The techniques and methods that can be applied to materials characterization on the microscale are numerous and well-established. Divided into two parts, Characterization of Nanostructures provides thumbnail sketches of the most widely used techniques and methods that apply to nanostructures, and discusses typical applications to single nanoscale o
This issue devoted to Esophageal Function Testing highlights these tests that are complimentary to endoscopy and should be considered after endoscopy is performed. In fact, a prerequisite for performing many of these studies is a negative endoscopy and thus, the endoscopist should be well-informed regarding the indication and utility of these tests. Additionally, some of these newer technologies require endoscopy to be performed during the study as the placement or positioning of the measurement tool will require endoscopic landmarks or direct placement. There have been major advances in most of these older techniques, and new novel measurement paradigms have been created that allow for a more visual and accurate depiction of physiologic and anatomic data. These technologies have evolved to be more akin to an imaging technique and thus, the visual display and data acquisition is much more intuitive and easier to teach to trainees. This review would be of the utmost importance to readers of GI Endoscospy Clinics.
This book is written as an introductory textbook on Resistive Random Access Memory (ReRAM). ReRAM is a prominent emerging memory among other competing Non-Volatile Memories (NVM) seeking to replace flash memory. This book is based on the author's peer-reviewed research conducted at the Chair of Computer Architecture, FAU, Germany. Referring to his research and the most relevant research from the literature, the author presents the developments in this field concisely. The purpose is to clarify basic concepts and introduce the reader to ReRAM with an emphasis on circuit design. Hence, this book is written for university students considering a career in the semiconductor industry. Since the author's research was conducted in collaboration with a silicon foundry, hardware engineers will find this book practical and industry-relevant. Researchers in the field of In-Memory Computing will also benefit from this book since the NVM array is the basic substrate for such computing paradigms. This three-part book condenses the research and development of the last decade into eight chapters. In Part I, a good foundation is laid for understanding the individual device structure, its electrical characteristics, and modeling methodology. The different array configurations in which these memory devices are fabricated are also discussed. In Part II, the peripheral circuits -the CMOS circuits around the ReRAM array are discussed. They include sense amplifiers, programming circuits, and row/column access circuits. Recent developments such as the possibility to perform certain computing tasks in the ReRAM array are discussed in Part III.
Upper gastrointestinal bleeding is the leading emergency leading to hospitalization and urgent endoscopy. The field of gastrointestinal bleeding is rapidly evolving. The epidemiology is changing with more complex older patients on anticoagulant and antithrombotic agents presenting with upper gastrointestinal bleeding. The initial management has rapidly evolved with new transfusion thresholds, the use of risk stratification scores and no more nasogastric tubes. There is new data and recommendations on optimal timing of endoscopy. Medical therapies have also evolved with changes in proton pump inhibitor administration and the use of prokinetics to improve endoscopic visualization. Many modifications in endoscopic therapy have recently been advanced including the use of endoscopic ultrasound guided angiotherapy, topical sprays (i.e. Hemospray) and over-the-scope clips. In order to give optimal care to patients, it is critical that practicing gastroenterologists are aware of the many recent advances in management of patients with upper gastrointestinal bleeding.
Structural phase transitions, mechanical deformations, and the embryonic stages of melting and crystallization are examples of phenomena that can now be imaged in unprecedented structural detail with high spatial resolution, and ten orders of magnitude as fast as hitherto. No monograph in existence attempts to cover the revolutionary dimensions that EM in its various modes of operation nowadays makes possible. The authors of this book chart these developments, and also compare the merits of coherent electron waves with those of synchrotron radiation. They judge it prudent to recall some important basic procedural and theoretical aspects of imaging and diffraction so that the reader may better comprehend the significance of the new vistas and applications now afoot. This book is not a vade mecum - numerous other texts are available for the practitioner for that purpose.
This book provides readers with a broad view of the field of molecular dosimetry by discussing its origins, underlying concepts, the wide range of approaches to making the measurements and applications for the results. Specific topics include the direct assessment of human carcinogens and assessment of low level risks, molecular epidemiology, validation of molecular epidemiologic methods, quantitative analysis of DNA adducts, the application of fluorescence to analysis of genotoxicity, exposure control versus risk assessment, genetic testing in the workplace, and medical screening for carcinogenesis.
