John Y. Chen's Books

Progress in Heterocyclic Chemistry

By: Gordon Gribble,John A. Joule

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Progress in Heterocyclic Chemistry

By: Gordon Gribble,John A. Joule

Progress in Heterocyclic Chemistry (PHC), Volume 28 is an annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year's literature on heterocyclic chemistry and articles on new and developing topics of particular interest to heterocyclic chemists. The highlight chapters in Volume 28 are all written by leading researchers and constitute a systematic survey of the important original material reported in the literature of heterocyclic chemistry during 2015. Additional articles in this volume include Semi-conjugated Heteroaromatic Rings and beta-Lactam Chemistry. As with previous volumes in the series, Volume 28 will enable academic and industrial chemists, and advanced students, to keep abreast of developments in heterocyclic chemistry in a convenient way. - Recognized as the premiere review of heterocyclic chemistry - Includes contributions from leading researchers in the field - Provides a systematic survey of the important 2015 heterocyclic chemistry literature - Presents articles on new and developing topics of interest to heterocyclic chemists

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Page Count

684

Publisher

Elsevier

Published Date

ISBN 10

0081007612

ISBN 13

9780081007617

Clinical Immuno-Oncology - E-Book

By: John E. Niederhuber

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Clinical Immuno-Oncology - E-Book

By: John E. Niederhuber

Offering focused, practical, and up-to-date content on immunotherapies used to treat a wide variety of cancer types, Clinical Immuno-Oncology covers the basic cellular and molecular mechanisms involved in cancer initiation and progression. The text reviews the development of tumor specific antigens and the challenges of developing cancer immunotherapies. Every effort is made to relate the fundamental aspects of host immunity to the efficacy of current immunotherapies and how they work in conjunction with the immune system to combat cancer. This foundational resource explains the basics of cancer immunotherapy, discusses best practices, and provides recommendations from experienced clinicians in the field. Dr. John E. Niederhuber and a team of expert contributing authors provide clinically focused information essential for integrating these new therapies into practice—making this an ideal resource for fellows, practitioners, and other cancer team members in medical oncology, radiation oncology, cancer surgery, immunology, and cancer research. - Offers balanced and synthesized content on clinical science, clinical and translational research, and evidence-based practice for cutting-edge immunotherapies. - Discusses clinical applications of immunotherapies in common types of cancer including melanoma, breast cancer, pancreatic cancer, colon and rectum cancer, prostate cancer, leukemias, and hematologic malignancies. - Includes dedicated chapters on immune responses, innate immunity, active immunization against cancer, and cell-based therapies by leading experts. - Covers key topics such as cancer immunotherapy in the presence of COVID-19, immunotherapeutics, new findings concerning the role of the microbiome in immunotherapy, advances in engineered cell-based therapies, and active immunization against cancer.

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419

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0323877648

ISBN 13

9780323877640

A Handbook of Derivatives for Mass Spectrometry

By: Vladimir Zaikin,John M. Halket

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A Handbook of Derivatives for Mass Spectrometry

By: Vladimir Zaikin,John M. Halket

Chemical derivatisation of functional groups has proved popular since the beginning of organic mass spectrometry as a means to enhance the stability and volatility of the analytes as well as facilitating structure elucidation. This book provides comprehensive information on the wide range of derivatisation methods. Each chapter looks at a particular area of derivatisation and includes extensive references to the literature for further research where necessary. There are nearly 1800 references, which, as well as full bibliographic information, include chapter/paper titles where appropriate and Digital Object Identifiers (DOIs) to allow easy retrieval of the online version of the referenced publication. The emergence of atmospheric pressure ionisation and other soft ionisation techniques has not diminished the interest in such chemical techniques, as witnessed by the many chemical tags used in quantitative proteomics (Chapter 9). The last two chapters, a substantial part of the book, deal with derivatisation for use with soft ionisation of both small and large molecules. Chapters Silylation Acylation Alkylation (Arylation) Cyclic derivatives Monofunctional compounds Polyfunctional compounds On-line derivatisation/degradation Soft ionisation—small molecules Soft ionisation—large molecules

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545

Publisher

IM Publications

Published Date

ISBN 10

1901019098

ISBN 13

9781901019094

Through-Silicon Vias for 3D Integration

By: John Lau

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Through-Silicon Vias for 3D Integration

By: John Lau

A comprehensive guide to TSV and other enabling technologies for 3D integration Written by an expert with more than 30 years of experience in the electronics industry, Through-Silicon Vias for 3D Integration provides cutting-edge information on TSV, wafer thinning, thin-wafer handling, microbumping and assembly, and thermal management technologies. Applications to highperformance, high-density, low-power-consumption, wide-bandwidth, and small-form-factor electronic products are discussed. This book offers a timely summary of progress in all aspects of this fascinating field for professionals active in 3D integration research and development, those who wish to master 3D integration problem-solving methods, and anyone in need of a low-power, wide-bandwidth design and high-yield manufacturing process for interconnect systems. Coverage includes: Nanotechnology and 3D integration for the semiconductor industry TSV etching, dielectric-, barrier-, and seed-layer deposition, Cu plating, CMP, and Cu revealing TSVs: mechanical, thermal, and electrical behaviors Thin-wafer strength measurement Wafer thinning and thin-wafer handling Microbumping, assembly, and reliability Microbump electromigration Transient liquid-phase bonding: C2C, C2W, and W2W 2.5D IC integration with interposers 3D IC integration with interposers Thermal management of 3D IC integration 3D IC packaging

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514

Publisher

McGraw Hill Professional

Published Date

ISBN 10

0071785140

ISBN 13

9780071785143

Naturally Occurring Small Molecules For Disease And Cancer Treatment: Therapeutic Benefits In Combination Therapy

By: John Wing Shing Ho

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Naturally Occurring Small Molecules For Disease And Cancer Treatment: Therapeutic Benefits In Combination Therapy

By: John Wing Shing Ho

Western drugs and target medicines for disease treatment come with undesirable side effects that have limited their use in patients for an extended period of time. It is warranted to develop a treatment strategy with alternative medicines to reduce toxicity relating to drugs, in particular, cancer drugs. Thus, a combination therapy with herbal medicines provides a more effective treatment method for hard-to-treat diseases. The recent breakthroughs in naturally occurring small molecules from herbal medicines have provided experimental evidence and are clinically significant in treatment strategies.This unique volume presents the recent developments in the field of herbal medicines for the treatment of diseases and cancer. Recent progress on small molecules isolated from herbal medicines that exhibit therapeutic benefits in humans is highlighted. The book provides an overview of the significant discoveries and pioneering contributions of herbal medicines in combination with other drugs; the author's evaluation of the combination therapy in cancer treatment; and a recent discovery of crocodile tissue extract with pharmacological properties.

