John Waddington's Books

The Deeper Genome

Why there is more to the human genome than meets the eye

By: John Parrington

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The Deeper Genome

Why there is more to the human genome than meets the eye

By: John Parrington

Over a decade ago, as the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought -- just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportion of DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'? Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact of its 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes of Neanderthals as well as that of chimps about the development of our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

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Page Count

354

Publisher

Oxford University Press

Published Date

ISBN 10

0192552473

ISBN 13

9780192552471

The Numismatic Chronicle and Journal of the Royal Numismatic Society Third Series

Vol. 13

By: John Evans,Barclay V. Head,Herbert A. Grueber

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The Numismatic Chronicle and Journal of the Royal Numismatic Society Third Series

Vol. 13

By: John Evans,Barclay V. Head,Herbert A. Grueber

Reprint of the original, first published in 1893.

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422

Publisher

BoD – Books on Demand

Published Date

ISBN 10

3368759701

ISBN 13

9783368759704

Handbook of Phosphorus-31 Nuclear Magnetic Resonance Data (1990)

By: John C. Tebby

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Handbook of Phosphorus-31 Nuclear Magnetic Resonance Data (1990)

By: John C. Tebby

To fully utilize Nuclear Magnetic Resonance (NMR) spectroscopy, a comprehensive and well-organized compilation of NMR data is necessary. While compilations have been available for other important NMR nuclei, such as carbon and fluorine, no comprehensive collection of data has been prepared for phosphorus-until now. The CRC Handbook of Phosphorus-31 Nuclear Magnetic Resonance Data provides a collection of 31P NMR chemical shifts for nearly 20,000 organic and inorganic phosphorus compounds. Each class of phosphorus compound is discussed. Bond types, stereochemistry (with the exception of metal complexes), media, important coupling constants, and data sources are included. The information is systematically organized according to coordination state, the atoms bound to phosphorus, and their connectivities. A comprehensive series of bar charts is also included to allow structure types to be assigned to chemical shift data. This handbook is an invaluable resource for all scientists working with phosphorus compounds, including chemists, biochemists, medical researchers, and pharmaceutical chemists.

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1140

Publisher

CRC Press

Published Date

ISBN 10

1351362038

ISBN 13

9781351362030

Quest Biographies Bundle — Books 6–10

John Franklin / Marshall McLuhan / Phyllis Munday / Wilfrid Laurier / Nellie McClung

By: Judith Fitzgerald,John Wilson,Kathryn Bridge,Roderick Stewart,Margaret Macpherson

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Quest Biographies Bundle — Books 6–10

John Franklin / Marshall McLuhan / Phyllis Munday / Wilfrid Laurier / Nellie McClung

By: Judith Fitzgerald,John Wilson,Kathryn Bridge,Roderick Stewart,Margaret Macpherson

Presenting five titles in the Quest Biography series that profiles prominent figures in Canada’s history. The important Canadian lives detailed here are: John Franklin, while not a Canadian, an explorer whose demise in the Arctic is an important part of Canada’s historical identity; Marshall McLuhan, the academic who predicted so much of the modern media world we live in today; mountaineer and explorer Phyllis Munday; influential Prime Minister Wilfrid Laurier; and early feminist icon Nellie McClung. Includes John Franklin Marshall McLuhan Phyllis Munday Wilfrid Laurier Nellie McClung

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588

Publisher

Dundurn

Published Date

ISBN 10

1459723961

ISBN 13

9781459723962

Canadian Adventurers and Explorers Bundle

David Thompson / Vilhjalmur Stefansson / Samuel de Champlain / John Franklin / George Simpson / Phyllis Munday

By: D.T. Lahey,Tom Henighan,John Wilson,Tom Shardlow,Kathryn Bridge,Francine Legaré

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Canadian Adventurers and Explorers Bundle

David Thompson / Vilhjalmur Stefansson / Samuel de Champlain / John Franklin / George Simpson / Phyllis Munday

By: D.T. Lahey,Tom Henighan,John Wilson,Tom Shardlow,Kathryn Bridge,Francine Legaré

Presenting six titles in the Quest Biography series that profiles prominent figures in Canada’s history. Canada is a vast land with many remote regions to be explored. Among the intrepid explorers who travelled the wilderness and mapped Canada’s geography are: the French founder of Quebec, Samuel de Champlain; surveyor David Thompson; doomed seeker of the Northwest Passage Sir John Franklin; Arctic explorer Vilhjamur Stefansson; legendary Upper Canada governor Sir George Simpson; and mountaineer Phyllis Munday. Their stories are detailed in these entertaining and informative biographies. Includes Samuel de Champlain John Franklin David Thompson Vilhjamur Stefansson George Simpson Phyllis Munday