In a familial disorder that can cause psychosis that is comorbid with physical symptoms of various metabolic disorders, evidence is presented which indicates that the metabolic derangement in the disorder likely centers on the hypofunction of SAR1B mediated COP2 transport, and the consequential hyperfunction of SAR1B/COP2 autophagy. This metabolic derangement has significant links to five genetic locations, three of which were previously reported on in the disorder - 5q31.1, 17p11.2 and 17p13.1. It is noted that a complete or partial failure of the PI3K product PI3P, or of PI4KA dependent PI4P, to bind with SEC23IP, as part of the COP2 transport process, would be almost entirely consistent with and provide a complete explanation for the presentation of this familial disorder.
This book covers both the practical and theoretical aspects of catastrophe modelling for insurance industry practitioners and public policymakers. Written by authors with both academic and industry experience it also functions as an excellent graduate-level text and overview of the field. Ours is a time of unprecedented levels of risk from both natural and anthropogenic sources. Fortunately, it is also an era of relatively inexpensive technologies for use in assessing those risks. The demand from both commercial and public interests—including (re)insurers, NGOs, global disaster management agencies, and local authorities—for sophisticated catastrophe risk assessment tools has never been greater, and contemporary catastrophe modelling satisfies that demand. Combining the latest research with detailed coverage of state-of-the-art catastrophe modelling techniques and technologies, this book delivers the knowledge needed to use, interpret, and build catastrophe models, and provides greater insight into catastrophe modelling’s enormous potential and possible limitations. The first book containing the detailed, practical knowledge needed to support practitioners as effective catastrophe risk modellers and managers Includes hazard, vulnerability and financial material to provide the only independent, comprehensive overview of the subject, accessible to students and practitioners alike Demonstrates the relevance of catastrophe models within a practical, decision-making framework and illustrates their many applications Includes contributions from many of the top names in the field, globally, from industry, academia, and government Natural Catastrophe Risk Management and Modelling: A Practitioner’s Guide is an important working resource for catastrophe modelling analysts and developers, actuaries, underwriters, and those working in compliance or regulatory functions related to catastrophe risk. It is also valuable for scientists and engineers seeking to gain greater insight into catastrophe risk management and its applications.
The book focuses on the design, materials, process, fabrication, and reliability of chiplet design and heterogeneous integraton packaging. Both principles and engineering practice have been addressed, with more weight placed on engineering practice. This is achieved by providing in-depth study on a number of major topics such as chip partitioning, chip splitting, multiple system and heterogeneous integration with TSV-interposers, multiple system and heterogeneous integration with TSV-less interposers, chiplets lateral communication, system-in-package, fan-out wafer/panel-level packaging, and various Cu-Cu hybrid bonding. The book can benefit researchers, engineers, and graduate students in fields of electrical engineering, mechanical engineering, materials sciences, and industry engineering, etc.
This comprehensive guide to fan-out wafer-level packaging (FOWLP) technology compares FOWLP with flip chip and fan-in wafer-level packaging. It presents the current knowledge on these key enabling technologies for FOWLP, and discusses several packaging technologies for future trends. The Taiwan Semiconductor Manufacturing Company (TSMC) employed their InFO (integrated fan-out) technology in A10, the application processor for Apple’s iPhone, in 2016, generating great excitement about FOWLP technology throughout the semiconductor packaging community. For many practicing engineers and managers, as well as scientists and researchers, essential details of FOWLP – such as the temporary bonding and de-bonding of the carrier on a reconstituted wafer/panel, epoxy molding compound (EMC) dispensing, compression molding, Cu revealing, RDL fabrication, solder ball mounting, etc. – are not well understood. Intended to help readers learn the basics of problem-solving methods and understand the trade-offs inherent in making system-level decisions quickly, this book serves as a valuable reference guide for all those faced with the challenging problems created by the ever-increasing interest in FOWLP, helps to remove roadblocks, and accelerates the design, materials, process, and manufacturing development of key enabling technologies for FOWLP.