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Page Count

170

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World Scientific

Published Date

ISBN 10

9814525642

ISBN 13

9789814525640

Chiplet Design and Heterogeneous Integration Packaging

By: John H. Lau

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Chiplet Design and Heterogeneous Integration Packaging

By: John H. Lau

The book focuses on the design, materials, process, fabrication, and reliability of chiplet design and heterogeneous integraton packaging. Both principles and engineering practice have been addressed, with more weight placed on engineering practice. This is achieved by providing in-depth study on a number of major topics such as chip partitioning, chip splitting, multiple system and heterogeneous integration with TSV-interposers, multiple system and heterogeneous integration with TSV-less interposers, chiplets lateral communication, system-in-package, fan-out wafer/panel-level packaging, and various Cu-Cu hybrid bonding. The book can benefit researchers, engineers, and graduate students in fields of electrical engineering, mechanical engineering, materials sciences, and industry engineering, etc.

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Page Count

542

Publisher

Springer Nature

Published Date

ISBN 10

9811999171

ISBN 13

9789811999178

Organic Syntheses, Volume 96

By: John L Wood

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Organic Syntheses, Volume 96

By: John L Wood

The current volume continues the tradition of the Organic Syntheses series, providing carefully checked and edited experimental procedures that describe important synthetic methods, transformations, reagents, and synthetic building blocks or intermediates with demonstrated utility in organic synthesis. These significant and interesting procedures should prove worthwhile to many synthetic chemists working in increasingly diverse areas. A trusted guide for professionals in organic and medicinal chemistry in academia, government, and industries, including pharmaceuticals, fine chemicals, agrochemicals, and biotechnological products.

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648

Publisher

John Wiley & Sons

Published Date

ISBN 10

1119707765

ISBN 13

9781119707769

Next Generation Sequencing and Whole Genome Selection in Aquaculture

By: Zhanjiang (John) Liu

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Next Generation Sequencing and Whole Genome Selection in Aquaculture

By: Zhanjiang (John) Liu

Recent developments in DNA marker technologies, in particular the emergence of Single Nucleotide Polymorphism (SNP) discovery, have rendered some of the traditional methods of genetic research outdated. Next Generation Sequencing and Whole Genome Selection in Aquaculture comprehensively covers the current state of research in whole genome selection and applies these discoveries to the aquaculture industry specifically. The text begins with a thorough review of SNP and transitions into topics such as next generation sequencing, EST data mining, SNP quality assessment, and whole genome selection principles. Ending with a discussion of the technology's specific applications to the industry, this text will be a valuable reference for those involved in all aspects of aquaculture research. Special Features: Unique linking of SNP technologies, next generation sequencing technologies, and whole genome selection in the context of aquaculture research Thorough review of Single Nucleotide Polymorphism and existing research 8-page color plate section featuring detailed illustrations

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248

Publisher

John Wiley and Sons

Published Date

ISBN 10

0470958928

ISBN 13

9780470958926

Heterogeneous Integrations

By: John H. Lau

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Heterogeneous Integrations

By: John H. Lau

Heterogeneous integration uses packaging technology to integrate dissimilar chips, LED, MEMS, VCSEL, etc. from different fabless houses and with different functions and wafer sizes into a single system or subsystem. How are these dissimilar chips and optical components supposed to talk to each other? The answer is redistribution layers (RDLs). This book addresses the fabrication of RDLs for heterogeneous integrations, and especially focuses on RDLs on: A) organic substrates, B) silicon substrates (through-silicon via (TSV)-interposers), C) silicon substrates (bridges), D) fan-out substrates, and E) ASIC, memory, LED, MEMS, and VCSEL systems. The book offers a valuable asset for researchers, engineers, and graduate students in the fields of semiconductor packaging, materials sciences, mechanical engineering, electronic engineering, telecommunications, networking, etc.

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381

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Springer

Published Date

ISBN 10

9811372241

ISBN 13

9789811372247

Digital Integrated Circuits

Analysis and Design, Second Edition

By: John E. Ayers

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Digital Integrated Circuits

Analysis and Design, Second Edition

By: John E. Ayers

Exponential improvement in functionality and performance of digital integrated circuits has revolutionized the way we live and work. The continued scaling down of MOS transistors has broadened the scope of use for circuit technology to the point that texts on the topic are generally lacking after a few years. The second edition of Digital Integrated Circuits: Analysis and Design focuses on timeless principles with a modern interdisciplinary view that will serve integrated circuits engineers from all disciplines for years to come. Providing a revised instructional reference for engineers involved with Very Large Scale Integrated Circuit design and fabrication, this book delves into the dramatic advances in the field, including new applications and changes in the physics of operation made possible by relentless miniaturization. This book was conceived in the versatile spirit of the field to bridge a void that had existed between books on transistor electronics and those covering VLSI design and fabrication as a separate topic. Like the first edition, this volume is a crucial link for integrated circuit engineers and those studying the field, supplying the cross-disciplinary connections they require for guidance in more advanced work. For pedagogical reasons, the author uses SPICE level 1 computer simulation models but introduces BSIM models that are indispensable for VLSI design. This enables users to develop a strong and intuitive sense of device and circuit design by drawing direct connections between the hand analysis and the SPICE models. With four new chapters, more than 200 new illustrations, numerous worked examples, case studies, and support provided on a dynamic website, this text significantly expands concepts presented in the first edition.

