Interest in green chemistry and clean processes has grown so much in recent years that topics such as fluorous biphasic catalysis, metal organic frameworks, and process intensification, which were barely mentioned in the First Edition, have become major areas of research. In addition, government funding has ramped up the development of fuel cells and biofuels. This reflects the evolving focus from pollution remediation to pollution prevention. Copiously illustrated with more than 800 figures, the Third Edition provides an update from the frontiers of the field. It features supplementary exercises at the end of each chapter relevant to the chemical examples introduced in each chapter. Particular attention is paid to a new concluding chapter on the use of green metrics as an objective tool to demonstrate proof of synthesis plan efficiency and to identify where further improvements can be made through fully worked examples relevant to the chemical industry. NEW AND EXPANDED RESEARCH TOPICS Metal-organic frameworks Metrics Solid acids for alkylation of isobutene by butanes Carbon molecular sieves Mixed micro- and mesoporous solids Organocatalysis Process intensification and gas phase enzymatic reactions Hydrogen storage for fuel cells Reactive distillation Catalysts in action on an atomic scale UPDATED AND EXPANDED CURRENT EVENTS TOPICS Industry resistance to inherently safer chemistry Nuclear power Removal of mercury from vaccines Removal of mercury and lead from primary explosives Biofuels Uses for surplus glycerol New hard materials to reduce wear Electronic waste Smart growth The book covers traditional green chemistry topics, including catalysis, benign solvents, and alternative feedstocks. It also discusses relevant but less frequently covered topics with chapters such as "Chemistry of Long Wear" and "Population and the Environment." This coverage highlights the importance of chemistry to everyday life and demonstrates the benefits the expanded exploitation of green chemistry can have for society.
This book provides a comprehensive clinical review of the diagnosis and treatment of patients with ischemic cerebrovascular disease. The book includes chapters on the clinical features of transient ischemic attacks and ischemic stroke, risk factors, and evaluations. Additional chapters discuss causes of stroke including atherosclerosis, cardioembolism, non-atherosclerotic vasculopathies, and pro-thrombotic disorders. The causes of stroke in children and young adults are highlighted. The final section of the book includes chapters on therapies to prevent stroke, acute stroke treatment, general management of the patient with recurrent stroke, and rehabilitation. The volume is heavily referenced with an emphasis on recent publications so that the reader can pursue additional information about a topic. It also includes several tables and algorithms that should aid the clinician treating patients with cerebrovascular disease.
The updated edition of Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas is designed to act as a one-stop medical reference book for the entire gastrointestinal system, providing exhaustive coverage and equipping you with all of the necessary tools to make a comprehensive diagnostic workup. You'll access thousands of high-quality illustrations and eight brand-new chapters, so you can recognize and diagnose any pathological slide you encounter. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Make a comprehensive diagnostic workup with data from ancillary techniques and molecular findings whenever appropriate. Effectively grasp complex topics and streamline decision-making by using extensive tables, graphs, and flowcharts. Avoid diagnostic errors thanks to practical advice on pitfalls in differential diagnosis. Navigate the book quickly with a "road map" featured at the beginning of each chapter. Provide the clinician with the most accurate and up-to-date diagnostic and prognostic indicators, including key molecular aspects of tumor pathology, with access to the latest classification and staging systems available. Evaluate diagnostically challenging cases using diagnostic algorithms. Stay abreast of the latest advances with eight new chapters: Autoimmune Disorders of the GI Tract; Drug Induced Disorders of the GI Tract; Molecular Diagnostics of Tubal Gut Neoplasms; Molecular Diagnostics of the Gallbladder, Extrahepatic Biliary Tree, and Pancreatic Tumors; Tumors of the Ampulla; Molecular Diagnostics of Hepatocellular Neoplasms; Approach to the Liver Biopsy, and Approach to Gastrointestinal Tract Biopsies. Remain at the forefront of your field with coverage of new molecular and genetic markers in GI neoplasms; updated knowledge on liver and biliary tree pathology; and expanded information on tumors of the ampulla. Recognize and diagnose any tissue sample under the microscope with help from over 3000 high-quality color illustrations.