Now in its 6th edition, Cummings Otolaryngology remains the world's most detailed and trusted source for superb guidance on all facets of head and neck surgery. Completely updated with the latest minimally invasive procedures, new clinical photographs, and line drawings, this latest edition equips you to implement all the newest discoveries, techniques, and technologies that are shaping patient outcomes. Be certain with expert, dependable, accurate answers for every stage of your career from the most comprehensive, multi-disciplinary text in the field! Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Overcome virtually any clinical challenge with detailed, expert coverage of every area of head and neck surgery, authored by hundreds of leading luminaries in the field. Experience clinical scenarios with vivid clarity through a heavily illustrated, full-color format which includes approximately 3,200 images and over 40 high quality procedural videos. Get truly diverse perspectives and worldwide best practices from a multi-disciplinary team of contributors and editors comprised of the world’s leading experts. Glean all essential, up-to-date, need-to-know information. All chapters have been meticulously updated; several extensively revised with new images, references, and content. Stay at the forefront of your field with the most updated information on minimally-invasive surgical approaches to the entire skull base, vestibular implants and vestibular management involving intratympanic and physical therapy-based approaches, radiosurgical treatment of posterior fossa and skull base neoplasms, and intraoperative monitoring of cranial nerve and CNS function. Apply the latest treatment options in pediatric care with new chapters on pediatric sleep disorders, pediatric infectious disease, and evaluation and management of the infant airway. Find what you need faster through a streamlined format, reorganized chapters, and a color design that expedites reference. Manage many of the most common disorders with treatment options derived from their genetic basis. Assess real-world effectiveness and costs associated with emergent technologies and surgical approaches introduced to OHNS over the past 10 years. Incorporate recent findings about endoscopic, microscopic, laser, surgically-implantable, radiosurgical, neurophysiological monitoring, MR- and CT-imaging, and other timely topics that now define contemporary operative OHNS. Take it with you anywhere! With Expert Consult, you'll have access the full text, video clips, and more online, and as an eBook - at no additional cost!
Asia contains the bulk of the world's poor, as many as 500 million people. A significant fraction of these poor are chronically poor, which means that they and their families have been poor for years and will remain in poverty unless governmental policies are adopted which can lift them out of poverty.This book focuses on rural poverty and those countries in Asia with the largest number of chronically poor, including the two emerging superpowers of China and India, other countries of South Asia and the Mekong region as well as Indonesia and Philippines in Southeast Asia. Systematic analysis of who is poor, where they live, and why they are poor is carried out. Microeconomic, sector and macroeconomic policies which have been adopted to address this important social issue are also discussed. Through specific country analysis, the book outlines additional concrete measures that can be taken to reduce chronic poverty and improve the welfare of these people.
Heterogeneous integration uses packaging technology to integrate dissimilar chips, LED, MEMS, VCSEL, etc. from different fabless houses and with different functions and wafer sizes into a single system or subsystem. How are these dissimilar chips and optical components supposed to talk to each other? The answer is redistribution layers (RDLs). This book addresses the fabrication of RDLs for heterogeneous integrations, and especially focuses on RDLs on: A) organic substrates, B) silicon substrates (through-silicon via (TSV)-interposers), C) silicon substrates (bridges), D) fan-out substrates, and E) ASIC, memory, LED, MEMS, and VCSEL systems. The book offers a valuable asset for researchers, engineers, and graduate students in the fields of semiconductor packaging, materials sciences, mechanical engineering, electronic engineering, telecommunications, networking, etc.
Progress in Heterocyclic Chemistry (PHC), Volume 28 is an annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year’s literature on heterocyclic chemistry and articles on new and developing topics of particular interest to heterocyclic chemists. The highlight chapters in Volume 28 are all written by leading researchers and constitute a systematic survey of the important original material reported in the literature of heterocyclic chemistry during 2015. Additional articles in this volume include Semi-conjugated Heteroaromatic Rings and beta-Lactam Chemistry. As with previous volumes in the series, Volume 28 will enable academic and industrial chemists, and advanced students, to keep abreast of developments in heterocyclic chemistry in a convenient way. Recognized as the premiere review of heterocyclic chemistry Includes contributions from leading researchers in the field Provides a systematic survey of the important 2015 heterocyclic chemistry literature Presents articles on new and developing topics of interest to heterocyclic chemists
This book is the first comprehensive guide to logic-based Benders decomposition (LBBD), a general and versatile method for breaking large, complex optimization problems into components that are small enough for practical solution. The author introduces logic-based Benders decomposition for optimization, which substantially generalizes the classical Benders method. It can reduce solution times by orders of magnitude and allows decomposition to be applied to a much wider variety of optimization problems. On the theoretical side, this book provides a full account of inference duality concepts that underlie LBBD, as well as a description of how LBBD can be combined with stochastic and robust optimization, heuristic methods, and decision diagrams. It also clarifies the connection between LBBD and combinatorial Benders cuts for mixed integer programming. On the practical side, it explains how LBBD has been applied to a rapidly growing variety of problem domains. After describing basic theory, this book provides a comprehensive review of the rapidly growing literature that describes these applications, in each case explaining how LBBD is adapted to the problem at hand. In doing so this work provides a sourcebook of ideas for applying LBBD to new problems as they arise.
