Signal Transduction in Leukocytes presents important principles and various aspects of cellular regulation in leukocytes. The book discusses receptor structure and signaling, emphasizing cytokine receptors and the T cell and B cell antigen receptors. It investigates the role of the heterotrimeric G proteins and small G proteins as transducers. Authorities in each field cover a wide range of topics. They explore propagation of signaling cascades through second messengers and serine/threonine kinases, the initiation of signaling from the B and T cell antigen receptors by tyrosine phosphorylation and protein recruitment, and the role of signaling in cell-cell interactions and the regulation of the cell cycle. The book outlines the relationship of receptor signaling to inflammatory reactions of neutrophils, eosinophils, and macrophages.
This book presents the first systematic and cross-cultural exploration of ideas of heresy, as well as orthodoxy, in a group of major religious traditions, including Neo-Confucianism, Sunni Islam, rabbinic Judaism, and early Christianity. It shows how authorities in all four of these traditions used common strategies to distinguish orthodox truth from heretical error. These same strategies often appear in modern ideological polemics and studies of deviance as well as in traditional religious controversies. The party that most effectively uses these strategies often gains a decisive advantage in the struggle among competing claimants to orthodoxy. The author also shows how orthodoxy depends on heresy. Without heresy, or at least ideas of heresy, orthodoxy could not establish or perpetuate itself. In fact, in all four traditions orthodoxy constructed itself by creating an inversion of the heretical other. By highlighting the common patterns in constructions of orthodoxy and heresy in four major religious traditions, this book also sets in relief subtler variations that give each tradition a special character. In this way this study strikes a balance between the universal and the particular: it illuminates a general pattern in world intellectual history, but also shows how the traditions that illustrate this pattern are distinctive.
Chronicling the world's most difficult race through the eyes of one who ran it, this vivid and humorous memoir shares the adventures of inspiring contestants--including a wheelchair-bound runner and three record-breaking grandmothers--as they trek across the daunting terrain of extinct volcanoes, craggy mountain peaks, and the turbulent Drake passage, all in a quest to complete the Antarctica Marathon. Revealing the runners' struggles against melting glaciers and hostile skuas, the narrative also recounts their unique experiences with curious penguins and whale sightings. Spotlighting the people and the place that make this annual event so remarkable, this account not only reflects why marathons are so successful but also presents a deeply funny meditation on what makes people run.
Martha Langford and John Langford examine their father's apparently innocuous photographic experience, revealing the complexity of both the images and their creator. An intelligent and personal look at the ways that the historical and the private are represented and remembered, A Cold War Tourist and His Camera stages the family slide show as you've never seen it before.
This is a highly readable and very interesting book that opens a new chapter in thinking about international health form a public health perspective. It makes a compelling case for not only understanding the health problem but the health context. This means looking at policies and politics that are upstream from where the problem is typically addressed. This book will give a new and clear direction to teaching and responding to public health issues in developing countries. It is chock full of examples that illustrate the important principles, values, and lessons that are nicely elaborated in the book. For anyone interested in making a difference in the public health of the developing world, this book will be a vital resource." —Lawrence Wallack, Portland State University "This excellent text is targeted to those with little international experience and those unfamiliar with social and behavioral approaches to enhancing public health. The book clearly explicates social and behavioral approaches to resolving health problems in global terms." —Noreen M. Clark, PhD, University of Michigan School of Public Health "John Elder pulls together the story of communication and public health. This book will be a unique guide for both health professionals, and communication students to the ideas and programs that have shaped the past thirty years. It goes beyond the story of advertising and campaigns and exposes the real contribution of social marketing and social advocacy to some of the biggest public health success stories of our time." —William Smith, Academy for Educational Development, Washington, D.C. This volume emphasizes experience in behavior change programs for the prevention and control of the world′s biggest killers: malnutrition, respiratory infections, diarrhea, vaccine-preventable diseases, wasteful fertility, HIV/AIDS, and tobacco use. These programs are linked to theories and models that most typically frame them: health communications and social marketing, learning theory, media advocacy, and community self-control. Descriptions of programs and related literature presented in the book were selected essentially for how well they represent the application of a theory to a specific health or disease target.