First written by Philip Stell and Arnold Maran in 1972, Stell & Maran's Textbook of Head and Neck Surgery and Oncology has been revised in both content and approach over the years to reflect the enormous progress made in the area. Now in its fifth edition, the book remains a key textbook for trainees in otolaryngology and head and neck surgery.
Focusing on the central and western parts of the region, this is the second of five volumes that comprehensively document rock art in Upper Tibet. It examines a panoply of graphic evidence found on stone surfaces, supplying an unprecedented view of the long-term development of culture and religion on a large swathe of the Tibetan Plateau.
The maturation of nanotechnology has revealed it to be a unique and distinct discipline rather than a specialization within a larger field. Its textbook cannot afford to be a chemistry, physics, or engineering text focused on nano. It must be an integrated, multidisciplinary, and specifically nano textbook. The archetype of the modern nano textbook
Concentrating on proven data and adopting a structure-function approach, this text provides grounding for an intricate understanding of the molecular biology, physiological mechanisms, and routine clinical use in disease settings of colony-stimulating factors (CSFs). This edition includes eight additional chapters, with updates of recently-discovered and established CSFs, each indexed individually.
This is the first book to concentrate on dysphagia in rare conditions those that occur infrequently or those that may occur more frequently but are only sometimes associated with dysphagia. Covering a wide range of conditions from progressive supranuclear palsy (PSP), through connective tissue disease, to conditions as diverse as West Nile virus the editors and expert contributors efficiently synthesize the available information to provide the essentials needed to help clinicians to perform sophisticated assessments, based on their knowledge of both the conditions and the expected swallowing signs and treatments. Each entry covers the neurology of the given condition, including the signs and symptoms, neuropathology, epidemiology and genetics. Thereafter, coverage of swallowing in each condition examines the diagnostic signs and symptoms, etiology, swallowing neuropathology, associated cognitive, linguistic, and communicative signs and symptoms, special diagnostic considerations, treatment, nutrition, hydration, and medications.
Big questions and issues arise about the role of the scientific life in our society and in our world. These have to do with trusting science at all, or with the wider roles of the scientist. The Whens and Wheres of a Scientific Life serves as an epilogue to author John R. Helliwell’s scientific life trilogy of books on the Hows (i.e. skills), the Whys and the Whats of a scientific life. When and where questions play a big role in major science facility decisions. When and where also play a big role in controlling a pandemic like the coronavirus COVID-19. The consequences of such work and the role science plays in society are discussed in this book. Key Features: Discusses when and where we can make new and better things happen and make new discoveries. Explains whens and wheres as examples in basic science and explaining these to the public User friendly and concise, this text provides a wide range of examples of science and discovery The author has diverse experience in career development, teaching and research The importance of open data to the reproducibility of science are described
This is an introductory textbook for the study of human evolution, and covers all major topics of human origins taught under paleoanthropology, anthropology, archaeology, and evolutionary biology courses. This book differs from the existing selection of textbooks in the following ways: • It incorporates the most recent fossil discoveries and interpretations.• It balances the discussion between descriptions of fossils and interpretations of behavior of hominins in different time periods. • It includes current findings of genomics into understanding the more recent stages of human evolution. This important subdiscipline is badly underserved by current texts.• It consistently addresses the relationship of evidence to our current hypotheses and interpretations. The book has an engaging and lucid style suitable for those entering the field. Students will find ample case studies, illustrations and examples helpful in understanding difficult concepts. Tables, timelines, and maps in every chapter include data summaries and key points. The book highlights peripheral points and background concepts in side boxes for easy reference and lists key ideas at the end of each chapter. This up-to-date and easy to read text is suitable for both classroom study and self-learning.