This book focuses on the assembly and reliability of lead-free solder joints. Both the principles and engineering practice are addressed, with more weight placed on the latter. This is achieved by providing in-depth studies on a number of major topics such as solder joints in conventional and advanced packaging components, commonly used lead-free materials, soldering processes, advanced specialty flux designs, characterization of lead-free solder joints, reliability testing and data analyses, design for reliability, and failure analyses for lead-free solder joints. Uniquely, the content not only addresses electronic manufacturing services (EMS) on the second-level interconnects, but also packaging assembly on the first-level interconnects and the semiconductor back-end on the 3D IC integration interconnects. Thus, the book offers an indispensable resource for the complete food chain of electronics products.
The book focuses on the design, materials, process, fabrication, and reliability of advanced semiconductor packaging components and systems. Both principles and engineering practice have been addressed, with more weight placed on engineering practice. This is achieved by providing in-depth study on a number of major topics such as system-in-package, fan-in wafer/panel-level chip-scale packages, fan-out wafer/panel-level packaging, 2D, 2.1D, 2.3D, 2.5D, and 3D IC integration, chiplets packaging, chip-to-wafer bonding, wafer-to-wafer bonding, hybrid bonding, and dielectric materials for high speed and frequency. The book can benefit researchers, engineers, and graduate students in fields of electrical engineering, mechanical engineering, materials sciences, and industry engineering, etc.
This second edition textbook offers an expanded conceptual synthesis of microbial ecology with plant and animal ecology. Drawing on examples from the biology of microorganisms and macroorganisms, this textbook provides a much-needed interdisciplinary approach to ecology. The focus is the individual organism and comparisons are made along six axes: genetic variation, nutritional mode, size, growth, life cycle, and influence of the environment. When it was published in 1991, the first edition of Comparative Ecology of Microorganisms and Macroorganisms was unique in its attempt to clearly compare fundamental ecology across the gamut of size. The explosion of molecular biology and the application of its techniques to microbiology and organismal biology have particularly demonstrated the need for interdisciplinary understanding. This updated and expanded edition remains unique. It treats the same topics at greater depth and includes an exhaustive compilation of both the most recent relevant literature in microbial ecology and plant/animal ecology, as well as the early research papers that shaped the concepts and theories discussed. Among the completely updated topics in the book are phylogenetic systematics, search algorithms and optimal foraging theory, comparative metabolism, the origins of life and evolution of multicellularity, and the evolution of life cycles. From Reviews of the First Edition: "John Andrews has succeeded admirably in building a bridge that is accessible to all ecologists." -Ecology "I recommend this book to all ecologists. It is a thoughtful attempt to integrate ideas from, and develop common themes for, two fields of ecology that should not have become fragmented." -American Scientist "Such a synthesis is long past due, and it is shameful that ecologists (both big and little) have been so parochial." -The Quarterly Review of Biology
The new edition of Electrophysiological Disorders of the Heart helps you diagnose and treat a full range of heart rhythm disorders using today’s latest technologies and therapies. It provides practical, hands-on coverage of hot topics such as pediatric EP, imaging, echocardiography-guided EP procedures, regenerative therapies, cardiac pacing, and more. Now available in a new full-color format, the title also includes easy online access at www.expertconsult.com. Discover new ways to treat and manage the full range of heart rhythm disorders with content focused on common clinical features, diagnosis, and management. Review expert management strategies to help you handle complex patient problems. Stay current with the latest molecular and technical advances as well as new treatment options implemented over the last few years. Use the latest technologies and devices to accurately diagnose and manage heart rhythm disorders. Consult new and expanded coverage of regenerative therapies, echo-guided procedures, cardiac pacing, and CRT, as well as a new section on pediatric electrophysiology and imaging. Enjoy improved visual guidance with many new full-color images. Log on to www.expertconsult.com to easily search the complete contents online and access a downloadable image library.