Founded in Richmond in 1968, Virginia Commonwealth University (VCU) began with a mission to build a university to serve a city emerging from the era of urban crisis—desegregation, white flight, political conflict, and economic decline. With the merger of the Medical College of Virginia and the Richmond Professional Institute into the single state-mandated institution of VCU, the two entities were able to embrace their mission and work together productively. In Fulfilling the Promise, John Kneebone and Eugene Trani tell the intriguing story of VCU and the context in which the university was forged and eventually thrived. Although VCU’s history is necessarily unique, Kneebone and Trani show how the issues shaping it are common to many urban institutions, from engaging with two-party politics in Virginia and African American political leadership in Richmond, to fraught neighborhood relations, the complexities of providing public health care at an academic health center, and an increasingly diverse student body. As a result, Fulfilling the Promise offers far more than a stale institutional saga. Rather, this definitive history of one urban-setting state university illuminates the past and future of American public higher education in the post-1960s era.
As a scholar of terrorism, John Maszka has examined how politics, the media, and the War on Terror play off one another. His most startling claim is that the War on Terror is a war for natural resources--and that terrorism has little to do with it. Once the military became mechanized, oil quickly became the most sought-after commodity on the planet, and the race for energy was eventually framed as a matter of national security. Ironically, Maszka argues, the true threats to national security are the massive oil conglomerates themselves. Maszka delves into the repercussions of a government that capitalizes on an us versus them mentality, such as the demonizing of an entire religion, sensationalizing "radical" violent attacks, and loosely applying the word "terrorism." Because the United States' current approach to terrorism has led to the politicization and abuse of the term, Maszka suggests a need for a standardized definition of terrorism. Currently, too many acts of violence can be labeled terrorism, resulting in state and nonstate actors labeling their enemies as "terrorists," yet claiming their own acts of violence as legitimate and retributive. Maszka argues that much of the violence labeled as terrorism today is not terrorism at all. In an ambitious attempt to connect seemingly unrelated events in politics and the media, Maszka offers an unflinching portrayal of the hypocrisy underlying our foreign policy.
Contemporary politics is dominated by a liberal creed that champions ‘negative liberty’ and individual happiness. This creed undergirds positions on both the right and the left – free-market capitalism, state bureaucracy and individualism in social life. The triumph of liberalism has had the effect of subordinating human association and the common good to narrow self-interest and short-term utility. By contrast, post-liberalism promotes individual fulfilment and mutual flourishing based on shared goals that have more substantive content than the formal abstractions of liberal law and contract, and yet are also adaptable to different cultural and local traditions. In this important book, John Milbank and Adrian Pabst apply this analysis to the economy, politics, culture, and international affairs. In each case, having diagnosed the crisis of liberalism, they propose post-liberal alternatives, notably new concepts and fresh policy ideas. They demonstrate that, amid the current crisis, post-liberalism is a programme that could define a new politics of virtue and the common good.
“Groundbreaking.” —Washington Examiner Economics is primed for—and in desperate need of—a revolution, respected economic forecaster John D. Mueller shows in this eye-opening book. To make the leap forward will require looking backward, for as Redeeming Economics reveals, the most important element of economic theory has been ignored for more than two centuries. Since the great Adam Smith tore down this pillar of economic thought, economic theory has been unable to account for a fundamental aspect of human experience: the relationships that define us, the loves (and hates) that motivate and distinguish us as persons. In trying to reduce human behavior to exchanges, modern economists have forgotten how these essential motivations are expressed: as gifts (or their opposite, crimes). Mueller makes economics whole again, masterfully reapplying the economic thought of Aristotle, Augustine, and Aquinas.
The history of the first national park in Texas—the politics, intrigues, controversies, and the people inspired by the stunning desert environment. A breathtaking country of rugged mountain peaks, uninhabited desert, and spectacular river canyons, Big Bend is one of the United States’ most remote national parks and among Texas’ most popular tourist attractions. Located in the great bend of the Rio Grande that separates Texas and Mexico, the park comprises some 800,000 acres, an area larger than the state of Rhode Island, and draws over 300,000 visitors each year. The Story of Big Bend National Park offers a comprehensive, highly readable history of the park from before its founding in 1944 up to the present. John Jameson opens with a fascinating look at the mighty efforts involved in persuading Washington officials and local landowners that such a park was needed. He details how money was raised and land acquired, as well as how the park was publicized and developed for visitors. Moving into the present, he discusses such issues as natural resource management, predator protection in the park, and challenges to land, water, and air. Along the way, he paints colorful portraits of many individuals, from area residents to park rangers to Lady Bird Johnson, whose 1966 float trip down the Rio Grande brought the park to national attention. This history will be required reading for all visitors and prospective visitors to Big Bend National Park. For everyone concerned about our national parks, it makes a persuasive case for continued funding and wise stewardship of the parks as they face the twin pressures of skyrocketing attendance and declining budgets.
