The management of multiple sclerosis (MS) is changing at a rapid rate, with the emergence of a host of new therapeutic interventions in various stages of development. Despite the enthusiasm with which the pharmaceutical industry is hailing these interventions, there remains a need for people involved in the management of MS to be circumspect regarding the true evidence base behind these treatments, particularly when considering prevention of sustained disability and the meaning of change to individuals with MS. MS remains a fundamentally unpredictable condition, which should be managed in the context of an experienced multidisciplinary team. Whilst it may be possible to “personalize” treatment in the future, especially if we can learn more from pharmacogenomics and genome screens, issues of balancing risk against potential benefit of drugs for individual patients are difficult to deal with. The goals of preventing progress from early MS to secondary progression, and making any impact on progressive disease, remain elusive.
Upon his retirement from active service as a Justice of the Supreme Court of Virginia in 2011, Justice Koontz had completed more than four decades of service to citizens of the Commonwealth of Virginia. In order to recognize that service and help preserve Justice Koontz's legacy as one of the outstanding jurists in Virginia and the United States, the Salem/Roanoke County Bar Association instituted this project to collect all of Justice Koontz's published opinions, both from his tenure as a Justice of the Supreme Court and as an inaugural member of the Court of Appeals of Virginia. The second volume to be produced by the Opinions Project includes opinions, concurrences and dissents authored by Justice Koontz during the majority of his second four-year term as Chief Judge of the Court of Appeals. This volume includes the opinions addressing the contempt citations brought against the United Mine Workers during the 1989-1990 Pittston Coal Strike.
Upon his retirement from active service as a Justice of the Supreme Court of Virginia in 2011, Justice Koontz had completed more than four decades of service to citizens of the Commonwealth of Virginia. In order to recognize that service and help preserve Justice Koontz's legacy as one of the outstanding jurists in Virginia and the United States, the Salem/Roanoke County Bar Association instituted this project to collect all of Justice Koontz's published opinions, both from his tenure as a Justice of the Supreme Court and as an inaugural member of the Court of Appeals of Virginia. This volume is dedicated to the memory of Judge Bernard G. Barrow, one of the "gang of ten" original members of the Court of Appeals. In January 1995, Judge Barrow announced his intention to retire from the Court in June of that year. Sadly, just over two month before his retirement would be come effective, Judge Barrow suffered a fatal seizure and died on March 21, 1995.
The Hematology: Diagnosis and Treatment eBook is the ideal mobile resource in hematology! It distills the most essential, practical information from Hematology: Basic Principles and Practice, 6th Edition - the comprehensive masterwork by Drs. Hoffman, Benz, Silberstein, Heslop, Weitz, and Anastasi - into a concise, clinically focused resource that's optimized for reference on any e-reader. Focusing on the dependable, state-of-the-art clinical strategies you need to optimally diagnose and manage the full range of blood diseases and disorders, this eBook is a must-have for every hematologist's mobile device! Apply the latest know-how on heparin-induced thrombocytopenia, stroke, acute coronary syndromes, hematologic manifestations of liver disease, hematologic manifestations of cancer, hematology in aging, and many other hot topics. Get quick, focused answers on the diagnosis and management of blood diseases - in a portable digital format that you can carry and consult anytime, anywhere. View abundant images that mirror the pivotal role hematopathology plays in the practice of modern hematology. Count on all the authority that has made Hematology: Basic Principles and Practice, 6th Edition, edited by Drs. Hoffman, Benz, Silberstein, Heslop, Weitz, and Anastasi, the go-to clinical reference for hematologists worldwide. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices.
Hematology, 6th Edition encompasses all of the latest scientific knowledge and clinical solutions in the field, equipping you with the expert answers you need to offer your patients the best possible outcomes. Ronald Hoffman, MD, Edward J. Benz, Jr., MD, Leslie E. Silberstein, MD, Helen Heslop, MD, Jeffrey Weitz, MD, John Anastasi, MD, and a host of world-class contributors present the expert, evidence-based guidance you need to make optimal use of the newest diagnostic and therapeutic options. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Make confident, effective clinical decisions by consulting the world's most trusted hematology reference. Access the complete contents online at www.expertconsult.com, with a downloadable image collection, regular updates, case studies, patient information sheets, and more. Apply all the latest knowledge on regulation of gene expression, transcription splicing, and RNA metabolism; pediatric transfusion therapy; principles of cell-based gene therapy; allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia and myelodysplastic syndrome in adults; hematology in aging; and much more, thanks to 27 brand-new chapters plus sweeping updates throughout. Find the information you need quickly and easily thanks to a completely reworked organization that better reflects today’s clinical practice. Visualize clinical problems more clearly with new and updated images that reflect the pivotal role of hematopathology in modern practice. Benefit from the experience and fresh perspective of new editor Dr. Jeffrey Weitz, Professor of Medicine at McMaster University School of Medicine and Executive Director of the Thrombosis and Atherosclerosis Research Institute in Ontario.
This monograph focuses upon the role Theodore de Bèze played in the gradual transformation of Calvin's biblically oriented theology into a new type of scholasticism, in which Predestination became the keystone.