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616

Publisher

CRC Press

Published Date

ISBN 10

1439894957

ISBN 13

9781439894958

Statistical Prediction and Machine Learning

By: John Tuhao Chen,Clement Lee,Lincy Y. Chen

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Statistical Prediction and Machine Learning

By: John Tuhao Chen,Clement Lee,Lincy Y. Chen

Written by an experienced statistics educator and two data scientists, this book unifies conventional statistical thinking and contemporary machine learning framework into a single overarching umbrella over data science. The book is designed to bridge the knowledge gap between conventional statistics and machine learning. It provides an accessible approach for readers with a basic statistics background to develop a mastery of machine learning. The book starts with elucidating examples in Chapter 1 and fundamentals on refined optimization in Chapter 2, which are followed by common supervised learning methods such as regressions, classification, support vector machines, tree algorithms, and range regressions. After a discussion on unsupervised learning methods, it includes a chapter on unsupervised learning and a chapter on statistical learning with data sequentially or simultaneously from multiple resources. One of the distinct features of this book is the comprehensive coverage of the topics in statistical learning and medical applications. It summarizes the authors’ teaching, research, and consulting experience in which they use data analytics. The illustrating examples and accompanying materials heavily emphasize understanding on data analysis, producing accurate interpretations, and discovering hidden assumptions associated with various methods. Key Features: Unifies conventional model-based framework and contemporary data-driven methods into a single overarching umbrella over data science. Includes real-life medical applications in hypertension, stroke, diabetes, thrombolysis, aspirin efficacy. Integrates statistical theory with machine learning algorithms. Includes potential methodological developments in data science.

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315

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CRC Press

Published Date

ISBN 10

1040096301

ISBN 13

9781040096307

Remote Sensing Digital Image Analysis

By: John A. Richards

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Remote Sensing Digital Image Analysis

By: John A. Richards

Remote Sensing Digital Image Analysis provides a comprehensive treatment of the methods used for the processing and interpretation of remotely sensed image data. Over the past decade there have been continuing and significant developments in the algorithms used for the analysis of remote sensing imagery, even though many of the fundamentals have substantially remained the same. As with its predecessors this new edition again presents material that has retained value but also includes newer techniques, covered from the perspective of operational remote sensing. The book is designed as a teaching text for the senior undergraduate and postgraduate student, and as a fundamental treatment for those engaged in research using digital image analysis in remote sensing. The presentation level is for the mathematical non-specialist. Since the very great number of operational users of remote sensing come from the earth sciences communities, the text is pitched at a level commensurate with their background. The chapters progress logically through means for the acquisition of remote sensing images, techniques by which they can be corrected, and methods for their interpretation. The prime focus is on applications of the methods, so that worked examples are included and a set of problems conclude each chapter.

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576

Publisher

Springer Nature

Published Date

ISBN 10

303082327X

ISBN 13

9783030823276

Hormones and Reality

Epigenetic Regulation of the Endocrine System

By: John S. Torday

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Hormones and Reality

Epigenetic Regulation of the Endocrine System

By: John S. Torday

Cellular-molecular approach to evolution has led to radical changes in our understanding of biologic principles ranging from the Cell, to the Life Cycle, Development, Homeostasis, Senescence/Aging, Heterochrony, Pleiotropy, Phenotype, and perhaps the purpose of life itself. Much of this new way of thinking about biology and medicine emanates from experimental evidence for epigenetic inheritance. This leads one to question whether our unicellular state is the actual primary level of selection. One particular system that is now recognized as being under the auspices of epigenetic inheritance is the endocrine system, which is conventionally thought to regulate physiologic homeostasis. However, because the sex hormones play such a major role in behaviors related to the acquisition of epigenetic data, and the processing of such epigenetic data by the gonads during meiosis, their role in the evolution of the organism become tractable. The composite of the activities of the individual over the course of its lifetime can now be understood causally, resulting from the orchestration of its physiology by hormones, prenatally, postnatally and during the aging process, across the entire life span of the organism. Specific behaviors over the course of the life cycle during childhood, adolescence, puberty, adulthood and aging can now be understood mechanistically rather than merely as milestones in the various stages of life. With the above considerations in mind, this book presents the cellular-evolutionary perspective towards the relationship of the organism with its surroundings, human and non-human alike renders biology and medicine a continuum instead of fragmented, un-related anecdotes.

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Page Count

158

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Springer Nature

Published Date

ISBN 10

3030936910

ISBN 13

9783030936914

Surrogate Endpoints in Medicine

By: John A. Wagner

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Surrogate Endpoints in Medicine

By: John A. Wagner

A review of the use of surrogate endpoints and biomarkers in drug development, validation and qualification of biomarkers, pharmacogenic biomarkers, and novel approaches to biomarker discovery. It also discusses specific biomarkers including QTc prolongation and biomarkers of early stage cancer.

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IOS Press

Published Date

ISBN 10

158603247X

ISBN 13

9781586032470

Broken Movement

The Neurobiology of Motor Recovery after Stroke

By: John W. Krakauer,S. Thomas Carmichael

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Broken Movement

The Neurobiology of Motor Recovery after Stroke

By: John W. Krakauer,S. Thomas Carmichael

An account of the neurobiology of motor recovery in the arm and hand after stroke by two experts in the field. Stroke is a leading cause of disability in adults and recovery is often difficult, with existing rehabilitation therapies largely ineffective. In Broken Movement, John Krakauer and S. Thomas Carmichael, both experts in the field, provide an account of the neurobiology of motor recovery in the arm and hand after stroke. They cover topics that range from behavior to physiology to cellular and molecular biology. Broken Movement is the only accessible single-volume work that covers motor control and motor learning as they apply to stroke recovery and combines them with motor cortical physiology and molecular biology. The authors cast a critical eye at current frameworks and practices, offer new recommendations for promoting recovery, and propose new research directions for the study of brain repair. Krakauer and Carmichael discuss such subjects as the behavioral phenotype of hand and arm paresis in human and non-human primates; the physiology and anatomy of the motor system after stroke; mechanisms of spontaneous recovery; the time course of early recovery; the challenges of chronic stroke; and pharmacological and stem cell therapies. They argue for a new approach in which patients are subjected to higher doses and intensities of rehabilitation in a more dynamic and enriching environment early after stroke. Finally they review the potential of four areas to improve motor recovery: video gaming and virtual reality, invasive brain stimulation, re-opening the sensitive period after stroke, and the application of precision medicine.