This important reference offers a comprehensive review of the graft-versus-leukemia (GVL) or -tumor (GVT) effect following allogeneic stem cell transplantation and lymphocyte transfusion, covering a wide range of topics from alloimmune responses to clinical applications of GVL, and providing the basics to understand the mechanisms of the GVL effect while demonstrating methods that use the GVL effect to cure a greater number of cancer patients. Presents preliminary data supporting the idea that allogeneic cell therapy can be used not only for the treatment of leukemia but also for metastatic solid tumors! Written by over 40 world renowned experts in the field and containing more than 1450 references for in-depth exploration of the subject, Allogeneic Immunotherapy for Malignant Diseases investigates the capacity of the donor-and the host-to destroy residual leukemia cells by allogeneic immune reaction determines how to direct immune reactions against hematopoietic malignancies safely reveals which other malignant conditions may be responsive to allogeneic-mediated graft-versus-tumor reactions covers the mechanisms that contribute to the development of responses to minor histocompatibility complex (mHC) molecules focuses on the biology of effector cells and their role in mediating GVL reactions in chronic myeloid leukemia (CML) summarizes the putative impact of human mHag on the GVL effect in bone marrow transplantation (BMT) addresses the potential and limitations of oncogene-based immunotherapy examines ways to isolate and control the GVL component of allograft immunity discusses efforts to develop specific anti-leukemic T-cell immunotherapy and more! Attributing the curative effect of allogeneic stem cell transplantation to the GVL or GVT effect, Allogeneic Immunotherapy for Malignant Diseases is an indispensable reference for hematologists, clinical oncologists, immunologists and researchers in the fields of tumor immunology and cancer immunotherapy, internists, residents, and medical school students in these disciplines.
Sets forth the state of the science and technology in plasma protein production With contributions from an international team of eighty leading experts and pioneers in the field, Production of Plasma Proteins for Therapeutic Use presents a comprehensive overview of the current state of knowledge about the function, use, and production of blood plasma proteins. In addition to details of the operational requirements for the production of plasma derivatives, the book describes the biology, development, research, manufacture, and clinical indications of essentially all plasma proteins with established clinical use or therapeutic potential. Production of Plasma Proteins for Therapeutic Use covers the key aspects of the plasma fractionation industry in five sections: Section 1: Introduction to Plasma Fractionation initially describes the history of transfusion and then covers the emergence of plasma collection and fractionation from its earliest days to the present time, with the commercial and not-for-profit sectors developing into a multi-billion dollar industry. Section 2: Plasma Proteins for Therapeutic Use contains 24 chapters dedicated to specific plasma proteins, including coagulation factors, albumin, immunoglobulin, and a comprehensive range of other plasma-derived proteins with therapeutic indications. Each chapter discusses the physiology, biochemistry, mechanism of action, and manufacture of each plasma protein including viral safety issues and clinical uses. Section 3: Pathogen Safety of Plasma Products examines issues and procedures for enhancing viral safety and reducing the risk of transmissible spongiform encephalopathy transmission. Section 4: The Pharmaceutical Environment Applied to Plasma Fractionation details the requirements and activities associated with plasma collection, quality assurance, compliance with regulatory requirements, provision of medical affairs support, and the manufacture of plasma products. Section 5: The Market for Plasma Products and the Economics of Fractionation reviews the commercial environment and economics of the plasma fractionation industry including future trends, highlighting regions such as Asia, which have the potential to exert a major influence on the plasma fractionation industry in the twenty-first century.
Optimality Theory in Phonology: A Reader is a collection of readings on this important new theory by leading figures in the field, including a lengthy excerpt from Prince and Smolensky’s never-before-published Optimality Theory: Constraint Interaction in Generative Grammar. Compiles the most important readings about Optimality Theory in phonology from some of the most prominent researchers in the field. Contains 33 excerpts spanning a range of topics in phonology and including many never-before-published papers. Includes a lengthy excerpt from Prince and Smolensky’s foundational 1993 manuscript Optimality Theory: Constraint Interaction in Generative Grammar. Includes introductory notes and study/research questions for each chapter.
