to their environment. While a lot of attention has been given to understanding international NGDOs like World Vision International, Oxfam, Care International and Plan International, this book offers a critical analysis of grassroots organizations – those NGDOs founded and established by locals and operate at the deepest end of the development contexts. This work will be of interest to students and scholars in a range of areas including Development Studies, International Organizations and Globalization.

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158

Publisher

Routledge

Published Date

ISBN 10

1317934512

ISBN 13

9781317934516

The Benderly Boys and American Jewish Education

By: Jonathan B. Krasner

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The Benderly Boys and American Jewish Education

By: Jonathan B. Krasner

The first full-scale history of the creation, growth, and ultimate decline of the dominant twentieth-century model for American Jewish education

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512

Publisher

UPNE

Published Date

ISBN 10

1611682932

ISBN 13

9781611682939

Whose America?

Culture Wars in the Public Schools

By: Jonathan Zimmerman

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Whose America?

Culture Wars in the Public Schools

By: Jonathan Zimmerman

What do America's children learn about American history, American values, and human decency? Who decides? In this absorbing book, Jonathan Zimmerman tells the dramatic story of conflict, compromise, and more conflict over the teaching of history and morality in twentieth-century America. In history, whose stories are told, and how? As Zimmerman reveals, multiculturalism began long ago. Starting in the 1920s, various immigrant groups--the Irish, the Germans, the Italians, even the newly arrived Eastern European Jews--urged school systems and textbook publishers to include their stories in the teaching of American history. The civil rights movement of the 1960s and '70s brought similar criticism of the white version of American history, and in the end, textbooks and curricula have offered a more inclusive account of American progress in freedom and justice. But moral and religious education, Zimmerman argues, will remain on much thornier ground. In battles over school prayer or sex education, each side argues from such deeply held beliefs that they rarely understand one another's reasoning, let alone find a middle ground for compromise. Here there have been no resolutions to calm the teaching of history. All the same, Zimmerman argues, the strong American tradition of pluralism has softened the edges of the most rigorous moral and religious absolutism.

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330

Publisher

Harvard University Press

Published Date

ISBN 10

0674045440

ISBN 13

9780674045446

The "Russian" Civil Wars, 1916-1926

Ten Years That Shook the World

By: Jonathan Smele

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The "Russian" Civil Wars, 1916-1926

Ten Years That Shook the World

By: Jonathan Smele

This volume offers a comprehensive and original analysis and reconceptualisation of the compendium of struggles that wracked the collapsing Tsarist empire and the emergent USSR, profoundly affecting the history of the twentieth century. Indeed, the reverberations of those decade-long wars echo to the present day - not despite, but because of the collapse of the Soviet Union, which re-opened many old wounds, from the Baltic to the Caucasus. Contemporary memorialising and 'de-memorialising' of these wars, therefore form part of the book's focus, but at its heart lie the struggles between various Russian political and military forces which sought to inherit and preserve, or even expand, the territory of the tsars, overlain with examinations of the attempts of many non-Russian national and religious groups to divide the former empire. The reasons why some of the latter were successful (Poland and Finland, for example), while others (Ukraine, Georgia and the Muslim Basmachi) were not, are as much the author's concern as are explanations as to why the chief victors of the 'Russian' Civil Wars were the Bolsheviks. Tellingly, the work begins and ends with battles in Central Asia - a theatre of the 'Russian' Civil Wars that was closer to Mumbai than it was to Moscow.

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Page Count

460

Publisher

Oxford University Press

Published Date

ISBN 10

0190613211

ISBN 13

9780190613211

The Complete Guide to Wealth Preservation and Estate Planning

By: Jonathan G. Blattmachr

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The Complete Guide to Wealth Preservation and Estate Planning

By: Jonathan G. Blattmachr

The Complete Guide to Wealth Preservation and Estate Planning is written for everyone from families to financial planners, lawyers, accountants, insurance underwriters, security and investment advisors and business owners.