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Page Count

709

Publisher

Dundurn

Published Date

ISBN 10

1459724739

ISBN 13

9781459724730

Kendall's Longitude

By: John Bendall

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Kendall's Longitude

By: John Bendall

LOST AT SEA: EVERY MARINER'S FEAR. Maritime navigational tools could find latitude, but finding longitude remained elusive until Harrison developed the reliable sea clock, H4. Building on H4's success, Kendall made a series of nautical timekeepers, K1, K2 and K3. This is the story of the K2 timekeeper; its adventurous voyages, the people it touched, and its place in history. K2's first voyage, accompanied by the young Nelson, was nearly its last in the crushing Arctic ice. The next two expeditions saw it survive kidnappings, nautical intrigue, and gunpowder plots of the American revolutionary wars. The slave coasts of Africa followed. Bligh took K2 on the Bounty, but lost it in a fight with the mutineers in 1789. It was recovered by an American Quaker from Nantucket, only to be stolen by the Spanish. It rode on mules along the Andes before sailing into the Opium Wars. K2 finally returned to Greenwich in 1963. DRAMATIC, THREE NATION 'STORY OF TIME

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Page Count

429

Publisher

Austin Macauley Publishers

Published Date

ISBN 10

1528953967

ISBN 13

9781528953962

The Diaries of Charlotte Downes Vol II

By: John Lane,Valerie Lane Kay

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The Diaries of Charlotte Downes Vol II

By: John Lane,Valerie Lane Kay

The Diaries of Charlotte Downes, Volume II, is the fourth in a four-volume set, covering years 1839-1858. The diaries afford the reader a glimpse of a small corner of rural England from the Regency through to the early-mid Victorian periods when life was based on a timeless and often precarious agricultural economy, a rigid, inequitable class system and deference to an authoritative Church. Charlotte, the daughter of an influential Wiltshire land-owner, was first cousin to the poet Shelley; she later married Richard Downes, rector of Berwick St John. Her diaries, together with those of her sister, Harriet, have been described by one authority as "like a novel by Jane Austen, but for real". This full transcription contains entries spanning a period of almost fifty years and provides a useful resource for scholars and social historians alike. Family historians will find recorded within these pages an extraordinary number of named individuals, from families representing all sections of society.

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Page Count

446

Publisher

Lulu.com

Published Date

ISBN 10

0955722640

ISBN 13

9780955722646

The Numismatic Chronicle and Journal of the Royal Numismatic Society Third Series

Vol. 1

By: W. S. W. Vaux,John Evans,Barclay V. Head

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The Numismatic Chronicle and Journal of the Royal Numismatic Society Third Series

Vol. 1

By: W. S. W. Vaux,John Evans,Barclay V. Head

Reprint of the original, first published in 1881.

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Page Count

418

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BoD – Books on Demand

Published Date

ISBN 10

336875954X

ISBN 13

9783368759544

The Numismatic Chronicle and Journal of the Royal Numismatic Society Second Series

Vol. 16

By: W. S. W. Vaux,John Evans,Barclay V. Head

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The Numismatic Chronicle and Journal of the Royal Numismatic Society Second Series

Vol. 16

By: W. S. W. Vaux,John Evans,Barclay V. Head

Reprint of the original, first published in 1876.

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Page Count

450

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BoD – Books on Demand

Published Date

ISBN 10

3368759477

ISBN 13

9783368759476

The diaries of Charlotte Downes

1828, 1829, 1831-1837

By: Charlotte Grove,John Lane

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The diaries of Charlotte Downes

1828, 1829, 1831-1837

By: Charlotte Grove,John Lane

The Diaries of Charlotte Downes, Volume I, is the third in a four-volume set, covering years 1828, 1829, 1831-1837. The diaries afford the reader a glimpse of a small corner of rural England from the Regency through to the early-mid Victorian periods when life was based on a timeless and often precarious agricultural economy, a rigid, inequitable class system and deference to an authoritative Church. Charlotte, the daughter of an influential Wiltshire land-owner, was first cousin to the poet Shelley; she later married Richard Downes, rector of Berwick St John. Her diaries, together with those of her sister, Harriet, have been described by one authority as "like a novel by Jane Austen, but for real". This full transcription contains entries spanning a period of almost fifty years and provides a useful resource for scholars and social historians alike. Family historians will find recorded within these pages an extraordinary number of named individuals, from families representing all sections of society.

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Page Count

498

Publisher

Lulu.com

Published Date

ISBN 10

0955722632

ISBN 13

9780955722639

Epigenetics, Nuclear Organization & Gene Function

With implications of epigenetic regulation and genetic architecture for human development and health

By: John C. Lucchesi

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Epigenetics, Nuclear Organization & Gene Function

With implications of epigenetic regulation and genetic architecture for human development and health

By: John C. Lucchesi

Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. Epigenetic modifications are manifest in all aspects of normal cellular differentiation and function, but they can also have damaging effects that result in pathologies such as cancer. Research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine. This book's primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin), and its distribution within a functionally compartmentalized nucleus. This architectural organization of the genome plays a major role in the subsequent retrieval, interpretation, and execution of both genetic and epigenetic information.