The book focuses on the design, materials, process, fabrication, and reliability of advanced semiconductor packaging components and systems. Both principles and engineering practice have been addressed, with more weight placed on engineering practice. This is achieved by providing in-depth study on a number of major topics such as system-in-package, fan-in wafer/panel-level chip-scale packages, fan-out wafer/panel-level packaging, 2D, 2.1D, 2.3D, 2.5D, and 3D IC integration, chiplets packaging, chip-to-wafer bonding, wafer-to-wafer bonding, hybrid bonding, and dielectric materials for high speed and frequency. The book can benefit researchers, engineers, and graduate students in fields of electrical engineering, mechanical engineering, materials sciences, and industry engineering, etc.
More than half a century has passed since man first stood on the summit of Mount Everest, and the story of man's attempts to climb higher and higher unaided is one of the more colourful and exciting in medicine and physiology. The past few decades have seen an explosion in the interest in mountain pursuits in general, as increasing numbers of peopl
Cellular-molecular approach to evolution has led to radical changes in our understanding of biologic principles ranging from the Cell, to the Life Cycle, Development, Homeostasis, Senescence/Aging, Heterochrony, Pleiotropy, Phenotype, and perhaps the purpose of life itself. Much of this new way of thinking about biology and medicine emanates from experimental evidence for epigenetic inheritance. This leads one to question whether our unicellular state is the actual primary level of selection. One particular system that is now recognized as being under the auspices of epigenetic inheritance is the endocrine system, which is conventionally thought to regulate physiologic homeostasis. However, because the sex hormones play such a major role in behaviors related to the acquisition of epigenetic data, and the processing of such epigenetic data by the gonads during meiosis, their role in the evolution of the organism become tractable. The composite of the activities of the individual over the course of its lifetime can now be understood causally, resulting from the orchestration of its physiology by hormones, prenatally, postnatally and during the aging process, across the entire life span of the organism. Specific behaviors over the course of the life cycle during childhood, adolescence, puberty, adulthood and aging can now be understood mechanistically rather than merely as milestones in the various stages of life. With the above considerations in mind, this book presents the cellular-evolutionary perspective towards the relationship of the organism with its surroundings, human and non-human alike renders biology and medicine a continuum instead of fragmented, un-related anecdotes.
This book is written as an introductory textbook on Resistive Random Access Memory (ReRAM). ReRAM is a prominent emerging memory among other competing Non-Volatile Memories (NVM) seeking to replace flash memory. This book is based on the author's peer-reviewed research conducted at the Chair of Computer Architecture, FAU, Germany. Referring to his research and the most relevant research from the literature, the author presents the developments in this field concisely. The purpose is to clarify basic concepts and introduce the reader to ReRAM with an emphasis on circuit design. Hence, this book is written for university students considering a career in the semiconductor industry. Since the author's research was conducted in collaboration with a silicon foundry, hardware engineers will find this book practical and industry-relevant. Researchers in the field of In-Memory Computing will also benefit from this book since the NVM array is the basic substrate for such computing paradigms. This three-part book condenses the research and development of the last decade into eight chapters. In Part I, a good foundation is laid for understanding the individual device structure, its electrical characteristics, and modeling methodology. The different array configurations in which these memory devices are fabricated are also discussed. In Part II, the peripheral circuits -the CMOS circuits around the ReRAM array are discussed. They include sense amplifiers, programming circuits, and row/column access circuits. Recent developments such as the possibility to perform certain computing tasks in the ReRAM array are discussed in Part III.
An in-depth look at what microplastics are, how prevalent they are, and what can be done about them for a professional and academic audience. The first part of the book provides an overview of plastics types, how they are released to the environment, and how they interact with organisms. This part also provides a background for several salient aspects of microplastics hazards (e.g., attachment of toxic chemicals, toxicity to organisms). Special attention will be paid to how microplastics decompose in the environment (which is significant in terms of mobility of toxicity). Subsequent chapters address how to sample and identify microplastics. The second part of the book examines technologies for removal of microplastics from water, wastewater, and soil. Biological, chemical, and physical technologies are presented--technologies that can destroy minute plastics or convert them into benign products. Theory of operation, practical considerations, and possible environmental impacts of their use are discussed. Key aspects include: * technologies available for removal of microplastics from wastewater and surface water; * how various toxins which are sorbed to microplastics adversely affect wastewater treatment processes; * technologies at the pilot- and field stage for removal of microplastics from sediment; and * the distribution of microplastics in the atmosphere. Written by John Pichtel, author of the acclaimed Fundamentals of Site Remediation, and Mathew Simpson.