Western drugs and target medicines for disease treatment come with undesirable side effects that have limited their use in patients for an extended period of time. It is warranted to develop a treatment strategy with alternative medicines to reduce toxicity relating to drugs, in particular, cancer drugs. Thus, a combination therapy with herbal medicines provides a more effective treatment method for hard-to-treat diseases. The recent breakthroughs in naturally occurring small molecules from herbal medicines have provided experimental evidence and are clinically significant in treatment strategies.This unique volume presents the recent developments in the field of herbal medicines for the treatment of diseases and cancer. Recent progress on small molecules isolated from herbal medicines that exhibit therapeutic benefits in humans is highlighted. The book provides an overview of the significant discoveries and pioneering contributions of herbal medicines in combination with other drugs; the author's evaluation of the combination therapy in cancer treatment; and a recent discovery of crocodile tissue extract with pharmacological properties.
Rather than claim that there exists a common concept of globalization that all parties can agree to, this book seeks to examine some of the conceptions and the way in which they render different interpretations of particular aspects of globalization. The last two decades have witnessed an explosive proliferation of academic writings on the subject of globalization, which has been accompanied by a high level of interest in the media and widespread usage of the term. This has inevitably resulted in the meaning of the concept broadening to include a whole host of issues, running the attendant risk of losing any conceptual focus it had. John Glenn examines five issue areas affected by globalization: the economy sovereignty civil society governance communication. In so doing, the book aims to articulate certain questions within each area, which will allow for some judgment to be made concerning the differing perspectives on globalization. Globalization will be of interest to students of international political economy and politics and international relations in general.
Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.
Describes new modification methods and applications for natural, synthetic, thermoplastic, and thermoset polymers that result from economic forces, commercial processes, and the latest research and development. Features chemical and physical technologies such as sulfonation, alkylation, acid/base hydrolysis, hydrogenation, stress orienting, anneal
Written for students studying intercultural communication for the first time, this textbook gives a thorough introduction to inter- and cross-cultural concepts with a focus on practical application and social action. Provides a thorough introduction to inter- and cross-cultural concepts for beginning students with a focus on practical application and social action Defines “communication” broadly using authors from a variety of sub disciplines and incorporating scientific, humanistic, and critical theory Constructs a complex version of culture using examples from around the world that represent a variety of differences, including age, sex, race, religion, and sexual orientation Promotes civic engagement with cues toward individual intercultural effectiveness and giving back to the community in socially relevant ways Weaves pedagogy throughout the text with student-centered examples, text boxes, applications, critical thinking questions, a glossary of key terms, and online resources for students and instructors Online resources for students and instructors available upon publication at www.wiley.com/go/baldwin
Our Internet-connected society increasingly relies on computers. As a result, attacks on computers from malicious software have never been a bigger concern. Computer Viruses and Malware draws together hundreds of sources to provide an unprecedented view of malicious software and its countermeasures. This book discusses both the technical and human factors involved in computer viruses, worms, and anti-virus software. It also looks at the application of malicious software to computer crime and information warfare. Computer Viruses and Malware is designed for a professional audience composed of researchers and practitioners in industry. This book is also suitable as a secondary text for advanced-level students in computer science.
NEW! Updated content reflects the latest changes in the industry. NEW! Two new chapters include Crisis Resource Management and Patient Safety and Infection Control and Prevention.