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288

Publisher

MIT Press

Published Date

ISBN 10

0262545837

ISBN 13

9780262545839

Mechanisms of Atmospheric Oxidation of the Oxygenates

By: Jack Calvert,Abdelwahid Mellouki,John Orlando,Michael Pilling,Timothy Wallington

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Mechanisms of Atmospheric Oxidation of the Oxygenates

By: Jack Calvert,Abdelwahid Mellouki,John Orlando,Michael Pilling,Timothy Wallington

Prepared by an international team of eminent atmospheric scientists, Mechanisms of Atmospheric Oxidation of the Oxygenates is an authoritative source of information on the role of oxygenates in the chemistry of the atmosphere. The oxygenates, including the many different alcohols, ethers, aldehydes, ketones, acids, esters, and nitrogen-atom containing oxygenates, are of special interest today due to their increased use as alternative fuels and fuel additives. This book describes the physical properties of oxygenates, as well as the chemical and photochemical parameters that determine their reaction pathways in the atmosphere. Quantitative descriptions of the pathways of the oxygenates from release or formation in the atmosphere to final products are provided, as is a comprehensive review and evaluation of the extensive kinetic literature on the atmospheric chemistry of the different oxygenates and their many halogen-atom substituted analogues. This book will be of interest to modelers of atmospheric chemistry, environmental scientists and engineers, and air quality planning agencies as a useful input for development of realistic modules designed to simulate the atmospheric chemistry of the oxygenates, their major oxidation products, and their influence on ozone and other trace gases within the troposhere.

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1634

Publisher

Oxford University Press

Published Date

ISBN 10

0199877475

ISBN 13

9780199877478

Scotland's Heritage

A Photographic Journey

By: Richard Haight,Frances Ross,James B. Hannon,John Hannavy

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Scotland's Heritage

A Photographic Journey

By: Richard Haight,Frances Ross,James B. Hannon,John Hannavy

... These volumes provide the very latest in this critical technology and are an invaluable resource for scientists in both academia and industry concerned with the semiconductor future and all of science.'Foreword by Leonard C Feldman (Director Institute for Advanced Materials, Devices and Nanotechnology, Rutgers University, USA)Highlights. As we delve more deeply into the physics and chemistry of functional materials and processes, we are inexorably driven to the nanoscale. And nowhere is the development of instrumentation and associated techniques more important to scientific progress than in the area of nanoscience. The dramatic expansion of efforts to peer into nanoscale materials and processes has made it critical to capture and summarize the cutting-edge instrumentation and techniques that have become indispensable for scientific investigation in this arena. This Handbook is a key resource developed for scientists, engineers and advanced graduate students in which eminent scientists present the forefront of instrumentation and techniques for the study of structural, optical and electronic properties of semiconductor nanostructures.

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644

Publisher

World Scientific

Published Date

ISBN 10

9814322806

ISBN 13

9789814322805

Epigenetics, Nuclear Organization & Gene Function

With implications of epigenetic regulation and genetic architecture for human development and health

By: John C. Lucchesi

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Epigenetics, Nuclear Organization & Gene Function

With implications of epigenetic regulation and genetic architecture for human development and health

By: John C. Lucchesi

Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. Epigenetic modifications are manifest in all aspects of normal cellular differentiation and function, but they can also have damaging effects that result in pathologies such as cancer. Research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine. This book's primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin), and its distribution within a functionally compartmentalized nucleus. This architectural organization of the genome plays a major role in the subsequent retrieval, interpretation, and execution of both genetic and epigenetic information.

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Page Count

240

Publisher

Oxford University Press

Published Date

ISBN 10

0192567160

ISBN 13

9780192567161

Solving Urban Infrastructure Problems Using Smart City Technologies

Handbook on Planning, Design, Development, and Regulation

By: John R. Vacca

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Solving Urban Infrastructure Problems Using Smart City Technologies

Handbook on Planning, Design, Development, and Regulation

By: John R. Vacca

Solving Urban Infrastructure Problems Using Smart City Technologies is the most complete guide for integrating next generation smart city technologies into the very foundation of urban areas worldwide, showing how to make urban areas more efficient, more sustainable, and safer. Smart cities are complex systems of systems that encompass all aspects of modern urban life. A key component of their success is creating an ecosystem of smart infrastructures that can work together to enable dynamic, real-time interactions between urban subsystems such as transportation, energy, healthcare, housing, food, entertainment, work, social interactions, and governance. Solving Urban Infrastructure Problems Using Smart City Technologies is a complete reference for building a holistic, system-level perspective on smart and sustainable cities, leveraging big data analytics and strategies for planning, zoning, and public policy. It offers in-depth coverage and practical solutions for how smart cities can utilize resident's intellectual and social capital, press environmental sustainability, increase personalization, mobility, and higher quality of life. - Brings together experts from academia, government and industry to offer state-of- the-art solutions for urban system problems, showing how smart technologies can be used to improve the lives of the billions of people living in cities across the globe - Demonstrates practical implementation solutions through real-life case studies - Enhances reader comprehension with learning aid such as hands-on exercises, questions and answers, checklists, chapter summaries, chapter review questions, exercise problems, and more

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Page Count

820

Publisher

Elsevier

Published Date

ISBN 10

012816817X

ISBN 13

9780128168172

Orthogonal Arrays

Theory and Applications

By: A.S. Hedayat,N.J.A. Sloane,John Stufken

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Orthogonal Arrays

Theory and Applications

By: A.S. Hedayat,N.J.A. Sloane,John Stufken

Orthogonal arrays have played a vital role in improving the quality of products manufactured throughout the world. This first book on the subject since its introduction more than fifty years ago serves as a key resource to this area of designing experiments. Most of the arrays obtained by the methods in this book are available electronically. Anyone running experiments - whether in a chemistry lab or a manufacturing plant, or in agricultural or medical research - will find this book useful.