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Page Count

240

Publisher

Oxford University Press

Published Date

ISBN 10

0192567160

ISBN 13

9780192567161

Luftwaffe Night Fighter Combat Claims, 1939-1945

By: John Foreman,Simon W. Parry,Johannes Matthews

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Luftwaffe Night Fighter Combat Claims, 1939-1945

By: John Foreman,Simon W. Parry,Johannes Matthews

A definitive list of nearly 7,000 claims submitted by Luftwaffe night fighter pilots for Allied aircraft shot down in WW2. These claims are listed with the following details; Date, Time, Location, Type of aircraft shot down, Claiming Pilot and his Unit. Entries feature claims against Russian, American as well as Bomber Command aircraft.

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Page Count

250

Publisher

Red Kite / Air Research

Published Date

ISBN 10

0953806146

ISBN 13

9780953806140

The Three O’Clock Dragon

A Tor.Com Original

By: John Wiswell

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The Three O’Clock Dragon

A Tor.Com Original

By: John Wiswell

Prosperity City’s corrupt mayor never guessed his greatest opponent would be a fire-breathing dragon and her unconventional platform... At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.

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Tor Books

Published Date

ISBN 10

125089638X

ISBN 13

9781250896384

RNA, the Epicenter of Genetic Information

By: John Mattick,Paulo Amaral

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RNA, the Epicenter of Genetic Information

By: John Mattick,Paulo Amaral

The origin story and emergence of molecular biology is muddled. The early triumphs in bacterial genetics and the complexity of animal and plant genomes complicate an intricate history. This book documents the many advances, as well as the prejudices and founder fallacies. It highlights the premature relegation of RNA to simply an intermediate between gene and protein, the underestimation of the amount of information required to program the development of multicellular organisms, and the dawning realization that RNA is the cornerstone of cell biology, development, brain function and probably evolution itself. Key personalities, their hubris as well as prescient predictions are richly illustrated with quotes, archival material, photographs, diagrams and references to bring the people, ideas and discoveries to life, from the conceptual cradles of molecular biology to the current revolution in the understanding of genetic information. Key Features Documents the confused early history of DNA, RNA and proteins - a transformative history of molecular biology like no other. Integrates the influences of biochemistry and genetics on the landscape of molecular biology. Chronicles the important discoveries, preconceptions and misconceptions that retarded or misdirected progress. Highlights major pioneers and contributors to molecular biology, with a focus on RNA and noncoding DNA. Summarizes the mounting evidence for the central roles of non-protein-coding RNA in cell and developmental biology. Provides a thought-provoking retrospective and forward-looking perspective for advanced students and professional researchers. The Open Access version of this book, available at www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.

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Page Count

879

Publisher

CRC Press

Published Date

ISBN 10

1000623114

ISBN 13

9781000623116

Evolution, the Logic of Biology

By: John S. Torday,Virender K. Rehan

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Evolution, the Logic of Biology

By: John S. Torday,Virender K. Rehan

By focusing on the cellular mechanisms that underlie ontogeny, phylogeny and regeneration of complex physiologic traits, Evolution, the Logic of Biology demonstrates the use of homeostasis, the fundamental principle of physiology and medicine, as the unifying mechanism for evolution as all of biology. The homeostasis principle can be used to understand how environmental stressors have affected physiologic mechanisms to generate condition-specific novelty through cellular mechanisms. Evolution, the Logic of Biology allows the reader to understand the vertebrate life-cycle as an intergenerational continuum in support of effective, on-going environmental adaptation. By understanding the principles of physiology from their fundamental unicellular origins, culminating in modern-day metazoans, the reader as student, researcher or practitioner will be encouraged to think in terms of the prevention of disease, rather than in the treatment of disease as the eradication of symptoms. By tracing the ontogeny and phylogeny of this and other phenotypic homologies, one can perceive and understand how complex physiologic traits have mechanistically evolved from their simpler ancestral and developmental origins as cellular structures and functions, providing a logic of biology for the first time. Evolution, the Logic of Biology will be an invaluable resource for graduate students and researchers studying evolutionary development, medicine and biology, anthropology, comparative and developmental biology, genetics and genomics, and physiology.

