This book is for physicists, historians and philosophers of physics as well as students seeking an introduction to ongoing debates in relativistic and quantum physics. This title covers the recent debates on the emergence of relativity and quantum theory. It includes chapters with an introductory character, comprehensible to students and science teachers. It strengthens the bonds between the communities of scientists, historians, and philosophers.
In Newton's classical mechanics, time played the role of a monotonically increasing evolution parameter. Einstein rejected the Newtonian concept and instead identified time as the fourth coordinate of a space-time four-vector. Today, scientists are considering different concepts of time as a means of resolving incompatibilities between relativity and quantum mechanics. Some view time as an emergent property of a system rather than a fundamental property, while others consider two temporal variables. The purpose of this book is to examine the role of time in modern physics so that the reader gains an increased awareness of time and its place in our understanding of nature.
BACE inhibitors and their use in the treatment of Alzheimer's Disease BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and its role in AD and comprehensively discusses: The development of BACE inhibitors as therapeutics for Alzheimer's disease The research that led to the identification of BACE New BACE inhibitors currently being clinically tested ADME (absorption, distribution, metabolism, excretion) and clinical trial design—topics not addressed in current field literature Cutting-edge technology such as high-throughput screening, structure-based drug design, and QSAR in context of BACE inhibitors and Alzheimer's drug discovery Other approaches to BACE inhibition based on interaction with the precursor protein APP By enhancing the reader's understanding of the various aspects of the BACE drug-discovery process, this much-needed reference will serve as a key resource for all scientists involved in Alzheimer's research—and inspire new approaches to treatment of AD.
This book discusses the physical phases of quantum chromodynamics (QCD) in ordinary environments and also in extreme environments of high temperatures and high baryon number. It introduces lattice gauge theory, covering fundamentals and important developments, and emphasises the application of QCD to the study of matter in extreme environments.
The Secret World of American Communism (1995), filled with revelations about Communist party covert operations in the United States, created an international sensation. Now the American authors of that book, along with Soviet archivist Kyrill M. Anderson, offer a second volume of profound social, political, and historical importance. Based on documents newly available from Russian archives, The Soviet World of American Communism conclusively demonstrates the continuous and intimate ties between the Communist Party of the United States of America (CPUSA) and Moscow. In a meticulous investigation of the personal, organizational, and financial links between the CPUSA and Soviet Communists, the authors find that Moscow maintained extensive control of the CPUSA, even of the American rank and file. The widely accepted view that the CPUSA was essentially an idealistic organization devoted to the pursuit of social justice must be radically revised, say the authors. Although individuals within the organization may not have been aware of Moscow’s influence, the leaders of the organization most definitely were. The authors explain and annotate ninety-five documents, reproduced here in their entirety or in large part, and they quote from hundreds of others to reveal the actual workings of the American Communist party. They show that: • the USSR covertly provided a large part of the CPUSA budget from the early 1920s to the end of the 1980s; • Moscow issued orders, which the CPUSA obeyed, on issues ranging from what political decisions the American party should make to who should serve in the party leadership; • the CPUSA endorsed Stalin’s purges and the persecution of Americans living in Russia.
This book reviews the basic models and theories of nuclear structure and gives an in-depth analysis of their experimental and mathematical foundations. It shows the relationships between the models and exhibits the value of following the strategy of: looking for patterns in all the data available, developing phenomenological models to explain them, and finally giving the models a foundation in a fundamental microscopic theory of interacting neutrons and protons.This unique book takes a newcomer from an introduction to nuclear structure physics to the frontiers of the subject along a painless path. It provides both the experimental and mathematical foundations of the essential models in a way that is accessible to a broad range of experimental and theoretical physicists. Thus, the book provides a unique resource and an exposition of the essential principles, mathematical structures, assumptions, and observational data on which the models and theories are based. It avoids discussion of many non-essential variations and technical details of the models.
Others hoped that peaceful coexistence with singularities could be achieved by proving a form of Roger Penrose's "cosmic censorship" hypothesis, which would place singularities safely inside black holes.
A wonderfully readable account of scientific development over the past five hundred years, focusing on the lives and achievements of individual scientists, by the bestselling author of In Search of Schrödinger’s Cat In this ambitious new book, John Gribbin tells the stories of the people who have made science, and of the times in which they lived and worked. He begins with Copernicus, during the Renaissance, when science replaced mysticism as a means of explaining the workings of the world, and he continues through the centuries, creating an unbroken genealogy of not only the greatest but also the more obscure names of Western science, a dot-to-dot line linking amateur to genius, and accidental discovery to brilliant deduction. By focusing on the scientists themselves, Gribbin has written an anecdotal narrative enlivened with stories of personal drama, success and failure. A bestselling science writer with an international reputation, Gribbin is among the few authors who could even attempt a work of this magnitude. Praised as “a sequence of witty, information-packed tales” and “a terrific read” by The Times upon its recent British publication, The Scientists breathes new life into such venerable icons as Galileo, Isaac Newton, Albert Einstein and Linus Pauling, as well as lesser lights whose stories have been undeservedly neglected. Filled with pioneers, visionaries, eccentrics and madmen, this is the history of science as it has never been told before.