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Page Count

433

Publisher

Springer Science & Business Media

Published Date

ISBN 10

1461214785

ISBN 13

9781461214786

Semiconductor Advanced Packaging

By: John H. Lau

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Semiconductor Advanced Packaging

By: John H. Lau

The book focuses on the design, materials, process, fabrication, and reliability of advanced semiconductor packaging components and systems. Both principles and engineering practice have been addressed, with more weight placed on engineering practice. This is achieved by providing in-depth study on a number of major topics such as system-in-package, fan-in wafer/panel-level chip-scale packages, fan-out wafer/panel-level packaging, 2D, 2.1D, 2.3D, 2.5D, and 3D IC integration, chiplets packaging, chip-to-wafer bonding, wafer-to-wafer bonding, hybrid bonding, and dielectric materials for high speed and frequency. The book can benefit researchers, engineers, and graduate students in fields of electrical engineering, mechanical engineering, materials sciences, and industry engineering, etc.

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Page Count

513

Publisher

Springer Nature

Published Date

ISBN 10

9811613761

ISBN 13

9789811613760

Coupled Thermo-Hydro-Mechanical-Chemical Processes in Geo-systems

By: Ove Stephansson,John Hudson,Lanru Jing

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Coupled Thermo-Hydro-Mechanical-Chemical Processes in Geo-systems

By: Ove Stephansson,John Hudson,Lanru Jing

Among the most important and exciting current steps forward in geo-engineering is the development of coupled numerical models. They represent the basic physics of geo-engineering processes which can include the effects of heat, water, mechanics and chemistry. Such models provide an integrating focus for the wide range of geo-engineering disciplines. The articles within this volume were originally presented at the inaugural GeoProc conference held in Stockholm and contain a collection of unusually high quality information not available elsewhere in an edited and coherent form. This collection not only benefits from the latest theoretical developments but also applies them to a number of practical and wide ranging applications. Examples include the environmental issues around radioactive waste disposal deep in rock, and the search for new reserves of oil and gas.

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853

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Elsevier

Published Date

ISBN 10

0080530060

ISBN 13

9780080530062

Logic-Based Benders Decomposition

Theory and Applications

By: John Hooker

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Logic-Based Benders Decomposition

Theory and Applications

By: John Hooker

This book is the first comprehensive guide to logic-based Benders decomposition (LBBD), a general and versatile method for breaking large, complex optimization problems into components that are small enough for practical solution. The author introduces logic-based Benders decomposition for optimization, which substantially generalizes the classical Benders method. It can reduce solution times by orders of magnitude and allows decomposition to be applied to a much wider variety of optimization problems. On the theoretical side, this book provides a full account of inference duality concepts that underlie LBBD, as well as a description of how LBBD can be combined with stochastic and robust optimization, heuristic methods, and decision diagrams. It also clarifies the connection between LBBD and combinatorial Benders cuts for mixed integer programming. On the practical side, it explains how LBBD has been applied to a rapidly growing variety of problem domains. After describing basic theory, this book provides a comprehensive review of the rapidly growing literature that describes these applications, in each case explaining how LBBD is adapted to the problem at hand. In doing so this work provides a sourcebook of ideas for applying LBBD to new problems as they arise.

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148

Publisher

Springer Nature

Published Date

ISBN 10

3031450396

ISBN 13

9783031450396

Odze and Goldblum Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas

By: Robert D. Odze,John R. Goldblum

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Odze and Goldblum Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas

By: Robert D. Odze,John R. Goldblum

Unparalleled in scope and content, Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas provides the most relevant and up-to-date clinical, etiologic, molecular, and therapeutic management information for surgical pathologists in training and in practice. The fully revised 4th Edition of this award-winning title offers a wealth of information in this fast-changing field, including recent advances in molecular biology and immunohistochemistry, in a clearly written, well-structured manner that is easy to read and navigate. This one-stop reference for the entire gastrointestinal system enables you to improve turnaround time when diagnosing a specimen and to clearly report on the prognosis and therapeutic management options to surgical and medical colleagues. Covers the latest developments in molecular technologies and immunohistochemical markers to provide useful diagnostic and prognostic information and inform therapeutic decisions. Provides all the necessary tools to make a comprehensive diagnostic workup, including data from ancillary techniques and molecular findings whenever appropriate. Incorporates more than 3000 high-quality color illustrations to help you recognize and diagnose any tissue sample under the microscope. Reviews next-generation sequencing (NGS) to help identify targetable mutations in gastrointestinal tract tumors and provide more accurate classification and precision therapies. Features extensive tables, graphs, and flowcharts to help you effectively grasp complex topics and streamline your decision-making. Helps you avoid diagnostic errors with practical advice on pitfalls in differential diagnosis. Incorporates the latest WHO guidelines throughout. Winner of the 2015 BMA Medical Book Awards First Prize Award in Pathology.

