This book shows how chemical principles can be used to understand the pressures on our world, spanning from greenhouse emissions through freshwater supplies to energy generation and storage.
John Emsley's Nature's Building Blocks was published in paperback in 2003. In this readable, informative, and fascinating guide to the elements are entries on each of the 100-odd chemical elements, arranged alphabetically from actinium to zirconium. Each entry comprises an explanation of where the element's name comes from, followed by Body element (the role it plays in living things), Element of history (how and when it was discovered), Economic element (what it is used for), Environmental element (where it occurs, how much), Chemical element (facts, figures, and narrative), and Element of surprise (an amazing, little-known fact). Since publication of the first edition there have been a number of developments. Three new chemical elements have been named and validated: darmstadtium, roetgenium, and copernicium and the section on 'transfermium elements' has now been incorporated into the main part of the book. Economic uses of elements have grown, and some quite rare elements such as Scandium are now economically important, along with updates to elements such as gold due to new roles in industry. Fully revised and updated for 2010, this browsable compendium holds a wealth of useful information.
Innovation is at the heart of all advances and has the capacity to solve problems facing humanity. Societies which have turned away from innovation and technological development have failed in their ability to support their populations. Understanding the nature of innovation in the life sciences and in particular healthcare, how it operates, what enables and hinders it is therefore of great importance to meeting the challenges ahead. This book, originally and concurrently published in the International Journal of Innovation Management, Vol. 11, No. 2, 2007, offers the latest research and insights concerning innovation in the biopharmaceutical industry.
Das Buch stellt den aktuellen Stand der kompletten Befestigungstechnik für Beton und Mauerwerk mit Einlegeteilen (Ankerschienen, Kopfbolzen), Dübeln (Metallspreizdübel, Hinterschnittdübel, Verbunddübel, Betonschrauben, Kunststoffdübel) und Setzbolzen umfassend dar. Die Befestigungselemente und ihre Wirkungsmechanismen werden ausführlich beschrieben und das Tragverhalten im ungerissenen und gerissenen Beton untersucht. Weiterhin werden das Korrosionsverhalten, das Verhalten bei Brandbeanspruchung sowie bei Erdbeben- und Schockbeanspruchung behandelt. Von besonderer internationaler Aktualität ist die Bemessung gemäß der europäischen und amerikanischen Normung. Praxisorientierte Kriterien zur Auswahl von Befestigungsmitteln und Bemessungsbeispiele runden das Werk zu einem einzigartigen Handbuch ab.
This article reviews progress made in the design and development of recombinant poxviral-based vaccines that express transgenes for tumor-associated antigens (TAAs) and human T-cell co-stimulatory molecules (designated TRICOM). The TRICOM vaccine platform consists of priming with a recombinant vaccinia (rV-) vector and multiple boosts with a replication defective fowlpox (rF-) vector. The rV, rF-PSA-TRICOM (PROSTVAC) has demonstrated survival benefit in randomized trials. rV, rF-CEA-MUC1-TRICOM (PANVAC) has demonstrated evidence of benefit in patients with colorectal, breast and ovarian cancers. Preclinical studies with TRICOM-based vaccines have demonstrated their ability to be used in combination with anti-CTLA4 monoclonal antibody, radiation, chemotherapeutics, and small molecule targeted therapies to enhance vaccine-mediated immune responses and antitumor activity. Randomized clinical studies have been completed, are ongoing, and are planned employing several of these TRICOM vaccine combination therapies. The importance of trial design in terms of patient population and clinical trial endpoint has been demonstrated in these studies.
The third edition of the defining text for the graduate-level course in Electricity and Magnetism has finally arrived! It has been 37 years since the first edition and 24 since the second. The new edition addresses the changes in emphasis and applications that have occurred in the field, without any significant increase in length.