Interest in microarrays has increased considerably in the last ten years. This increase in the use of microarray technology has led to the need for good standards of microarray experimental notation, data representation, and the introduction of standard experimental controls, as well as standard data normalization and analysis techniques. Statistics for Microarrays: Design, Analysis and Inference is the first book that presents a coherent and systematic overview of statistical methods in all stages in the process of analysing microarray data – from getting good data to obtaining meaningful results. Provides an overview of statistics for microarrays, including experimental design, data preparation, image analysis, normalization, quality control, and statistical inference. Features many examples throughout using real data from microarray experiments. Computational techniques are integrated into the text. Takes a very practical approach, suitable for statistically-minded biologists. Supported by a Website featuring colour images, software, and data sets. Primarily aimed at statistically-minded biologists, bioinformaticians, biostatisticians, and computer scientists working with microarray data, the book is also suitable for postgraduate students of bioinformatics.
The book focuses on the design, materials, process, fabrication, and reliability of chiplet design and heterogeneous integraton packaging. Both principles and engineering practice have been addressed, with more weight placed on engineering practice. This is achieved by providing in-depth study on a number of major topics such as chip partitioning, chip splitting, multiple system and heterogeneous integration with TSV-interposers, multiple system and heterogeneous integration with TSV-less interposers, chiplets lateral communication, system-in-package, fan-out wafer/panel-level packaging, and various Cu-Cu hybrid bonding. The book can benefit researchers, engineers, and graduate students in fields of electrical engineering, mechanical engineering, materials sciences, and industry engineering, etc.
Structural phase transitions, mechanical deformations, and the embryonic stages of melting and crystallization are examples of phenomena that can now be imaged in unprecedented structural detail with high spatial resolution, and ten orders of magnitude as fast as hitherto. No monograph in existence attempts to cover the revolutionary dimensions that EM in its various modes of operation nowadays makes possible. The authors of this book chart these developments, and also compare the merits of coherent electron waves with those of synchrotron radiation. They judge it prudent to recall some important basic procedural and theoretical aspects of imaging and diffraction so that the reader may better comprehend the significance of the new vistas and applications now afoot. This book is not a vade mecum - numerous other texts are available for the practitioner for that purpose.
Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.
Progress in Heterocyclic Chemistry (PHC), Volume 28 is an annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year’s literature on heterocyclic chemistry and articles on new and developing topics of particular interest to heterocyclic chemists. The highlight chapters in Volume 28 are all written by leading researchers and constitute a systematic survey of the important original material reported in the literature of heterocyclic chemistry during 2015. Additional articles in this volume include Semi-conjugated Heteroaromatic Rings and beta-Lactam Chemistry. As with previous volumes in the series, Volume 28 will enable academic and industrial chemists, and advanced students, to keep abreast of developments in heterocyclic chemistry in a convenient way. Recognized as the premiere review of heterocyclic chemistry Includes contributions from leading researchers in the field Provides a systematic survey of the important 2015 heterocyclic chemistry literature Presents articles on new and developing topics of interest to heterocyclic chemists
2015 BMA Medical Book Awards Highly Commended in Oncology Category!The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts thoroughly explains the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Detailed descriptions of topics from molecular abnormalities in common cancers to new approaches for cancer therapy equip you to understand and apply the complexities of ongoing research in everyday clinical application. Effectively determine the course of malignancy and design appropriate treatment protocols by understanding the scientific underpinnings of cancer. Visually grasp and retain difficult concepts easily thanks to a user-friendly format with abundant full-color figures. Find critical information quickly with chapters following a logical sequence that moves from pathogenesis to therapy. Stay current with the latest discoveries in molecular and genomic research. Sweeping revisions throughout include eight brand-new chapters on: Tumor Suppressor Genes; Inflammation and Cancer; Cancer Systems Biology: The Future; Biomarkers Assessing Risk of Cancer; Understanding and Using Information About Cancer Genomes; The Technology of Analyzing Nucleic Acids in Cancer; Molecular Abnormalities in Kidney Cancer; and Molecular Pathology. Access the entire text and illustrations online, fully searchable, at Expert Consult.