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2356

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Elsevier Health Sciences

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ISBN 10

0323872646

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9780323872645

Solvent Microextraction

Theory and Practice

By: John M Kokosa,Andrzej Przyjazny,Michael Jeannot

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Solvent Microextraction

Theory and Practice

By: John M Kokosa,Andrzej Przyjazny,Michael Jeannot

This book offers both a practical as well a theoretical approach to Solvent Microextraction (SME) and will help analytical chemists to evaluate SME for a given sample preparation. Introductory chapters overview a comparison of SME with other sample preparation methods, a summary of the technical aspects, and a detailed theoretical treatment of SME. The book then describes the practical aspects of the technique, with detailed “how to” chapters devoted to the preparation and analysis of atmospheric, solid and liquid environmental, clinical and industrial samples. This text will serve as both a handy laboratory desk-reference and an indispensible instructional tool.

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340

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John Wiley & Sons

Published Date

ISBN 10

0470278595

ISBN 13

9780470278598

Heterocyclic Chemistry

By: John A. Joule,Keith Mills

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Heterocyclic Chemistry

By: John A. Joule,Keith Mills

This book has so closely matched the requirements of its readership over the years that it has become the first choice for chemists worldwide. Heterocyclic chemistry comprises at least half of all organic chemistry research worldwide. In particular, the vast majority of organic work done in the pharmaceutical and agrochemical industries is heterocyclic chemistry. The fifth edition of Heterocyclic Chemistry maintains the principal objective of earlier editions – to teach the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable to second- and third-year undergraduate chemistry students. The inclusion of more advanced and current material also makes the book a valuable reference text for postgraduate taught courses, postgraduate researchers, and chemists at all levels working with heterocyclic compounds in industry. Fully updated and expanded to reflect important 21st century advances, the fifth edition of this classic text includes the following innovations: Extensive use of colour to highlight changes in structure and bonding during reactions Entirely new chapters on organometallic heterocyclic chemistry, heterocyclic natural products, especially in biochemical processes, and heterocycles in medicine New sections focusing on heterocyclic fluorine compounds, isotopically labeled heterocycles, and solid-phase chemistry, microwave heating and flow reactors in the heterocyclic context Essential teaching material in the early chapters is followed by short chapters throughout the text which capture the essence of heterocyclic reactivity in concise resumés suitable as introductions or summaries, for example for examination preparation. Detailed, systematic discussions cover the reactivity and synthesis of all the important heterocyclic systems. Original references and references to reviews are given throughout the text, vital for postgraduate teaching and for research scientists. Problems, divided into straightforward revision exercises, and more challenging questions (with solutions available online), help the reader to understand and apply the principles of heterocyclic reactivity and synthesis.

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719

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John Wiley & Sons

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ISBN 10

1118681649

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9781118681640

Redesigning Life

How genome editing will transform the world

By: John Parrington

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Redesigning Life

How genome editing will transform the world

By: John Parrington

Since the birth of civilisation, human beings have manipulated other life-forms. We have selectively bred plants and animals for thousands of years to maximise agricultural production and cater to our taste in pets. The observation of the creation of artificial animal and plant variants was a key stimulant for Charles Darwin's theory of evolution. The ability to directly engineer the genomes of organisms first became possible in the 1970s, when the gene for human insulin was introduced into bacteria to produce this protein for diabetics. At the same time, mice were modified to produce human growth hormone, and grew huge as a result. But these were only our first tottering steps into the possibilities of genetic engineering. In the past few years, the pace of progress has accelerated enormously. We can now cut and paste genes using molecular scissors with astonishing ease, and the new technology of genome editing can be applied to practically any species of plants or animals. 'Mutation chain reaction' can be used to alter the genes of a population of pests, such as flies; as the modified creatures breed, the mutation is spread through the population, so that within a few generations the organism is almost completely altered. At the same time, scientists are also beginning to synthesize new organisms from scratch. These new technologies hold much promise for improving lives. Genome editing has already been used clinically to treat AIDS patients, by genetically modifying their white blood cells to be resistant to HIV. In agriculture, genome editing could be used to engineer species with increased food output, and the ability to thrive in challenging climates. New bacterial forms may be used to generate energy. But these powerful new techniques also raise important ethical dilemmas and potential dangers, pressing issues that are already upon us given the speed of scientific developments. To what extent should parents be able to manipulate the genetics of their offspring — and would designer babies be limited to the rich? Can we effectively weigh up the risks from introducing synthetic lifeforms into complex ecosystems? In this extensively revised paperback edition, John Parrington explains the nature and possibilities of these new scientific developments, which could usher in a brave, new world. We must rapidly come to understand its implications if we are to direct its huge potential to the good of humanity and the planet.

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399

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Oxford University Press

Published Date

ISBN 10

0191079723

ISBN 13

9780191079726

Viroids

Properties, Detection, Diseases and their Control

By: Ahmed Hadidi,Ricardo Flores,John Randles,Joseph Semancik

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Viroids

Properties, Detection, Diseases and their Control

By: Ahmed Hadidi,Ricardo Flores,John Randles,Joseph Semancik

This comprehensive volume presents indispensable and up-to-date information on viroids and viroid diseases. It provides a single source of information on the properties of viroids, the economic impact of viroid diseases, and methods for their detection and control. It examines the diseases associated with different plant species, the geographic distribution and epidemiology of viroids, diseases of possible viroid etiology, and the future applications of viroids. Viroids examines the biology of viroids, molecular characteristics, localization and movement, replication, pathogenesis, viroids and gene silencing, classification, viroid-like satellite RNAs, detection of viroids using bioamplification hosts, biological indexing, polyacrylamide gel electrophoresis, molecular hybridisation and polymerase chain reaction. The book looks at the geographical distribution and epidemiology of viroids in North America, Australasia, China, Japan, Europe, the Middle East, Africa, South America, and at the global level. It covers the control of viroids including quarantine of imported germplasm, availability of viroid-tested propagation materials, thermotherapy, tissue culture, and other conventional strategies as well as biotechnological control approaches. Special topics such as ribozyme reaction of viroids and economic advantages of viroid infection are also included. Other chapters summarise the current state of knowledge concerning viroid diseases of the crop in question and aspects of the natural history of viroids in horticulture. Among the crops covered are potato, tomato, tobacco, cucumber, pome fruits, stone fruits, avocado, citrus, grapevines, hop, chrysanthemum, coleus, columnea, and coconut palm. The four eminent editors of this watershed volume have assembled an international group of more than 70 scientists who have substantial experience with viroids and viroid diseases. They have produced a cohesive and comprehensive work that can be used by students, researchers, extension agents, and regulators. It may also be of a great value to science managers, policy makers, and industries in formulating policies and products to obtain viroid-free plants and control viroid diseases. The information on plant quarantine and certification programs will help anyone concerned with the safe movement of plant material across international boundaries or within a single country.