John Meurig Thomas is a former Director of the Royal Institution of Great Britain, a former head of the Department of Physical Chemistry and former Master of Peterhouse, University of Cambridge. A world-renowned solid-state, materials and surface chemist, he has been an educator, researcher, academic administrator, author of university texts, government advisor, industrial consultant and trustee of national museums in a career spanning over 50 years. Recipient of many international awards, including the Linus Pauling, Willard–Gibbs, Kapitza, Natta, Stokes, Davy and Faraday medals, he is also a fellow of the Royal Society (1977), of the American Philosophical Society (1993) and of ten other national academies. He is best known for his fundamental work in heterogeneous catalysis, chemical electron microscopy and in the popularisation of science, for which, in conjunction with his services to chemistry, he was knighted (1991). He is also founding editor of three scientific journals and editor or co-editor of some 30 monographs. A new mineral, meurigite, was named in his honour (1995). Most recently in 2016, Sir John was awarded the Royal Medal for Physical Sciences by the Royal Society. Drawn from over 1200 publications, this volume contains a summarised account of Sir John's work, with a selection of the new techniques pioneered and discovered by him and his colleagues. Also included are popular science articles, and various illustrations of techniques which have enhanced our knowledge of many facets of condensed matter science. Contributions from 80 peers, colleagues, former co-workers, students and friends worldwide who have interacted with or been influenced by him are a tribute to the professional and personal life of Sir John, making this book a unique reflective summary of the work of one of the greatest achievers in modern British physical science.
Collecting an extensive amount of information from thousands of publications by leading investigators in this rapidly developing field, this book provides a convenient and up-to-date one volume source for research in neural tumors of various cellular origins. With over 3,500 references, 110 figures and 120 tables, this volume gathers an astonishing body of knowledge regarding human neural tumors. This book is the first of its kind, encyclopedic and wide-ranging.
Easily accessible and clinically focused, Abeloff's Clinical Oncology, 6th Edition, covers recent advances in our understanding of the pathophysiology of cancer, cellular and molecular causes of cancer initiation and progression, new and emerging therapies, current trials, and much more. Masterfully authored by an international team of leading cancer experts, it offers clear, practical coverage of everything from basic science to multidisciplinary collaboration on diagnosis, staging, treatment and follow up. Includes new chapters on Cancer Metabolism and Clinical Trial Designs in Oncology and a standalone chapter on lifestyles and cancer prevention. Features extensive updates including the latest clinical practice guidelines, decision-making algorithms, and clinical trial implications, as well as new content on precision medicine, genetics, and PET/CT imaging. Includes revised diagnostic and treatment protocols for medical management, surgical considerations, and radiation oncology therapies, stressing a multispecialty, integrated approach to care. Helps you find information quickly with updated indexing related to management recommendations, focused fact summaries, updated key points at the beginning of each chapter ideal for quick reference and board review, and algorithms for patient evaluation, diagnosis, and treatment options. Offers more patient care coverage in disease chapters, plus new information on cancer as a chronic illness and cancer survivorship. Discusses today’s key topics such as immuno-oncology, functional imaging, precision medicine, the application of genetics in pathologic diagnosis and sub-categorization of tumors as well as the association of chronic infectious diseases such as HIV and cancer.
This book describes the emerging point-of-care (POC) technologies that are paving the way to the next generation healthcare monitoring and management. It provides the readers with comprehensive, up-to-date information about the emerging technologies, such as smartphone-based mobile healthcare technologies, smart devices, commercial personalized POC technologies, paper-based immunoassays (IAs), lab-on-a-chip (LOC)-based IAs, and multiplex IAs. The book also provides guided insights into the POC diabetes management software and smart applications, and the statistical determination of various bioanalytical parameters. Additionally, the authors discuss the future trends in POC technologies and personalized and integrated healthcare solutions for chronic diseases, such as diabetes, stress, obesity, and cardiovascular disorders. Each POC technology is described comprehensively and analyzed critically with its characteristic features, bioanalytical principles, applications, advantages, limitations, and future trends. This book would be a very useful resource and teaching aid for professionals working in the field of POC technologies, in vitro diagnostics (IVD), mobile healthcare, Big Data, smart technology, software, smart applications, biomedical engineering, biosensors, personalized healthcare, and other disciplines.
Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. Epigenetic modifications are manifest in all aspects of normal cellular differentiation and function, but they can also have damaging effects that result in pathologies such as cancer. Research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine. This book's primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin), and its distribution within a functionally compartmentalized nucleus. This architectural organization of the genome plays a major role in the subsequent retrieval, interpretation, and execution of both genetic and epigenetic information.
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.