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Page Count

375

Publisher

John Wiley & Sons

Published Date

ISBN 10

1118729285

ISBN 13

9781118729281

Crime and Criminal Justice

By: Ian Marsh,Gaynor Melville,Keith Morgan,Gareth Norris,John Cochrane

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Crime and Criminal Justice

By: Ian Marsh,Gaynor Melville,Keith Morgan,Gareth Norris,John Cochrane

This book provides students with a comprehensive and engaging introduction to the study of criminology by taking an interdisciplinary approach to explaining criminal behaviour and criminal justice. It is divided into two parts, which address the two essential bases that form the discipline of criminology. Part One describes, discusses and evaluates a range of theoretical approaches that have offered explanations for crime. Part Two offers an accessible but detailed review of the major philosophical aims and sociological theories of punishment, and examines the main areas of the contemporary criminal justice system.

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Page Count

537

Publisher

Routledge

Published Date

ISBN 10

1136845755

ISBN 13

9781136845758

Asymmetry, Developmental Stability and Evolution

By: Anders Pape MØller,John P. Swaddle

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Asymmetry, Developmental Stability and Evolution

By: Anders Pape MØller,John P. Swaddle

Why does nature love symmetry? In Asymmetry, Developmental Stability and Evolution, M--oslash--;ller and Swaddle analyse the evolutionary implications of symmetry. They advance and explain their theory that asymmetry is related to genetic stability and fitness, and that symmetric individuals appear to have quantifiable and significant advantages over their asymmetric counterparts. When assessing potential mates or competitors, animals may be able to use symmetry as an honest indication of quality. This interdisciplinary book, with its associated Web-site, will be of interest to students and researchers in the fields of ecology, evolutionary biology, genetics, and animal behaviour. - ;Why does nature love symmetry? In Asymmetry, Developmental Stability and Evolution, M--oslash--;ller and Swaddle analyse the evolutionary implications of symmetry. They advance and explain their theory that symmetry is related to genetic stability and fitness, and that symmetric individuals appear to have quantifiable and significant advantages over their asymmetric counterparts. When assessing potential mates or competitors, animals may be able to use symmetry as an honest indication of quality. This interdisciplinary book, with its associated Web-site, will be of interest to students and researchers in the fields of ecology, evolutionary biology, genetics, and animal behaviour. -

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Page Count

306

Publisher

Oxford University Press, UK

Published Date

ISBN 10

019158939X

ISBN 13

9780191589393

Rethinking Industrial Relations

Mobilization, Collectivism, and Long Waves

By: John E. Kelly

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Rethinking Industrial Relations

Mobilization, Collectivism, and Long Waves

By: John E. Kelly

Discusses theories of labour relations and labour mobilization. Looks at the influence of long term economic changes on labour relations during the 19th century. Speculates on the future of the labour movement.

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Page Count

198

Publisher

Psychology Press

Published Date

ISBN 10

0415186722

ISBN 13

9780415186728

Why Religions Matter

By: John Bowker

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Why Religions Matter

By: John Bowker

John Bowker demonstrates why we need to examine both negative and positive aspects of religion to understand religion in the modern world.

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Page Count

361

Publisher

Cambridge University Press

Published Date

ISBN 10

110708511X

ISBN 13

9781107085114

Abbeys, Castles, and Ancient Halls of England and Wales

Vol. III

By: John Timbs

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Abbeys, Castles, and Ancient Halls of England and Wales

Vol. III

By: John Timbs

Reprint of the original, first published in 1872. The publishing house Anatiposi publishes historical books as reprints. Due to their age, these books may have missing pages or inferior quality. Our aim is to preserve these books and make them available to the public so that they do not get lost.

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Page Count

606

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BoD – Books on Demand

Published Date

ISBN 10

3382166526

ISBN 13

9783382166526

The Evolution of Complexity by Means of Natural Selection

By: John Tyler Bonner

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The Evolution of Complexity by Means of Natural Selection

By: John Tyler Bonner

John Tyler Bonner makes a new attack on an old problem: the question of how progressive increase in the size and complexity of animals and plants has occurred. "How is it," he inquires, "that an egg turns into an elaborate adult? How is it that a bacterium, given many millions of years, could have evolved into an elephant?" The author argues that we can understand this progression in terms of natural selection, but that in order to do so we must consider the role of development--or more precisely the role of life cycles--in evolutionary change. In a lively writing style that will be familiar to readers of his work The Evolution of Culture in Animals (Princeton, 1980), Bonner addresses a general audience interested in biology, as well as specialists in all areas of evolutionary biology. What is novel in the approach used here is the comparison of complexity inside the organism (especially cell differentiation) with the complexity outside (that is, within an ecological community). Matters of size at both these levels are closely related to complexity. The book shows how an understanding of the grand course of evolution can come from combining our knowledge of genetics, development, ecology, and even behavior.

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Page Count

276

Publisher

Princeton University Press

Published Date

ISBN 10

0691222118

ISBN 13

9780691222110

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