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392

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CSIRO PUBLISHING

Published Date

ISBN 10

0643099786

ISBN 13

9780643099784

The Genetics and Molecular Biology of Neural Tumors

By: Avery A. Sandberg,John F. Stone

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The Genetics and Molecular Biology of Neural Tumors

By: Avery A. Sandberg,John F. Stone

Collecting an extensive amount of information from thousands of publications by leading investigators in this rapidly developing field, this book provides a convenient and up-to-date one volume source for research in neural tumors of various cellular origins. With over 3,500 references, 110 figures and 120 tables, this volume gathers an astonishing body of knowledge regarding human neural tumors. This book is the first of its kind, encyclopedic and wide-ranging.

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453

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Springer Science & Business Media

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ISBN 10

1597455105

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9781597455107

Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases E-Book

2-Volume Set

By: John E. Bennett,Raphael Dolin,Martin J. Blaser

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Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases E-Book

2-Volume Set

By: John E. Bennett,Raphael Dolin,Martin J. Blaser

For four decades, physicians and other healthcare providers have trusted Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases to provide expert guidance on the diagnosis and treatment of these complex disorders. The 9th Edition continues the tradition of excellence with newly expanded chapters, increased global coverage, and regular updates to keep you at the forefront of this vitally important field. Meticulously updated by Drs. John E. Bennett, Raphael Dolin, and Martin J. Blaser, this comprehensive, two-volume masterwork puts the latest information on challenging infectious diseases at your fingertips. - Provides more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than any other infectious disease resource. - Features an increased focus on antibiotic stewardship; new antivirals for influenza, cytomegalovirus, hepatitis C, hepatitis B., and immunizations; and new recommendations for vaccination against infection with pneumococci, papillomaviruses, hepatitis A, and pertussis. - Covers newly recognized enteroviruses causing paralysis (E-A71, E-D68); emerging viral infections such as Ebola, Zika, Marburg, SARS, and MERS; and important updates on prevention and treatment of C. difficile infection, including new tests that diagnose or falsely over-diagnose infectious diseases. - Offers fully revised content on bacterial pathogenesis, antibiotic use and toxicity, the human microbiome and its effects on health and disease, immunological mechanisms and immunodeficiency, and probiotics and alternative approaches to treatment of infectious diseases. - Discusses up-to-date topics such as use of the new PCR panels for diagnosis of meningitis, diarrhea and pneumonia; current management of infected orthopedic implant infections; newly recognized infections transmitted by black-legged ticks in the USA: Borrelia miyamotoi and Powassan virus; infectious complications of new drugs for cancer; new drugs for resistant bacteria and mycobacteria; new guidelines for diagnosis and therapy of HIV infections; and new vaccines against herpes zoster, influenza, meningococci. - PPID continues its tradition of including leading experts from a truly global community, including authors from Australia, Canada and countries in Europe, Asia, and South America. - Includes regular updates online for the life of the edition. - Features more than 1,500 high-quality, full-color photographs—with hundreds new to this edition. - Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices.

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5208

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Elsevier Health Sciences

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ISBN 10

0323550274

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9780323550277

Steroids in the Laboratory and Clinical Practice

By: John William Honour

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Steroids in the Laboratory and Clinical Practice

By: John William Honour

Steroids in the Laboratory and Clinical Practice covers both basic chemistry and therapeutic application of steroids in a single source. The comprehensive reference addresses the specificity of steroid determinations to clarify confusion arising from the laboratory results. The book covers important advancements in the field and is a valuable addition in the literature addressing all existing knowledge gaps. This is a must have reference for pathologists, laboratorians, endocrinologists, analytical/clinical chemists and biochemists. - Addresses the normal production of steroids and concentrations found in biological fluids and tissues - Presents the changes in steroid concentrations at life events as reference points for clinical investigations - Reviews the genetic disorders of steroids in relation to specific enzyme changes and clinical presentation

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1014

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Elsevier

Published Date

ISBN 10

0128181257

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9780128181256

Resistive RAM and Peripheral Circuitry

An Integrated Circuit Perspective

By: John Reuben

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Resistive RAM and Peripheral Circuitry

An Integrated Circuit Perspective

By: John Reuben

This book is written as an introductory textbook on Resistive Random Access Memory (ReRAM). ReRAM is a prominent emerging memory among other competing Non-Volatile Memories (NVM) seeking to replace flash memory. This book is based on the author's peer-reviewed research conducted at the Chair of Computer Architecture, FAU, Germany. Referring to his research and the most relevant research from the literature, the author presents the developments in this field concisely. The purpose is to clarify basic concepts and introduce the reader to ReRAM with an emphasis on circuit design. Hence, this book is written for university students considering a career in the semiconductor industry. Since the author's research was conducted in collaboration with a silicon foundry, hardware engineers will find this book practical and industry-relevant. Researchers in the field of In-Memory Computing will also benefit from this book since the NVM array is the basic substrate for such computing paradigms. This three-part book condenses the research and development of the last decade into eight chapters. In Part I, a good foundation is laid for understanding the individual device structure, its electrical characteristics, and modeling methodology. The different array configurations in which these memory devices are fabricated are also discussed. In Part II, the peripheral circuits -the CMOS circuits around the ReRAM array are discussed. They include sense amplifiers, programming circuits, and row/column access circuits. Recent developments such as the possibility to perform certain computing tasks in the ReRAM array are discussed in Part III.