Dr. John Kellum has assembled an essential update on the topic of Nephrology as it relates to Critical Care Medicine. Articles include: Diagnostic criteria, Biomarkers for AKI, Sepsis-induced AKI,Drug-induced AKI, Cardio-renal syndrome,Surgery Associated AKI,Contrast-induced AKI, Principles of Fluid Therapy,Fluid composition and clinical effects, Renal replacement therapy, and Understanding acid-base.
For more than half a century, this book has been a fixture in architecture and construction firms the world over. Twice awarded the AIA's Citation for Excellence in International Architecture Book Publishing, Mechanical and Electrical Equipment for Buildings is recognized for its comprehensiveness, clarity of presentation, and timely coverage of new design trends and technologies. Addressing mechanical and electrical systems for buildings of all sizes, it provides design guidelines and detailed design procedures for each topic covered. Thoroughly updated to cover the latest technologies, new and emerging design trends, and relevant codes, this latest edition features more than 2,200 illustrations--200 new to this edition--and a companion Website with additional resources.
This absorbing study of the first phase of World War II tells not only how events happened but why. Eminent historian Lukacs presents an extraordinary narrative of these two years, followed by a detailed sequential analysis of the political, military, and intellectual relations and events.
The investigation of union with Christ and justification has been dominated by the figure of John Calvin. Calvin's influence, however, has been exaggerated in our own day. Theologians within the Early Modern Reformed tradition contributed to the development of these doctrines and did not view Calvin as the normative theologian of the tradition. John V. Fesko, therefore, goes beyond Calvin and explores union with Christ and justification in the Reformation, Early Orthodox, and High Orthodox periods of the Reformed tradition and covers lesser known but equally important figures such as Juan de Valdes, Peter Martyr Vermigli, Girolamo Zanchi, William Perkins, John Owen, Francis Turretin, and Herman Witsius. The study also covers theologians that either lie outside or transgress the Reformed tradition, such as Martin Luther, Philip Melanchthon, Faustus Socinus, Jacob Arminius, and Richard Baxter. By treating this diverse body of figures the study reveals areas of agreement and diversity on these two doctrines. The author demonstrates that among the diverse formulations, all surveyed Reformed theologians accord justification priority over sanctification within the broader rubric of union with Christ. Fesko shows that Reformed theologians affirm both union with Christ and the golden chain of salvation, ideas that moderns find incompatible. In sum, rather than reading an individual theologian isolated from his context, this study provides a contextual reading of union with Christ and justification in the Early Modern Reformed context.
Peripheral neuropathies represent a challenging subject for most physicians. This is an up-to-date, comprehensive, and readable book on peripheral neuropathies that includes concise information on the clinical, electrophysiological, pathological, pathogenic, and treatment aspects of the most important disorders. New molecular and serologic diagnostic tests are discussed. Sections are devoted to nerve and skin biopsy techniques and findings, quantitative sensory and autonomic reflex tests. Case examples are used liberally throughout the text. The editors: Mendell, Kissel, and Cornblath are experienced clinicians that bring complementary knowledge to each of the subjects. Additional authors have been handpicked for specific topics which add to the value of the edition.
Unlike other textbooks on this subject, which are more focused on end of life, the 4th edition of Principles and Practice of Palliative Care and Supportive Oncology focuses on supportive oncology. In fact, the goal of this textbook is to provide a source of both help and inspiration to all those who care for patients with cancer. Written in a more reader-friendly format, this textbook not only offers authoritative and up-to-date reviews of research and clinical care best practices, but also practical clinical applications to help readers put everything they learn to use.
With unique features for maximum clarity and convenience, this newly expanded edition of a respected classic offers students, teachers, and scholars alike an updated reference to the Latin language—both written and oral—that is unsurpassed in affordability, dependability, and ease of use.
For over 60 years, residents and practicing pathologists have turned to Rosai and Ackerman's Surgical Pathology for definitive guidance on every aspect of the field, delivered in a readable, easy-to-digest, and engaging manner. In the 11th Edition, a dynamic new author team ensures that this classic text retains its signature anecdotal style, while revising the content to bring you fully up to date. Widely used for board exam preparation, as well as for everyday reference in practice, this leading resource equips you to effectively and efficiently diagnose the complete range of neoplastic and non-neoplastic entities. - Provides comprehensive coverage of the clinical presentation, gross and microscopic features, ultrastructural and immunohistochemical findings, prognosis, and therapy for virtually every pathologic lesion. - Presents content now grouped in sections corresponding to organs and systems, making disease entities easier to locate. - Includes state-of-the-art coverage of the latest disease classifications, molecular biology and pathology, immunohistochemistry, genetics, prognostic/predictive markers, and more – all highlighted by more than 3,000 full-color illustrations of commonly seen pathologies. - Showcases the knowledge and expertise of an innovative new author team: prolific author John R. Goldblum, MD (GI pathology, soft tissue tumors); Laura Lamps, MD (hepatobiliary, endocrine tumors, infectious disease); Jesse McKenney, MD (GU/GYN, soft tissue tumors); and Jeff Myers, MD (pulmonary, pleural, mediastinum); accompanied by a select list of subspecialty contributors. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.
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