Comprehensive Vascular and Endovascular Surgery, 2nd Edition, edited by John W. Hallett, Jr., MD, FACS, Joseph L. Mills, MD, Jonothan Earnshaw, DM, FRCS, Jim A. Reekers, MD, PhD, and Thom Rooke, MD delivers in-depth, clinically focused coverage of all aspects of vascular surgery in an exceptionally well-designed single reference. Each disease chapter follows the same consistent format, for quick consultation and better comprehension. The revised 2nd Edition features several new chapters, increased endovascular treatment coverage, and updated data from the latest trials...bringing you the newest advances from the field. More than 1,000 photographs, line drawings and tables-including many revised illustrations now in color-depict key concepts and procedures. With its practical user friendly approach-and online access through Expert Consult functionality-this resource offers convenient access to complete guidance. Presents the work of a team of nearly 80 internationally respected vascular surgeons and interventional radiologists who focus on the issues and challenges you face in everyday practice. Uses a highly structured, templated format in each chapter to quickly and consistently deliver information on basic science, clinical presentation, non-invasive testing, medical management, surgical management, complications, outcome, and follow up-making information easy to access and understand. Includes Key Points boxes in every chapter that allow for quick reference and efficient study. Features over 1,000 photographs, line drawings, charts and tables that make important information easy to comprehend. Integrates clinical information with basic science making the material relevant to everyday practice. Covers treatment and interventions from an evidence-based perspective, whenever possible. Provides short, clinical vignettes in the same style as those found on oral exams. Provides online access to the text via expertconsult.com where you can perform quick searches of the complete contents, download all of the images, further your study with bonus review and self assessment questions, and follow links to PubMed abstracts for convenient consultation whwere and when you need it most. Offers new chapters on vascular diagnosis, graft infections, aortic dissection, and visceral aneurysms for greater coverage of the field. Includes a significant increase in endovascular treatment coverage in many of the chapters, reflecting the growing need for experience in these procedures. Presents current data from DREAM and EVAR 1 and 2 trials. Features a revised artwork program-including many revised illustrations and former black and white images now in color-for an enhanced visual understanding of concepts. Includes bonus review and self assessment questions accompany the online version. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
This book is a revised and updated version of the most comprehensive text on nuclear physics, first published in 1995. It maintains the original goal of providing a clear, logical, in-depth and unifying treatment of modern nuclear theory, ranging from the nonrelativistic many-body problem to the standard model of the strong, electromagnetic, and weak interactions. In addition, new chapters on the theoretical and experimental advances made in nuclear physics in the past decade have been incorporated." "This book is designed to provide graduate students with a basic understanding of modern nuclear and hadronic physics needed to explore the frontiers of the field. Researchers will benefit from the updates on developments and the bibliography."--Jacket.
This book reports on the latest developments in the field of Superfluidity. The phenomenon has had a tremendous impact on the fundamental sciences as well as a host of technologies. It began with the discovery of superconductivity in mercury in 1911, which was ultimately described theoretically by the theory of Bardeen Cooper and Schriever (BCS) in 1957. The analogous phenomena, superfluidity, was discovered in helium in 1938 and tentatively explained shortly thereafter as arising from a Bose-Einstein Condensation (BEC) by London. But the importance of superfluidity, and the range of systems in which it occurs, has grown enormously. In addition to metals and the helium liquids the phenomena has now been observed for photons in cavities, excitons in semiconductors, magnons in certain materials, and cold gasses trapped in high vacuum. It very likely exist for neutrons in a neutron star and, possibly, in a conjectured quark state at their center. Even the Universe itself can be regarded as being in a kind of superfluid state. All these topics are discussed by experts in the respective subfields.
This book is a revised and updated version of the most comprehensive text on nuclear and subnuclear physics, first published in 1995. It maintains the original goal of providing a clear, logical, in-depth, and unifying treatment of modern nuclear theory, ranging from the nonrelativistic many-body problem to the standard model of the strong, electromagnetic, and weak interactions. In addition, new chapters on the theoretical and experimental advances made in nuclear and subnuclear physics in the past decade have been incorporated.Four key topics are emphasized: basic nuclear structure, the relativistic nuclear many-body problem, strong-coupling QCD, and electroweak interactions with nuclei. New chapters have been added on the many-particle shell model, effective field theory, density functional theory, heavy-ion reactions and quark-gluon plasma, neutrinos, and electron scattering.This book is designed to provide graduate students with a basic understanding of modern nuclear and hadronic physics needed to explore the frontiers of the field. Researchers will benefit from the updates on developments and the bibliography.