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764

Publisher

Regnery Publishing

Published Date

ISBN 10

0895262541

ISBN 13

9780895262547

Get Capone

The Secret Plot That Captured America's Most Wante

By: Jonathan Eig

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Get Capone

The Secret Plot That Captured America's Most Wante

By: Jonathan Eig

The real story of how the federal government finally apprehended and convicted America’s most notorious criminal, Al Capone. Drawing on recently discovered government documents, wiretap transcripts, and Al Capone’s handwritten personal letters, New York Times bestselling author Jonathan Eig tells the dramatic story of the rise and fall of the nation’s most infamous criminal in rich new detail. From the moment he arrived in Chicago in 1920, Capone found himself in a world with limitless opportunity. Within a few years Capone controlled an illegal bootlegging business with annual revenue rivaling that of some of the nation’s largest corporations. Along the way he corrupted the Chicago police force and local courts while becoming one of the world’s first international celebrities. Legend credits Eliot Ness and his “Untouchables” with apprehending Capone, but Eig shows that this wasn’t so. In Get Capone, the man known as “Scarface” emerges as a complex man, doomed as much by his ego as by his vicious criminality. This is the real Al Capone.

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Page Count

498

Publisher

Simon and Schuster

Published Date

ISBN 10

1439199892

ISBN 13

9781439199893

Augusta Georgia, the Canal

By: Jonathan Covington

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Augusta Georgia, the Canal

By: Jonathan Covington

A historical and Photographic Journey down the Power and Navigation Canal that made Augusta Georgia into the Lowell of the south. Contains Historic Reports and Photography Detailing the rich history that stretches along the Augusta Canal.

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234

Publisher

Lulu.com

Published Date

ISBN 10

0557035147

ISBN 13

9780557035144

Geotechnical Earthquake Engineering

By: Steven L. Kramer,Jonathan P. Stewart

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Geotechnical Earthquake Engineering

By: Steven L. Kramer,Jonathan P. Stewart

This fully updated second edition provides an introduction to geotechnical earthquake engineering for first-year graduate students in geotechnical or earthquake engineering graduate programs with a level of detail that will also be useful for more advanced students as well as researchers and practitioners. It begins with an introduction to seismology and earthquake ground motions, then presents seismic hazard analysis and performance-based earthquake engineering (PBEE) principles. Dynamic soil properties pertinent to earthquake engineering applications are examined, both to facilitate understanding of soil response to seismic loads and to describe their practical measurement as part of site characterization. These topics are followed by site response and its analysis and soil–structure interaction. Ground failure in the form of soil liquefaction, cyclic softening, surface fault rupture, and seismically induced landslides are also addressed, and the book closes with a chapter on soil improvement and hazard mitigation. The first edition has been widely used around the world by geotechnical engineers as well as many seismologists and structural engineers. The main text of this book and the four appendices: • Cover fundamental concepts in applied seismology, geotechnical engineering, and structural dynamics. • Contain numerous references for further reading, allowing for detailed exploration of background or more advanced material. • Present worked example problems that illustrate the application of key concepts emphasized in the text. • Include chapter summaries that emphasize the most important points. • Present concepts of performance-based earthquake engineering with an emphasis on uncertainty and the types of probabilistic analyses needed to implement PBEE in practice. • Present a broad, interdisciplinary narrative, drawing from the fields of seismology, geotechnical engineering, and structural engineering to facilitate holistic understanding of how geotechnical earthquake engineering is applied in seismic hazard and risk analyses and in seismic design.

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1061

Publisher

CRC Press

Published Date

ISBN 10

1040115942

ISBN 13

9781040115947

Book's by Jonathan F. Russell

Genetic Steroid Disorders

Genetic Steroid Disorders

The Second Crusade

The Second Crusade

Non-Governmental Development Organizations and the Poverty Reduction Agenda

Non-Governmental Development Organizations and the Poverty Reduction Agenda

The Benderly Boys and American Jewish Education

The Benderly Boys and American Jewish Education

Whose America?

Whose America?

The "Russian" Civil Wars, 1916-1926

The "Russian" Civil Wars, 1916-1926

The Complete Guide to Wealth Preservation and Estate Planning

The Complete Guide to Wealth Preservation and Estate Planning

Get Capone

Get Capone

Augusta Georgia, the Canal

Augusta Georgia, the Canal

Geotechnical Earthquake Engineering

Geotechnical Earthquake Engineering

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