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163

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John Reuben

Published Date

ISBN 10

3000778489

ISBN 13

9783000778483

Handbook of Heterocyclic Chemistry

By: Alan R. Katritzky,Christopher A. Ramsden,John A. Joule,Viktor V. Zhdankin

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Handbook of Heterocyclic Chemistry

By: Alan R. Katritzky,Christopher A. Ramsden,John A. Joule,Viktor V. Zhdankin

Heterocyclic compounds play a vital role in the metabolism of living cells. Their practical applications range from extensive clinical use to fields as diverse as agriculture, photography, biocide formulation and polymer science. Written by leading scholars and industry experts, the Handbook of Heterocyclic Chemistry is thoroughly updated with over 50% new content. It has been rewritten with a new expanded author team, who have carefully distilled essential information on the reactivity, structure and synthesis of heterocycles from the 2008 major reference work Comprehensive Heterocyclic Chemistry III. To bring the work up to date the author team have also added new synthetic examples and structures, key applications and new references from 2008-2010. Contains more than 1500 clearly drawn structures and reactions. The highly systematic coverage given to the subject makes this one of the most authoritative single-volume accounts of modern heterocyclic chemistry available and should be useful reference for those teaching a heterocyclic course. - Covers the structure, reactivity and synthesis of all heterocyclic compounds as distilled from the larger 15-volume reference work - Saves researchers time when they require important information on heterocycles--speeding them to thousands of clearly drawn chemical structures and pertinent reviews by leading experts - Features 35% new material to compliment the completely revised text

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1011

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Elsevier

Published Date

ISBN 10

0080958443

ISBN 13

9780080958446

Plant Breeding: Past, Present and Future

By: John E. Bradshaw

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Plant Breeding: Past, Present and Future

By: John E. Bradshaw

This book aims to help plant breeders by reviewing past achievements, currently successful practices, and emerging methods and techniques. Theoretical considerations are also presented to strike the right balance between being as simple as possible but as complex as necessary. The United Nations predicts that the global human population will continue rising to 9.0 billion by 2050. World food production will need to increase between 70-100 per cent in just 40 years. First generation bio-fuels are also using crops and cropland to produce energy rather than food. In addition, land area used for agriculture may remain static or even decrease as a result of degradation and climate change, despite more land being theoretically available, unless crops can be bred which tolerate associated abiotic stresses. Lastly, it is unlikely that steps can be taken to mitigate all of the climate change predicted to occur by 2050, and beyond, and hence adaptation of farming systems and crop production will be required to reduce predicted negative effects on yields that will occur without crop adaptation. Substantial progress will therefore be required in bridging the yield gap between what is currently achieved per unit of land and what should be possible in future, with the best farming methods and best storage and transportation of food, given the availability of suitably adapted cultivars, including adaptation to climate change. My book is divided into four parts: Part I is an historical introduction; Part II deals with the origin of genetic variation by mutation and recombination of DNA; Part III explains how the mating system of a crop species determines the genetic structure of its landraces; Part IV considers the three complementary options for future progress: use of sexual reproduction in further conventional breeding, base broadening and introgression; mutation breeding; and genetically modified crops.

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710

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Springer

Published Date

ISBN 10

3319232851

ISBN 13

9783319232850

The Image Processing Handbook

By: John C. Russ,F. Brent Neal

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The Image Processing Handbook

By: John C. Russ,F. Brent Neal

Consistently rated as the best overall introduction to computer-based image processing, The Image Processing Handbook covers two-dimensional (2D) and three-dimensional (3D) imaging techniques, image printing and storage methods, image processing algorithms, image and feature measurement, quantitative image measurement analysis, and more. Incorporating image processing and analysis examples at all scales, from nano- to astro-, this Seventh Edition: Features a greater range of computationally intensive algorithms than previous versions Provides better organization, more quantitative results, and new material on recent developments Includes completely rewritten chapters on 3D imaging and a thoroughly revamped chapter on statistical analysis Contains more than 1700 references to theory, methods, and applications in a wide variety of disciplines Presents 500+ entirely new figures and images, with more than two-thirds appearing in color The Image Processing Handbook, Seventh Edition delivers an accessible and up-to-date treatment of image processing, offering broad coverage and comparison of algorithms, approaches, and outcomes.

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1035

Publisher

CRC Press

Published Date

ISBN 10

1498740286

ISBN 13

9781498740289

Asian Comics

By: John A. Lent

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Asian Comics

By: John A. Lent

Grand in its scope, Asian Comics dispels the myth that, outside of Japan, the continent is nearly devoid of comic strips and comic books. Relying on his fifty years of Asian mass communication and comic art research, during which he traveled to Asia at least seventy-eight times and visited many studios and workplaces, John A. Lent shows that nearly every country had a golden age of cartooning and has experienced a recent rejuvenation of the art form. As only Japanese comics output has received close and by now voluminous scrutiny, Asian Comics tells the story of the major comics creators outside of Japan. Lent covers the nations and regions of Bangladesh, Cambodia, China, Hong Kong, India, Indonesia, Korea, Malaysia, Myanmar, Nepal, the Philippines, Singapore, Sri Lanka, Taiwan, Thailand, and Vietnam. Organized by regions of East, Southeast, and South Asia, Asian Comics provides 178 black-and-white illustrations and detailed information on comics of sixteen countries and regions—their histories, key creators, characters, contemporary status, problems, trends, and issues. One chapter harkens back to predecessors of comics in Asia, describing scrolls, paintings, books, and puppetry with humorous tinges, primarily in China, India, Indonesia, and Japan. The first overview of Asian comic books and magazines (both mainstream and alternative), graphic novels, newspaper comic strips and gag panels, plus cartoon/humor magazines, Asian Comics brims with facts, fascinating anecdotes, and interview quotes from many pioneering masters, as well as younger artists.

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Page Count

907

Publisher

Univ. Press of Mississippi

Published Date

ISBN 10

1626742944

ISBN 13

9781626742949

Book's by John Y. Chen

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