With the 13th edition, Wintrobe’s Clinical Hematology once again bridges the gap between the clinical practice of hematology and the basic foundations of science. Broken down into eight parts, this book provides readers with a comprehensive overview of: Laboratory Hematology, The Normal Hematologic System, Transfusion Medicine, Disorders of Red Cells, Hemostasis and Coagulation; Benign Disorders of Leukocytes, The Spleen and/or Immunoglobulins; Hematologic Malignancies, and Transplantation. Within these sections, there is a heavy focus on the morphological exam of the peripheral blood smear, bone marrow, lymph nodes, and other tissues. With the knowledge about gene therapy and immunotherapy expanding, new, up-to-date information about the process and application of these therapies is included. Likewise, the editors have completely revised material on stem cell transplantation in regards to both malignant and benign disorders, graft versus host disease, and the importance of long-term follow-up of transplantation survivors.
What conceptual blind spot kept the ancient Greeks (unlike the Indians and Maya) from developing a concept of zero? Why did St. Augustine equate nothingness with the Devil? What tortuous means did 17th-century scientists employ in their attempts to create a vacuum? And why do contemporary quantum physicists believe that the void is actually seething with subatomic activity? You’ll find the answers in this dizzyingly erudite and elegantly explained book by the English cosmologist John D. Barrow. Ranging through mathematics, theology, philosophy, literature, particle physics, and cosmology, The Book of Nothing explores the enduring hold that vacuity has exercised on the human imagination. Combining high-wire speculation with a wealth of reference that takes in Freddy Mercury and Shakespeare alongside Isaac Newton, Albert Einstein, and Stephen Hawking, the result is a fascinating excursion to the vanishing point of our knowledge.
This volume is a review on coherent states and some of their applications. The usefulness of the concept of coherent states is illustrated by considering specific examples from the fields of physics and mathematical physics. Particular emphasis is given to a general historical introduction, general continuous representations, generalized coherent states, classical and quantum correspondence, path integrals and canonical formalism. Applications are considered in quantum mechanics, optics, quantum chemistry, atomic physics, statistical physics, nuclear physics, particle physics and cosmology. A selection of original papers is reprinted.
This leading text reflects both the new direction and explosive growth of the field of hematology. Edited and written by practitioners who are the leaders in the field, the book covers basic scientific foundations of hematology while focusing on its clinical aspects. This edition has been thoroughly updated and includes ten new chapters on cellular biology, haploidentical transplantation, hematologic manifestations of parasitic diseases, and more. The table of contents itself has been thoroughly revised to reflect the rapidly changing nature of the molecular and cellular areas of the specialty. Over 1,000 vivid images, now all presented in full color for the first time, include a collection of detailed photomicrographs in every chapter, selected by a hematopathology image consultant. What's more, this Expert Consult Premium Edition includes access to the complete contents of the book online, fully searchable and updated quarterly by Dr. Hoffman himself. - Publisher.
A concise introduction to clinical diagnosis and management―with 1,500+ practice questions and answers for effective board prep LANGE Vascular and Endovascular Surgery: Clinical Diagnosis and Management is an essential, quick-reference guide for residents and attending physicians in vascular surgery, general surgery, interventional cardiology, and interventional radiology. Divided into four sections—General Vascular, Venous Disease, Arterial Disease, and Special Vascular Conditions—the text covers all aspects of vascular disease diagnosis and management. Each chapter begins with an overview of the disease process and includes symptoms, general considerations, anatomy, clinical findings, treatment, complications of therapy and management, guidelines, and management algorithms. The high-yield content and multiple-choice questions are ideal for board prep. This unparalled guide is perfect for a range of providers, including vascular surgeons, general surgeons, interventional radiologists, interventional cardiologists, and nurse practitioners and physician assistants who specialize in vascular medicine. LANGE Vascular and Endovascular Surgery: Clinical Diagnosis and Management features: Clear, succinct presentation of the etiology, pathogenesis, clinical findings, differential diagnosis, and medical/surgical treatment of major vascular conditions High-yield descriptions of the latest diagnostic modalities and management protocols“/li> 800+ illustrations and images, including CT scans, MRIs, x-rays, and anatomic renderings 1,500+ multiple-choice questions and answers for board preparation
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