Highly Commended, BMA Medical Book Awards 2014Comprehensive and erudite, Forensic Psychiatry: Clinical, Legal and Ethical Issues, Second Edition is a practical guide to the psychiatry of offenders, victims, and survivors of crime. This landmark publication has been completely updated but retains all the features that made the first edition such a w
Using data from the 2000 Census, this collection examines the major demographic and employment trends in the rural Midwestern states with special attention to the issues that state and local policy makers must address in the near future.
The book features real-life examples and amazing diversity focusing on sociology's unique ability to personally resonate well with students' experiences. Throughout the text, the author carefully balances coverage of core topics and contemporary changes in society. Every chapter explores unique topics, such as same-sex marriage, Boko Haram, mob justice, Sharia law, as well as issues of inequality related to race, ethnicity, gender, social class, and urbanization.The text empowers students to use the lenses of sociological imagination to see sociology in everyday life. Using sociological imagination, theory, and sociological perspectives, the text helps students move beyond individual perspective to gain a sociological perspective.
The astonishing untold story of the WWII airmen who risked it all in the deadly race to become the greatest American fighter pilot. In 1942, America's deadliest fighter pilot, or "ace of aces" -- the legendary Eddie Rickenbacker -- offered a bottle of bourbon to the first U.S. fighter pilot to break his record of twenty-six enemy planes shot down. Seizing on the challenge to motivate his men, General George Kenney promoted what they would come to call the "race of aces" as a way of boosting the spirits of his war-weary command. What developed was a wild three-year sprint for fame and glory, and the chance to be called America's greatest fighter pilot. The story has never been told until now. Based on new research and full of revelations, John Bruning's brilliant, original book tells the story of how five American pilots contended for personal glory in the Pacific while leading Kenney's resurgent air force against the most formidable enemy America ever faced. The pilots -- Richard Bong, Tommy McGuire, Neel Kearby, Charles MacDonald and Gerald Johnson -- riveted the nation as they contended for Rickenbacker's crown. As their scores mounted, they transformed themselves from farm boys and aspiring dentists into artists of the modern dogfight. But as the race reached its climax, some of the pilots began to see how the spotlight warped their sense of duty. They emerged as leaders, beloved by their men as they chose selfless devotion over national accolades. Teeming with action all across the vast Pacific theater, Race of Aces is a fascinating exploration of the boundary between honorable duty, personal glory, and the complex landscape of the human heart. "Brings you into the cockpit of the lethal, fast-paced world of fighter pilots . . . Fascinating." -- Sara Vladic"Extraordinary . . . a must-read." -- US Navy Captain Dan Pedersen"A heart-pounding narrative of the courage, sacrifice, and tragedy of America's elite fighter pilots." -- James M. Scott"Vivid and gripping . . . Confirms Bruning's status as the premier war historian of the air." -- Saul David
Heart disease is currently the leading cause of maternal mortality in developed countries and is expected to increase further due to advanced maternal age and conditions such as type 2 diabetes. Maternal Cardiac Care: A Guide to Managing Pregnant Women with Heart Disease is an up-to-date, multidisciplinary resource for physicians and advanced practice nurses caring for pregnant patients with a variety of preexisting and emerging cardiac issues. - Offers comprehensive information on caring for women with heart disease, in an easy-to-follow, quick-access format. - Shares knowledge from a multidisciplinary group of experts who are well versed in the team approach needed to treat this high-risk patient population. - Includes extensive references for readers who want to delve more deeply into specific subjects. - Ideal for obstetricians, internists, cardiologists, critical care specialists, and advanced practice nurses involved in caring for pregnant patients, as well as institutions and departments that need detailed guidance on establishing a maternal cardiac care program.
This book is about the recent advances in the structural and functional characterization of receptors that influence intracellular signalling events through interaction with intracellular GTP-binding proteins (G proteins). Molecular cloning of members of the G protein-coupled receptor superfamily has complemented pharmacological investigations in providing a realization of the structural and functional diversity of these receptors. An increased understanding of the involvement of particular receptor subtypes in normal and pathophysiological processes represents exciting possibilities for the development of highly specific and effective therapeutic agents.
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