This 2nd edition of the Practical Guide to Emergency Ultrasound addresses your need for a practical, comprehensive, how-to book on ultrasound techniques in the emergency department, including new and expanded applications. Organized in an easy-to-navigate problem-based and symptom-based approach, chapters cover many uses for ultrasound in the ED and proper ultrasound technique. Over 900 images, many in full color, illustrate key concepts and diagnoses, including the use of echocardiography in the ED and newer applications for imaging ocular, musculoskeletal injuries and the use of ultrasound in the management of undifferentiated hypotension and dyspnea.
Campbell’s Complete Casting Handbook: Metal Casting Processes, Techniques and Design, Second Edition provides an update to the first single-volume guide to cover modern principles and processes in such breadth and depth, while also retaining a clear, practical focus. The work has a unique viewpoint, interpreting the behavior of castings, and metals as a whole, in terms of their biofilm content, the largely invisible casting defects which control much of the structure and behavior of metals. This new edition includes new findings, many from John Campbell’s own research, on crack initiation, contact pouring, vortex gates, and the Cosworth Process. Delivers the expert advice that engineers need to make successful and profitable casting decisions Ideal reference for those interested in solidification, vortex gates, nucleation, biofilm, remelting, and molding Follows a logical, two-part structure that covers both casting metallurgy and casting manufacture Contains established, must-have information, such as Campbell’s ‘10 Rules’ for successful casting manufacture Includes numerous updates and revisions based on recent breakthroughs in the industry
Practical Management of Pediatric and Adult Brachial Plexus Palsies covers in-depth surgical techniques for managing disorders of this crucial nerve complex so that you can most effectively treat injuries in patients of any age. Drs. Kevin Chung, Lynda Yan, and John McGillicuddy present a multidisciplinary approach to pediatric brachial plexus injury treatment and rehabilitation, obstetric considerations, and other hot topics in the field. With access to the full text and surgical videos online at expertconsult.com, you’ll have the dynamic, visual guidance you need to manage injuries to the brachial plexus. Access the fully searchable text online at www.expertconsult.com, along with surgical videos demonstrating how to perform key procedures. See cases as they present in practice through color illustrations, photos, and diagrams that highlight key anatomical structures and relationships. Apply multidisciplinary best practices with advice from internationally respected authorities in neurosurgery, orthopaedics, plastic surgery, and other relevant fields. Hone your technique with coverage that emphasizes optimizing outcomes with pearls and discussions of common pitfalls. Prepare for collaborating with other physicians thanks to a multidisciplinary approach that covers medical and legal aspects in addition to surgery. Find information quickly and easily with a full-color layout.
A leading anthropologist studies the science behind "feeling at home" to show us how home made us human Home is where the heart is. Security, comfort, even love, are all feelings that are centered on the humble abode. But what if there is more to the feeling of being at home? Neuroanthropologist John S. Allen believes that the human habitat is one of the most important products of human cognitive, technological, and cultural evolution over the past two million years. In Home, Allen argues that to "feel at home" is more than just an expression, but reflects a deep-seated cognitive basis for the human desire to have, use, and enjoy a place of one's own. Allen addresses the very basic question: How did a place to sleep become a home? Within human evolution, he ranks house and home as a signature development of our species, as it emerged alongside cooperative hunting, language, and other critical aspects of humanity. Many animals burrow, making permanent home bases, but primates, generally speaking, do not: most wander, making nests at night wherever they might find themselves. This is often in home territory, but it isn't quite home. Our hominid ancestors were wanderers, too -- so how did we, over the past several million years, find our way home? To tell that story Allen will take us through evolutionary anthropology, neuroscience, the study of emotion, and modern sociology. He examines the home from the inside (of our heads) out: homes are built with our brains as much as with our hands and tools. Allen argues that the thing that may have been most critical in our evolution is not the physical aspect of a home, but developing a feeling of defining, creating, and being in a home, whatever its physical form. The result was an environment, relatively secure against whatever horrors lurked outside, that enabled the expensive but creative human mind to reach its full flowering. Today, with the threat of homelessness, child foster-care, and foreclosure, this idea of having a home is more powerful than ever. In a clear and accessible writing style, Allen sheds light on the deep, cognitive sources of the pleasures of having a home, the evolution of those behaviors, and why the deep reasons why they matter. Home is the story about how humans evolved to create a space not only for shelter, but also for nurturing creativity, innovation, and culture -- and why "feeling at home" is a fundamental aspect of the human condition.