In August. 1982. a conference was held at the University of Califor nia. Davis. to discuss both molecular and traditional approaches to plant genetic analysis and plant breeding. Papers presented at the meeting were published in Genetic Engineering of Plants: An Agricultural Perspective. A second conference. entitled "Tailoring Genes for Crop Improvement." spon sored by the UC-Davis College of Agricultural and Environmental Sciences and the College's Biotechnology Program. was held at Davis in August. 1986. to discuss the notable advances that had been made during the intervening years in the technology for gene modification. transfer. and expression in plants. This volume contains papers that were presented at this meeting and provides readers with examples of how the new experimental strategies are being used to gain a clearer understanding of the biology of the plants we grow for food and fiber; it also discusses how molecular biology approaches are being used to introduce new genes into plants for plant breeding programs. We are grateful to the speakers for their excellent presentations for the conference and extend our sincere thanks to those who contributed manuscripts for this volume.
That the field of Mossbauer spectroscopy continues for the remarks section of the index, and the inclusion to be an important growth area in science and tech of some new appendices and tables (such as the en nology, despite recent economic pressures, is ade ergy conversion tables, nuclear radius and moment quately evidenced by the present volume. Covering re data, and the report of the ASTM Task Group on search published only in the year 1969, its size is com Mossbauer Nomenclature and Conventions). The parable to its predecessor, Mossbauer Effect Data advertisement section, too, provides a collection of Index 1958-1965. With such continuing growth in information useful to many readers. many fields, the need for specialized information re In summary, the new editors are to be congratulated trieval tools for the research worker is now becoming for their excellent and tremendous effort in putting together such a fine compilation in a remarkably short an increasingly important internationally recognized time. The user community, I am sure, will strongly concern. MEDI 1969 satisfies much of this need for the community it addresses in a timely manner. urge them to continue this series, as I know their pred This work not only follows in the footsteps of its ecessor has been urged to help fill the gap for the years 1966-1968. predecessor, but also includes a number of important and very useful innovations. Among these are the classification of substances investigated according to ARTHUR H. MUIR, JR.
In his landmark volume Space, Time and Architecture, Sigfried Giedion paired images of two iconic spirals: Tatlin’s Monument to the Third International and Borromini’s dome for Sant’Ivo alla Sapienza. The values shared between the baroque age and the modern were thus encapsulated on a single page spread. As Giedion put it, writing of Sant’Ivo, Borromini accomplished 'the movement of the whole pattern [...] from the ground to the lantern, without entirely ending even there.' And yet he merely 'groped' towards that which could 'be completely effected' in modern architecture-achieving 'the transition between inner and outer space.' The intellectual debt of modern architecture to modernist historians who were ostensibly preoccupied with the art and architecture of earlier epochs is now widely acknowledged. This volume extends this work by contributing to the dual projects of the intellectual history of modern architecture and the history of architectural historiography. It considers the varied ways that historians of art and architecture have historicized modern architecture through its interaction with the baroque: a term of contested historical and conceptual significance that has often seemed to shadow a greater contest over the historicity of modernism. Presenting research by an international community of scholars, this book explores through a series of cross sections the traffic of ideas between practice and history that has shaped modern architecture and the academic discipline of architectural history across the long twentieth century. The editors use the historiography of the baroque as a lens through which to follow the path of modern ideas that draw authority from history. In doing so, the volume defines a role for the baroque in the history of architectural historiography and in the history of modern architectural culture.
The hidden world of American communism can now be examined with the help of documents from the recently opened archives of the former Soviet Union. Interweaving narrative and documents, the authors of this book present a convincing new picture of the Communist Part of the the United States of America (CPUSA), providing proof that it was involved in espionage and other subversive activitives. 16 illustrations.
John D. Frey leads readers on a fascinating journey in this book that seeks to prove that Albert Einsteins theory of special relativity is all wrong. He begins by sharing an overview of special relativity, including its history, principles, and how these principles bring about time dilation and length contraction. The author examines six experiments that show that the theorys claims and principles can disqualify themselves by producing impossible, opposing results. He also explains how experiments that supposedly have verified special relativity and its claims actually help prove that the theory is flawed. Behind this book was over 10 years of research by the author concerning every aspect of special relativity. In addition, the author consulted with over 30 professors of physics concerning his ideas and experiments and their feedback was extremely important in the creation of this book. Written in everyday, nontechnical language, the book will make sense to those without a background in physics. No matter what you do for a living, you can participate in a vital discussion about our universe and join the author in Challenging the Unchallengeable.
The autobiography of one of the foremost physicists decribes his career in science, and chronicles the great scientific discoveries of the twentieth century.
Reprint of the original, first published in 1873. The publishing house Anatiposi publishes historical books as reprints. Due to their age, these books may have missing pages or inferior quality. Our aim is to preserve these books and make them available to the public so that they do not get lost.
Every Thing Must Go argues that the only kind of metaphysics that can contribute to objective knowledge is one based specifically on contemporary science as it really is, and not on philosophers' a priori intuitions, common sense, or simplifications of science. In addition to showing how recent metaphysics has drifted away from connection with all other serious scholarly inquiry as a result of not heeding this restriction, they demonstrate how to build a metaphysics compatible with current fundamental physics ('ontic structural realism'), which, when combined with their metaphysics of the special sciences ('rainforest realism'), can be used to unify physics with the other sciences without reducing these sciences to physics itself. Taking science metaphysically seriously, Ladyman and Ross argue, means that metaphysicians must abandon the picture of the world as composed of self-subsistent individual objects, and the paradigm of causation as the collision of such objects. Every Thing Must Go also assesses the role of information theory and complex systems theory in attempts to explain the relationship between the special sciences and physics, treading a middle road between the grand synthesis of thermodynamics and information, and eliminativism about information. The consequences of the author's metaphysical theory for central issues in the philosophy of science are explored, including the implications for the realism vs. empiricism debate, the role of causation in scientific explanations, the nature of causation and laws, the status of abstract and virtual objects, and the objective reality of natural kinds.
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