This comprehensive text presents a critical discussion of the scopes and limitations of various organic synthetic methodologies that are available for performing asymmetric transformations. In addition to purely chemical methods, the book covers applications of new enzymes and other biological systems that are increasingly useful in asymmetric methodology.
The clinical management of patients with diabetes is rapidly evolving. Evidence-based Management of Diabetes provides a succinct summary of a range of topics, including areas where there is already well developed evidence for a particular treatment, but also those areas where the evidence is perhaps doubtful or there is some associated controversy or ambiguity. Where possible throughout the book treatment recommendations are given based on the available evidence and practice guidelines. The book also highlights the gaps in evidence where further research is needed. In the practice of diabetes care, there are many issues influencing practitoners currently. This book addresses many of the most pertinent issues concerning delivery of diabetes care. The authors are internationally renowned experts in the field of diabetes care who successfully and succinctly present state-of-the-art reviews based on the medical evidence designed to help the clinician be as best informed as possible in the care of patients with diabetes.
Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. Epigenetic modifications are manifest in all aspects of normal cellular differentiation and function, but they can also have damaging effects that result in pathologies such as cancer. Research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine. This book's primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin), and its distribution within a functionally compartmentalized nucleus. This architectural organization of the genome plays a major role in the subsequent retrieval, interpretation, and execution of both genetic and epigenetic information.
COVID-19 in Alzheimer’s Disease and Dementia crucially summarizes the current status of the coronavirus in patients suffering from these conditions, describing why they are a common cause of morbidity among those with COVID-19. The first section includes chapters that provide a general description of COVID-19, including SARS-CoV-2 structure, function, and biology, and its impact on the elderly with chronic conditions include hypertension, diabetes, obesity, kidney disease, respiratory illnesses, and infectious diseases. Also discussed are effects of the virus on the immune system. The second section shifts to the impact of COVID-19 on those with dementia or Alzheimer’s disease, with special emphasis on age, gender, ethnic background, and lifestyle. Bringing this focus on neurodegenerative disease in one comprehensive resource, this volume is an essential reference for neuroscientists, clinicians, biomedical scientists, and all others working or interested in the field. Discusses Alzheimer’s disease and dementia as morbidities for COVID-19 Describes SARS-CoV-2 structure, function, and biology Examines impact on elderly with chronic conditions including hypertension, diabetes, obesity, kidney disease, respiratory illnesses, and infectious diseases Covers the effect of race, gender, and sex as additional risk factors
Get expert insight and practical guidance to master the latest techniques, including minimally invasive techniques for instability, rotator cuff pathology, and arthritis. Now in a case-based format: each author describes the case, addresses alternative approaches and controversies, and offers evidence and experience to support the recommended approach.
This comprehensive textbook provides a modern, self-contained treatment for upper undergraduate and graduate level students. It emphasizes the links between structure, defects, bonding, and properties throughout, and provides an integrated treatment of a wide range of materials, including crystalline, amorphous, organic and nano- materials. Boxes on synthesis methods, characterization tools, and technological applications distil specific examples and support student understanding of materials and their design. The first six chapters cover the fundamentals of extended solids, while later chapters explore a specific property or class of material, building a coherent framework for students to master core concepts with confidence, and for instructors to easily tailor the coverage to fit their own single semester course. With mathematical details given only where they strengthen understanding, 400 original figures and over 330 problems for hands-on learning, this accessible textbook is ideal for courses in chemistry and materials science.
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